CN113171428A - Traditional Chinese medicine plaster for orthopedics department and preparation method and application thereof - Google Patents
Traditional Chinese medicine plaster for orthopedics department and preparation method and application thereof Download PDFInfo
- Publication number
- CN113171428A CN113171428A CN202110601401.2A CN202110601401A CN113171428A CN 113171428 A CN113171428 A CN 113171428A CN 202110601401 A CN202110601401 A CN 202110601401A CN 113171428 A CN113171428 A CN 113171428A
- Authority
- CN
- China
- Prior art keywords
- parts
- radix
- mass
- plaster
- chinese medicine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/241—Lead; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/234—Cnidium (snowparsley)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/285—Aucklandia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/324—Boswellia, e.g. frankincense
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/328—Commiphora, e.g. mecca myrrh or balm of Gilead
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/51—Gentianaceae (Gentian family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/714—Aconitum (monkshood)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8984—Dendrobium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7076—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising ingredients of undetermined constitution or reaction products thereof, e.g. rosin or other plant resins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Inorganic Chemistry (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses an orthopedic traditional Chinese medicine plaster and a preparation method and application thereof, wherein the traditional Chinese medicine plaster comprises the following traditional Chinese medicine components: radix astragali, lignum sappan, herba Erodii seu Geranii, herba speranskiae tuberculatae, radix Aconiti Kusnezoffii, radix Syringae, radix Angelicae sinensis, sanguis Draxonis, Myrrha, Olibanum, flos Carthami, rhizoma Chuanxiong, radix Paeoniae Rubra, radix Cyathulae, caulis Lonicerae, rhizoma Acori Tatarinowii, rhizoma Atractylodis, radix aucklandiae, radix Gentianae Macrophyllae, fructus Cnidii, cortex Cinnamomi, radix Aconiti lateralis Preparata, and herba Dendrobii. The traditional Chinese medicine components can effectively treat traumatic injury, wind-cold-dampness arthralgia, numbness of hands and feet, contracture of limbs and joint pain. The plaster is prepared, and has the advantages of safety, no wound, convenient use, simple operation and easy acceptance by patients.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to an orthopedic traditional Chinese medicine plaster as well as a preparation method and application thereof.
Background
With the aging of society, the incidence of diseases of people suffering from symptoms such as traumatic injury, wind-cold-dampness arthralgia, numbness of hands and feet, contracture of limbs, joint swelling and pain and the like is increased greatly, and how to treat the diseases effectively is crucial. The clinical common treatment methods comprise dozens of means of oral administration and external application of Chinese and western medicines, massage, acupuncture, physical therapy, cupping, scraping therapy, operation and the like, and each means has advantages and disadvantages.
A great deal of clinical observation literature indicates that the controlled release preparation which is applied to the skin to achieve the systemic therapeutic effect has the unique advantages over the general drug delivery system, can bypass the first pass effect of the liver and the damage of the gastrointestinal tract, provides a predictable and longer action time and maintains stable and lasting blood concentration. The traditional Chinese medicine ointment formula has the advantages of obvious curative effect, small toxic and side effect, safety, no wound, convenience in use, simplicity in operation, easiness in acceptance of patients and the like. Clinically, various traditional Chinese medicine ointments are selected for treating traumatic injury, wind-cold-dampness arthralgia, numbness of hands and feet, spasm of limbs and joint swelling and pain, the ointment formula is selected according to experience and syndrome differentiation treatment of various doctors, and the traditional Chinese medicine ointment with wide application range and remarkable curative effect is urgently needed to be developed.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine plaster which can effectively treat traumatic injury, wind-cold-dampness arthralgia, numbness of hands and feet, spasm of limbs and joint pain.
The technical scheme adopted by the invention is as follows:
the invention provides a traditional Chinese medicine composition, which comprises the following components: radix astragali, lignum sappan, herba Erodii seu Geranii, herba speranskiae tuberculatae, radix Aconiti Kusnezoffii, radix Syringae, radix Angelicae sinensis, sanguis Draxonis, Myrrha, Olibanum, flos Carthami, rhizoma Chuanxiong, radix Paeoniae Rubra, radix Cyathulae, caulis Lonicerae, rhizoma Acori Tatarinowii, rhizoma Atractylodis, radix aucklandiae, radix Gentianae Macrophyllae, fructus Cnidii, cortex Cinnamomi, radix Aconiti lateralis Preparata, and herba Dendrobii.
In some embodiments of the present invention, the composition comprises the following raw material drugs in parts by weight: 15-30 parts of astragalus membranaceus, 5-15 parts of sappan wood, 5-12 parts of geranium wilfordii, 5-10 parts of garden balsam stem, 5-10 parts of raw kusnezoff monkshood root, 5-10 parts of lilac root, 5-10 parts of Chinese angelica, 5-10 parts of dragon's blood, 10-12 parts of myrrh, 10-12 parts of frankincense, 3-10 parts of safflower, 5-10 parts of ligusticum wallichii, 5-10 parts of red paeony root, 3-5 parts of medicinal cyathula root, 5-15 parts of honeysuckle stem, 2-5 parts of grassleaf sweelflag rhizome, 5-10 parts of rhizoma atractylodis, 3-5 parts of costustoot, 3-5 parts of large-leaved gentian, 2-5 parts of common cnidium fruit, 10-15 parts of cinnamon, 10-15 parts of medicinal cyathula root and 3-5 parts of dendrobium.
In some preferred embodiments of the present invention, the composition comprises the following raw materials in parts by weight: 15-20 parts of astragalus membranaceus, 5-10 parts of sappan wood, 5-10 parts of geranium wilfordii, 8-10 parts of garden balsam stem, 8-10 parts of raw kusnezoff monkshood root, 5-8 parts of lilac root, 5-8 parts of Chinese angelica, 5-8 parts of dragon's blood, 10-12 parts of myrrh, 10-12 parts of frankincense, 3-8 parts of safflower, 5-8 parts of ligusticum wallichii, 5-8 parts of red paeony root, 3-5 parts of medicinal cyathula root, 5-10 parts of honeysuckle stem, 2-3 parts of grassleaf sweelflag rhizome, 5-8 parts of rhizoma atractylodis, 3-5 parts of costustoot, 3-5 parts of large-leaved gentian, 2-5 parts of common cnidium fruit, 10-15 parts of cinnamon, 10-15 parts of medicinal cyathula root and 3-5 parts of dendrobium.
In some more preferred embodiments of the present invention, the composition comprises the following raw materials in parts by weight: 15 parts of astragalus mongholicus, 10 parts of sappan wood, 5 parts of geranium wilfordii, 10 parts of garden balsam stem, 10 parts of raw kusnezoff monkshood root, 5 parts of syringyl root, 5 parts of Chinese angelica, 5 parts of dragon's blood, 10 parts of myrrh, 10 parts of frankincense, 3 parts of safflower carthamus, 5 parts of ligusticum wallichii, 5 parts of red paeony root, 3 parts of medicinal cyathula root, 10 parts of honeysuckle stem, 2 parts of rhizoma acori graminei, 5 parts of rhizoma atractylodis, 3 parts of costus root, 3 parts of large-leaved gentian, 2 parts of common cnidium fruit, 10 parts of cinnamon, 10 parts of monkshood and 3 parts of dendrobium.
The invention also provides a traditional Chinese medicine preparation, which is any one of powder, tablets, injections, capsules, decoctions, granules, pills, paste or targeted preparations prepared from the traditional Chinese medicine composition.
The invention also provides a plaster, which comprises the following components: the Chinese medicinal composition, oil and yellow lead.
In some embodiments of the invention, the oil is sesame oil, olive oil, rapeseed oil, or cottonseed oil.
In some embodiments of the invention, the mass ratio of the traditional Chinese medicine composition to the oil to the yellow lead is 149-300: 400-600: 120 to 300.
The invention also provides a preparation method of the plaster, which comprises the following steps:
s1: heating the oil, decocting radix astragali, lignum sappan, radix Syringae, radix Angelicae sinensis, rhizoma Ligustici Chuanxiong, radix Paeoniae Rubra, radix Cyathulae, caulis Lonicerae, rhizoma Acori Graminei, rhizoma Atractylodis, radix Gentianae Marcrophyllae, fructus Cnidii, cortex Cinnamomi, radix Aconiti lateralis Preparata, and herba Dendrobii, taking out, and decocting herba Erodii seu Geranii, herba Speranskiae Tuberculatae, Carthami flos, and radix aucklandiae to obtain medicinal oil A;
s2: removing residues from the medicinal oil A, decocting, collecting filtrate, and decocting until water drops form bead to obtain medicinal oil B;
s3: adding Plumbum Preparatium, mixing with the medicinal oil B, cooling, adding sanguis Draxonis, Myrrha, and Olibanum, and stirring to obtain plaster;
s4: decocting the plaster, soaking in cold water, spreading the plaster on the plaster, and freezing.
In some embodiments of the present invention, the oil is heated at a temperature of 40 to 80 ℃ in step S1.
In some embodiments of the present invention, the frying temperature in step S1 is 170-230 ℃ for 50-80 min.
In some preferred embodiments of the present invention, the frying temperature in step S1 is 200 deg.C and the time is 60 min.
In some embodiments of the present invention, the decocting time in step S2 is 10-20 min.
In some embodiments of the present invention, the decocting temperature of step S2 to form water drops into beads is 300-360 ℃, and the time is 2.5-3.5 hours.
In some embodiments of the present invention, the soaking time in step S4 is 4 to 7 days.
In some preferred embodiments of the present invention, the soaking time in step S4 is 4 days.
In some embodiments of the present invention, the freezing time in step S4 is 3 to 5 days.
In some preferred embodiments of the present invention, the freezing time in step S4 is 3 days.
The application method of the plaster comprises the step of sticking the prepared plaster to the pain part of a patient and applying the plaster to the affected part for 6-8 hours.
The invention also provides application of the composition in preparing medicaments for treating traumatic injury, wind-cold-dampness arthralgia, numbness of hands and feet, contracture of limbs and joint pain.
In some embodiments of the present invention, the pharmaceutical ingredients of the Chinese medicinal composition are described in Table 1.
TABLE 1 Chinese medicine ingredients
The invention has the beneficial effects that:
the invention discloses a traditional Chinese medicine composition which can effectively treat traumatic injury, wind-cold-dampness arthralgia, numbness of hands and feet, spasm of limbs and swelling and pain of joints. The plaster is prepared, and has the advantages of safety, no wound, convenient use, simple operation and easy acceptance by patients. In the formula, the geranium wilfordii has the effects of expelling wind-damp, dredging channels and collaterals, and the dragon's blood is specially used in blood, promoting blood circulation, removing blood stasis, relieving pain, astringing and stopping bleeding, and the geranium wilfordii and the dragon's blood can be used together for relieving swelling and pain, and dispersing the wind-damp of the whole body to relieve arthralgia, and are monarch drugs; the frankincense, the myrrh, the sappan wood and the safflower are used for removing stasis and promoting qi circulation, and relieving swelling and pain, the gentiana macrophylla, the garden balsam stem and the Chinese magnoliavine root are used for dispelling wind and eliminating dampness, activating collaterals and relaxing tendons, the rhizoma atractylodis is used for eliminating dampness and eliminating arthralgia, the lilac root and the honeysuckle stem are used for clearing heat and promoting diuresis, the raw kusnezoff monkshood root and the monkshood are used for generating great heat, quickly warming yang and expelling cold, the red paeony root, the elecampane and the rhizoma acori graminei are used for promoting qi circulation and relieving pain, and the medicines are matched to dispel wind, cold and dampness arthralgia, and relieve symptoms of numbness of hands and feet, spasm of limbs and joint pain; radix cyathulae draws blood downward, ligusticum wallichii nourishes blood and activates blood, the meaning of 'treating wind first and treating blood, blood circulation and wind self-extinguishing' is combined, cinnamon warms the interior and dispels cold, passes blood vessels, fructus cnidii warms the kidney and eliminates dampness, radix astragali and angelica sinensis invigorate qi and enrich blood, and the prescription of 'promoting blood circulation and then draining pus and self-healing' is an adjuvant drug; dendrobe is used as adjuvant and guiding for clearing deficiency heat, tonifying stomach and promoting fluid production. The medicines are used together to play the functions of promoting blood circulation, removing blood stasis, relieving pain, dispelling wind and dredging collaterals.
Detailed Description
The concept and technical effects of the present invention will be clearly and completely described below in conjunction with the embodiments to fully understand the objects, features and effects of the present invention. It is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments, and those skilled in the art can obtain other embodiments without inventive effort based on the embodiments of the present invention, and all embodiments are within the protection scope of the present invention.
Example 1
The raw materials of a Chinese medicinal ointment for treating traumatic injury, arthralgia due to wind-cold-dampness, numbness of limbs, spasm of limbs, and swelling and pain of joints are shown in Table 2.
TABLE 2 Chinese medicinal ointment formulation
A preparation method of a traditional Chinese medicine plaster for treating traumatic injury, wind-cold-dampness arthralgia, numbness of hands and feet, contracture of limbs and joint pain comprises the following steps:
s1: putting sesame oil into a pot, heating and decocting to 40 deg.C, putting the materials into the oil in batches, decocting radix astragali, lignum sappan, Syringa oblata, radix Angelicae sinensis, rhizoma Ligustici Chuanxiong, radix Paeoniae Rubra, radix Cyathulae, caulis Lonicerae, rhizoma Acori Graminei, rhizoma Atractylodis, radix Gentianae Marcrophyllae, fructus Cnidii, cortex Cinnamomi, radix Aconiti lateralis Preparata, and herba Dendrobii, taking out when the appearance of the traditional Chinese medicine is dark brown and the interior is brown, decocting herba Erodii seu Geranii, herba Speranskiae Tuberculatae, Carthami flos, and radix aucklandiae, taking out the residue, and keeping the process at 230 deg.C for 50 min;
s2: removing residues, decocting the medicinal oil for 10min, and adding the filtered medicinal oil into the pan at 360 deg.C under stirring until the water drops form beads. Dripping water into beads, namely dipping oil drops into cold water by using a stirring rod, wherein the oil drops are not dispersed in the water and are agglomerated into a cake shape, and the process is about 3.5 hours;
s3: adding Plumbum Preparatium to make the pill and medicinal oil fully act, cooling after about 5min, adding sanguis Draxonis powder, Myrrha powder and Olibanum powder, and stirring;
s4: decocting the plaster, pouring into cold water basin, stirring water in one direction when pouring to make the plaster aggregate into whole mass, soaking for 4 days, changing cold water every day, removing fire toxin, spreading the plaster on kraft paper, covering with thin film, freezing at-20 deg.C for 3 days, and removing fire toxin.
Example 2
Weighing the following traditional Chinese medicine raw materials in proportion:
20 parts by mass of astragalus mongholicus, 15 parts by mass of sappan wood, 10 parts by mass of geranium wilfordii, 5 parts by mass of garden balsam stem, 10 parts by mass of raw kusnezoff monkshood root, 5 parts by mass of lilac root, 10 parts by mass of Chinese angelica, 5 parts by mass of dragon's blood, 10 parts by mass of myrrh, 10 parts by mass of frankincense, 3 parts by mass of safflower carthamus, 5 parts by mass of ligusticum wallichii, 5 parts by mass of red paeony root, 3 parts by mass of medicinal cyathula root, 5 parts by mass of honeysuckle stem, 5 parts by mass of grassleaf sweelflag rhizome, 10 parts by mass of rhizoma atractylodis, 5 parts by mass of costustoot, 5 parts by mass of large-leaved gentian, 2 parts by mass of common cnidium fruit, 10 parts by mass of cinnamon, 10 parts by mass of monkshood and 3 parts by mass of dendrobium.
A preparation method of a traditional Chinese medicine plaster for treating traumatic injury, wind-cold-dampness arthralgia, numbness of hands and feet, contracture of limbs and joint pain comprises the following steps:
s1: putting sesame oil into a pot, heating and decocting to 80 ℃, putting the medicines into the oil in batches, decocting firstly radix astragali, sappan wood, lilac root, angelica, ligusticum wallichii, red paeony root, medicinal cyathula root, honeysuckle stem, rhizoma acori graminei, rhizoma atractylodis, gentiana macrophylla, fructus cnidii, cinnamon, monkshood and dendrobe, fishing out the medicines when the appearance of the traditional Chinese medicines is dark brown and the interior is brown, decocting the geranium, garden balsam stem, safflower and elecampane, fishing out residues, and keeping the temperature at 200 ℃ till the process lasts for 1 h;
s2: removing residues, decocting the medicinal oil for 20min, and adding the filtered medicinal oil into the pan at 300 deg.C under stirring until the water drops form beads. Dripping water into beads, namely dipping oil drops into cold water by using a stirring rod, wherein the oil drops are not dispersed in the water and are agglomerated into a cake shape, and the process takes about 2.5 hours;
s3: adding Plumbum Preparatium to make the pill and medicinal oil fully act, cooling after about 10min, adding sanguis Draxonis powder, Myrrha powder and Olibanum powder, and stirring;
s4: decocting the plaster, pouring into cold water basin, stirring water in one direction when pouring to make the plaster aggregate into whole mass, soaking for 7 days, changing cold water every day, removing fire toxin, spreading the plaster on kraft paper, covering with thin film, freezing in refrigerator at-20 deg.C for 5 days, and removing fire toxin.
Example 3
Weighing the following traditional Chinese medicine raw materials in proportion:
18 parts by mass of astragalus membranaceus, 10 parts by mass of sappan wood, 12 parts by mass of geranium wilfordii, 10 parts by mass of garden balsam stem, 5 parts by mass of raw kusnezoff monkshood root, 10 parts by mass of lilac root, 8 parts by mass of Chinese angelica, 8 parts by mass of dragon's blood, 12 parts by mass of myrrh, 10 parts by mass of frankincense, 10 parts by mass of safflower, 10 parts by mass of ligusticum wallichii, 8 parts by mass of red paeony root, 5 parts by mass of medicinal cyathula root, 5 parts by mass of honeysuckle stem, 3 parts by mass of grassleaf sweelflag rhizome, 8 parts by mass of rhizoma atractylodis, 3 parts by mass of costustoot, 3 parts by mass of large-leaved gentian, 5 parts by mass of common cnidium fruit, 15 parts by mass of cinnamon, 15 parts by mass of szechuan lovage rhizome and 5 parts by mass of dendrobium.
A preparation method of a traditional Chinese medicine plaster for treating traumatic injury, wind-cold-dampness arthralgia, numbness of hands and feet, contracture of limbs and joint pain comprises the following steps:
s1: putting sesame oil into a pot, heating and decocting to 60 deg.C, putting the materials into the oil in batches, decocting radix astragali, lignum sappan, Syringa oblata, radix Angelicae sinensis, rhizoma Ligustici Chuanxiong, radix Paeoniae Rubra, radix Cyathulae, caulis Lonicerae, rhizoma Acori Graminei, rhizoma Atractylodis, radix Gentianae Marcrophyllae, fructus Cnidii, cortex Cinnamomi, radix Aconiti lateralis Preparata, and herba Dendrobii, taking out when the appearance of the traditional Chinese medicine is dark brown and the interior is brown, decocting herba Erodii seu Geranii, herba Speranskiae Tuberculatae, Carthami flos, and radix aucklandiae, taking out the residue, and keeping the process at 170 deg.C for 80 min;
s2: removing residues, decocting the medicinal oil for 15min, adding the filtered medicinal oil into the pan, and stirring at 330 deg.C till the water drops form beads. Dripping water into beads, namely dipping oil drops into cold water by a stirring rod, wherein the oil drops are not dispersed in the water and are agglomerated into a cake shape, and the process takes about 3 hours;
s3: adding Plumbum Preparatium to make the pill and medicinal oil fully act, cooling after about 8min, adding sanguis Draxonis powder, Myrrha powder and Olibanum powder, and stirring;
s4: decocting the plaster, pouring into cold water basin, stirring water in one direction when pouring to make the plaster aggregate into whole mass, soaking for 8 days, changing cold water every day, removing fire toxin, spreading the plaster on kraft paper, covering with thin film, freezing at-20 deg.C for 4 days, and removing fire toxin.
Example 4
Weighing the following traditional Chinese medicine raw materials in proportion:
30 parts by mass of astragalus mongholicus, 5 parts by mass of sappan wood, 5 parts by mass of geranium wilfordii, 5 parts by mass of garden balsam stem, 10 parts by mass of raw kusnezoff monkshood root, 5 parts by mass of lilac root, 5 parts by mass of Chinese angelica, 5 parts by mass of dragon's blood, 10 parts by mass of myrrh, 12 parts by mass of frankincense, 3 parts by mass of safflower carthamus, 5 parts by mass of ligusticum wallichii, 5 parts by mass of red paeony root, 3 parts by mass of medicinal cyathula root, 15 parts by mass of honeysuckle stem, 2 parts by mass of grassleaf sweelflag rhizome, 5 parts by mass of rhizoma atractylodis, 3 parts by mass of costustoot, 3 parts by mass of large-leaved gentian, 2 parts by mass of common cnidium fruit, 10 parts by mass of cinnamon, 10 parts by mass of monkshood and 3 parts by mass of dendrobium. The preparation method is the same as example 1.
Example 5
Weighing the following traditional Chinese medicine raw materials in proportion:
25 parts by mass of astragalus membranaceus, 12 parts by mass of sappan wood, 10 parts by mass of geranium wilfordii, 8 parts by mass of garden balsam stem, 8 parts by mass of raw kusnezoff monkshood root, 8 parts by mass of lilac root, 5 parts by mass of Chinese angelica, 10 parts by mass of dragon's blood, 10 parts by mass of myrrh, 10 parts by mass of frankincense, 8 parts by mass of safflower, 8 parts by mass of ligusticum wallichii, 10 parts by mass of red paeony root, 3 parts by mass of medicinal cyathula root, 15 parts by mass of honeysuckle stem, 2 parts by mass of grassleaf sweelflag rhizome, 5 parts by mass of rhizoma atractylodis, 3 parts by mass of costustoot, 3 parts by mass of large-leaved gentian, 2 parts by mass of common cnidium fruit, 10 parts by mass of cinnamon, 10 parts by mass of monkshood and 5 parts by mass of dendrobium. The preparation method is the same as example 1.
Comparative example 1
The same procedures as in example 1 were repeated except that 10 parts by mass of lycopodium clavatum, 5 parts by mass of musk, 10 parts by mass of pyrite, 3 parts by mass of acanthopanax bark, 5 parts by mass of alpine rush, 10 parts by mass of pinellia ternate, 3 parts by mass of yam rhizome, 3 parts by mass of pilose antler, 10 parts by mass of dog bone, 3 parts by mass of nux vomica, 5 parts by mass of borneol and 5 parts by mass of camphor were added to the Chinese medicinal composition of example 1 of the present invention.
Comparative example 2
The method is the same as that of example 1 except that astragalus, sappan wood, raw kusnezoff monkshood root and honeysuckle stem are removed from the traditional Chinese medicine composition of example 1, 10 parts by mass of common clubmoss herb, 5 parts by mass of musk, 10 parts by mass of native copper, 3 parts by mass of cortex acanthopanacis, 5 parts by mass of couchgrass, 10 parts by mass of pinellia ternate, 3 parts by mass of yam rhizome, 3 parts by mass of pilose antler, 10 parts by mass of dog bone, 3 parts by mass of nux vomica, 5 parts by mass of borneol and 5 parts by mass of camphor are added.
Comparative example 3
The method is the same as that of example 1 except that 3 parts by mass of artificial musk, 5 parts by mass of unprocessed radix aconiti kusnezoffii, 5 parts by mass of unprocessed radix aconiti, 3 parts by mass of unprocessed semen strychni and 10 parts by mass of rhizoma drynariae are added into the traditional Chinese medicine composition of example 1.
Comparative example 4
The method is the same as that of example 1 except that 3 parts by mass of artificial musk, 5 parts by mass of raw kusnezoff monkshood root, 5 parts by mass of raw radix aconiti, 3 parts by mass of raw semen strychni and 10 parts by mass of rhizoma drynariae are added to the traditional Chinese medicine composition of example 1.
Test example:
1) general data
352 cases of patients with traumatic injury, wind-cold-dampness arthralgia, limb numbness, limb spasm, joint swelling and pain and the like who come to hospital for diagnosis in 5/1/2020 to 6/30/2020 are selected, wherein 198 cases of men, 154 cases of women, 30-59 years of age and the average age is 40 years of age. The longest course of disease is 3 years, and the shortest is 7 days. The patients were divided into A, B groups, 176 patients in group A and 176 patients in group B, and there was no significant difference in sex, age and disease course between the two groups.
2. Method of treatment
Group a patients: the black plaster prepared in the embodiment 1 of the invention is externally applied for 1 time 1 day for 6-8 hours, and 7 days are 1 course of treatment. The treatment is continued for 2 courses.
Patients in group B: the black plaster prepared in the comparative example 1 of the invention is externally applied for 1 time 1 day for 6 to 8 hours, and 7 days are 1 course of treatment. The treatment is continued for 2 courses.
3. Criteria for efficacy assessment
And (3) curing: the symptom signs are completely disappeared, the VAS pain score is 0, the affected part can freely move, and no recurrence is caused;
the effect is shown: the symptom and sign basically disappear, the affected part is obviously improved, and the VAS pain score is 1-2, so that the original work can be basically recovered;
the method has the following advantages: pain was significantly reduced, VAS pain scored 3-4, with slight discomfort from excessive movement;
and (4) invalidation: pain and activity of affected parts did not change significantly before and after treatment, and VAS pain score was greater than 4.
The basic method for VAS pain scoring is to use a moving scale with the length of about 10cm, one side of the scale is marked with 10 scales, the two ends of the scale are respectively a 0-point and a 10-point, the 0-point represents no pain, and the 10-point represents the most severe pain which is difficult to bear. The participators do not need to fill in complicated questionnaires, only need to look at a pain ruler and then speak a number between 0 and 10.
4. Therapeutic effects
Group A: 98 patients are cured, accounting for 55.7%; 47 cases of remarkable effect account for 26.7 percent; 25 cases are effective, accounting for 14.2%; the number of the ineffective cases is 6, and the ineffective case accounts for 3.4 percent. The total effective rate is 96.6%.
Group B: 96 patients are cured, and the cure rate accounts for 54.5%; 47 cases of remarkable effect account for 26.7 percent; 28 effective cases account for 15.9%; and 5 invalid cases account for 2.8 percent. The total effective rate is 97.2%.
The treatment effects of the group a and the group B are not significantly different, so while the pharmaceutical cost is reduced and the safety of the patient is ensured, the treatment effect of the traditional Chinese medicine composition in the embodiment 1 is not significantly different from that of the traditional Chinese medicine composition added with lycopodium clavatum, musk, native copper, cortex acanthopanacis, Maoshan, pinellia ternate, yam rhizome, pilose antler, dog bone, nux vomica, borneol and camphor.
2) General data
410 patients with traumatic injury, wind-cold-dampness arthralgia, limb numbness, limb spasm, joint swelling and pain and the like who come to hospital for diagnosis in 6 months 1 to 7 months 7 to 30 days 2020 are selected, wherein 199 male patients, 210 female patients, 27 to 65 years old and 42 years old are selected. The longest course of disease is 5 years, and the shortest is 4 days. The patients were divided into A, B groups, 205 patients in group A and 205 patients in group B, and there was no significant difference in sex, age and disease course between the two groups.
2. Method of treatment
Group a patients: the black plaster prepared in the embodiment 1 of the invention is externally applied for 1 time 1 day for 6-8 hours, and 7 days are 1 course of treatment. The treatment is continued for 2 courses.
Patients in group B: the black plaster prepared in the comparative example 2 of the invention is externally applied for 1 time 1 day for 6 to 8 hours, and 7 days are 1 course of treatment. The treatment is continued for 2 courses.
3. Criteria for efficacy assessment
And (3) curing: the symptom signs are completely disappeared, the VAS pain score is 0, the affected part can freely move, and no recurrence is caused;
the effect is shown: the symptom and sign basically disappear, the affected part is obviously improved, and the VAS pain score is 1-2, so that the original work can be basically recovered;
the method has the following advantages: pain was significantly reduced, VAS pain scored 3-4, with slight discomfort from excessive movement;
and (4) invalidation: pain and activity of affected parts did not change significantly before and after treatment, and VAS pain score was greater than 4.
The basic method for VAS pain scoring is to use a moving scale with the length of about 10cm, one side of the scale is marked with 10 scales, the two ends of the scale are respectively a 0-point and a 10-point, the 0-point represents no pain, and the 10-point represents the most severe pain which is difficult to bear. The participators do not need to fill in complicated questionnaires, only need to look at a pain ruler and then speak a number between 0 and 10.
4. Therapeutic effects
Group A: among 205 patients, 120 patients are cured, accounting for 58.5%; 54 cases of remarkable effect account for 26.3 percent; 24 effective cases account for 11.7 percent; and 7 invalid cases account for 3.4 percent. The total effective rate is 96.6%.
Group B: of 205 patients, 102 were cured, accounting for 49.8%; 52 cases of obvious effect account for 25.4 percent; 24 effective cases account for 11.7 percent; the number of the ineffective 27 cases is 13.2 percent. The total effective rate is 86.8%.
The treatment effects of the group A and the group B are remarkably different, which shows that the effect of the product is reduced by removing astragalus, sappan wood, raw kusnezoff monkshood root and honeysuckle stem and adding lycopodium clavatum, musk, native copper, cortex acanthopanacis, couchgrass, pinellia ternate, yam rhizome, pilose antler, dog bone, nux vomica, borneol and camphor. Therefore, the traditional Chinese medicine composition in the embodiment 1 has better curative effect while stabilizing the drug effect and ensuring the safety of patients.
3) General data
306 patients with traumatic injury, wind-cold-dampness arthralgia, limb numbness, limb spasm, joint swelling and pain and the like are selected for hospitalization from 7/1/2020 to 8/30/2020, wherein 123 male patients, 183 female patients, 30-75 years old and the average age is 43 years old. The longest course of disease is 5 years, and the shortest course of disease is 3 days. The patients were divided into A, B groups, 153 patients in group A and 153 patients in group B, and there was no significant difference in sex, age and disease course between the two groups.
2. Method of treatment
Group a patients: the black plaster prepared in the embodiment 1 of the invention is externally applied for 1 time 1 day for 6-8 hours, and 7 days are 1 course of treatment. The treatment is continued for 2 courses.
Patients in group B: the black plaster prepared in the comparative example 3 of the invention is externally applied for 1 time 1 day for 6 to 8 hours, and 7 days are 1 course of treatment. The treatment is continued for 2 courses.
3. Criteria for efficacy assessment
And (3) curing: the symptom signs are completely disappeared, the VAS pain score is 0, the affected part can freely move, and no recurrence is caused;
the effect is shown: the symptom and sign basically disappear, the affected part is obviously improved, and the VAS pain score is 1-2, so that the original work can be basically recovered;
the method has the following advantages: pain was significantly reduced, VAS pain scored 3-4, with slight discomfort from excessive movement;
and (4) invalidation: pain and activity of affected parts did not change significantly before and after treatment, and VAS pain score was greater than 4.
The basic method for VAS pain scoring is to use a moving scale with the length of about 10cm, one side of the scale is marked with 10 scales, the two ends of the scale are respectively a 0-point and a 10-point, the 0-point represents no pain, and the 10-point represents the most severe pain which is difficult to bear. The participators do not need to fill in complicated questionnaires, only need to look at a pain ruler and then speak a number between 0 and 10.
4. Therapeutic effects
Group A: among 153 patients, 80 patients are cured and account for 52.3%; 45 cases of obvious effect account for 29.4 percent; 23 cases of effectiveness account for 15.0 percent; and 5 invalid cases account for 3.3 percent. The total effective rate is 96.7%.
Group B: among 153 patients, 85 patients are cured, accounting for 55.6%; 40 cases of obvious effect account for 28.1 percent; 25 effective cases account for 17.6 percent; ineffective 3 cases, account for 2.0%. The total effective rate is 98.0%.
The treatment effects of the group A and the group B are not obviously different, and compared with the example 1, the artificial musk, the raw kusnezoff monkshood root, the raw common monkshood mother root, the raw nux vomica and the rhizoma drynariae are additionally added in the comparative example 3, but the treatment effects are basically identical to those in the example 1, and the traditional Chinese medicine composition in the example 1 is shown to be not simply added.
4) General data
500 patients with traumatic injury, wind-cold-dampness arthralgia, numbness of limbs, contracture of limbs, joint pain and the like are selected from patients who come to hospital for diagnosis in 2020, 8, 1 and 2020, 9 and 30, wherein 223 male patients, 277 female patients, 23 to 70 years old and the average age is 40 years old. The longest course of disease is 7 years, and the shortest is 1 day. The patients were divided into A, B groups, 250 patients in group A and 250 patients in group B, and there was no significant difference in sex, age and course of disease between the two groups.
2. Method of treatment
Group a patients: the black plaster prepared in the embodiment 1 of the invention is externally applied for 1 time 1 day for 6-8 hours, and 7 days are 1 course of treatment. The treatment is continued for 2 courses.
Patients in group B: the black plaster prepared in the comparative example 4 of the invention is externally applied for 1 time 1 day for 6 to 8 hours, and 7 days are 1 course of treatment. The treatment is continued for 2 courses.
3. Criteria for efficacy assessment
And (3) curing: the symptom signs are completely disappeared, the VAS pain score is 0, the affected part can freely move, and no recurrence is caused;
the effect is shown: the symptom and sign basically disappear, the affected part is obviously improved, and the VAS pain score is 1-2, so that the original work can be basically recovered;
the method has the following advantages: pain was significantly reduced, VAS pain scored 3-4, with slight discomfort from excessive movement;
and (4) invalidation: pain and activity of affected parts did not change significantly before and after treatment, and VAS pain score was greater than 4.
The basic method for VAS pain scoring is to use a moving scale with the length of about 10cm, one side of the scale is marked with 10 scales, the two ends of the scale are respectively a 0-point and a 10-point, the 0-point represents no pain, and the 10-point represents the most severe pain which is difficult to bear. The participators do not need to fill in complicated questionnaires, only need to look at a pain ruler and then speak a number between 0 and 10.
4. Therapeutic effects
Group A: 137 cases of patients are cured, and the cure rate accounts for 54.8%; 69 cases of obvious effect account for 27.6 percent; 35 effective cases account for 14.0 percent; the number of the ineffective 9 cases is 3.6 percent. The total effective rate is 96.4%.
Group B: 100 patients are cured, accounting for 40.0 percent, among 250 patients; 38 cases of obvious effect account for 15.2 percent; 82 effective cases account for 32.8 percent; 30 cases of invalid, accounting for 12.0 percent. The total effective rate is 88.0%.
The treatment effects of the group a and the group B are significantly different, wherein compared with example 1, in comparative example 4, the treatment effects are reduced on the contrary by removing astragalus, sappan wood, raw kusnezoff monkshood root and geranium wilfordii, and adding artificial musk, raw kusnezoff monkshood root, raw monkshood, raw nux vomica and drynaria rhizome, while the drugs such as nux vomica and monkshood are common drugs for treating wind-cold-dampness arthralgia, joint swelling and pain or traumatic injury, but the treatment effects are reduced by replacing the astragalus, sappan wood, raw kusnezoff monkshood root and geranium wilfordii in example 1, which further illustrates that the traditional Chinese medicine composition in example 1 gains each other and cannot be replaced randomly. Therefore, the medicine has more curative effect while stabilizing the medicine effect and ensuring the safety of patients.
The present invention is not limited to the above embodiments, and various changes can be made without departing from the spirit of the present invention within the knowledge of those skilled in the art. Furthermore, the embodiments of the present invention and the features of the embodiments may be combined with each other without conflict.
Claims (10)
1. A traditional Chinese medicine composition comprises the following raw material medicines: radix astragali, lignum sappan, herba Erodii seu Geranii, herba speranskiae tuberculatae, radix Aconiti Kusnezoffii, radix Syringae, radix Angelicae sinensis, sanguis Draxonis, Myrrha, Olibanum, flos Carthami, rhizoma Chuanxiong, radix Paeoniae Rubra, radix Cyathulae, caulis Lonicerae, rhizoma Acori Tatarinowii, rhizoma Atractylodis, radix aucklandiae, radix Gentianae Macrophyllae, fructus Cnidii, cortex Cinnamomi, radix Aconiti lateralis Preparata, and herba Dendrobii.
2. The traditional Chinese medicine composition of claim 1, which is prepared from the following raw materials in parts by weight: 15-30 parts of astragalus membranaceus, 5-15 parts of sappan wood, 5-12 parts of geranium wilfordii, 5-10 parts of garden balsam stem, 5-10 parts of raw kusnezoff monkshood root, 5-10 parts of lilac root, 5-10 parts of Chinese angelica, 5-10 parts of dragon's blood, 10-12 parts of myrrh, 10-12 parts of frankincense, 3-10 parts of safflower, 5-10 parts of ligusticum wallichii, 5-10 parts of red paeony root, 3-5 parts of medicinal cyathula root, 5-15 parts of honeysuckle stem, 2-5 parts of grassleaf sweelflag rhizome, 5-10 parts of rhizoma atractylodis, 3-5 parts of costustoot, 3-5 parts of large-leaved gentian, 2-5 parts of common cnidium fruit, 10-15 parts of cinnamon, 10-15 parts of medicinal cyathula root and 3-5 parts of dendrobium.
3. The traditional Chinese medicine composition according to claim 1, which is characterized by comprising the following raw material medicines in parts by weight: 15-20 parts of astragalus membranaceus, 5-10 parts of sappan wood, 5-10 parts of geranium wilfordii, 8-10 parts of garden balsam stem, 8-10 parts of raw kusnezoff monkshood root, 5-8 parts of lilac root, 5-8 parts of Chinese angelica, 5-8 parts of dragon's blood, 10-12 parts of myrrh, 10-12 parts of frankincense, 3-8 parts of safflower, 5-8 parts of ligusticum wallichii, 5-8 parts of red paeony root, 3-5 parts of medicinal cyathula root, 5-10 parts of honeysuckle stem, 2-3 parts of grassleaf sweelflag rhizome, 5-8 parts of rhizoma atractylodis, 3-5 parts of costustoot, 3-5 parts of large-leaved gentian, 2-5 parts of common cnidium fruit, 10-15 parts of cinnamon, 10-15 parts of medicinal cyathula root and 3-5 parts of dendrobium.
4. Powder, tablets, injections, capsules, decoctions, granules, pills, ointments or targeted preparations prepared from the traditional Chinese medicine composition of any one of claims 1 to 3.
5. A plaster prepared from the Chinese medicinal composition of any one of claims 1 to 3, oil and Plumbum Preparatium.
6. A process for preparing a plaster according to claim 5, comprising the steps of:
s1: heating the oil, decocting radix astragali, lignum sappan, radix Syringae, radix Angelicae sinensis, rhizoma Ligustici Chuanxiong, radix Paeoniae Rubra, radix Cyathulae, caulis Lonicerae, rhizoma Acori Graminei, rhizoma Atractylodis, radix Gentianae Marcrophyllae, fructus Cnidii, cortex Cinnamomi, radix Aconiti lateralis Preparata, and herba Dendrobii, taking out, and decocting herba Erodii seu Geranii, herba Speranskiae Tuberculatae, Carthami flos, and radix aucklandiae to obtain medicinal oil A;
s2: removing residues from the medicinal oil A, decocting, collecting filtrate, and decocting until water drops form bead to obtain medicinal oil B;
s3: adding Plumbum Preparatium, mixing with the medicinal oil B, cooling, adding sanguis Draxonis, Myrrha, and Olibanum, and stirring to obtain plaster;
s4: decocting the plaster, soaking in cold water, spreading the plaster on the plaster, and freezing.
7. The method according to claim 6, wherein the frying temperature in step S1 is 170-230 ℃ for 50-80 min.
8. The preparation method of claim 6, wherein the decoction temperature of the decoction until the water drops into beads in the step S2 is 300-360 ℃, and the time is 2.5-3.5 h.
9. The use method of the plaster of claim 5, wherein the plaster is applied to the pain part of the patient for 6-8 h.
10. Use of the Chinese medicinal composition of any one of claims 1-3 in the preparation of medicaments for treating traumatic injury, wind-cold-dampness arthralgia, numbness of limbs, spasm of limbs and joint pain.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110601401.2A CN113171428A (en) | 2021-05-31 | 2021-05-31 | Traditional Chinese medicine plaster for orthopedics department and preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110601401.2A CN113171428A (en) | 2021-05-31 | 2021-05-31 | Traditional Chinese medicine plaster for orthopedics department and preparation method and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN113171428A true CN113171428A (en) | 2021-07-27 |
Family
ID=76927227
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110601401.2A Pending CN113171428A (en) | 2021-05-31 | 2021-05-31 | Traditional Chinese medicine plaster for orthopedics department and preparation method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN113171428A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101352503A (en) * | 2008-08-27 | 2009-01-28 | 杨振才 | Plaster for treating joint ache and preparation method thereof |
| CN103071055A (en) * | 2013-01-04 | 2013-05-01 | 河南科技大学 | Externally applied traditional Chinese medicine composition for curing diseases of orthopedics and traumatology and preparation method of externally applied traditional Chinese medicine |
-
2021
- 2021-05-31 CN CN202110601401.2A patent/CN113171428A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101352503A (en) * | 2008-08-27 | 2009-01-28 | 杨振才 | Plaster for treating joint ache and preparation method thereof |
| CN103071055A (en) * | 2013-01-04 | 2013-05-01 | 河南科技大学 | Externally applied traditional Chinese medicine composition for curing diseases of orthopedics and traumatology and preparation method of externally applied traditional Chinese medicine |
Non-Patent Citations (2)
| Title |
|---|
| 杨豪: "《骨伤方药临床应用荟萃》", 30 September 2003 * |
| 林万国，等: "活络膏制备工艺改进", 《黑龙江医药》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107693767B (en) | External traditional Chinese medicine composition for preventing and treating diabetic foot, and preparation method and application thereof | |
| CN102973862B (en) | Chinese medicine preparation for treating skin itch | |
| CN102309723B (en) | Traditional Chinese medicine composition for treating arthralgia and preparation method of ointment thereof | |
| CN102008610B (en) | Traditional Chinese medicine composition for curing hyperosteogeny | |
| CN102488812B (en) | Bone fracture oral medicine, preparation method thereof, and application method thereof | |
| CN104383445A (en) | Traumatic injury analgesic | |
| CN108295128B (en) | Traditional Chinese medicine compound preparation for treating rheumatoid arthritis and preparation method thereof | |
| CN103251766A (en) | Chinese medicine composition, and clinical preparation and preparation method thereof | |
| CN105287721A (en) | Chinese herbal compound for treating arthritis, cataplasm preparation of Chinese herbal compound for treating arthritis and method for preparing cataplasm preparation | |
| CN1066054C (en) | Medicine for treating rheumatic diseases | |
| CN113171428A (en) | Traditional Chinese medicine plaster for orthopedics department and preparation method and application thereof | |
| CN101057922A (en) | Traditional Chinese medicine preparation for treating vitiligo | |
| CN102614464A (en) | Traditional Chinese medicine composition for treating diabetic foot | |
| CN102028768B (en) | Traditional Chinese medicament for treating lumbar canal stenosis | |
| CN105362456A (en) | Oral medicine for treating early stage cervical cancer and preparation method thereof | |
| CN104800302A (en) | Externally applied plaster for treating thromboangiitis obliterans and preparation method | |
| CN104721427A (en) | Traditional Chinese medicine preparation for treating rheumatic bone diseases | |
| CN100423767C (en) | Medicine for curing burn and scald wound and its preparation method | |
| CN109674918B (en) | Compound Chinese medicine liniment for eliminating arthralgia and its preparation | |
| CN113244363B (en) | Traditional Chinese medicine cake moxibustion for orthopedics department as well as preparation method and application thereof | |
| CN102188629B (en) | External pain relieving tincture for muscular rheumatism | |
| CN108815415B (en) | Externally-applied medicine for treating rheumatic ostealgia and preparation method thereof | |
| CN107281444B (en) | Analgesic pharmaceutical composition and preparation method and application thereof | |
| CN1422639A (en) | Dral medicine for treating rheumatism and atrophic diseases | |
| CN105998500A (en) | Fracture-setting and ache-removing traditional Chinese medicine as well as preparation method and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20210727 |
|
| RJ01 | Rejection of invention patent application after publication |