CN113171406A

CN113171406A - Mongolian medicine composition for treating joint swelling and pain, preparation method, preparation and application

Info

Publication number: CN113171406A
Application number: CN202110649664.0A
Authority: CN
Inventors: 赖苏雅拉吐; 徐晓霞; 斯琴格日勒; 赵智娟; 周乌恩其
Original assignee: Individual
Current assignee: Individual
Priority date: 2021-06-10
Filing date: 2021-06-10
Publication date: 2021-07-27

Abstract

The application provides a Mongolian medicine composition for treating joint swelling and pain, a preparation method, a preparation and application. The method comprises the following steps: pulverizing lignum Xanthoceratis, fructus Chebulae, radix Gentianae Marcrophyllae and cortex Phellodendri; sieving pulverized lignum Xanthoceratis, fructus Chebulae, radix Gentianae Marcrophyllae and cortex Phellodendri; and uniformly mixing the sieved shiny-leaved yellowhorn, myrobalan, gentiana macrophylla and phellodendron bark to obtain the mongolian medicine composition for treating the joint swelling and pain. The application comprehensively acts the shiny-leaved yellowhorn, the large-leaved gentian, the golden cypress and the myrobalan, can be suitable for heat arthritis, edema and migratory rheumatism of each joint and soft tissue of a body, achieves multiple effects of clearing heat, reducing swelling and relieving pain, can be suitable for treating various diseases, and has wider applicability.

Description

Mongolian medicine composition for treating joint swelling and pain, preparation method, preparation and application

Technical Field

The application relates to the technical field of medicines, in particular to a Mongolian medicine composition for treating joint swelling and pain, a preparation method, a preparation and application.

Background

Arthritis generally refers to inflammatory diseases occurring in the joints and their surrounding tissues of the human body, and is clinically manifested as redness, swelling, heat, pain, dysfunction and deformity of the joints.

At present, traditional Chinese herbal medicines or Mongolian medicinal materials with the effects of clearing heat, relieving swelling or pain are selected for medicines for treating heat arthritis, edema and wandering wind-damp heat diseases in a targeted manner, are crushed, soaked or decocted in water, supernatant liquid is taken for decoction and concentration, and egg white, vinegar, sesame oil and the like are mixed and pasted on the body surface of an affected part. The existing medicine is mainly applied to a narrow symptom range, or only applied to one single symptom of heat arthritis, edema and wandering wind-damp heat disease, or only applied to local parts, such as knee joints, ankle joints and the like, and can not be widely applied to heat arthritis of all parts of a body, and can not be widely applied to various uncomfortable symptoms of heat arthritis, edema and wandering wind-damp heat disease.

Disclosure of Invention

The application provides a Mongolian medicine composition for treating joint swelling and pain, a preparation method, a preparation and application, and aims to solve the problem that the application range of the medicine is not wide.

In a first aspect, the present application provides a method for preparing a Mongolian medicinal composition for treating joint swelling and pain, comprising: pulverizing lignum Xanthoceratis, fructus Chebulae, radix Gentianae Marcrophyllae and cortex Phellodendri;

sieving pulverized lignum Xanthoceratis, fructus Chebulae, radix Gentianae Marcrophyllae and cortex Phellodendri;

mixing sieved lignum Xanthoceratis, fructus Chebulae, radix Gentianae Marcrophyllae and cortex Phellodendri uniformly to obtain Mongolian medicinal composition.

As an alternative embodiment of the present application, the xanthoceras sorbifolia bunge, myrobalan, gentiana macrophylla and phellodendron amurense are subjected to a pulverization treatment comprising:

pulverizing lignum Xanthoceratis, fructus Chebulae, radix Gentianae Marcrophyllae and cortex Phellodendri to obtain middle powder;

sieving the pulverized radix Curcumae, fructus Chebulae, radix Gentianae Marcrophyllae and cortex Phellodendri, including:

sieving pulverized lignum Xanthoceratis, fructus Chebulae, radix Gentianae Marcrophyllae and cortex Phellodendri with 80 mesh sieve.

As an alternative embodiment of the present application, the xanthoceras sorbifolia bunge, myrobalan, gentiana macrophylla and phellodendron amurense are subjected to a pulverization treatment comprising: pulverizing 230-690 parts by weight of lignum Xanthoceratis, 90-270 parts by weight of fructus Chebulae, 90-270 parts by weight of radix Gentianae Marcrophyllae and 90-270 parts by weight of cortex Phellodendri.

As an alternative embodiment of the present application, 460 parts by weight of shinyleaf yellowhorn, 180 parts by weight of myrobalan, 180 parts by weight of gentiana macrophylla and 180 parts by weight of phellodendron amurense are subjected to a pulverization treatment.

In a second aspect, the application provides a Mongolian medicinal composition for treating joint swelling and pain, which comprises shinyleaf yellowhorn, myrobalan fruit, large-leaved gentian and golden cypress.

As an optional embodiment of the application, the weight parts of the shinyleaf yellowhorn are 230-690, the weight parts of the myrobalan are 90-270, the weight parts of the gentiana macrophylla are 90-270 and the weight parts of the phellodendron amurense are 90-270.

As an alternative embodiment of the present application, wenguanmu is 460 parts by weight, myrobalan is 180 parts by weight, gentiana macrophylla is 180 parts by weight and phellodendron bark is 180 parts by weight.

In a third aspect, the application provides a pharmaceutical preparation for treating joint swelling and pain, which comprises a Mongolian medicine composition for treating joint swelling and pain or a Mongolian medicine composition for treating arthritis, wherein the Mongolian medicine composition for treating joint swelling and pain is prepared by a preparation method of the Mongolian medicine composition for treating arthritis.

The dosage form of the pharmaceutical preparation includes a liquid dosage form, a solid dosage form, a semi-solid dosage form, or a gaseous dosage form.

As an alternative embodiment of the present application,

liquid dosage forms include solutions or injections; and/or the presence of a gas in the gas,

solid dosage forms include tablets, pills, capsules or powders; and/or the presence of a gas in the gas,

semisolid dosage forms include ointments, gels, or creams; and/or the presence of a gas in the gas,

the gaseous dosage form comprises an aerosol or spray.

In a fourth aspect, the application provides an application of a Mongolian medicine composition for treating joint swelling and pain or a Mongolian medicine composition obtained by a preparation method of the Mongolian medicine composition for treating joint swelling and pain in preparation of a medicine for treating joint swelling and pain.

The Mongolian medicine composition for treating the joint swelling and pain, the preparation method, the preparation and the application thereof have the advantages that the Mongolian medicine composition containing the shinyleaf yellowhorn herb achieves the effects of drying yellow water, removing blood stasis and clearing blood heat; the effects of relieving arthritis and accelerating the elimination of swelling are realized by containing the gentiana macrophylla; the phellodendron bark is contained, so that the effects of relieving pain, reducing swelling and clearing heat are achieved; the medicine has the effect of harmonizing the medicines by containing the myrobalan. The shinyleaf yellowhorn, the large-leaved gentian, the golden cypress and the myrobalan are all suitable for all parts of a body, so that the shinyleaf yellowhorn, the large-leaved gentian, the golden cypress and the myrobalan are comprehensively acted, can be suitable for heat arthritis, edema and migratory rheumatism of all joints and soft tissues of the body, achieve multiple effects of clearing heat, relieving swelling and pain, can be suitable for treating various diseases, and have wider applicability; each raw material component contains a plurality of active substances and has pertinence to etiology, so that the cure rate is high.

Drawings

In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings needed to be used in the description of the embodiments or the prior art will be briefly described below, and it is obvious that the drawings in the following description are some embodiments of the present application, and other drawings can be obtained by those skilled in the art without creative efforts.

Fig. 1 is a flowchart of a method for preparing a Mongolian medicinal composition for treating joint pain according to an embodiment of the present application.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions in the embodiments of the present application are clearly and completely described below, and it is obvious that the described embodiments are a part of the embodiments of the present application, but not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.

The application provides a Mongolian medicine composition for treating joint swelling and pain, a preparation method, a preparation and an application, wherein the Mongolian medicine composition mainly comprises shinyleaf yellowhorn, myrobalan, large-leaved gentian and golden cypress, and can be used for treating symptoms such as joint swelling and pain, fever edema, oral ulcer, shoulder joint heat rheumatism, knee joint heat rheumatism, ankle joint heat rheumatism and the like.

Wherein, the xanthoceras sorbifolia bunge refers to the dry stems of xanthoceras sorbifolia bunge of Sapindaceae. Cutting stems in summer, removing branches and leaves, and drying in the sun to obtain the medicinal material of the shinyleaf yellowhorn. The Tibetan medicine is also called as Candansheng, and has the following properties and tastes: cool and astringent. Has the functions of relieving swelling and pain, drying blood and drying yellow water. It is commonly used for rheumatic arthritis, rheumatic fever and leprosy. The traditional Chinese medicine theory considers that the yellow water is a source of all diseases, and the yellow water discharged can be used for treating the diseases; wind-cold-dampness and strain can cause heat arthritis and edema of bone and joint such as shoulder, neck, waist, leg, chest and back; according to traditional Mongolian medicine of China, the symptoms are mostly caused by excessive yellow water, combination of viscous evil and local obstruction of qi and blood. Therefore, the yellow water discharge is the key for treating the diseases, and the shiny-leaved yellowhorn is a monarch drug, not only has the efficacy of drying the yellow water, but also can reduce swelling, relieve pain, dry blood, improve the body condition from multiple aspects, and relieve and treat swelling and pain of various bone joints and connective tissues of the body.

Gentiana macrophylla is a perennial herb. The shape of the cylinder is similar to a cylinder, the upper part is thick, the lower part is thin, the torsion is not straight, the length is 10-30 cm, and the diameter is 1-3 cm. The surface is yellowish brown or gray yellow, and has longitudinal wrinkles or twisted wrinkles, and the top has residual stem base and fibrous leaf sheath. Hard and brittle, easily broken, slightly oily cross section, yellow or brown yellow skin and yellow wood. Special smell, bitter and slightly astringent taste. The gentiana macrophylla is used as a ministerial drug and has the effects of dispelling wind-damp, clearing damp-heat and relieving arthralgia.

Cortex Phellodendri is the dried bark of phellodendron amurense belonging to Rutaceae. It is commonly called Chuan Huang Bai. Peeling the bark, removing the coarse bark, and sun drying to obtain cortex Phellodendri medicine. The phellodendron bark is bitter and cold in property and subsides, clears heat and dries dampness, purges fire and releases toxicity, and has the efficacy of yellow water drainage; eliminating dampness, purging pathogenic fire, removing toxic substances, and improving body resistance. Febrile arthritis, edema, and migratory wind-damp heat syndrome are usually caused by pathogenic wind-cold-dampness combined with viscous pathogen, and further yellow water predominance. The phellodendron bark is an adjuvant drug, has the effect of dry yellow water, can fundamentally treat the body immunity reduction caused by wind-cold-dampness pathogen and combined adhesion pathogen, and simultaneously regulates the internal environment of the body. Eliminating yellow water, improving body resistance, and fundamentally treating to gradually relieve symptoms of febrile arthritis, edema, and migratory rheumatism; achieves the effects of detumescence and relieving pain and achieves better cure rate.

Fructus Chebulae is the dried fruit of Terminalia chebula or Terminalia tomentosa of Combretaceae. Harvesting in winter when the fruit is ripe, removing impurities, and drying in the sun. Dry and astringent taste and mild nature. The myrobalan is a guiding drug and has the effects of clearing heat and removing toxicity, astringing and nourishing blood and harmonizing the drugs.

Fig. 1 is a flowchart of a method for preparing a Mongolian medicinal composition for treating joint swelling and pain according to an embodiment of the present application, as shown in fig. 1, the method of this embodiment includes:

s101, smashing shinyleaf yellowhorn, myrobalan, large-leaved gentian and golden cypress.

In this embodiment, the above-mentioned herbs are selected and screened through a second or third screen, dust is screened out, non-medicinal parts and deterioration failure parts are selected, and the selected and sorted herbs, such as shinyleaf yellowhorn, myrobalan, gentiana macrophylla and phellodendron bark, are sent into a pulverizer to be pulverized. The pulverizer may be a mortar, ball mill, impact pulverizer, or fluid energy mill. It should be noted that the above materials should be kept as dry as possible before pulverizing.

In an alternative embodiment, the embodiment is that 230-690 parts by weight of shinyleaf yellowhorn, 90-270 parts by weight of myrobalan, 90-270 parts by weight of gentiana macrophylla and 90-270 parts by weight of phellodendron are crushed. Specifically, selecting shinyleaf yellowhorn, myrobalan, large-leaved gentian and amur corktree bark, screening dust, selecting non-medicinal parts, deterioration failure parts and the like, weighing 230-690 parts by weight of shinyleaf yellowhorn, 90-270 parts by weight of myrobalan, 90-270 parts by weight of large-leaved gentian and 90-270 parts by weight of amur corktree bark from the selected and sorted medicinal materials, and sending the medicinal materials into a crusher for crushing.

Optionally, in this embodiment, 460 parts by weight of shinyleaf yellowhorn, 180 parts by weight of myrobalan, 180 parts by weight of gentiana macrophylla and 180 parts by weight of phellodendron bark are pulverized. Specifically, selecting shinyleaf yellowhorn, myrobalan, large-leaved gentian and amur corktree bark, screening dust, selecting non-medicinal parts, deterioration failure parts and the like, weighing 460 parts by weight of shinyleaf yellowhorn, 180 parts by weight of myrobalan, 180 parts by weight of large-leaved gentian and 180 parts by weight of amur corktree bark from the selected and sorted medicinal materials, and feeding the medicinal materials into a crusher for crushing.

S102, sieving the crushed shiny-leaved yellowhorn, myrobalan, gentiana macrophylla and phellodendron.

In the embodiment, the smashed shinyleaf yellowhorn, myrobalan, gentiana macrophylla and phellodendron are taken out from a discharge hole of the smashing machine and evenly spread on the screen mesh, the medicinal materials should move in a large range in enough room on the screen mesh, the powder sieving machine is started, and the screen mesh is continuously vibrated by the powder sieving machine for sieving treatment. The powder sieving machine can be an oscillating sieving instrument, a rotary vibrating sieve and the like. It should be noted that the above materials should be kept dry as much as possible during the pulverizing and sieving process.

S103, uniformly mixing the sieved shiny-leaved yellowhorn, myrobalan, gentiana macrophylla and phellodendron bark to obtain the mongolian medicine composition for treating the joint swelling and pain.

In the embodiment, the screened shiny-leaved yellowhorn, myrobalan, gentiana macrophylla and phellodendron are taken out from a discharge port of a screening machine and sent into a mixing machine to be fully mixed for one hour to obtain the Mongolian medicine composition, so that all medicine components are uniformly distributed.

It should be noted that the composition should be kept as dry as possible during the process of pulverizing, sieving, mixing and packaging, and the obtained Mongolian medicinal composition should not exceed 12.0% of water content as measured by moisture determination method.

In an alternative embodiment of the present application, the above herbs (shinyleaf yellowhorn, myrobalan, gentiana macrophylla and phellodendron bark) are pulverized into medium powder, wherein the medium powder is powder which can pass through a fourth sieve completely but is mixed with powder which can pass through a fifth sieve by no more than 60%. The fourth sieve is a sieve with 65 meshes, and the fifth sieve is a sieve with 80 meshes. The medicinal materials are crushed, so that the granularity of the solid medicine can be greatly reduced, the surface area of the medicine is increased, the dissolution of active ingredients in the medicinal materials is promoted, the medicine effect is further exerted, and the subsequent preparation of various medicinal preparations is facilitated. But the pulverized medicinal materials should not be too fine to reach the medium powder, so as to save energy and reduce the loss of the medicine in the pulverizing process. Then, the crushed shiny-leaved yellowhorn, myrobalan, gentiana macrophylla and phellodendron are sieved by a 80-mesh sieve. Optionally, the medicinal materials with diameter larger than 80 meshes can not pass through the screen, and should be pulverized again, and then the above-mentioned sieving treatment is carried out. Optionally, the thicknesses of the pulverized medicinal material powders are greatly different, and the powders with different grades are separated from the powder mixed in the thicknesses through sieves with different mesh diameters, so that the subsequent preparation of various different dosage forms is facilitated.

Optionally, the Mongolian medicine composition obtained by uniformly mixing can be subpackaged according to the specification of 3-5 g/bag, the limitation of the filling amount difference is +/-7%, and the Mongolian medicine composition is used for preparing decoction. The mixing can ensure that various medicinal materials contained in each bag of the medicinal composition after subpackaging are uniform and consistent, and the phenomenon that a certain medicinal material is lacked in one bag is avoided.

In another alternative embodiment of the present application, the above herbs (shinyleaf yellowhorn, myrobalan, gentiana macrophylla and phellodendron bark) are pulverized into fine powder, wherein the fine powder is powder which can pass through a fifth sieve and contains not less than 95% of powder which can pass through a sixth sieve. The sieve five is a sieve of 80 meshes, and the sieve six is a sieve of 100 meshes. Then, the crushed shiny-leaved yellowhorn, myrobalan, gentiana macrophylla and phellodendron are sieved by a 100-mesh sieve. The Mongolian medicine composition obtained by uniformly mixing can be subpackaged with the specification of 1.5-3 g/bag to prepare powder.

In another alternative embodiment of the present application, the above herbs (shinyleaf yellowhorn, myrobalan, gentiana macrophylla and phellodendron bark) are pulverized into the finest powder, wherein the finest powder is the powder which can pass through the six-mesh sieve and contains not less than 95% of the powder which can pass through the seven-mesh sieve. The number six sieve is a sieve with 100 meshes, and the number seven sieve is a sieve with 120 meshes. Then, sieving the smashed shinyleaf yellowhorn, myrobalan, large-leaved gentian and amur corktree bark by adopting a 120-mesh sieve. The Mongolian medicine composition obtained by uniformly mixing can be subpackaged, the specification of the subpackage is 1 g/bag, and the subpackage is used for preparing pills.

In this example, shinyleaf yellowhorn and myrobalan are addedThe Mongolian medicine composition for treating the joint swelling and pain is obtained by crushing, sieving and mixing seeds, gentiana macrophylla and phellodendron, and has the characteristics that: a light yellowish brown powder; light smell, astringent taste. Placing the above Mongolian medicinal composition on smooth paper, and spreading for about 5cm²The surface of the glass is flattened, and the glass is observed in a bright place, and the glass should have uniform color and luster and no decorative patterns or color spots.

According to the preparation method of the Mongolian medicine composition for treating the joint swelling and pain, the Mongolian medicine composition for treating the joint swelling and pain is prepared according to the scheme, comprises shinyleaf yellowhorn, myrobalan, gentiana macrophylla and phellodendron, and can be used for treating symptoms such as joint swelling and pain, fever and edema, oral ulcer, shoulder joint heat rheumatism, knee joint heat rheumatism, ankle joint heat rheumatism and the like.

As an optional implementation manner of the application, in the Mongolian medicine composition for treating joint swelling and pain in the embodiment, 230-690 parts by weight of shinyleaf yellowhorn, 90-270 parts by weight of myrobalan, 90-270 parts by weight of gentiana macrophylla and 90-270 parts by weight of phellodendron bark are used.

As an alternative embodiment of the present application, in the mongolian medicine composition for treating joint pain of the present example, the weight parts of shiny-leaved yellowhorn are 460 parts, the weight parts of myrobalan are 180 parts, the weight parts of gentiana macrophylla are 180 parts, and the weight parts of phellodendron bark are 180 parts.

The Mongolian medicine composition for treating joint swelling and pain provided by the application has the effects of drying yellow water, removing blood stasis and clearing blood heat by containing the shinyleaf yellowhorn; the effects of relieving arthritis and accelerating the elimination of swelling are realized by containing the gentiana macrophylla; the phellodendron bark is contained, so that the effects of relieving pain, reducing swelling and clearing heat are achieved; the medicine has the effect of harmonizing the medicines by containing the myrobalan. The shinyleaf yellowhorn, the large-leaved gentian, the golden cypress and the myrobalan are all suitable for all parts of a body, so that the shinyleaf yellowhorn, the large-leaved gentian, the golden cypress and the myrobalan are comprehensively acted, can be suitable for heat arthritis, edema and migratory rheumatism of all joints and soft tissues of the body, achieve multiple effects of clearing heat, relieving swelling and pain, can be suitable for treating various diseases, and have wider applicability; each raw material component contains a plurality of active substances and has pertinence to etiology, so that the cure rate is high.

Because the components in the Mongolian medicine composition for treating joint swelling and pain have the same or different functions in the formula, the medicines with the same effect are uniformly distributed, and the dosage can be correspondingly reduced. Aiming at diseases mainly caused by dryness-heat and excessive yellow water, the dosages of the shinyleaf yellowhorn and the gentiana macrophylla are increased in the Mongolian medicine composition, so that better effects of removing fire and drying yellow water are achieved; for skin lesions such as canker sores, the dosage should be reduced accordingly.

In addition, the application also provides a pharmaceutical preparation for treating the joint swelling and pain, which comprises the Mongolian medicine composition for treating the joint swelling and pain in the above embodiments. The dosage form of the pharmaceutical preparation includes a liquid dosage form, a solid dosage form, a semi-solid dosage form, or a gaseous dosage form.

As an alternative embodiment of the present application, the liquid dosage form comprises a solution or an injection.

As an alternative embodiment of the present application, the solid dosage form comprises a tablet, a pill, a capsule or a powder.

As an alternative embodiment of the present application, the semisolid dosage form comprises an ointment, gel or cream.

As an alternative embodiment of the present application, the gaseous dosage form comprises an aerosol or spray.

The medicinal preparation can be in various dosage forms, as long as the Mongolian medicine composition for treating joint swelling and pain is contained, and various medicinal preparations can be prepared by adding different medicinal auxiliary materials according to different medicinal preparations. The solid preparation is convenient to carry, the powder is convenient to dissolve, and the gas preparation is suitable for trauma.

The medicinal adjuvants refer to excipient and additive used in production of medicine and prescription preparation; is a substance which has been reasonably evaluated in terms of safety in addition to the active ingredient and is contained in a pharmaceutical preparation. The pharmaceutical excipients not only have the functions of excipient, carrier and stability improvement, but also have the important functions of solubilization, dissolution assistance, sustained and controlled release and the like, and are important components which may influence the quality, safety and effectiveness of the medicine.

Taking the solution as an example, after obtaining the Mongolian medicine composition for treating the joint swelling and pain, 50ml of water is added into every 5g of the Mongolian medicine composition, the Mongolian medicine composition is decocted for 10-15 minutes, and the liquid is prepared by extracting supernatant after separating dregs of a decoction and can be orally taken.

In addition, the application also provides application of the Mongolian medicine composition for treating the joint swelling and pain or the Mongolian medicine composition obtained by the preparation method for treating the joint swelling and pain in preparation of a medicine for treating the joint swelling and pain.

The application has the same advantages as the Mongolian medicine composition for treating the joint swelling and pain, and has wide applicable symptoms.

The present application is further illustrated below by the following examples and comparative examples, but it should be understood that these examples are for illustrative purposes only and are not to be construed as limiting the present application in any way.

Example 1

460 parts by weight of shinyleaf yellowhorn, 180 parts by weight of myrobalan, 180 parts by weight of large-leaved gentian and 180 parts by weight of amur corktree bark are crushed into medium powder, the crushed shinyleaf yellowhorn, myrobalan, large-leaved gentian and amur corktree bark are sieved by an 80-mesh sieve, and then the sieved shinyleaf yellowhorn, myrobalan, large-leaved gentian and amur corktree bark are uniformly mixed to obtain the mongolian medicine composition in the embodiment 1.

Example 2

230 parts by weight of shinyleaf yellowhorn, 90 parts by weight of myrobalan, 90 parts by weight of large-leaved gentian and 90 parts by weight of amur corktree bark are crushed into medium powder, the crushed shinyleaf yellowhorn, myrobalan, large-leaved gentian and amur corktree bark are sieved by an 80-mesh sieve, and then the sieved shinyleaf yellowhorn, myrobalan, large-leaved gentian and amur corktree bark are uniformly mixed to obtain the mongolian medicine composition in the embodiment 2.

Example 3

690 parts by weight of shinyleaf yellowhorn, 270 parts by weight of myrobalan, 270 parts by weight of large-leaved gentian and 270 parts by weight of amur corktree bark are crushed into medium powder, the crushed shinyleaf yellowhorn, myrobalan, large-leaved gentian and amur corktree bark are sieved by an 80-mesh sieve, and then the sieved shinyleaf yellowhorn, myrobalan, large-leaved gentian and amur corktree bark are uniformly mixed to obtain the mongolian medicine composition in the embodiment 3.

Example 4

690 parts by weight of shinyleaf yellowhorn, 180 parts by weight of myrobalan, 180 parts by weight of large-leaved gentian and 180 parts by weight of amur corktree bark are crushed into medium powder, the crushed shinyleaf yellowhorn, myrobalan, large-leaved gentian and amur corktree bark are sieved by an 80-mesh sieve, and then the sieved shinyleaf yellowhorn, myrobalan, large-leaved gentian and amur corktree bark are uniformly mixed to obtain the mongolian medicine composition of the embodiment 4.

Example 5

460 parts by weight of shinyleaf yellowhorn, 180 parts by weight of myrobalan, 270 parts by weight of large-leaved gentian and 180 parts by weight of amur corktree bark are crushed into medium powder, the crushed shinyleaf yellowhorn, myrobalan, large-leaved gentian and amur corktree bark are sieved by an 80-mesh sieve, and then the sieved shinyleaf yellowhorn, myrobalan, large-leaved gentian and amur corktree bark are uniformly mixed to obtain the mongolian medicine composition in the embodiment 5.

Example 6

460 parts by weight of shinyleaf yellowhorn, 180 parts by weight of myrobalan, 180 parts by weight of large-leaved gentian and 270 parts by weight of amur corktree bark are crushed into medium powder, the crushed shinyleaf yellowhorn, myrobalan, large-leaved gentian and amur corktree bark are sieved by an 80-mesh sieve, and then the sieved shinyleaf yellowhorn, myrobalan, large-leaved gentian and amur corktree bark are uniformly mixed to obtain the mongolian medicine composition in the embodiment 6.

Example 7

460 parts by weight of shinyleaf yellowhorn, 270 parts by weight of myrobalan, 180 parts by weight of large-leaved gentian and 180 parts by weight of amur corktree bark are crushed into medium powder, the crushed shinyleaf yellowhorn, myrobalan, large-leaved gentian and amur corktree bark are sieved, and the sieved shinyleaf yellowhorn, myrobalan, large-leaved gentian and amur corktree bark are uniformly mixed to obtain the Mongolian medicine composition of the embodiment 7.

Comparative example 1

Crushing 180 parts by weight of myrobalan, 180 parts by weight of gentiana macrophylla and 180 parts by weight of phellodendron amurense into medium powder, sieving the crushed myrobalan, gentiana macrophylla and phellodendron amurense by using an 80-mesh sieve, and uniformly mixing the sieved myrobalan, gentiana macrophylla and phellodendron amurense to obtain the Mongolian medicine composition of the comparative example 1. Comparative example 1 differs from example 1 only in that the feedstock components of comparative example 1 do not contain xanthoceras sorbifolia.

Comparative example 2

460 parts by weight of shinyleaf yellowhorn, 180 parts by weight of myrobalan and 180 parts by weight of amur corktree bark are crushed into medium powder, the crushed shinyleaf yellowhorn, myrobalan and amur corktree bark are sieved by an 80-mesh sieve, and the sieved shinyleaf yellowhorn, myrobalan and amur corktree bark are uniformly mixed to obtain the Mongolian medicine composition of the comparative example 2. Comparative example 2 is different from example 1 only in that gentiana macrophylla is not contained in the raw material components of comparative example 2.

Comparative example 3

Pulverizing 460 parts by weight of shinyleaf yellowhorn, 180 parts by weight of myrobalan and 180 parts by weight of gentiana macrophylla into medium powder, sieving the pulverized shinyleaf yellowhorn, myrobalan and gentiana macrophylla by using an 80-mesh sieve, and uniformly mixing the sieved shinyleaf yellowhorn, myrobalan and gentiana macrophylla to obtain the Mongolian medicine composition of the comparative example 3. Comparative example 3 differs from example 1 only in that no phellodendron bark is present in the raw material components of comparative example 3.

Comparative example 4

Pulverizing 460 parts by weight of shinyleaf yellowhorn, 180 parts by weight of golden cypress and 180 parts by weight of large-leaved gentian into medium powder, sieving the pulverized shinyleaf yellowhorn, golden cypress and large-leaved gentian by using an 80-mesh sieve, and uniformly mixing the sieved shinyleaf yellowhorn, golden cypress and large-leaved gentian to obtain the Mongolian medicine composition of the comparative example 4. Comparative example 4 differs from example 1 only in that myrobalan is not included in the raw material components of comparative example 4.

Test examples

The Mongolian medicine compositions of examples 1 to 7 and comparative examples 1 to 4 are respectively crushed into medium powder, the mesh number after sieving is 80 meshes, and the medium powder is mixed evenly and then subpackaged. Adding 50ml of water into every 5g of the medicine composition, decocting for 10-15 minutes, separating dregs of a decoction, and then taking supernatant liquid orally.

1100 patients with knee joint rheumatism with heat are randomly selected, 100 patients are divided into one group, the oral liquid obtained according to the oral administration embodiment and the comparative example scheme is used for treatment, 1-2 times per day and 15 days of treatment course are carried out, the cure rate after 15 days is counted, and the statistical result is shown in the following table.

1100 patients with shoulder joint febrile rheumatism were randomly selected, and each 100 patients were divided into one group, and the oral liquid obtained according to the oral example and comparative example was treated 1 to 2 times a day for 15 days as a treatment course, and the cure rate after 15 days was counted, and the statistical results are shown in table two below.

1100 patients with oral ulcer are randomly selected, 100 patients are divided into one group, the oral liquid obtained according to the oral administration embodiment and the comparative example scheme is used for treatment, 1-2 times per day and 7 days of treatment course are carried out, the cure rate after 7 days is counted, and the statistical result is shown in the third table below.

TABLE one example and comparative example for 15 days after treatment of patients with knee joint heat rheumatism

TABLE II EXAMPLES AND COMPARATIVE EXAMPLES OF HELMOLOGICAL HOMOSEOUS PATIENTS TREATED 15-DAY

Examples	Cure rate of swelling	Fever cure rate	Rate of pain healing
				Example 1	98％	99％	97％
Example 2	92％	92％	90％
				Example 3	90％	91％	90％
Example 4	92％	93％	94％
				Example 5	92％	93％	94％
Example 6	97％	98％	96％
				Example 7	97％	97％	98％
Comparative example 1	84％	86％	83％
				Comparative example 2	89％	84％	81％
Comparative example 3	82％	80％	81％
				Comparative example 4	84％	84％	82％

Oral ulcer patients treated for 7 days in the table three example groups and the comparative example group

As can be seen from the therapeutic effects of the examples 1-7 in the tables I-III on rheumatism and oral ulcer of knee joints and shoulder joints, the pharmaceutical composition of the invention is suitable for a plurality of parts of the body, can achieve better curative effects on knee joints, shoulder joints and oral diseases, and has a cure rate of over 90 percent.

According to the results of comparative examples 1 to example 4 in tables one to three, the therapeutic effects on knee joints, shoulder joints and oral ulcers are seen, and the lack of any one of wenguanmu, gentiana macrophylla, phellodendron amurense and myrobalan leads to low cure rate, poor therapeutic effect, failure to comprehensively solve the problems of swelling, fever or pain, and failure to cure the symptoms left at a large rate.

As can be seen from the treatment effects of examples 1 to 3 in tables one to three, the adjustment of the parts of the drugs within a certain range can achieve a better treatment effect, and the drug has a better treatment effect on the symptoms of knee joint, shoulder joint or oral ulcer, and has a higher cure rate for swelling, fever and pain.

According to the comparison of the healing results of the example 1 and the example 4 in the table I to the table III, the change of the parts of the monarch drug xanthoceras sorbifolia has little influence on the healing rate, and the similar healing rate can be achieved by adjusting the parts within a proper range.

According to the comparison of the healing results of the example 5 and the comparative example 2 in the first to third tables, the addition of the ministerial drug gentiana macrophylla plays a role in adjuvant therapy, and the healing rate can be improved.

According to the comparison of the cure results of the first to third tables of the table, the change of the parts of gentiana macrophylla of the ministerial drug can be adjusted within a proper range, and the similar cure rate can be achieved.

As can be seen from the comparison of the cure results of example 6 and comparative example 3 in tables I to III, the addition of cortex Phellodendri, which is an adjuvant drug, can improve the cure rate.

As can be seen from the comparison of the cure results of example 1 and example 6 in tables I to III, the dose of the adjuvant drug phellodendron bark can be adjusted within the range of the present invention to achieve similar cure rate, and the dose of the adjuvant drug has little influence on the cure rate.

According to the comparison of the healing results of the example 1 and the example 7 in the table I to the table III, under the condition that the formula contains the adjuvant drug of phellodendron amurense, the medicine myrobalan is added to play the role of adjuvant therapy only, and the achieved healing rate is similar.

Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present application, and not for limiting the same; although the present application has been described in detail with reference to the foregoing embodiments, it will be understood by those skilled in the art; the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; and the modifications or the substitutions do not make the essence of the corresponding technical solutions depart from the scope of the technical solutions of the embodiments of the present application.

Claims

1. A preparation method of a Mongolian medicine composition for treating joint swelling and pain is characterized by comprising the following steps:

pulverizing lignum Xanthoceratis, fructus Chebulae, radix Gentianae Marcrophyllae and cortex Phellodendri;

and uniformly mixing the sieved shiny-leaved yellowhorn, myrobalan, gentiana macrophylla and phellodendron bark to obtain the mongolian medicine composition.

2. The method of claim 1,

the method comprises the following steps of crushing shinyleaf yellowhorn, myrobalan, large-leaved gentian and amur corktree bark:

the screening treatment of the smashed shinyleaf yellowhorn, myrobalan, gentiana macrophylla and phellodendron bark comprises the following steps:

3. The method of claim 1, wherein the step of pulverizing xanthoceras sorbifolia, myrobalan, gentiana macrophylla and phellodendron amurense comprises:

pulverizing 230-690 parts by weight of lignum Xanthoceratis, 90-270 parts by weight of fructus Chebulae, 90-270 parts by weight of radix Gentianae Marcrophyllae and 90-270 parts by weight of cortex Phellodendri.

4. The Mongolian medicinal composition as claimed in claim 3, wherein 230-690 parts by weight of lignum Xanthoceratis, 90-270 parts by weight of fructus Chebulae, 90-270 parts by weight of radix Gentianae Marcrophyllae and 90-270 parts by weight of cortex Phellodendri are pulverized, and the process comprises:

pulverizing 460 parts by weight of shinyleaf yellowhorn, 180 parts by weight of myrobalan, 180 parts by weight of gentiana macrophylla and 180 parts by weight of phellodendron.

5. A Mongolian medicinal composition for treating joint swelling and pain, which comprises: lignum Xanthoceratis, fructus Chebulae, radix Gentianae Marcrophyllae and cortex Phellodendri.

6. The Mongolian medicinal composition as claimed in claim 5, wherein the weight parts of the plant Wenchui wood are 230-690, the weight parts of the myrobalan fruit are 90-270, the weight parts of the gentiana macrophylla are 90-270 and the weight parts of the phellodendron bark are 90-270.

7. The Mongolian medicinal composition as claimed in claim 6, wherein the weight parts of the shinyleaf yellowhorn is 460, the weight parts of the myrobalan fruit is 180, the weight parts of the gentiana macrophylla is 180 and the weight parts of the phellodendron bark is 180.

8. A pharmaceutical formulation for the treatment of joint pain, comprising a Mongolian composition prepared by the process of any one of claims 1 to 4 or a Mongolian composition according to any one of claims 5 to 7;

the dosage form of the pharmaceutical preparation comprises a liquid dosage form, a solid dosage form, a semi-solid dosage form or a gas dosage form.

9. The pharmaceutical formulation of claim 8,

the liquid dosage form comprises a solution or an injection; and/or the presence of a gas in the gas,

the solid dosage form comprises a tablet, a pill, a capsule or a powder; and/or the presence of a gas in the gas,

the semisolid dosage form comprises an ointment, gel, or cream medicament; and/or the presence of a gas in the gas,

the gaseous dosage form comprises an aerosol or spray.

10. Use of a Mongolian composition prepared by a process according to any one of claims 1 to 4 or a Mongolian composition according to any one of claims 5 to 7 for the manufacture of a medicament for the treatment of joint pain.