CN111184854A

CN111184854A - Chinese medicinal prescription for preventing virus infection

Info

Publication number: CN111184854A
Application number: CN202010117903.3A
Authority: CN
Inventors: 钱承美; 李为春; 钱永昌; 曹云; 俞芹; 贾典荣; 崔琪; 李龙海
Original assignee: Taizhou Jiangyan Hospital Of Traditional Chinese Medicine
Current assignee: Taizhou Jiangyan Hospital Of Traditional Chinese Medicine
Priority date: 2020-02-26
Filing date: 2020-02-26
Publication date: 2020-05-22

Abstract

The invention discloses a traditional Chinese medicine prescription for preventing virus infection, which consists of the following traditional Chinese medicines in parts by weight: 20 parts of astragalus membranaceus, 5 parts of honeysuckle, 5 parts of platycodon grandiflorum, 6 parts of dried orange peel and 2 parts of dried ginger. The traditional Chinese medicine formula disclosed by the invention has the advantages that the selected medicinal materials are compatible, the traditional Chinese medicine formula accords with the theories of traditional Chinese medicine and modern medicine, the traditional Chinese medicine is adopted as the raw materials, the curative effect is definite, the price is low, no toxic or side effect exists, the traditional Chinese medicine formula has the functions of strengthening the body resistance and consolidating the exterior, and eliminating turbid pathogen and detoxifying, and is used for preventing influenza virus and coronavirus infection.

Description

Chinese medicinal prescription for preventing virus infection

Technical Field

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine prescription for preventing virus infection.

Background

The TCM is considered to be a natural product of nature and generated by the essence of nature, and is made according to the four-hour method. The human body is also composed of qi, which is the most basic substance constituting the human body and also the most basic substance for maintaining the life activities of the human body. In traditional Chinese medicine, healthy qi represents the disease resistance of human body, pathogenic qi marks all pathogenic factors, and healthy qi fails to resist the invasion of pathogenic qi to explain the disease. If the body is vigorous, pathogenic qi will not invade easily, or even if there is pathogenic qi invasion, the disease will not be caused, only if the body's vital qi is relatively deficient, the pathogenic qi can invade by deficiency. The earliest classic book of traditional Chinese medicine, Huangdi's internal classic, has a discussion of the existence of healthy qi and the failure of pathogenic factors to dry.

The traditional Chinese medicine plays an important role in preventing and controlling epidemic situations regardless of ancient typhoid fever, pestilence and epidemic diseases such as current SARS. Aiming at the pneumonia epidemic situation infected by the current novel coronavirus, the characteristic advantages of the traditional Chinese medicine are fully exerted, and the prevention before illness is necessary. The people with pneumonia infected by the novel coronavirus generally have the characteristics of susceptibility, deficiency of vital qi, excess pathogenic factors, mixed cold and heat and the like, and have the advantages of acute onset, strong infectivity, high incidence and long course of disease. Therefore, the research and development of products for preventing the infection of the influenza virus and the coronavirus, which have obvious curative effect, can enhance the immunity of human bodies, resist viruses and have low toxic and side effects, have important significance.

Disclosure of Invention

The invention mainly solves the technical problems in the prior art, thereby providing a traditional Chinese medicine prescription for preventing virus infection.

In order to achieve the purpose, the invention provides the following technical scheme:

a traditional Chinese medicine prescription for preventing virus infection is composed of the following traditional Chinese medicines in parts by weight: 20 parts of astragalus membranaceus, 5 parts of honeysuckle, 5 parts of platycodon grandiflorum, 6 parts of dried orange peel and 2 parts of dried ginger.

Preferably, the traditional Chinese medicine prescription is an oral liquid preparation.

Preferably, the traditional Chinese medicine prescription is a capsule preparation.

Preferably, the Chinese medicinal preparation is a tablet.

Preferably, the traditional Chinese medicine prescription is a medicinal granule.

The raw materials used in the invention have the following effects:

astragalus root, radix astragali, sweet in taste and warm in nature, enters spleen and lung channels, has thin and thick smell, can rise and fall, is specially used for qi system to express superficies, and is good at tonifying qi. According to pharmacological research, astragalus can enhance and regulate the immune function of an organism, resist viruses and improve the disease resistance of the organism. Zhang shan Lei recorded in Ben Cao Zheng Yi (Zheng Cao Zheng Yi) of Huang Qi, tonifying middle-jiao soil, warming and nourishing spleen and stomach, so it is most suitable for treating deficiency of middle-jiao energy, weakness of spleen soil and sinking of clear qi. It is the best remedy for diseases due to exterior deficiency because its skin directly reaches the skin surface and muscles of human body, strengthens and protects yang, and fills the exterior and interior. The original menstrual period was: 'Huang Qi can tonify deficiency of five zang organs, remove lung heat, without sweating to cause sweating, stopping sweating, entering lung to consolidate superficial deficiency and spontaneous sweating' Ben Cao gang mu Shi Yi (supplement to compendium of materia Medica): for lung deficiency, it can tonify lung qi. The "kojiu" is recorded: the main symptoms of the disease are also the main symptoms of the disease. For wind-rain and pathogenic wind, the qi must be deficient, so Huang Qi can be used to promote healthy qi. "

Honeysuckle flower is cold in nature and sweet in taste, has light and aromatic smell, enters lung, stomach and large intestine channels, has the effects of clearing heat, detoxifying and dispelling wind and heat, can clear qi and nourish yin, can clear heat in the qi system and detoxify toxin in the blood system, is mainly used for treating warm diseases due to heat permeating through the upper half body. It is said to be fragrant and sweet in the original meridian, entering spleen and dredging lung, tonifying in diarrhea. In the formula, astragalus root, radix astragali, sweet in taste and sweet in flavor, warms the spleen and tonifies middle-warmer energy, is preferred to tonify spleen qi, astragalus root is used for strengthening body resistance, and honeysuckle is used for eliminating pathogenic factors, so that the formula can be used for treating two sides of the contradiction of deficiency of body resistance and excess of pathogenic factors, and reflects the compatibility of both principal and secondary aspects.

Platycodon grandiflorum is bitter and pungent in flavor, neutral in nature, enters lung meridian, is pungent in flavor and bitter in flavor and releases its flavor, is light in weight and floating, is an agent for yellow millet, is good at ventilating lung qi, relieving exterior syndrome and relieving sore throat, eliminating phlegm and discharging pus, and has the function of guiding drugs to float upwards into the lung. The combination of the two herbs of Jie Geng and jin Yin Hua can achieve the actions of dispersing wind, clearing heat, dispersing lung qi and relieving cough. According to pharmacological research, the platycodon grandiflorum has the effects of relieving cough, clearing heat and enhancing immunity. In the book of meridian origin, ascending of qi and clearing lung qi, relieving sore throat, leading to meridian of lung. Platycodon grandiflorum is reported in the pearl sac, and is used for treating sore throat, benefiting lung qi and treating nasal obstruction. "can be either minister or envoy.

The dried orange peel is pungent, bitter and warm, enters spleen, lung, stomach and large intestine channels, mostly enters spleen, has the functions of regulating qi, strengthening spleen, eliminating dampness, eliminating turbid pathogen, regulating stomach and is a ministerial drug. The dried orange peel is pungent and opens up with bitter taste to lower, so that the qi can moisten, the spleen can invigorate the stomach, and the dried orange peel is used together with the astragalus root to supplement and disperse, the astragalus root can be used for the dried orange peel without the defect of retention of pathogens, the dried orange peel can be used for the dried orange peel without too much dispersion, and the dried orange peel can be used for both supplementing the middle and dispersing. The compendium of materia Medica records: orange peel, bitter in flavor and dry in flavor and pungent in flavor and warm in flavor, is used for treating various diseases, and has the actions of regulating qi and drying dampness, tonifying with tonics, purging with purgatives, ascending with ascending-qi herbs, descending with descending-qi herbs, spleen being mother of original qi, and lung being punt-qi-controlling herbs, so orange peel is a herb for qi in two meridians, but can be used for tonifying and purging with ascending and descending with the herbs. "the essentials of medilin" is called: the upper part of the body is used for purging pathogenic lung and descending adverse qi; dryness-dampness in the middle energizer and harmonizing the middle energizer; when it is downward, it can disperse liver qi and moisten kidney. It is mainly used for regulating qi, resolving phlegm and resolving stagnation. "

Gan Jiang is pungent and warm in property, and enters spleen, stomach, kidney, heart and lung meridians. It can warm the heart and lung, middle-jiao, spleen and stomach, and lower-jiao. The combination of the astragalus root and the astragalus root has the functions of tonifying deficiency of spleen and stomach, restoring yang of middle jiao, enabling middle-jiao to be transported and managed, warming yang among qi, tonifying qi among yang, tonifying qi when yang is obtained, transforming qi when yang is obtained, and strengthening qi, supporting yang, consolidating superficial resistance and arresting sweating. Both gan Jiang and Chen Pi are pungent and warm in flavor and warm in nature, enter spleen meridian, and they are combined together to mutually reinforce each other to take the effect of warming middle energizer and resolving turbidity. The combination of gan Jiang and jin Yin Hua can tonify spleen yang, clear excess heat, pungent flavor and bitter taste, and induce heat to disperse from middle energizer, so it is indicated for various syndromes of cold-heat combination. Honeysuckle flower and dried ginger are used as adjuvant drugs.

Through the technical scheme, the invention provides a traditional Chinese medicine prescription for preventing virus infection, which is supported by an oral liquid preparation through the proportion of five traditional Chinese medicines. The oral preparation has effects of strengthening body resistance, consolidating constitution, eliminating turbid pathogen, and removing toxic substance, and also has spleen invigorating effect. All the medicinal materials are medicinal and edible traditional Chinese medicines, are safe and reliable, and are suitable for the public to prevent the infection of influenza virus and coronavirus.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Preferably, the traditional Chinese medicine prescription is any one dosage form in traditional Chinese pharmacology, and can be prepared into capsule preparations, tablets, granules, oral liquid preparations, soft capsule preparations and the like.

Example 1: the traditional Chinese medicine composition is prepared into an oral liquid preparation, and 200ml of the oral liquid preparation is prepared in one bottle. The usage and dosage are as follows: it is administered orally with empty stomach in the morning and evening, with dosage of 10ml for adult (weight more than 40-50 kg) and 5ml for children (weight 15-40 kg).

Example 2: the traditional Chinese medicine composition is prepared into capsule preparation, and 3g of the capsule preparation is prepared. The usage and dosage are as follows: is administered with warm water, and is administered with empty stomach in the morning and evening, 2 granules for adult (weight of 40-50 kg) and 1 granule for children (weight of 15-40 kg).

Example 3: the traditional Chinese medicine composition is prepared into granular preparation, and 3g of the granular preparation is packaged. The usage and dosage are as follows: it is administered with warm water, and is administered with empty stomach in the morning and evening, 2 bags for adult (weight above 40-50 kg) and 1 bag for children (weight 15-40 kg).

Example 4A tablet of the Chinese medicinal composition of the present invention is prepared, one tablet being 1 g. The usage and dosage are as follows: is administered with warm water, and is administered with empty stomach in the morning and evening, 2 tablets for adult (weight of 40-50 kg) and 1 tablet for children (weight of 15-40 kg).

Clinical cases:

the therapeutic effects of the Chinese medicinal compositions of examples 1 to 4 on viral influenza were clinically observed, and 100 out of outpatient adult patients were clearly diagnosed as having mild, moderate and severe viral influenza, and were divided into a treatment group and a control group, respectively, and the patients with mild, moderate and severe influenza were equally distributed.

Treatment group 1: wherein 20 patients are treated by the traditional Chinese medicine composition of the embodiment 1, and the traditional Chinese medicine composition is taken 2 times a day, 10ml each time, on an empty stomach in the morning and evening; treatment effect data were collected 4 days after treatment.

Treatment group 2: wherein 20 patients are treated by the traditional Chinese medicine composition of the embodiment 2, and the composition is taken 2 times a day in the morning and evening on an empty stomach, 2 granules for each time; treatment effect data were collected 4 days after treatment.

Treatment group 3: wherein 20 patients are treated by the traditional Chinese medicine composition of the embodiment 3, and the composition is taken 2 times a day, on an empty stomach in the morning and evening, 2 bags each time; treatment effect data were collected 4 days after treatment.

Treatment group 4: wherein 20 patients are treated by the traditional Chinese medicine composition of the embodiment 4, and the composition is taken 2 times a day in the morning and evening on an empty stomach, 2 tablets each time; treatment effect data were collected 4 days after treatment.

Control group: the other 20 patients are treated by using the traditional Chinese medicine antiviral capsules produced by a certain pharmaceutical factory on the market, and are taken 2 times a day, 2 capsules each time in the morning and evening on an empty stomach; treatment effect data were collected 4 days after treatment.

The treatment results data for the treated and control groups after the treatment period are shown in table 1.

Table 1 comparative treatment results table

Distinguishing	Can completely cure the disease	Obviously improve	The effect is not obvious	Without significant improvement
					Treatment group 1	95%	10%	0%	0%
Treatment group 2	92%	8%	0%	0%
					Treatment group 3	90%	7%	0%	0%
Treatment group 4	94%	9%	0%	0%
					Control group	65%	6%	10%	5%

Typical cases

1. In a male, age 36, the diagnosis of viral cold is confirmed, and the clinical manifestations are: the symptoms of low fever, anorexia, nausea, emesis, etc. can be repeatedly attacked for 4 times, and the clinical symptoms can be improved after taking the Chinese medicinal composition prepared by the first preparation for 3 days, and no recurrence can be observed after tracking for 1 month.

2. Some young, female, 22 years old, has confirmed the diagnosis of viral cold, with the clinical manifestations: the symptoms of low fever, hypodynamia, nausea, vomiting and the like repeatedly attack for 2 times, the clinical symptoms are obviously improved after the traditional Chinese medicine composition prepared in the second administration example is taken for 4 days, and the clinical symptoms are improved after the traditional Chinese medicine composition is continuously taken for the third day and are tracked for 1 month without relapse.

3. When a man is in age of 45 years, the disease is diagnosed as a viral cold, and the clinical manifestations are as follows: the symptoms of low fever, hypodynamia, nausea, vomiting and the like repeatedly attack for 2 times, the clinical symptoms are obviously improved after the traditional Chinese medicine composition prepared in the third example is taken for 2 days, and the clinical symptoms are improved after the traditional Chinese medicine composition is continuously taken for the fifth day and are tracked for 1 month without relapse.

4. Xuan somebody, male, 56 years old, confirmed to be a viral cold, with clinical manifestations: the symptoms of low fever, hypodynamia, nausea, vomiting and the like repeatedly attack for 2 times, and the clinical symptoms are obviously improved after taking the traditional Chinese medicine composition prepared in the third embodiment for 4 days, and the relapse is not seen after tracking for 1 month.

In view of the process of infecting the epithelium of human lung vacuoles, viruses firstly utilize the Spike protein of the virus to interact with ACE2 protein, so as to invade the human body. The interface inhibitor aiming at the interaction of the Spike and the ACE2 protein is developed, so that the combination of the two proteins can be effectively cut off, the virus is blocked from invading human cells, and the effect of preventing infection is achieved. Aiming at the research and development of a virus Spike protein/ACE 2 interaction interface inhibitor, particularly effective molecules are screened from medicine-food homologous molecules, hot spots and key residues of a protein-protein interaction interface of a 2019_ nCov virus CTD 1/human ACE2 compound are clarified by comparing the combination mode of SARS virus Spike protein/human ACE2 protein, a pharmacophore model is constructed by ACE2 amino acid residues by utilizing a structure-based pharmacophore method, the surface of a CTD1 region combined with ACE2 is targeted, candidate inhibitors are screened, and the recognition and combination of viruses and human ACE2 protein are blocked. Finally, through a constructed pharmacophore model and a molecular docking screening method, 13 traditional Chinese medicines of potential inhibitors of the targeted S protein are screened from a patent medicine compound library (2373 compounds) and a medicine and food homology source database (5632 compounds), wherein 4 medicines (astragalus, honeysuckle, platycodon grandiflorum and dried ginger) are contained in the invention.

The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A traditional Chinese medicine prescription for preventing virus infection is characterized by comprising the following traditional Chinese medicines in parts by weight: 20 parts of astragalus membranaceus, 5 parts of honeysuckle, 5 parts of platycodon grandiflorum, 6 parts of dried orange peel and 2 parts of dried ginger.

2. The Chinese medicinal formulation for preventing viral infection according to claim 1, wherein the Chinese medicinal formulation is an oral liquid formulation.

3. The Chinese medicinal formulation for preventing viral infection according to claim 1, wherein the Chinese medicinal formulation is a capsule formulation.

4. The Chinese medicinal formulation for preventing viral infection according to claim 1, wherein the Chinese medicinal formulation is a tablet.

5. The Chinese medicinal formulation for preventing viral infection according to claim 1, wherein the Chinese medicinal formulation is a granule.