CN113210144B - Multi-sample ultracentrifuge for exosome separation - Google Patents
Multi-sample ultracentrifuge for exosome separation Download PDFInfo
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- CN113210144B CN113210144B CN202110532788.0A CN202110532788A CN113210144B CN 113210144 B CN113210144 B CN 113210144B CN 202110532788 A CN202110532788 A CN 202110532788A CN 113210144 B CN113210144 B CN 113210144B
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- exosome
- ultracentrifuge
- bottom plate
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- supporting column
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B5/00—Other centrifuges
- B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
- B04B5/0407—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B7/00—Elements of centrifuges
- B04B7/02—Casings; Lids
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B7/00—Elements of centrifuges
- B04B7/08—Rotary bowls
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B9/00—Drives specially designed for centrifuges; Arrangement or disposition of transmission gearing; Suspending or balancing rotary bowls
- B04B9/02—Electric motor drives
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Abstract
The invention relates to the technical field of exosomes, in particular to a multi-sample ultracentrifuge for exosome separation, wherein a motor shaft connected with a rotating shaft is arranged at the middle side of the inner end of a protective shell in a penetrating way, wherein the upper end of the motor shaft is provided with a transmission gear connected with a screw, one side of the inner end of the protective shell is provided with a first support column connected with a rotating shaft, wherein the upper end of the first supporting column is provided with a first follow-up gear connected with a screw, the other side of the inner end of the protective shell is provided with a second supporting column connected with a rotating shaft, wherein the upper end of the second supporting column is provided with a second follow-up gear connected with a screw, the outer end of the placing bottom plate is provided with a sealed inner shell connected with the placing bottom plate in a welding way, a temperature variable device connected by glue is embedded at the lower side of the inner end of the sealed inner shell, a limit ring is arranged at the inner end of the sealed inner shell, and a square rod connected with a screw is arranged on one side of the middle end of the sealing end cover, and a sponge cushion connected with glue is arranged at the inner end of the sealing end cover.
Description
Technical Field
The invention relates to the technical field of exosomes, in particular to a multi-sample ultracentrifuge for exosome separation.
Background
Many cells and body fluids in the human body can secrete exosomes including endothelial cells, immune cells, platelets, smooth muscle cells, and the like. When secreted into a recipient cell by a host cell, exosomes may modulate the biological activity of the recipient cell by the proteins, nucleic acids, lipids, etc. they carry. The exosome-mediated cell-cell communication is mainly realized through three ways, namely that exosome membrane proteins can be combined with target cell membrane proteins to activate signal channels in target cell cells. Secondly, in the extracellular matrix, the exosome membrane protein can be cut by protease, and the cut fragment can be used as a ligand to be combined with a receptor on a cell membrane, so that a signal path in the cell is activated. It has been reported that some proteins on the membrane of exosomes are not detectable on the cell membrane from which they were derived. And thirdly, the exosome membrane can be directly fused with a target cell membrane, and the contained protein, mRNA and microRNA are released non-selectively. At present, the most common method for exosome extraction is an ultracentrifugation extraction method.
A exosome under prior art separates with many samples ultracentrifuge, the structure is made oversimplely, and then do not have the operational capability that ultracentrifuge operation that accomplishes possesses, specifically do, current device can not carry out effectual fixed to exosome household utensils, and exosome can appear the problem of leaking in high-speed rotation, and then can lead to the exosomal volume of results to reduce, current device carries out the temperature setting to the demand of different exosomes in addition, but this device can't carry out ultracentrifuge simultaneously to the exosomal of different temperature demands simultaneously, and then current device receives the restriction in work.
Disclosure of Invention
The present invention is directed to a multi-sample ultracentrifuge for exosome separation to solve the above-mentioned problems.
In order to achieve the purpose, the invention provides the following technical scheme: a multi-sample ultracentrifuge for exosome separation is characterized in that a motor shaft connected with a rotating shaft is arranged in the middle of the inner end of a protective shell in a penetrating mode, a transmission gear connected with a screw is arranged at the upper end of the motor shaft, a first supporting column connected with the rotating shaft is arranged on one side of the inner end of the protective shell, a first follow-up gear connected with the screw is arranged at the upper end of the first supporting column, a second supporting column connected with the rotating shaft is arranged on the other side of the inner end of the protective shell, a second follow-up gear connected with the screw is arranged at the upper end of the second supporting column, a sealed inner shell connected with a welding mode is arranged at the outer end of a placing bottom plate, a temperature variable device connected with glue is embedded into the lower side of the inner end of the sealed inner shell, a limiting ring is placed at the inner end of the sealed inner shell, a clamping plate is arranged above the limiting ring, an internal groove is uniformly arranged on the clamping plate in a penetrating mode, and an exosome vessel is arranged at the inner end of the internal groove in a penetrating mode, the sealing end cover is characterized in that a square rod connected through a screw is arranged on one side of the middle end of the sealing end cover, a sponge cushion connected through glue is arranged at the inner end of the sealing end cover, a protective film is arranged on the outer side of the sponge cushion, and a fixed pressing plate connected through a buckle is arranged at the inner end of the sealing end cover.
Preferably, one side of the upper end of the protective shell is provided with a hinged cover, wherein the two sides of the middle end of the cover are symmetrically penetrated and provided with ejector rods, one end of each ejector rod is sleeved with a clamping spring, the clamping spring is positioned at the inner end of the cover, and the ejector rods are I-shaped.
Preferably, the placing bottom plate is connected with the first supporting column in a welding mode, adjusting sliding grooves are evenly formed in the upper end of the placing bottom plate, the connecting column is arranged on the middle side of the upper end of the placing bottom plate in a welding mode, and a square groove is formed in the upper end of the connecting column. The size of the square groove corresponds to that of the square rod.
Preferably, the connecting column penetrates through the clamping plate, wherein the connecting column is fixedly connected with the clamping plate, the clamping plate is located above the limiting ring, and the limiting ring is sleeved on the connecting column.
Preferably, spacing ring inner evenly is provided with integrated into one piece's branch pole, and wherein branch pole is arranging the setting of in-process staggered exosome household utensils, the one end of branch pole sets up welded connection's locking ring, and wherein the locking ring cover is on the spliced pole, carry out welded connection between locking ring and the spliced pole.
Preferably, the lower end of the limiting ring is uniformly provided with arc-shaped rods connected through screws, wherein the arc-shaped rods are arranged in an octave manner towards the inner side of the limiting ring, the lower end of each arc-shaped rod is provided with a pushing plate connected through screws, wherein the pushing plate is attached to an exosome vessel, and the pushing plate is semicircular.
Preferably, the first follow-up gear is meshed with one side of the transmission gear, the second follow-up gear is meshed with the other side of the transmission gear, and the structure arranged on the second support column is identical to that on the first support column.
Preferably, the maximum diameter of the sealing end cover is larger than the outer diameter of the sealing inner shell, the inner diameters of the spongy cushion and the sealing inner shell are the same, the thickness of the protective film is not less than two millimeters, and the protective film is made of a plastic film.
Compared with the prior art, the invention has the beneficial effects that:
1. through the arrangement of the invention, the limiting protection can be carried out in the rotating process of the exosome vessel, so that accidents can be prevented in the rotating process of the vessel, the normal operation of the exosome vessel is ensured, and meanwhile, the invention has the capability of sealing the exosome, and the phenomenon of leakage of the exosome can be prevented;
2. by the arrangement of the invention, exosomes with different temperature requirements can be simultaneously and centrifugally rotated, so that the centrifugation speed of the exosomes can be increased, great convenience is further brought to the work of workers, and the device has a simple and understandable structure, is suitable for the workers to get on hand quickly and can be popularized and used.
Drawings
FIG. 1 is a schematic perspective view of the present invention;
FIG. 2 is a schematic semi-sectional perspective view of the protective housing of the present invention;
FIG. 3 is a schematic perspective view of a sealed inner shell according to the present invention in half section;
FIG. 4 is a schematic semi-sectional perspective view of the end closure of the present invention;
FIG. 5 is a perspective view of the placement base of the present invention;
FIG. 6 is an enlarged view taken at A in FIG. 3 according to the present invention;
fig. 7 is an enlarged view of the invention at B in fig. 4.
In the figure: the device comprises a protective shell 1, a closing cover 11, a motor shaft 12, a transmission gear 13, a first supporting column 14, a first follow-up gear 15, a second supporting column 16, a second follow-up gear 17, a push rod 1101, a clamping spring 1102, a placing bottom plate 2, an adjusting sliding groove 201, a connecting column 202, a square groove 203, a sealed inner shell 21, a temperature variable device 22, a limiting ring 23, a branch rod 2301, a locking ring 2302, an arc-shaped rod 2303, a pushing plate 2304, a clamping plate 24, an internal groove 25, an exosome vessel 26, a sealing end cover 3, a square rod 31, a spongy cushion 32, a protective membrane 33 and a fixed pressing plate 34.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Referring to fig. 1 to 7, the present invention provides a technical solution: the protective casing 1, the placing bottom plate 2 and the sealing end cover 3, wherein the placing bottom plate 2 is positioned inside the protective casing 1, the sealing end cover 3 is positioned above the placing bottom plate 2, the middle side of the inner end of the protective casing 1 is provided with a motor shaft 12 connected with a rotating shaft in a penetrating way, one end of the motor shaft 12 is fixedly connected with a high-speed motor in the prior art, the upper end of the motor shaft 12 is provided with a transmission gear 13 connected with a screw, one side of the inner end of the protective casing 1 is provided with a first supporting column 14 connected with the rotating shaft, the upper end of the first supporting column 14 is provided with a first follow-up gear 15 connected with the screw, the other side of the inner end of the protective casing 1 is provided with a second supporting column 16 connected with the rotating shaft, the upper end of the second supporting column 16 is provided with a second follow-up gear 17 connected with the screw, the outer end of the placing bottom plate 2 is provided with a sealing inner casing 21 connected with a welding way, and the lower side of the inner end of the sealing inner casing 21 is embedded with a temperature variable device 22 connected with glue, place spacing ring 23 at the inner of sealed inner shell 21, wherein spacing ring 23 top is provided with cardboard 24, built-in groove 25 has evenly been seted up in running through on the cardboard 24, the inner of built-in groove 25 sets up the blotter of gluing connection, wherein the blotter cover is on exosome household utensils 26, and the inner of built-in groove 25 runs through and sets up exosome household utensils 26, end cover 3 middle-end one side sets up the square pole 31 of screw connection, wherein end cover 3's the inner foam-rubber cushion 32 that sets up gluing connection, foam-rubber cushion 32's the outside sets up protecting film 33, end cover 3's the inner set up the fixed pressing plate 34 that the buckle is connected.
A hinged cover 11 is arranged on one side of the upper end of the protective shell 1, push rods 1101 are symmetrically arranged on two sides of the middle end of the cover in a penetrating mode, a clamping spring 1102 is sleeved at one end of each push rod 1101, the clamping spring 1102 is located at the inner end of the cover 11, and the push rods 1101 are I-shaped.
The push rod 1101 can push the sealing end cover 3 under the action of the clamping spring 1102, and then the sealing end cover 3 achieves the sealing effect.
Placing and carrying out welded connection between bottom plate 2 and first support column 14, wherein place bottom plate 2 upper end and evenly set up regulation spout 201, place bottom plate 2 upper end medial side and set up welded connection's spliced pole 202, wherein square groove 203 is seted up to spliced pole 202 upper end, and the size of square groove 203 is corresponding with the size of square pole 31.
The connecting column 202 penetrates through the clamping plate 24, wherein the connecting column 202 and the clamping plate 24 are fixedly connected, the clamping plate 24 is located above the limiting ring 23, and the limiting ring 23 is sleeved on the connecting column 202.
The inner end of the limiting ring 23 is uniformly provided with integrally formed branch rods 2301, wherein the branch rods 2301 are arranged in the arranging process in a staggered mode in an exosome vessel 26, one end of each branch rod 2301 is provided with a locking ring 2302 connected in a welded mode, the locking ring 2302 is sleeved on the connecting column 202, and the locking ring 2302 is connected with the connecting column 202 in a welded mode.
The evenly set up bolted connection's of spacing ring 23 lower extreme arc pole 2303, wherein arc pole 2303 is to the inboard slope octave setting of spacing ring 23, and the lower extreme of arc pole 2303 sets up bolted connection's slurcam 2304, and wherein slurcam 2304 laminating exosome household utensils 26 sets up, and slurcam 2304's shape is semi-circular.
The first follow-up gear 15 is meshed with one side of the transmission gear 13, the second follow-up gear 17 is meshed with the other side of the transmission gear 13, and the structure arranged on the second support column 16 is the same as that on the first support column 14.
The temperature variable device 22 located on the first support column 14 is a refrigeration pill, wherein the temperature variable device 22 located on the second support column 16 is a heating pill.
The maximum diameter of the sealing end cover 3 is larger than the outer diameter of the sealing inner shell 21, wherein the inner diameters of the spongy cushion 32 and the sealing inner shell 21 are the same, the thickness of the protective film 33 is not less than two millimeters, and the protective film 33 is made of a plastic film.
The working principle is as follows: the exosome vessel 26 filled with exosomes is inserted into the internal groove 25, then the exosome vessel 26 penetrates through the limiting circular ring 23, the bottom of the exosome vessel 26 is placed on the bottom plate 2, at the moment, under the action of the arc-shaped rod 2303 and the pushing plate 2304, the lower end of the exosome vessel 26 applies force to the middle of the limiting circular ring 23, at the moment, the transverse position of the exosome vessel 26 is fixed, different temperature variable devices 22 are further adjusted according to the temperature requirements of exosomes, the internal temperature of the sealed inner shell 21 meets the requirements of exosomes, the square rod 31 is further inserted into the square groove 203, at the moment, the sealed inner shell 21 is sealed by the sealed end cover 3, simultaneously, under the action of the sponge cushion 32, the protective film 33 can be attached to the upper end of the exosome vessel 26, then the closing cover 11 is closed, under the action of the clamping spring 1102, the mandril 1101 limits the position of the sealing end cover 3, the motor is further started, the motor shaft 12 rotates, the transmission gear 13 rotates at the moment, the first supporting column 14 and the second supporting column 16 both rotate under the action of the first follow-up gear 15 and the second follow-up gear 17, and the bottom plate 2 and the clamping plate 24 are placed to rotate under the action of the connecting column 202 at the moment.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (8)
1. The utility model provides an exosome is separated with many samples ultracentrifuge, protecting sheathing (1), place bottom plate (2) and end cover (3), wherein place bottom plate (2) and be located the inside of protecting sheathing (1), end cover (3) are located the top of placing bottom plate (2), its characterized in that: a motor shaft (12) connected with a rotating shaft is arranged in the middle of the inner end of the protective shell (1) in a penetrating manner, a transmission gear (13) connected with a screw is arranged at the upper end of the motor shaft (12), a first supporting column (14) connected with the rotating shaft is arranged at one side of the inner end of the protective shell (1), a first follow-up gear (15) connected with the screw is arranged at the upper end of the first supporting column (14), a second supporting column (16) connected with the rotating shaft is arranged at the other side of the inner end of the protective shell (1), a second follow-up gear (17) connected with the screw is arranged at the upper end of the second supporting column (16), a sealed inner shell (21) connected with a welding manner is arranged at the outer end of the placing bottom plate (2), a temperature variable device (22) connected with glue is embedded into the lower side of the inner end of the sealed inner shell (21), a limiting ring (23) is arranged at the inner end of the sealed inner shell (21), and a clamping plate (24) is arranged above the limiting ring (23), the disposable excretion instrument is characterized in that a built-in groove (25) is uniformly formed in the clamping plate (24) in a penetrating mode, an inner end of the built-in groove (25) is formed in a penetrating mode to form an excretion instrument (26), a square rod (31) connected through screws is arranged on one side of the middle end of the sealing end cover (3), a sponge mat (32) connected through glue is arranged on the inner end of the sealing end cover (3), a protective film (33) is arranged on the outer side of the sponge mat (32), and a fixing pressing plate (34) connected through buckles is arranged on the inner end of the sealing end cover (3).
2. A multi-sample ultracentrifuge for exosome separation according to claim 1, characterized in that: the protective housing (1) upper end one side sets up the articulated lid (11) that closes of connecting, wherein close and cover middle-end bilateral symmetry and run through and set up ejector pin (1101), the one end cover of ejector pin (1101) has screens spring (1102), and wherein screens spring (1102) are located the inner of closing lid (11), the shape of ejector pin (1101) is the I-shaped.
3. A multi-sample ultracentrifuge for exosome separation according to claim 1, characterized in that: placing and carrying out welded connection between bottom plate (2) and first support column (14), wherein place bottom plate (2) upper end and evenly set up regulation spout (201), place bottom plate (2) upper end medial side and set up welded connection's spliced pole (202), wherein square groove (203) is seted up to spliced pole (202) upper end, the size of square groove (203) is corresponding with the size of square pole (31).
4. A multi-sample ultracentrifuge for exosome separation according to claim 3, characterized in that: the connecting column (202) penetrates through the clamping plate (24), wherein the connecting column (202) is fixedly connected with the clamping plate (24), the clamping plate (24) is located above the limiting ring (23), and the limiting ring (23) is sleeved on the connecting column (202).
5. A multi-sample ultracentrifuge for exosome separation according to claim 4, characterized in that: spacing ring (23) inner evenly is provided with integrated into one piece's branch pole (2301), and wherein branch pole (2301) stagger exosome household utensils (26) and set up arranging in-process, the one end of dividing branch pole (2301) sets up welded connection's locking ring (2302), and wherein locking ring (2302) cover is on spliced pole (202), carry out welded connection between locking ring (2302) and spliced pole (202).
6. A multi-sample ultracentrifuge for exosome separation according to claim 5, characterized in that: spacing ring (23) lower extreme evenly sets up the arc pole (2303) of screw connection, wherein arc pole (2303) are to the inboard slope octave setting of spacing ring (23), the lower extreme of arc pole (2303) sets up slurcam (2304) of screw connection, wherein slurcam (2304) laminating exosome household utensils (26) set up, the shape of slurcam (2304) is semi-circular.
7. A multi-sample ultracentrifuge for exosome separation according to claim 1, characterized in that: the first follow-up gear (15) is meshed with one side of the transmission gear (13), the second follow-up gear (17) is meshed with the other side of the transmission gear (13), and the structure arranged on the second supporting column (16) is identical to that on the first supporting column (14).
8. A multi-sample ultracentrifuge for exosome separation according to claim 1, characterized in that: the maximum diameter that sealing end cover (3) set up is greater than the external diameter of sealed inner shell (21), and wherein the internal diameter of foam-rubber cushion (32) is the same with sealed inner shell (21), the thickness that protective film (33) set up must not be less than two millimeters, and wherein protective film (33) set up the material that adopts and be plastic film.
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| CN202110532788.0A CN113210144B (en) | 2021-05-17 | 2021-05-17 | Multi-sample ultracentrifuge for exosome separation |
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| CN202110532788.0A CN113210144B (en) | 2021-05-17 | 2021-05-17 | Multi-sample ultracentrifuge for exosome separation |
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| CN113210144B true CN113210144B (en) | 2021-12-24 |
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| CN113802405A (en) * | 2021-09-23 | 2021-12-17 | 山东北方造纸机械有限公司 | High-efficiency energy-saving paper machine |
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| CN113210144A (en) | 2021-08-06 |
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