CN113209235A

CN113209235A - Traditional Chinese medicine composition for improving cancer-induced fatigue and sub-health chronic fatigue syndrome of tumor patients

Info

Publication number: CN113209235A
Application number: CN202110599074.1A
Authority: CN
Inventors: 孔令玉; 路欣; 孙江勇; 周维寿; 于海鹏; 于建春; 张国伟; 陈杰勇
Original assignee: Individual
Current assignee: Individual
Priority date: 2021-05-31
Filing date: 2021-05-31
Publication date: 2021-08-06

Abstract

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for improving tumor immune microenvironment and cancer-induced fatigue deficiency, which comprises the following components in parts by weight: 2-3 parts of grifola frondosa, 1-2 parts of raw coix seed and 0.5-1 part of lucid ganoderma. The invention has the functions of detumescence, spleen strengthening, qi tonifying, nerve calming, immunity enhancement and effective promotion of the organism metabolism of patients.

Description

Traditional Chinese medicine composition for improving cancer-induced fatigue and sub-health chronic fatigue syndrome of tumor patients

Technical Field

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for improving cancer-induced fatigue and sub-health chronic fatigue syndrome of a tumor patient.

Background

Cancer continues to be a problem in humans, with increasing incidence and increasing trend toward younger cancers, and is one of the most frequent side effects in or after cancer treatment, and is also known as cancer-related fatigue, which is one of the common symptoms of clinical malignancies, and is now described medically as "a feeling of subjective fatigue and exhaustion of energy in terms of restlessness, persistence of physical, emotional, and/or cognitive aspects caused by tumor or anti-tumor therapy, and interference with daily living and function". Symptoms of cancer-related fatigue are mainly nonspecific weakness, general decline, lethargy, fatigue, etc., which have persistent and non-universal characteristics such as weakness, weakness in activity, inattention, reduced power or interest, etc. In short, cancer-induced fatigue does not only occur in tumor patients, but also occurs for a long time after the tumor patients are cured, and cannot be relieved by rest.

Immunotherapy relies on its own immune function to kill cancer cells by activating the body's own immune system. It has been shown to have potent antitumor activity in the treatment of various tumors such as melanoma, non-small cell lung cancer, renal cancer, and prostate cancer, among other solid tumors. Although the success of immunotherapy is exciting, countless patients achieve significant efficacy with its intervention. Yet a subset of patients do not respond to immunotherapy. With the advance of technology, the complexity and diversity of the immune environment of the tumor microenvironment and its important impact on immunotherapy are increasingly understood. Further analysis and understanding of the tumor immune microenvironment will contribute to the improvement of immunotherapy responsiveness.

Chronic fatigue syndrome, CFS for short, is a disease characterized by persistent fatigue, insomnia, inability to concentrate thought, general pain, fever, and other debilitating fatigue manifestations throughout the body. The disease was formally named by the united states Center for Disease Control (CDC) in 1998, but the pathogenesis of the disease is not clear in modern medicine, and no effective treatment has been proposed. Although this disease has no life risk, the debilitation of the functions of all the viscera throughout the body has a great influence on health. However, at present, because of no organic lesions, the traditional Chinese medicine and western medicine clinicians do not have good clinical schemes and consensus and lack safety and convenience, and an intervention method with certain effect and acceptance is provided.

Disclosure of Invention

In order to solve the technical problems, the invention provides a traditional Chinese medicine composition which has no side effect on human bodies and is anti-fatigue and used for improving tumor immune microenvironment and cancer-induced fatigue deficiency.

The invention adopts the following technical scheme:

a traditional Chinese medicine composition for improving tumor immune microenvironment and cancer-induced fatigue deficiency comprises the following components in parts by weight: 2-3 parts of grifola frondosa, 1-2 parts of raw coix seed and 0.5-1 part of lucid ganoderma.

The main Chinese herbal medicines of the prescription are analyzed according to the traditional medicine and the modern medicine, and the medicine property and the pharmacological action are as follows:

grifola frondosa: it is also called Maitake Mushroom, pungent and sweet in flavor and warm in nature, entering liver, spleen and large intestine meridians. Has effects of invigorating qi, invigorating spleen, tonifying deficiency, and strengthening body resistance, and can be used for treating asthenia, listlessness, laziness in speaking, spleen deficiency, asthenia, abdominal distention, etc.

Coix seed: sweet and bland in taste, slightly cold in nature. It enters spleen, stomach and lung meridians. Has effects in clearing away heat, eliminating dampness, relieving swelling, expelling pathogenic accumulation, and invigorating spleen, and can be used for treating rheumatism, strengthening muscle and bone, invigorating qi, promoting gastrointestinal function, promoting urination, and eliminating edema.

Ganoderma lucidum: sweet in flavor and neutral in nature, and enter heart, lung, liver and kidney meridians. Has effects of invigorating qi, tranquilizing mind, relieving cough and asthma, and prolonging life, and can be used for treating restlessness of heart-mind, insomnia, palpitation, tiredness, listlessness, asthenia, short breath, anorexia, cold limbs, and deficiency of qi and blood.

Compared with the prior art, the invention has the beneficial effects that:

the traditional Chinese medicine composition can strengthen spleen, reduce swelling, tonify deficiency, strengthen body resistance, tonify qi, soothe nerves, enhance the immune function of an organism and promote the metabolism of the organism, and has obvious effects of treating and improving cancer-caused fatigue and sub-health chronic fatigue syndrome of a tumor patient.

Further, the invention adopts the following preferable scheme:

the components and the parts by weight are as follows: 3 parts of grifola frondosa, 2 parts of raw coix seeds and 1 part of lucid ganoderma.

The Chinese medicinal composition can be in the form of decoction, pill, powder, unguent, pellet, and granule.

Detailed Description

The invention is further illustrated by the following specific examples.

(1) The application method of the decoction comprises adding clear water into the Chinese medicinal composition (less than or equal to 100 g) and decocting for at least one hour (no need of drying the pot), and administering 150ml per time before or after meals in the morning, noon and evening; pills, powder, paste, pellets and granules are orally taken 12g (equivalent to the raw material medicines) in parts before or after meals in the morning and evening each day.

(2) The preparation method comprises the following steps: decocting the Chinese medicinal composition (less than or equal to 100 g) in clear water for at least one hour (no need of drying the pot); the traditional Chinese medicine composition is added with proper excipient to prepare pills, powder, paste, pellets and granules, and the excipient comprises but is not limited to: sugar powder, dextrin and soluble starch.

The first embodiment is as follows:

a traditional Chinese medicine composition for improving tumor immune microenvironment and cancer-induced fatigue deficiency comprises the following components in parts by weight: 3 parts of grifola frondosa, 2 parts of raw coix seeds and 1 part of lucid ganoderma.

Wei in women, 56 years old, lung nodule resection in the people hospital of Hebei province in 2019, postoperative pathology: adenocarcinoma, lung nodules were not completely removed, remaining nodules were observed clinically, and hospitals did not recommend chemotherapy based on pathological stage. Patients often feel tired and dizziness, poor appetite and unsmooth defecation after operation. The inventor introduces the Chinese herbal medicine formula of 3 parts of grifola frondosa, 2 parts of raw coix seed and 1 part of lucid ganoderma to seek diagnosis, and the Chinese herbal medicine formula is decocted with water for more than 1 hour and is taken orally three times in the morning, at noon and at night every day. After 3 months of administration, the self-induced asthenia of the whole body is obviously relieved earlier, the energy is sufficient earlier, the stool is smooth earlier, and the curative effect is consolidated after 3 months of administration.

Example two:

2 parts of grifola frondosa, 2 parts of raw coix seeds and 1 part of lucid ganoderma.

A patient Cao is a certain female in the age of 63 years, because of ovarian cancer and ovariectomy and hysterectomy and cleaning operation in a department of gynecology, such as the department of Tianjin, the patient has pathological serous cell cancer after operation, chemotherapy is applied for 6 cycles after the operation, weakness appears in the whole body after 4 th chemotherapy, nausea and vomiting are caused occasionally, the patient is lack of spirit, the patient is diagnosed in the department through human recommendation, and on the basis of conventional treatment, 2 parts of grifola frondosa, 2 parts of raw coix lacryma-jobiseed and 1 part of lucid ganoderma are given, decocted with water for more than 1 hour, and the oral administration is carried out three times in the morning, at noon and evening every day. After the formula is taken for 6 months, fatigue and fatigue are obviously relieved earlier, the appetite is good and sufficient, the tongue is pale red, and the tongue coating is thin and white.

Example three:

3 parts of grifola frondosa, 1 part of raw coix seeds and 0.5 part of lucid ganoderma.

A patient has a certain Liu, a woman is 36 years old, the weight of the patient is increased by about 2 kilograms recently, plain is often overtime, the patient is impatient in mood, and the patient has fatigue of different degrees all the time since the birth, occasionally has dizziness, lassitude and frequent constipation. Clinical examination shows that other diseases such as anemia and the like are eliminated, the patient is diagnosed with the disease, the chronic fatigue syndrome is primarily diagnosed, the traditional Chinese medicine formula of 3 parts of grifola frondosa, 1 part of raw coix seed and 0.5 part of lucid ganoderma is given, the materials are decocted for more than 1 hour every day by a health preserving pot, and the tea is drunk in the morning, noon and evening every day. The exhaust is increased in the taking process, and after the medicine is taken for 3 months, patients feel weak and are obviously improved, the energy is improved to some extent, and the stool is more smooth.

The above description is only for the specific embodiment of the present invention, but the protection of the present invention is not limited thereto, and all equivalent changes or substitutions to the technical features of the present invention that can be made by those skilled in the art are included in the protection scope of the present invention.

Claims

1. A traditional Chinese medicine composition for improving cancer-induced fatigue and sub-health chronic fatigue syndrome of tumor patients is characterized in that: the components and the parts by weight are as follows: 2-3 parts of grifola frondosa, 1-2 parts of raw coix seed and 0.5-1 part of lucid ganoderma.

2. The Chinese medicinal composition for improving cancer-induced fatigue and sub-health chronic fatigue syndrome of a tumor patient according to claim 1, wherein: the components and the parts by weight are as follows: 3 parts of grifola frondosa, 2 parts of raw coix seeds and 1 part of lucid ganoderma.

3. The Chinese medicinal composition for improving cancer-induced fatigue and sub-health chronic fatigue syndrome of a tumor patient according to claims 1 to 2, wherein: the Chinese medicinal composition can be in the form of decoction, pill, powder, unguent, pellet, and granule.