CN113166154A - 氘代二氢嘧啶类化合物及其在药物中的应用 - Google Patents

氘代二氢嘧啶类化合物及其在药物中的应用 Download PDF

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Publication number
CN113166154A
CN113166154A CN201980070730.XA CN201980070730A CN113166154A CN 113166154 A CN113166154 A CN 113166154A CN 201980070730 A CN201980070730 A CN 201980070730A CN 113166154 A CN113166154 A CN 113166154A
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alkyl
deuterium
substituted
hooc
methyl
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CN113166154B (zh
Inventor
任青云
刘辛昌
张英俊
S·戈尔德曼
王猛
丘荣茂
颜光华
雷斗兴
李凤
邹致富
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Guangdong HEC Pharmaceutical
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Sunshine Lake Pharma Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

本发明涉及一种氘代二氢嘧啶类化合物及其作为药物的用途，尤其是作为治疗和预防乙型肝炎的药物的应用。具体地说，本发明涉及通式(I)或(Ia)所示的化合物或其立体异构体、互变异构体、氮氧化物、溶剂化物、代谢产物、药学上可接受的盐或它的前药，其中各变量如说明书所定义。本发明还涉及通式(I)或(Ia)所示的化合物或其立体异构体、互变异构体、氮氧化物、溶剂化物、代谢产物、药学上可接受的盐作为药物的用途，尤其是作为治疗和预防乙型肝炎的药物的用途。

Description

PCT国内申请，说明书已公开。

Claims (10)

  1. PCT国内申请，权利要求书已公开。
CN201980070730.XA 2018-12-25 2019-12-24 氘代二氢嘧啶类化合物及其在药物中的应用 Active CN113166154B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201811592167 2018-12-25
CN2018115921676 2018-12-25
PCT/CN2019/128015 WO2020135439A1 (zh) 2018-12-25 2019-12-24 氘代二氢嘧啶类化合物及其在药物中的应用

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CN113166154A true CN113166154A (zh) 2021-07-23
CN113166154B CN113166154B (zh) 2022-12-27

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111825676A (zh) * 2019-04-15 2020-10-27 广东东阳光药业有限公司 二氢嘧啶类化合物及其在药物中的应用
CN114702498A (zh) * 2021-12-23 2022-07-05 华南理工大学 二氢嘧啶衍生物的酸加成盐及其在药物中的应用

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112707910A (zh) * 2019-10-24 2021-04-27 广东东阳光药业有限公司 二氢嘧啶类化合物及其在药物中的应用
US20240025905A1 (en) * 2020-11-30 2024-01-25 Sunshine Lake Pharma Co., Ltd. Salts of dihydropyrimidine derivatives, complexes and uses thereof in medicine
CN114621219A (zh) * 2020-12-09 2022-06-14 上海维申医药有限公司 一种二氢嘧啶类化合物、其制备方法及应用
CN114853761A (zh) * 2021-02-05 2022-08-05 刘沛 一种含有二氢嘧啶的双功能衍生物及其用途
US20240166649A1 (en) * 2021-02-09 2024-05-23 Shanghai Visonpharma Co., Ltd. Dihydropyrimidine compound, preparation method therefor and application thereof

Citations (4)

* Cited by examiner, † Cited by third party
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CN106061978A (zh) * 2014-03-07 2016-10-26 豪夫迈·罗氏有限公司 用于治疗和预防乙型肝炎病毒感染的新的6‑稠合的杂芳基二氢嘧啶
WO2017064156A1 (en) * 2015-10-16 2017-04-20 F. Hoffmann-La Roche Ag Novel 6-fused and 2-heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection
CN108567784A (zh) * 2017-03-08 2018-09-25 张广德 一种治疗脑缺血的药物组合物
CN109678859A (zh) * 2017-10-18 2019-04-26 广东东阳光药业有限公司 二氢嘧啶类化合物及其在药物中的应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3658554A4 (en) * 2017-06-26 2021-03-03 Sunshine Lake Pharma Co., Ltd. DIHYDROPYRIMIDINE COMPOUNDS AND THEIR USES IN MEDICINE

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106061978A (zh) * 2014-03-07 2016-10-26 豪夫迈·罗氏有限公司 用于治疗和预防乙型肝炎病毒感染的新的6‑稠合的杂芳基二氢嘧啶
WO2017064156A1 (en) * 2015-10-16 2017-04-20 F. Hoffmann-La Roche Ag Novel 6-fused and 2-heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection
CN108567784A (zh) * 2017-03-08 2018-09-25 张广德 一种治疗脑缺血的药物组合物
CN109678859A (zh) * 2017-10-18 2019-04-26 广东东阳光药业有限公司 二氢嘧啶类化合物及其在药物中的应用

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111825676A (zh) * 2019-04-15 2020-10-27 广东东阳光药业有限公司 二氢嘧啶类化合物及其在药物中的应用
CN111825676B (zh) * 2019-04-15 2023-10-17 广东东阳光药业股份有限公司 二氢嘧啶类化合物及其在药物中的应用
CN114702498A (zh) * 2021-12-23 2022-07-05 华南理工大学 二氢嘧啶衍生物的酸加成盐及其在药物中的应用

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Address after: 523808 No.1, Gongye North Road, Songshanhu Park, Dongguan City, Guangdong Province

Patentee after: Guangdong Dongyangguang Pharmaceutical Co.,Ltd.

Address before: 523808 Songshan Lake Science and Technology Industrial Park, Dongguan City, Guangdong Province

Patentee before: SUNSHINE LAKE PHARMA Co.,Ltd.