CN113209137A - 一种驴皮胶代血浆及其制备方法 - Google Patents
一种驴皮胶代血浆及其制备方法 Download PDFInfo
- Publication number
- CN113209137A CN113209137A CN202110188930.4A CN202110188930A CN113209137A CN 113209137 A CN113209137 A CN 113209137A CN 202110188930 A CN202110188930 A CN 202110188930A CN 113209137 A CN113209137 A CN 113209137A
- Authority
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- China
- Prior art keywords
- donkey
- hide gelatin
- hide
- plasma substitute
- gelatin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 108010010803 Gelatin Proteins 0.000 title claims abstract description 84
- 239000008273 gelatin Substances 0.000 title claims abstract description 82
- 229920000159 gelatin Polymers 0.000 title claims abstract description 82
- 235000019322 gelatine Nutrition 0.000 title claims abstract description 82
- 235000011852 gelatine desserts Nutrition 0.000 title claims abstract description 82
- 239000003058 plasma substitute Substances 0.000 title claims abstract description 42
- 238000002360 preparation method Methods 0.000 title claims abstract description 11
- 238000001914 filtration Methods 0.000 claims abstract description 44
- 239000000243 solution Substances 0.000 claims abstract description 25
- 229920002307 Dextran Polymers 0.000 claims abstract description 19
- 238000002347 injection Methods 0.000 claims abstract description 18
- 239000007924 injection Substances 0.000 claims abstract description 18
- 238000000034 method Methods 0.000 claims abstract description 12
- 239000012535 impurity Substances 0.000 claims abstract description 9
- 102000004190 Enzymes Human genes 0.000 claims abstract description 8
- 108090000790 Enzymes Proteins 0.000 claims abstract description 8
- 230000008569 process Effects 0.000 claims abstract description 7
- 241000283074 Equus asinus Species 0.000 claims description 31
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 21
- 239000007788 liquid Substances 0.000 claims description 15
- 239000000843 powder Substances 0.000 claims description 15
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 14
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 11
- 239000003814 drug Substances 0.000 claims description 11
- 239000002510 pyrogen Substances 0.000 claims description 10
- 239000012153 distilled water Substances 0.000 claims description 9
- 238000004519 manufacturing process Methods 0.000 claims description 9
- 239000011780 sodium chloride Substances 0.000 claims description 8
- 239000002994 raw material Substances 0.000 claims description 7
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 6
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 6
- 238000005238 degreasing Methods 0.000 claims description 6
- 238000001035 drying Methods 0.000 claims description 6
- 235000015110 jellies Nutrition 0.000 claims description 6
- 239000008274 jelly Substances 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 230000000975 bioactive effect Effects 0.000 claims description 5
- 229940079593 drug Drugs 0.000 claims description 5
- 108090000145 Bacillolysin Proteins 0.000 claims description 4
- 102000035092 Neutral proteases Human genes 0.000 claims description 4
- 108091005507 Neutral proteases Proteins 0.000 claims description 4
- 238000001802 infusion Methods 0.000 claims description 4
- 238000005406 washing Methods 0.000 claims description 4
- 102000008186 Collagen Human genes 0.000 claims description 3
- 108010035532 Collagen Proteins 0.000 claims description 3
- 230000001580 bacterial effect Effects 0.000 claims description 3
- 125000002091 cationic group Chemical group 0.000 claims description 3
- 229920001436 collagen Polymers 0.000 claims description 3
- 238000005520 cutting process Methods 0.000 claims description 3
- 239000000499 gel Substances 0.000 claims description 3
- 238000000227 grinding Methods 0.000 claims description 3
- 238000012545 processing Methods 0.000 claims description 3
- 239000011347 resin Substances 0.000 claims description 3
- 229920005989 resin Polymers 0.000 claims description 3
- 238000012216 screening Methods 0.000 claims description 3
- 238000002791 soaking Methods 0.000 claims description 3
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 3
- 229910001220 stainless steel Inorganic materials 0.000 claims description 3
- 239000010935 stainless steel Substances 0.000 claims description 3
- 238000011082 depyrogenation Methods 0.000 claims description 2
- 239000003292 glue Substances 0.000 claims description 2
- 230000001954 sterilising effect Effects 0.000 claims description 2
- 210000004369 blood Anatomy 0.000 abstract description 18
- 239000008280 blood Substances 0.000 abstract description 18
- 230000036772 blood pressure Effects 0.000 abstract description 15
- 230000000694 effects Effects 0.000 abstract description 15
- 238000011160 research Methods 0.000 abstract description 12
- 206010002198 Anaphylactic reaction Diseases 0.000 abstract description 7
- 208000003455 anaphylaxis Diseases 0.000 abstract description 7
- 231100000331 toxic Toxicity 0.000 abstract description 7
- 230000002588 toxic effect Effects 0.000 abstract description 7
- 238000002474 experimental method Methods 0.000 abstract description 6
- 241001465754 Metazoa Species 0.000 abstract description 3
- 230000004089 microcirculation Effects 0.000 abstract description 3
- 239000002245 particle Substances 0.000 abstract description 3
- 231100000419 toxicity Toxicity 0.000 abstract description 3
- 230000001988 toxicity Effects 0.000 abstract description 3
- 230000009471 action Effects 0.000 abstract description 2
- 230000000711 cancerogenic effect Effects 0.000 abstract description 2
- 231100000315 carcinogenic Toxicity 0.000 abstract description 2
- 210000002381 plasma Anatomy 0.000 description 15
- 229920001612 Hydroxyethyl starch Polymers 0.000 description 5
- 229940050526 hydroxyethylstarch Drugs 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 4
- 239000012530 fluid Substances 0.000 description 4
- 239000008103 glucose Substances 0.000 description 4
- 241000282472 Canis lupus familiaris Species 0.000 description 3
- 206010015719 Exsanguination Diseases 0.000 description 3
- 208000018525 Postpartum Hemorrhage Diseases 0.000 description 3
- 239000000084 colloidal system Substances 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 210000004185 liver Anatomy 0.000 description 3
- 230000003204 osmotic effect Effects 0.000 description 3
- 230000035939 shock Effects 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 241000283690 Bos taurus Species 0.000 description 2
- 208000032843 Hemorrhage Diseases 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- 239000005909 Kieselgur Substances 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000000703 anti-shock Effects 0.000 description 2
- 239000002473 artificial blood Substances 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000000740 bleeding effect Effects 0.000 description 2
- 208000019425 cirrhosis of liver Diseases 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 230000003907 kidney function Effects 0.000 description 2
- 230000003908 liver function Effects 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 239000013589 supplement Substances 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 206010007269 Carcinogenicity Diseases 0.000 description 1
- 208000020406 Creutzfeldt Jacob disease Diseases 0.000 description 1
- 208000003407 Creutzfeldt-Jakob Syndrome Diseases 0.000 description 1
- 208000010859 Creutzfeldt-Jakob disease Diseases 0.000 description 1
- 208000000624 Esophageal and Gastric Varices Diseases 0.000 description 1
- 206010016654 Fibrosis Diseases 0.000 description 1
- 206010062713 Haemorrhagic diathesis Diseases 0.000 description 1
- 208000034767 Hypoproteinaemia Diseases 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 206010052211 Oesophageal rupture Diseases 0.000 description 1
- 206010056091 Varices oesophageal Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 230000002009 allergenic effect Effects 0.000 description 1
- 208000030961 allergic reaction Diseases 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 230000007670 carcinogenicity Effects 0.000 description 1
- 231100000260 carcinogenicity Toxicity 0.000 description 1
- 230000007882 cirrhosis Effects 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000002635 electroconvulsive therapy Methods 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 208000024170 esophageal varices Diseases 0.000 description 1
- 201000010120 esophageal varix Diseases 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 208000031169 hemorrhagic disease Diseases 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 239000004973 liquid crystal related substance Substances 0.000 description 1
- 201000007270 liver cancer Diseases 0.000 description 1
- 208000014018 liver neoplasm Diseases 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 239000013618 particulate matter Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 238000011076 safety test Methods 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Epidemiology (AREA)
- Developmental Biology & Embryology (AREA)
- Diabetes (AREA)
- Virology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Description
Claims (7)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202110188930.4A CN113209137A (zh) | 2021-02-19 | 2021-02-19 | 一种驴皮胶代血浆及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202110188930.4A CN113209137A (zh) | 2021-02-19 | 2021-02-19 | 一种驴皮胶代血浆及其制备方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN113209137A true CN113209137A (zh) | 2021-08-06 |
Family
ID=77084683
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202110188930.4A Withdrawn CN113209137A (zh) | 2021-02-19 | 2021-02-19 | 一种驴皮胶代血浆及其制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN113209137A (zh) |
Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB863544A (en) * | 1956-04-28 | 1961-03-22 | Kyosei Seiyaku Kabushiki Kaish | Improvements in or relating to blood plasma substitutes |
US5084558A (en) * | 1987-10-13 | 1992-01-28 | Biopure Corporation | Extra pure semi-synthetic blood substitute |
CN101185657A (zh) * | 2007-09-05 | 2008-05-28 | 中国人民解放军北京军区白求恩国际和平医院256临床部 | 驴皮阿胶代血浆生产工艺及装置 |
CN101190236A (zh) * | 2006-11-30 | 2008-06-04 | 溧阳市宏兴生物工程有限公司 | 驴皮阿胶注射液代血浆及其制备方法 |
US20080132682A1 (en) * | 2006-03-03 | 2008-06-05 | Jellice Co., Ltd. | Method for manufacturing gelatin with reduced endotoxin content and low endotoxin gelatin |
CN102210705A (zh) * | 2011-06-03 | 2011-10-12 | 江苏建中投资有限公司 | 多肽驴皮胶代血浆生产工艺 |
CN102210703A (zh) * | 2011-06-02 | 2011-10-12 | 江苏建中投资有限公司 | 多肽驴皮胶的代血浆 |
CN102218080A (zh) * | 2011-06-03 | 2011-10-19 | 江苏建中投资有限公司 | 多肽驴皮胶代血浆高速过滤制备工艺 |
CN103432567A (zh) * | 2013-08-16 | 2013-12-11 | 武汉华龙生物制药有限公司 | 一种驴皮明胶代血浆注射液的制备方法 |
-
2021
- 2021-02-19 CN CN202110188930.4A patent/CN113209137A/zh not_active Withdrawn
Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB863544A (en) * | 1956-04-28 | 1961-03-22 | Kyosei Seiyaku Kabushiki Kaish | Improvements in or relating to blood plasma substitutes |
US5084558A (en) * | 1987-10-13 | 1992-01-28 | Biopure Corporation | Extra pure semi-synthetic blood substitute |
US20080132682A1 (en) * | 2006-03-03 | 2008-06-05 | Jellice Co., Ltd. | Method for manufacturing gelatin with reduced endotoxin content and low endotoxin gelatin |
CN101190236A (zh) * | 2006-11-30 | 2008-06-04 | 溧阳市宏兴生物工程有限公司 | 驴皮阿胶注射液代血浆及其制备方法 |
CN101185657A (zh) * | 2007-09-05 | 2008-05-28 | 中国人民解放军北京军区白求恩国际和平医院256临床部 | 驴皮阿胶代血浆生产工艺及装置 |
CN102210703A (zh) * | 2011-06-02 | 2011-10-12 | 江苏建中投资有限公司 | 多肽驴皮胶的代血浆 |
CN102210705A (zh) * | 2011-06-03 | 2011-10-12 | 江苏建中投资有限公司 | 多肽驴皮胶代血浆生产工艺 |
CN102218080A (zh) * | 2011-06-03 | 2011-10-19 | 江苏建中投资有限公司 | 多肽驴皮胶代血浆高速过滤制备工艺 |
CN103432567A (zh) * | 2013-08-16 | 2013-12-11 | 武汉华龙生物制药有限公司 | 一种驴皮明胶代血浆注射液的制备方法 |
Non-Patent Citations (1)
Title |
---|
杨穆等: "明胶类血浆代用品", 《明胶科学与技术》, no. 03, 31 December 2001 (2001-12-31) * |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
TA01 | Transfer of patent application right | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20221219 Address after: 501-349, Block D, Zhigu Science and Technology Complex, No. 186, Yangzijiang Middle Road, Yangzijin Street, Yangzhou Economic Development Zone, Jiangsu Province, 225000 Applicant after: Jiangsu Zhongxin Emergency Plasma Substitution Research Institute Co.,Ltd. Address before: 050000 No. 0902, unit 3, building 3, No. 486, Zhongshan West Road, Qiaoxi District, Shijiazhuang City, Hebei Province Applicant before: Lin Yueyun |
|
WW01 | Invention patent application withdrawn after publication | ||
WW01 | Invention patent application withdrawn after publication |
Application publication date: 20210806 |