CN113209198A

CN113209198A - A Chinese medicinal composition for treating hepatitis B

Info

Publication number: CN113209198A
Application number: CN202110536835.9A
Authority: CN
Inventors: 仲崇允
Original assignee: Individual
Current assignee: Individual
Priority date: 2020-05-28
Filing date: 2021-05-18
Publication date: 2021-08-06
Also published as: CN111419956A

Abstract

The invention discloses a traditional Chinese medicine for treating hepatitis B, which is prepared from the following raw material medicines in parts by weight: 1-3 parts by weight of catechu; 5-10 parts of nutgall and cimicifuga foetida; 7-15 parts of silybum marianum; 10-20 parts of trichosanthes root; 15-30 parts of penthorum chinense pursh, ampelopsis grossedentata, evodia lepta, blumea balsamifera and ricefield eel vine. The invention has the characteristics of obvious treatment effect, short treatment period, no toxic or side effect and the like.

Description

A Chinese medicinal composition for treating hepatitis B

Technical Field

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating hepatitis B.

Background

Hepatitis B is part of the manifestation of the pathophysiological response caused by infection with group A type B hemolytic streptococci.

Acute hepatitis is generally not treated by antiviral therapy, while chronic viral hepatitis requires antiviral therapy. Interferon: recombinant DNA leukocyte interferon (IFN-alpha) can inhibit the replication of HBV. Intramuscular injection is carried out every other day for 6 months, and only 30-50% of patients obtain a relatively long-lasting effect. The first choice of the hepatitis C drug is interferon, which can be used in combination with ribavirin. Lamivudine: is a synthesized dideoxy cytosine riboside medicine and has the function of resisting HBV. When the lamivudine is orally taken, the serum HBV-DNA level can be obviously reduced, and the HBV-DNA negative conversion rate reaches over 90 percent after the lamivudine is taken for 12 weeks. The long-term administration can reduce ALT and improve liver inflammation, but the negative conversion rate of HBeAg is only 16-18%, the variation of HBV can occur after the treatment for more than 6 months, the administration can be continued, and the administration can be continued for 1-4 years with little side effect. ③ famciclovir: is a guanosine drug, has long half-life and high intracellular concentration, and can inhibit the replication of HBV-DNA. The medicine has less side effect and can be used together with lamivudine interferon to improve the curative effect. Fourthly, other antiviral drugs: such as acyclovir, adefovir, entecavir, foscarnet and the like, have certain HBV inhibiting effect.

Chronic hepatitis B is very difficult to treat and is a consensus of medical circles at home and abroad, and at present, no specific medicine for treating chronic hepatitis B exists.

Disclosure of Invention

The invention aims to improve the defects of the prior art and provide the traditional Chinese medicine composition for treating hepatitis B, which can effectively improve or even eliminate the clinical symptoms of patients and has the characteristics of obvious treatment effect, short treatment period, no toxic or side effect and the like.

Hepatitis B arthritis belongs to the category of bone impediment, stubborn arthralgia, wangbi, historical arthritis and the like in the traditional Chinese medicine. The rheumatism mainly occurs when internal injury occurs to the liver, spleen and kidney, if the qi of yin and yang of human body is unbalanced, the preponderance and decline appear, the wind, cold and damp evil invade the human body, the victory of wind qi is migratory arthralgia, and the cold qi is the pain arthralgia; the victory dampness is arthralgia, and wind-cold-dampness obstructs meridians and joints, resulting in pain and swelling of joints. The rheumatism usually progresses in a chronic way, and if the disease lasts for a long time, the pathogenic factors enter the interior from the exterior, and the pathogenic factors are mild and severe, which causes dysfunction of the viscera and blood stasis, and the condition of the disease is lingering and difficult to treat. Therefore, it should invigorate spleen and warm middle energizer, tonify kidney and strengthen bone, expel wind and remove dampness, relax tendons and activate collaterals, activate blood and relieve swelling, remove toxicity and alleviate pain. The human body is regulated as a whole to achieve a new equilibrium state, thereby achieving the purpose of thorough cure.

Based on the theory, the invention provides a traditional Chinese medicine for treating hepatitis B, which is prepared from the following raw material medicines in parts by weight: 1-3 parts by weight of catechu; 5-10 parts of nutgall and cimicifuga foetida; 7-15 parts of silybum marianum; 10-20 parts of trichosanthes root; 15-30 parts of penthorum chinense pursh, ampelopsis grossedentata, evodia lepta, blumea balsamifera and ricefield eel vine.

In a preferred embodiment, the traditional Chinese medicine composition for treating hepatitis B consists of the following raw material medicines in parts by weight: 3 parts of catechu; 10 parts of nutgall and cimicifuga foetida; 15 parts of silybum marianum; 20 parts of trichosanthes root; penthorum chinense pursh, ampelopsis grossedentata, evodia lepta, blumea balsamifera and ricefield eel vine 30 parts by weight.

Wherein, trichosanthes root: sweet, slightly bitter and slightly cold. It enters lung and stomach meridians. Clear heat and promote fluid production, relieve swelling and expel pus. Trichosanthis radix can inhibit hepatitis B virus, and increase with the increase of the concentration of Tianfen protein.

Nutgall: is bitter in taste; and (4) temperature. Entering the lung; a spleen; the kidney channel. Astringing intestines; securing essence; relieving cough; hemostasis is carried out; and (5) healing the sore. Gallic acid has good anti-HBV effect.

Penthorum chinense pursh: sweet and warm in flavor. Induce diuresis to remove dampness, dispel stasis to alleviate pain. The penthorum chinense pursh obviously resists hepatitis B virus, and obviously or extremely obviously reduces the overall level of DHBY-DNA titer.

Catechu: bitter, astringent and slightly cold. It enters lung meridian. Astringe dampness, promote granulation, heal wound, protect liver and promote bile flow. The contained d-catechin and epicatechin both have obvious liver protection function, can obviously reduce alanine Aminotransferase (ALT), reverse inverted albumin/globulin (A/G), and increase glutathione-S-transferase (GST) activity to improve liver detoxification function. It can inhibit the migration of leukocytes of hepatitis B infected patients and sensitive to hepatitis B surface antigen, and amplify cell-mediated immune response to promote the elimination of hepatitis B antigen.

B, ampelopsis: is bitter in taste; and (6) cooling. Returning to the heart; liver; the kidney channel. Clearing heat and promoting diuresis; stasis dissipating and bleeding stopping; detoxicate, remarkably reduce alanine aminotransferase and aspartate aminotransferase, and has effects of protecting liver, lowering transaminase, and resisting free radical.

Bitter taste in trigeminal: bitter and cold in flavor. Clearing away heat and toxic material, removing blood stasis and relieving pain. Obviously reduces the content of serum glutamic-pyruvic transaminase ALT, glutamic-oxalacetic transaminase AST and liver homogenate malondialdehyde, improves the activity of liver GSH-Px, and has obvious high-dose effect.

Cimicifugae foetidae: pungent, slightly sweet and slightly cold. It enters lung, spleen, stomach and large intestine meridians. Releasing exterior and promoting eruption, clearing heat and removing toxicity, and lifting yang qi. Cimicifugae rhizoma can obviously reduce serum aspartate Aminotransferase (AST) and alanine Aminotransferase (ALT), improve liver injury, and reduce degeneration and necrosis of liver cells.

Big wind and Chinese mugwort: pungent, slightly bitter and slightly warm. Dispel wind and alleviate swelling, activate blood and dissipate blood stasis. The blumea balsamifera can reduce serum alanine aminotransferase and triglyceride in liver, and obviously reduce pathological damage of liver tissue.

Silybum marianum: bitter and cool. Clearing away heat and toxic material, protecting liver, promoting function of gallbladder, protecting brain, and resisting X-ray. Silybum marianum has definite curative effect on resisting liver injury, and is a liver-protecting medicine with high drug effect, low toxicity and no side effect. Can rapidly improve subjective symptoms and certain biochemical indexes of patients with liver diseases, such as serum bilirubin, coefficients of Baiwan and wan, thromboplastin, glutamic-pyruvic transaminase, etc.

And (3) ricefield eel vines: sweet in taste; astringency; and (5) slightly warming. Liver diseases entering; the gallbladder meridian. Dispelling wind and removing dampness; promoting blood circulation to arrest pain. The Monopteri albi vine can relieve liver cell inflammation, prevent cell necrosis, prevent hepatic fibrosis, repair liver pathological tissue injury and promote liver cell regeneration.

The invention is prepared from Chinese traditional herbal medicines, and according to the principles of traditional Chinese medicine dialectical treatment and modern medicine, the traditional Chinese medicine for effectively treating hepatitis B is combined by orderly matching certain natural extracts with determined components and clear effects, and can effectively prevent and treat liver cirrhosis.

The invention can be applied throughout the whole process of hepatitis B treatment, one dose of the prescription is used for treatment every day, 100 ml of water decoction is added, the medicine is divided into two parts, one part is taken in the morning and at night, one month is taken as a treatment course, generally, one treatment course has effect, the three treatment courses can be obviously improved, the effect of treating hepatitis B is obvious, both the symptoms and root causes are treated, the cure rate is high, the medicine is not easy to relapse, the medicine is safe and reliable, no obvious toxic or side reaction exists, the medicine is convenient for a patient to insist on taking for a long time, the patient does not have any adverse reaction after taking the medicine for many years, and the blood examination is tracked to be normal.

The traditional Chinese medicine composition has the advantages of easily available raw materials, simple process, low cost and high efficiency, and is beneficial to pharmaceutical enterprises for medicine production and quality control; the product has low price and is easy to be accepted by patients.

The invention also provides an oral preparation prepared from the traditional Chinese medicine composition for treating hepatitis B, which comprises oral liquid, tablets, capsules, pills and the like, preferably the dosage forms are tablets and capsules, and one dose is taken every day in the morning and at night.

The traditional Chinese medicine composition can be prepared into various dosage forms. For example, the decocted liquid medicine is sterilized and disinfected and then packaged to prepare oral liquid; or concentrating the decoction, oven drying, adding pharmaceutically acceptable adjuvants, and making into tablet, capsule, pill, etc.

The medically acceptable auxiliary materials comprise starch, dextrin, sodium carboxymethylcellulose, polyethylene glycol, calcium hydrophosphate, sodium alginate, potassium sorbate and the like.

The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the present invention in any way, and it will be apparent to those skilled in the art that the above description of the present invention can be applied to various modifications, equivalent variations or modifications without departing from the spirit and scope of the present invention.

Claims

1. The traditional Chinese medicine for treating hepatitis B is characterized by consisting of the following raw material medicines in parts by weight: 1-3 parts by weight of catechu; 5-10 parts of nutgall and cimicifuga foetida; 7-15 parts of silybum marianum; 10-20 parts of trichosanthes root; 15-30 parts of penthorum chinense pursh, ampelopsis grossedentata, evodia lepta, blumea balsamifera and ricefield eel vine.

2. The traditional Chinese medicine for treating hepatitis B according to claim 1, which is characterized by comprising the following raw material medicines in parts by weight: 3 parts of catechu; 10 parts of nutgall and cimicifuga foetida; 15 parts of silybum marianum; 20 parts of trichosanthes root; penthorum chinense pursh, ampelopsis grossedentata, evodia lepta, blumea balsamifera and ricefield eel vine 30 parts by weight.

3. An oral preparation for treating hepatitis B, which is characterized by being prepared from the traditional Chinese medicine composition of any one of claims 1 or 2.

4. The oral preparation for treating hepatitis B according to claim 3, which is characterized by comprising oral liquid, tablets, capsules and pills, and preferably oral liquid and tablets.