CN113166018B - 用于制备假紫罗酮和羟基假紫罗酮的装置和方法 - Google Patents

用于制备假紫罗酮和羟基假紫罗酮的装置和方法 Download PDF

Info

Publication number
CN113166018B
CN113166018B CN201980082278.9A CN201980082278A CN113166018B CN 113166018 B CN113166018 B CN 113166018B CN 201980082278 A CN201980082278 A CN 201980082278A CN 113166018 B CN113166018 B CN 113166018B
Authority
CN
China
Prior art keywords
reactor chamber
feed
aqueous mixture
starting material
hydroxide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201980082278.9A
Other languages
English (en)
Chinese (zh)
Other versions
CN113166018A (zh
Inventor
J·J·尼乌沃特
B·布伦纳
S·赖宁
T·施托克
B·凯贝尔
A·齐普
O·拜
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF SE
Original Assignee
BASF SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BASF SE filed Critical BASF SE
Priority to CN202410867731.XA priority Critical patent/CN118847021A/zh
Publication of CN113166018A publication Critical patent/CN113166018A/zh
Application granted granted Critical
Publication of CN113166018B publication Critical patent/CN113166018B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J14/00—Chemical processes in general for reacting liquids with liquids; Apparatus specially adapted therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0053—Details of the reactor
    • B01J19/006—Baffles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/24—Stationary reactors without moving elements inside
    • B01J19/2415—Tubular reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/24—Stationary reactors without moving elements inside
    • B01J19/2415—Tubular reactors
    • B01J19/244—Concentric tubes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/24—Stationary reactors without moving elements inside
    • B01J19/2455—Stationary reactors without moving elements inside provoking a loop type movement of the reactants
    • B01J19/246—Stationary reactors without moving elements inside provoking a loop type movement of the reactants internally, i.e. the mixture circulating inside the vessel such that the upward stream is separated physically from the downward stream(s)
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/30—Loose or shaped packing elements, e.g. Raschig rings or Berl saddles, for pouring into the apparatus for mass or heat transfer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J4/00—Feed or outlet devices; Feed or outlet control devices
    • B01J4/001—Feed or outlet devices as such, e.g. feeding tubes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J4/00—Feed or outlet devices; Feed or outlet control devices
    • B01J4/001—Feed or outlet devices as such, e.g. feeding tubes
    • B01J4/005—Feed or outlet devices as such, e.g. feeding tubes provided with baffles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • C07C45/74—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/203—Unsaturated compounds containing keto groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00049—Controlling or regulating processes
    • B01J2219/00051—Controlling the temperature
    • B01J2219/00054—Controlling or regulating the heat exchange system
    • B01J2219/00056—Controlling or regulating the heat exchange system involving measured parameters
    • B01J2219/00058—Temperature measurement
    • B01J2219/00063—Temperature measurement of the reactants
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00049—Controlling or regulating processes
    • B01J2219/00051—Controlling the temperature
    • B01J2219/00054—Controlling or regulating the heat exchange system
    • B01J2219/00056—Controlling or regulating the heat exchange system involving measured parameters
    • B01J2219/00067—Liquid level measurement
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00049—Controlling or regulating processes
    • B01J2219/00051—Controlling the temperature
    • B01J2219/00054—Controlling or regulating the heat exchange system
    • B01J2219/00056—Controlling or regulating the heat exchange system involving measured parameters
    • B01J2219/00069—Flow rate measurement
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00049—Controlling or regulating processes
    • B01J2219/00162—Controlling or regulating processes controlling the pressure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00049—Controlling or regulating processes
    • B01J2219/00184—Controlling or regulating processes controlling the weight of reactants in the reactor vessel
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00761—Details of the reactor
    • B01J2219/00763—Baffles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00761—Details of the reactor
    • B01J2219/00763—Baffles
    • B01J2219/00765—Baffles attached to the reactor wall
    • B01J2219/0077—Baffles attached to the reactor wall inclined

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Thermal Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN201980082278.9A 2018-11-13 2019-11-13 用于制备假紫罗酮和羟基假紫罗酮的装置和方法 Active CN113166018B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202410867731.XA CN118847021A (zh) 2018-11-13 2019-11-13 用于制备假紫罗酮和羟基假紫罗酮的装置和方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP18206006 2018-11-13
EP18206006.1 2018-11-13
PCT/EP2019/081125 WO2020099461A1 (en) 2018-11-13 2019-11-13 Apparatus for and process of making pseudoionone and hydroxy pseudoionone

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202410867731.XA Division CN118847021A (zh) 2018-11-13 2019-11-13 用于制备假紫罗酮和羟基假紫罗酮的装置和方法

Publications (2)

Publication Number Publication Date
CN113166018A CN113166018A (zh) 2021-07-23
CN113166018B true CN113166018B (zh) 2024-07-19

Family

ID=64564548

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201980082278.9A Active CN113166018B (zh) 2018-11-13 2019-11-13 用于制备假紫罗酮和羟基假紫罗酮的装置和方法
CN202410867731.XA Pending CN118847021A (zh) 2018-11-13 2019-11-13 用于制备假紫罗酮和羟基假紫罗酮的装置和方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN202410867731.XA Pending CN118847021A (zh) 2018-11-13 2019-11-13 用于制备假紫罗酮和羟基假紫罗酮的装置和方法

Country Status (8)

Country Link
US (1) US12280353B2 (https=)
EP (1) EP3880638B1 (https=)
JP (1) JP7635122B2 (https=)
KR (1) KR102898135B1 (https=)
CN (2) CN113166018B (https=)
CA (1) CA3118525A1 (https=)
ES (1) ES2936631T3 (https=)
WO (1) WO2020099461A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117986103A (zh) * 2022-10-28 2024-05-07 浙江医药股份有限公司昌海生物分公司 一种连续合成假性紫罗兰酮的方法
CN120054374B (zh) * 2025-04-25 2025-08-08 山东新和成精化科技有限公司 一种假性紫罗兰酮的制备装置及方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1277619A (zh) * 1998-07-08 2000-12-20 蒙特尔技术有限公司 气相聚合的方法和设备

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6704541A (https=) 1967-03-30 1968-10-01
US3840601A (en) * 1972-02-07 1974-10-08 Rhodia Process for preparation of methyl ionones
DE3114071A1 (de) * 1981-04-08 1982-10-28 Basf Ag, 6700 Ludwigshafen Verbessertes verfahren zur herstellung mehrfach ungesaettigter ketone
US4874900A (en) * 1987-06-16 1989-10-17 Union Camp Corporation Preparation of pseudoionones
US6949685B2 (en) 2001-09-28 2005-09-27 Werner Bonrath Ethynylation process
EP1562885B1 (de) * 2002-11-07 2007-09-05 Basf Aktiengesellschaft Kontinuierliches verfahren zur herstellung von pseudojononen und jononen
DE10359026A1 (de) 2003-12-15 2005-07-21 Basf Ag Verfahren zur Herstellung von Tetrahydrogeranylaceton
US9073027B2 (en) * 2010-09-09 2015-07-07 Basell Poliolefine Italia S.R.L. Process and apparatus for the gas-phase polymerization of olefins
MY169083A (en) * 2012-11-30 2019-02-14 Basf Se Method for the catalytic aldol condensation of aldehydes
CN103566862B (zh) 2013-11-01 2015-10-07 太原理工大学 一种强剪切力化学反应器
KR102359834B1 (ko) 2016-07-06 2022-02-07 이네오스 유럽 아게 중합 방법
CN112469501A (zh) 2018-07-24 2021-03-09 诺拉姆国际公司 硝化反应器和方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1277619A (zh) * 1998-07-08 2000-12-20 蒙特尔技术有限公司 气相聚合的方法和设备

Also Published As

Publication number Publication date
US12280353B2 (en) 2025-04-22
JP2022507150A (ja) 2022-01-18
EP3880638A1 (en) 2021-09-22
CN113166018A (zh) 2021-07-23
JP7635122B2 (ja) 2025-02-25
US20240116019A1 (en) 2024-04-11
CA3118525A1 (en) 2020-05-22
EP3880638B1 (en) 2023-01-11
CN118847021A (zh) 2024-10-29
KR102898135B1 (ko) 2025-12-10
WO2020099461A1 (en) 2020-05-22
ES2936631T3 (es) 2023-03-21
KR20210092237A (ko) 2021-07-23

Similar Documents

Publication Publication Date Title
TWI454452B (zh) 製造α，β－不飽和Ｃ－醛類的方法
EP2390242B1 (en) Apparatus for producing alcohols from olefins
JP2024123075A (ja) 第１及び第２の量の水酸化物を添加するステップを含む、シトラール及びアセトンを含む水性混合物中でプソイドイオノン及びヒドロキシプソイドイオノンを製造する方法
CN113166018B (zh) 用于制备假紫罗酮和羟基假紫罗酮的装置和方法
CN103025695A (zh) 用于由烯烃联产异型反应产物和醇的设备以及使用该设备联产异型反应产物和醇的方法
US9868681B2 (en) Production method for γ,δ-unsaturated alcohols
CN103492352B (zh) 用于进行多相羟醛缩合反应以获得混合的α,β-不饱和醛的方法
JP2022507150A5 (https=)
CN1145603C (zh) 连续制备不饱和酮的方法
CN106831360B (zh) 一种连续制备β-萘甲醚的工艺方法
CN116099218B (zh) 一种连续式制备α,α'-联氮杂苯的方法
CN211677677U (zh) 丙醛生产用连续化反应系统
KR101298343B1 (ko) 올레핀의 하이드로포밀화 반응장치 및 이를 이용하는 하이드로포밀화 방법
KR20190005328A (ko) 하이드로포밀화 반응에 의한 알데히드 제조방법
CN110330416A (zh) 一种异戊烯醛的制备方法
CN113004143A (zh) 一种氯乙酸乙酯的合成方法及装置
CN219482688U (zh) 一种连续生产2，3-戊二酮的反应装置
CN112638854B (zh) 通过不对称氢化连续制备光学活性羰基化合物
CN106111041B (zh) 一种连续反应装置及采用该装置合成糠硫醇的方法

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant