CN113209160A

CN113209160A - Oral ulcer gel and preparation method thereof

Info

Publication number: CN113209160A
Application number: CN202110529278.8A
Authority: CN
Inventors: 王进取
Original assignee: Yunnan Zhaoyao Health Industry Co ltd
Current assignee: Yunnan Zhaoyao Health Industry Co ltd
Priority date: 2021-05-14
Filing date: 2021-05-14
Publication date: 2021-08-06

Abstract

The invention belongs to the technical field of oral care, and particularly relates to an oral ulcer gel and a preparation method thereof; the method comprises the following raw materials: polyhexamethylene biguanide, carboxypropyltrimethylammonium chloride, sodium fluoride, ceramide, hyaluronic acid, menthol, borneol, chrysanthemum extract, baicalin, EDTA guar gum, clove basil oil, blumea balsamifera oil, glycerol and purified water; has the advantages of better repairing the oral ulcer and long-term preservation.

Description

Oral ulcer gel and preparation method thereof

Technical Field

The invention belongs to the technical field of oral care, and particularly relates to oral ulcer gel and a preparation method thereof.

Background

The oral cavity is the portal for microorganisms to enter respiratory tract, digestive tract and blood. Due to the special structural and physiological characteristics of the oral cavity, a complex microbial community is colonized in the oral cavity. The close and complex interactions between oral microflora, microbes and the host, normally maintain host health. If this ecological balance is broken, disease will be triggered. The oral microbiome is closely related to major diseases of the oral cavity and some systemic diseases. The frequently encountered diseases in oral cavity include dental caries, periodontal diseases (including gingivitis, periodontitis, etc.), oral mucosa diseases (oral ulcer, recurrent aphtha, lichen planus, cheilitis, etc.). These oral diseases are common diseases and frequently encountered diseases in the social population. With the progress and development of society and improvement of living standard of people, the understanding and the requirement of people on oral health are greatly improved, more and more people begin to pay attention to the oral health, and the awareness of oral health care is gradually enhanced.

Oral ulcer, commonly known as "aphtha", is a common ulcerative injury to the oral mucosa, which is usually found in the inner labial, tongue abdomen, buccal mucosa, vestibular sulcus, soft palate, etc., where the mucosa lacks cutinization layer or has poor keratosis. Tongue ulcer refers to oral ulcer occurring on tongue and tongue abdomen. The pain is severe when the oral ulcer is attacked, the local burning pain is obvious, and serious patients can influence diet and speaking, thereby causing great inconvenience to daily life; can be used for treating halitosis, chronic pharyngitis, constipation, headache, dizziness, nausea, asthenia, dysphoria, fever, and lymphadenectasis.

The oral cavity nursing gel is a thick liquid or semisolid preparation which is prepared by medicaments and auxiliary materials capable of forming gel and is in a uniform, suspension or emulsion type, and is a new oral cavity health nursing product after toothpaste, tooth powder and mouthwash.

Disclosure of Invention

The invention aims to provide oral ulcer gel and a preparation method thereof, which can better repair oral ulcer and can be stored for a long time.

In order to solve the technical problems, the invention adopts the following technical scheme:

the oral ulcer gel comprises the following raw materials: polyhexamethylene biguanide, carboxypropyltrimethylammonium chloride, sodium fluoride, ceramide, hyaluronic acid, menthol, borneol, chrysanthemum extract, baicalin, disodium EDTA, guar gum, clove basil oil, blumea balsamifera oil, glycerol and purified water.

Further, the feed comprises the following raw materials in percentage by mass: 1% of polyhexamethylene biguanide, 1% of carboxypropyltrimethylammonium chloride, 0.22% of sodium fluoride, 0.5% of ceramide, 0.5% of hyaluronic acid, 0.3% of menthol, 0.15% of borneol, 0.5% of chrysanthemum extract, 0.05% of baicalin, 0.03% of EDTA disodium, 0.03% of guar gum, 0.15% of clove basil oil, 0.15% of blumea balsamifera oil, 30% of glycerol and 66.42% of purified water.

The preparation method of the oral ulcer gel comprises the following steps:

s1, preparing the menthol and borneol inclusion complex: weighing borneol and menthol according to mass fraction, and then adding octenyl succinic acid starch sodium to prepare a volatile oil inclusion complex;

s2, weighing polyhexamethylene biguanide, carboxypropyltrimethylammonium chloride, sodium fluoride, ceramide, hyaluronic acid, chrysanthemum extract, baicalin, EDTA disodium, guar gum, clove basil oil, blumea balsamifera oil, glycerol, purified water and the inclusion compound prepared in the step S1 according to the proportion;

s3, adding the weighed guar gum and purified water into a sol-gel machine for soaking, stirring uniformly after soaking for a period of time, dissolving, adding polyhexamethylene biguanide, carboxypropyltrimethylammonium chloride, sodium fluoride and EDTA disodium, and stirring for dissolving when the temperature is reduced to about 60 ℃;

s4, adding the mixture of oleum Ocimi Gratissimi, oleum Blumeae Balsamiferae, and S1 into glycerol, stirring, adding ceramide, flos Chrysanthemi extract, baicalin, and hyaluronic acid, and mixing;

s5, adding S4 into S3, and stirring to obtain the oral ulcer gel.

Further, in step S1, starch sodium octenyl succinate is added in an amount 3-5 times the weight of borneol and menthol.

Further, step S1 is carried out at a temperature of 55-65 ℃.

Compared with the prior art, the invention has at least one of the following beneficial effects:

1. the invention selects the raw materials with small stimulation and small side effect on human body, so that the prepared oral ulcer gel has better repairing effect on oral ulcer and smaller side effect on human body.

2. According to the invention, the blumea balsamifera oil and the clove basil oil are prepared, and then the menthol and the borneol are prepared into the menthol and borneol inclusion complex, so that more effective components can be extracted, and the storage time of the menthol and borneol inclusion complex can be prolonged.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.

Example 1

The oral ulcer gel comprises the following raw materials in percentage by mass: 1% of polyhexamethylene biguanide, 1% of carboxypropyltrimethylammonium chloride, 0.22% of sodium fluoride, 0.5% of ceramide, 0.5% of hyaluronic acid, 0.3% of menthol, 0.15% of borneol, 0.5% of chrysanthemum extract, 0.05% of baicalin, 0.03% of EDTA disodium, 0.03% of guar gum, 0.15% of clove basil oil, 0.15% of blumea balsamifera oil, 30% of glycerol and 66.42% of purified water;

the preparation method of the oral ulcer gel comprises the following steps:

s1, preparing the menthol and borneol inclusion complex: weighing borneol and menthol according to mass fraction, then adding starch sodium octenyl succinate to prepare a volatile oil inclusion complex, wherein the amount of the added starch sodium octenyl succinate is 3 times of the weight of the borneol and the menthol, and the step S1 is carried out at the temperature of 55 ℃;

s5, adding S4 into S3, and stirring to obtain the oral ulcer gel.

Example 2

the preparation method of the oral ulcer gel comprises the following steps:

s1, preparing the menthol and borneol inclusion complex: weighing borneol and menthol according to mass fraction, then adding starch sodium octenyl succinate to prepare a volatile oil inclusion complex, wherein the amount of the added starch sodium octenyl succinate is 3 times of the weight of the borneol and the menthol, and the step S1 is carried out at the temperature of 65 ℃;

s5, adding S4 into S3, and stirring to obtain the oral ulcer gel.

Example 3

the preparation method of the oral ulcer gel comprises the following steps:

s1, preparing the menthol and borneol inclusion complex: weighing borneol and menthol according to mass fraction, then adding starch sodium octenyl succinate to prepare a volatile oil inclusion complex, wherein the amount of the added starch sodium octenyl succinate is 5 times of the weight of the borneol and the menthol, and the step S1 is carried out at the temperature of 65 ℃;

s5, adding S4 into S3, and stirring to obtain the oral ulcer gel.

Example 4

the preparation method of the oral ulcer gel comprises the following steps:

s1, preparing the menthol and borneol inclusion complex: weighing borneol and menthol according to mass fraction, then adding starch sodium octenyl succinate to prepare a volatile oil inclusion complex, wherein the amount of the added starch sodium octenyl succinate is 4 times of the weight of the borneol and the menthol, and the step S1 is carried out at the temperature of 60 ℃;

s5, adding S4 into S3, and stirring to obtain the oral ulcer gel.

Example 5

the preparation method of the oral ulcer gel comprises the following steps:

s1, preparing the menthol and borneol inclusion complex: weighing borneol and menthol according to mass fraction, then adding starch sodium octenyl succinate to prepare a volatile oil inclusion complex, wherein the amount of the added starch sodium octenyl succinate is 5 times of the weight of the borneol and the menthol, and the step S1 is carried out at the temperature of 55 ℃;

s5, adding S4 into S3, and stirring to obtain the oral ulcer gel.

Experimental analysis:

first, animal safety and effectiveness experiment

Subject: selecting 70 guinea pigs, anesthetizing, burning 60S under the tongue of the mice with a cotton ball stained with phenol solution to prepare ulcer surfaces with diameter of 5mm, and randomly dividing into 1-5 groups of experimental group and 1-2 groups of control group, each group containing 10 mice;

the administration method comprises the following steps: experimental groups 1 to 5 groups applied the oral ulcer gel prepared in examples 1 to 5 twice a day, 1mg each time, for 5 days continuously; the control group is coated with saline solution twice a day, 1mg each time, and continuously for 5 days;

evaluation of the effects: 0 degree: no ulcer under tongue; degree I: the ulcer exists, and no false membrane is obvious at the ulcer part; II degree: a layer of yellowish white thin false membrane is arranged on the surface of the ulcer part; and III degree: the thick false membrane is arranged on the surface of the ulcer, and inflammatory edema is formed around the ulcer; IV degree: the ulcer surface is thick pseudo-membrane, and inflammatory edema around the ulcer is serious.

And (3) analyzing an experimental result: the effect evaluation statistics are carried out after 5 days of the experiment, and the statistical results are shown in table 1:

	0 degree	Degree I	II degree	Degree III	Degree of IV
						Experimental group 1	8	2
Experimental group 2	9	1
						Experimental group 3	10	0
Experimental group 4	8	1	1
						Experimental group 5	9	1
Control group 1	1	2	2	5
						Control group 2	1	1	1	6	1

As can be seen from Table 1, the oral ulcer gel of the present invention has a better repairing effect on oral ulcers.

Second, shelf life test

Subject: experimental groups: inventive examples 1-5 prepared oral ulcer gels;

control group: prepared according to the formulation and method of examples 1-5 of the present invention (except that menthol and borneol were not prepared into an inclusion, but were used directly) to obtain the oral ulcer gels of control groups 1-5;

the experimental process comprises the following steps: the oral ulcer gels of the experimental groups 1 to 5 and the oral ulcer gels prepared in the control groups 1 to 5 were placed in an open container and stored for 3 months, and the mass fraction of menthol was measured by gas chromatography at 15 days, 30 days, 45 days, 60 days, and 90 days, and the measurement results are shown in table 2:

	15 days/%)	30 days/%)	45 days/%)	60 days/%)	90 days/%)
						Experimental group 1	0.29％	0.28％	0.26％	0.24％	0.20％
Experimental group 2	0.29％	0.27％	0.26％	0.24％	0.22％
						Experimental group 3	0.29％	0.28％	0.26％	0.24％	0.20％
Experimental group 4	0.29％	0.26％	0.25％	0.24％	0.19％
						Experimental group 5	0.29％	0.28％	0.26％	0.24％	0.20％
Control group 1	0.26％	0.22％	0.18％	0.17％	0.14％
						Control group 2	0.27％	0.22％	0.19％	0.17％	0.13％
Control group 3	0.29％	0.22％	0.18％	0.17％	0.15％
						Control group 4	0.26％	0.20％	0.18％	0.15％	0.14％
Control group 5	0.26％	0.21％	0.18％	0.16％	0.13％

As can be seen from Table 2, the present invention has a good effect of preserving the beneficial ingredients, and the beneficial ingredients are less volatile and can be preserved for a long time.

Although the invention has been described herein with reference to a number of illustrative embodiments thereof, it should be understood that numerous other modifications and embodiments can be devised by those skilled in the art that will fall within the spirit and scope of the principles of this disclosure. More specifically, various variations and modifications are possible in the component parts and/or arrangements of the subject combination arrangement within the scope of the disclosure and claims of this application. In addition to variations and modifications in the component parts and/or arrangements, other uses will also be apparent to those skilled in the art.

Claims

1. A dental ulcer gel characterized by: the method comprises the following raw materials: polyhexamethylene biguanide, carboxypropyltrimethylammonium chloride, sodium fluoride, ceramide, hyaluronic acid, menthol, borneol, chrysanthemum extract, baicalin, disodium EDTA, guar gum, clove basil oil, blumea balsamifera oil, glycerol and purified water.

2. The ulcerative stomatitis gel of claim 1, wherein: the material comprises the following raw materials in percentage by mass: 1% of polyhexamethylene biguanide, 1% of carboxypropyltrimethylammonium chloride, 0.22% of sodium fluoride, 0.5% of ceramide, 0.5% of hyaluronic acid, 0.3% of menthol, 0.15% of borneol, 0.5% of chrysanthemum extract, 0.05% of baicalin, 0.03% of EDTA disodium, 0.03% of guar gum, 0.15% of clove basil oil, 0.15% of blumea balsamifera oil, 30% of glycerol and 66.42% of purified water.

3. The method for preparing a gel for oral ulcer according to claim 1 or 2, wherein: the method comprises the following steps:

s5, adding S4 into S3, and stirring to obtain the oral ulcer gel.

4. The method of preparing a gel for oral ulcer according to claim 3, wherein: in step S1, the amount of starch sodium octenyl succinate added is 3-5 times of the weight of Borneolum Syntheticum and Mentholum.

5. The method of preparing a gel for oral ulcer according to claim 3, wherein: step S1 is performed at a temperature of 55-65 ℃.