CN113215115B - 用于体外病毒基因组工程的组合物和方法 - Google Patents
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| PCT/US2015/065891 WO2016100389A1 (en) | 2014-12-16 | 2015-12-15 | Compositions of and methods for in vitro viral genome engineering |
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| JP5548121B2 (ja) | 2007-05-14 | 2014-07-16 | リサーチ ファウンデーション オブ ステイト ユニバーシティ オブ ニューヨーク | バイオフィルム中の細菌細胞における生理学的分散応答の誘導 |
| US10323236B2 (en) | 2011-07-22 | 2019-06-18 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| US9163284B2 (en) | 2013-08-09 | 2015-10-20 | President And Fellows Of Harvard College | Methods for identifying a target site of a Cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| US9228207B2 (en) | 2013-09-06 | 2016-01-05 | President And Fellows Of Harvard College | Switchable gRNAs comprising aptamers |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| US20150165054A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting caspase-9 point mutations |
| ES2781323T3 (es) | 2014-06-23 | 2020-09-01 | Regeneron Pharma | Montaje de ADN mediado por nucleasas |
| US10077453B2 (en) | 2014-07-30 | 2018-09-18 | President And Fellows Of Harvard College | CAS9 proteins including ligand-dependent inteins |
| CN113215115B (zh) | 2014-12-16 | 2024-07-02 | C3J治疗公司 | 用于体外病毒基因组工程的组合物和方法 |
| US20160362667A1 (en) * | 2015-06-10 | 2016-12-15 | Caribou Biosciences, Inc. | CRISPR-Cas Compositions and Methods |
| US10513732B2 (en) * | 2015-07-13 | 2019-12-24 | New York University | Sequencing methods and kits |
| IL310721B2 (en) | 2015-10-23 | 2025-11-01 | Harvard College | Nucleobase editors and uses thereof |
| US11433260B2 (en) | 2015-12-21 | 2022-09-06 | Gholam A. Peyman | Cancer treatment methods using thermotherapy and/or enhanced immunotherapy |
| US10136820B2 (en) * | 2015-12-21 | 2018-11-27 | Gholam A. Peyman | Method to visualize very early stage neoplasm or other lesions |
| WO2017172645A2 (en) * | 2016-03-28 | 2017-10-05 | The Charles Stark Draper Laboratory, Inc. | Bacteriophage engineering methods |
| CN110214183A (zh) | 2016-08-03 | 2019-09-06 | 哈佛大学的校长及成员们 | 腺苷核碱基编辑器及其用途 |
| WO2018031683A1 (en) | 2016-08-09 | 2018-02-15 | President And Fellows Of Harvard College | Programmable cas9-recombinase fusion proteins and uses thereof |
| US11542509B2 (en) | 2016-08-24 | 2023-01-03 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| DK3503915T5 (da) | 2016-08-26 | 2024-09-02 | Telesis Bio Inc | Genetisk modificerede Vibro natriegen |
| KR102622411B1 (ko) | 2016-10-14 | 2024-01-10 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵염기 에디터의 aav 전달 |
| WO2018071841A1 (en) * | 2016-10-14 | 2018-04-19 | The Forsyth Institute | Compositions and methods for evading bacterial defense mechanisms |
| WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| WO2018148410A1 (en) * | 2017-02-09 | 2018-08-16 | The Charles Stark Draper Laboratory Inc. | Bacteriophage recombination followed by blockage of nonrecombinant bacteriophage replication |
| EP3592846A1 (en) | 2017-03-06 | 2020-01-15 | Massachusetts Institute of Technology | Methods of cloning prophages and producing lytic phage particles |
| EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
| US12390514B2 (en) | 2017-03-09 | 2025-08-19 | President And Fellows Of Harvard College | Cancer vaccine |
| US11542496B2 (en) | 2017-03-10 | 2023-01-03 | President And Fellows Of Harvard College | Cytosine to guanine base editor |
| KR20240116572A (ko) | 2017-03-23 | 2024-07-29 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵산 프로그램가능한 dna 결합 단백질을 포함하는 핵염기 편집제 |
| US11560566B2 (en) | 2017-05-12 | 2023-01-24 | President And Fellows Of Harvard College | Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation |
| US11535843B2 (en) | 2017-06-01 | 2022-12-27 | The Charles Stark Draper Laboratory, Inc. | Phage engineering: protection by circularized intermediate |
| CN111801345A (zh) | 2017-07-28 | 2020-10-20 | 哈佛大学的校长及成员们 | 使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物 |
| US10174295B1 (en) * | 2017-08-01 | 2019-01-08 | The Charles Stark Draper Laboratory, Inc. | Composition of matter: engineering of Escherichia coli phage K1E |
| US11891630B2 (en) | 2017-08-08 | 2024-02-06 | The Charles Stark Draper Laboratory, Inc. | Bacteriophage engineering via semi-synthesis |
| EP3676376B1 (en) | 2017-08-30 | 2025-01-15 | President and Fellows of Harvard College | High efficiency base editors comprising gam |
| KR20250107288A (ko) | 2017-10-16 | 2025-07-11 | 더 브로드 인스티튜트, 인코퍼레이티드 | 아데노신 염기 편집제의 용도 |
| US12406749B2 (en) | 2017-12-15 | 2025-09-02 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| JP6923862B2 (ja) * | 2018-05-22 | 2021-08-25 | 学校法人自治医科大学 | 抗菌ファージ、治療用組成物、殺菌剤、食品、細菌判別キット、治療用組成物製造方法、細菌除去方法、細菌判別方法、及び動物治療方法 |
| US12157760B2 (en) | 2018-05-23 | 2024-12-03 | The Broad Institute, Inc. | Base editors and uses thereof |
| US11541105B2 (en) | 2018-06-01 | 2023-01-03 | The Research Foundation For The State University Of New York | Compositions and methods for disrupting biofilm formation and maintenance |
| US12522807B2 (en) | 2018-07-09 | 2026-01-13 | The Broad Institute, Inc. | RNA programmable epigenetic RNA modifiers and uses thereof |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| WO2020092748A1 (en) * | 2018-11-01 | 2020-05-07 | The Trustees Of Princeton University | System for protein inactivation and recombinant phages for targeted bacterial killing, infection, biodetection, and as a means of protein extraction |
| WO2020109339A1 (en) * | 2018-11-27 | 2020-06-04 | Eligo Bioscience | Chimeric receptor binding proteins for use in bacterial delivery vehicles |
| KR20210107053A (ko) * | 2018-12-21 | 2021-08-31 | 엘리고 바이오사이언스 | 박테리아 전달 비히클에서 사용을 위한 분지형 수용체 결합 다수-서브유닛 단백질 복합체 |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| CA3128507A1 (en) | 2019-02-06 | 2020-08-13 | Fred Hutchinson Cancer Research Center | Minicircle producing bacteria engineered to differentially methylate nucleic acid molecules therein |
| WO2020191233A1 (en) | 2019-03-19 | 2020-09-24 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
| RU2771374C1 (ru) | 2019-04-04 | 2022-05-04 | Редженерон Фармасьютикалс, Инк. | Способы для бесшовного внесения целевых модификаций в направленные векторы |
| US12473543B2 (en) | 2019-04-17 | 2025-11-18 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| IL297761A (en) | 2020-05-08 | 2022-12-01 | Broad Inst Inc | Methods and compositions for simultaneously editing two helices of a designated double-helix nucleotide sequence |
| CN114540389B (zh) * | 2020-11-26 | 2024-05-14 | 深圳华大生命科学研究院 | 一种制备基因工程病毒的方法及其应用 |
| CN112778399A (zh) * | 2021-01-21 | 2021-05-11 | 南开大学 | 一类源自毒性淀粉样纤维纳米抗菌肽的制备及性质表征方法 |
| JP2022117439A (ja) * | 2021-01-29 | 2022-08-10 | 学校法人立教学院 | インビトロパッケージングを用いた多断片ｄｎａの連結および細胞内導入方法 |
| WO2022251644A1 (en) | 2021-05-28 | 2022-12-01 | Lyell Immunopharma, Inc. | Nr4a3-deficient immune cells and uses thereof |
| EP4347826A1 (en) | 2021-06-02 | 2024-04-10 | Lyell Immunopharma, Inc. | Nr4a3-deficient immune cells and uses thereof |
| AU2022323171A1 (en) * | 2021-08-02 | 2024-03-07 | Armata Pharmaceuticals, Inc. | Bacteriophages with improved antimicrobial activity |
| CN113755451B (zh) * | 2021-09-03 | 2023-06-06 | 广西大学 | 一株大肠杆菌噬菌体gn6及其应用 |
| EP4248987A1 (en) * | 2022-03-21 | 2023-09-27 | Nomad Bioscience GmbH | Chimeric bacteriocins and method for the control of pseudomonas |
| JP2025516823A (ja) | 2022-05-19 | 2025-05-30 | ライエル・イミュノファーマ・インコーポレイテッド | Ｎｒ４ａ３を標的とするポリヌクレオチド及びその使用 |
| WO2024064952A1 (en) | 2022-09-23 | 2024-03-28 | Lyell Immunopharma, Inc. | Methods for culturing nr4a-deficient cells overexpressing c-jun |
| WO2024064958A1 (en) | 2022-09-23 | 2024-03-28 | Lyell Immunopharma, Inc. | Methods for culturing nr4a-deficient cells |
| WO2024077174A1 (en) | 2022-10-05 | 2024-04-11 | Lyell Immunopharma, Inc. | Methods for culturing nr4a-deficient cells |
| WO2025208072A1 (en) * | 2024-03-29 | 2025-10-02 | The General Hospital Corporation | Methods and materials for treating disorders related to bacterial infections |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006137847A2 (en) * | 2004-09-13 | 2006-12-28 | Trustees Of Boston University | Engineered enzymatically active bacteriophages and methods of uses thereof |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5877279A (en) * | 1994-10-13 | 1999-03-02 | Nanoframes, Llc | Materials for the production of nanometer structures and use thereof |
| EP1030861A4 (en) * | 1997-10-31 | 2001-09-05 | Maxygen Inc | MODIFICATION OF VIRUSTROPISMIUS AND THE ECONOMIC SPECTRUM BY VIRAL GENOM MIXING |
| GB9803351D0 (en) * | 1998-02-17 | 1998-04-15 | Oxford Biomedica Ltd | Anti-viral vectors |
| GB9809414D0 (en) * | 1998-05-02 | 1998-07-01 | Scottish Crop Research Inst | Method |
| US7019122B1 (en) | 1998-10-30 | 2006-03-28 | Janssen Pharmaceutica N.V. | Unusual retrotransposon from the yeast Candida albicans |
| ES2252263T3 (es) * | 2000-07-25 | 2006-05-16 | The Government Of The Usa, As Represented By The Secretary, Department Of Health And Human Services | Bacteriofago que tiene una gama de hospedadores multiple. |
| WO2006021944A1 (en) | 2004-08-12 | 2006-03-02 | Leanway Automatic Areanas Ltd. | Enhanced database structure configuration |
| JP5136766B2 (ja) * | 2004-12-15 | 2013-02-06 | ユニバーシティ オブ ノース カロライナ アット チャペル ヒル | キメラベクター |
| WO2007005053A1 (en) | 2005-06-30 | 2007-01-11 | Codon Devices, Inc. | Hierarchical assembly methods for genome engineering |
| ATE474909T1 (de) | 2005-12-29 | 2010-08-15 | Abl Biotechnologies Ltd | Neuer schizochytrium-limacinum-stamm, der sich für die produktion von lipiden und extrazellulären polysacchariden eignet, sowie verfahren hierfür |
| WO2008027472A2 (en) | 2006-08-29 | 2008-03-06 | Danisco Us, Inc., Genencor Division | Compositions and methods for improved protein production |
| WO2008141757A1 (en) | 2007-05-23 | 2008-11-27 | Cognis Ip Management Gmbh | Efficient astaxanthin production strains derived from haematococcus pluvialis |
| GB0715416D0 (en) | 2007-08-07 | 2007-09-19 | Phico Therapeutics Ltd | Modified bacteriophage |
| JP2011518543A (ja) * | 2008-01-10 | 2011-06-30 | トラスティーズ オブ ボストン ユニバーシティ | 抗微生物剤のための佐剤としての改変バクテリオファージならびにその組成物および使用方法 |
| AU2009214435C1 (en) | 2008-02-15 | 2014-07-17 | Synthetic Genomics, Inc. | Methods for in vitro joining and combinatorial assembly of nucleic acid molecules |
| US8207363B2 (en) | 2009-03-19 | 2012-06-26 | Martek Biosciences Corporation | Thraustochytrids, fatty acid compositions, and methods of making and uses thereof |
| CN101928670B (zh) | 2009-09-24 | 2012-02-22 | 上海天伟生物制药有限公司 | 一种抗生素的高产菌株及其制备方法和用途 |
| US8524220B1 (en) | 2010-02-09 | 2013-09-03 | David Gordon Bermudes | Protease inhibitor: protease sensitivity expression system composition and methods improving the therapeutic activity and specificity of proteins delivered by bacteria |
| SG188566A1 (en) | 2010-09-17 | 2013-04-30 | Tecnifar Ind Tecnica Farmaceutica S A | Antibacterial phage, phage peptides and methods of use thereof |
| EP3597764A3 (en) * | 2012-02-01 | 2020-05-06 | SGI-DNA, Inc. | Material and methods for the synthesis of error-minimized nucleic acid molecules |
| AU2013266968B2 (en) | 2012-05-25 | 2017-06-29 | Emmanuelle CHARPENTIER | Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription |
| US8697359B1 (en) | 2012-12-12 | 2014-04-15 | The Broad Institute, Inc. | CRISPR-Cas systems and methods for altering expression of gene products |
| US9234213B2 (en) | 2013-03-15 | 2016-01-12 | System Biosciences, Llc | Compositions and methods directed to CRISPR/Cas genomic engineering systems |
| WO2015035168A1 (en) * | 2013-09-05 | 2015-03-12 | Massachusetts Institute Of Technolgy | Tuning bacteriophage host range |
| JP2017537650A (ja) * | 2014-10-09 | 2017-12-21 | ライポテック・ピーティーワイ・リミテッド | キメラタンパク質 |
| CN113215115B (zh) | 2014-12-16 | 2024-07-02 | C3J治疗公司 | 用于体外病毒基因组工程的组合物和方法 |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006137847A2 (en) * | 2004-09-13 | 2006-12-28 | Trustees Of Boston University | Engineered enzymatically active bacteriophages and methods of uses thereof |
Non-Patent Citations (2)
| Title |
|---|
| "Bacteriophages as an Alternative Strategy for Fighting Biofilm Development";SYLWIA PARASION等;《Polish Journal of Microbiology》;137-145 * |
| "The Use of Phages for the Removal of Infectious Biofilms";J. Azeredo等;《Current Pharmaceutical Biotechnology》;261-266 * |
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