CN113164963A - 用于生化反应容器的温度监测的方法和系统 - Google Patents

用于生化反应容器的温度监测的方法和系统 Download PDF

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Publication number
CN113164963A
CN113164963A CN201980080230.4A CN201980080230A CN113164963A CN 113164963 A CN113164963 A CN 113164963A CN 201980080230 A CN201980080230 A CN 201980080230A CN 113164963 A CN113164963 A CN 113164963A
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chamber
light
temperature
reaction vessel
reaction
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CN201980080230.4A
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Chinese (zh)
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奥斯汀·索
孙俊豪
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Kriptos Biotechnology Co ltd
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Kriptos Biotechnology Co ltd
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0006—Controlling or regulating processes
    • B01J19/0013—Controlling the temperature of the process
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/08—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Rigid containers without fluid transport within
    • B01L3/5085—Rigid containers without fluid transport within for multiple samples, e.g. microtitration plates
    • B01L3/50851—Rigid containers without fluid transport within for multiple samples, e.g. microtitration plates specially adapted for heating or cooling samples
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M31/00—Means for providing, directing, scattering or concentrating light
    • C12M31/08—Means for providing, directing, scattering or concentrating light by conducting or reflecting elements located inside the reactor or in its structure
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00049—Controlling or regulating processes
    • B01J2219/00051—Controlling the temperature
    • B01J2219/00139—Controlling the temperature using electromagnetic heating
    • B01J2219/00144—Sunlight; Visible light
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00049—Controlling or regulating processes
    • B01J2219/00051—Controlling the temperature
    • B01J2219/00139—Controlling the temperature using electromagnetic heating
    • B01J2219/00146—Infrared radiation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00761—Details of the reactor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/143—Quality control, feedback systems
    • B01L2200/147—Employing temperature sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0654—Lenses; Optical fibres
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0819—Microarrays; Biochips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0825—Test strips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0829—Multi-well plates; Microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0848—Specific forms of parts of containers
    • B01L2300/0851—Bottom walls
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/168—Specific optical properties, e.g. reflective coatings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1838—Means for temperature control using fluid heat transfer medium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1861—Means for temperature control using radiation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1883—Means for temperature control using thermal insulation

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Sustainable Development (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Thermal Sciences (AREA)
  • Hematology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
CN201980080230.4A 2018-10-16 2019-10-16 用于生化反应容器的温度监测的方法和系统 Pending CN113164963A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862746492P 2018-10-16 2018-10-16
US201862746488P 2018-10-16 2018-10-16
US62/746,492 2018-10-16
US62/746,488 2018-10-16
PCT/US2019/056560 WO2020081700A1 (en) 2018-10-16 2019-10-16 Method and system for temperature monitoring of a biochemical reaction vessel

Publications (1)

Publication Number Publication Date
CN113164963A true CN113164963A (zh) 2021-07-23

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US (3) US11628442B2 (https=)
EP (1) EP3866976A4 (https=)
JP (1) JP2022504858A (https=)
CN (1) CN113164963A (https=)
WO (1) WO2020081700A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114634869A (zh) * 2022-03-21 2022-06-17 诺美纳瑞(广州)医疗技术有限公司 一种pcr的检测系统
CN114672405A (zh) * 2022-03-21 2022-06-28 诺美纳瑞(广州)医疗技术有限公司 一种pcr扩增检测集成系统及其pcr反应控制方法

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KR102292998B1 (ko) * 2015-01-16 2021-08-26 더 리전트 오브 더 유니버시티 오브 캘리포니아 핵산 증폭용 led 구동 플라즈몬 가열 장치
US10473591B2 (en) * 2017-05-01 2019-11-12 Wyatt Technology Corporation High throughput method and apparatus for measuring multiple optical properties of a liquid sample
JP2022504858A (ja) 2018-10-16 2022-01-13 クリプトス バイオテクノロジーズ，インコーポレイテッド 生化学反応容器の温度監視のための方法およびシステム
KR102506675B1 (ko) * 2022-03-14 2023-03-08 서강대학교산학협력단 IoT 기반 휴대용 dPCR 시스템
EP4389280A3 (en) * 2022-12-19 2024-10-09 Samsung Electronics Co., Ltd. Nanostructured system for nucleic acid amplification
DE102022213874A1 (de) * 2022-12-19 2024-06-20 Dermagnostix GmbH Probenkartusche für die Durchführung eines Analyseprozesses mittels einer Fluoreszenz-Analyse

Citations (11)

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US6210882B1 (en) * 1998-01-29 2001-04-03 Mayo Foundation For Medical Education And Reseach Rapid thermocycling for sample analysis
US7081226B1 (en) * 1996-06-04 2006-07-25 University Of Utah Research Foundation System and method for fluorescence monitoring
CN101002322A (zh) * 2004-06-07 2007-07-18 先锋生物科技股份有限公司 用于微流体器件的光学透镜系统和方法
CN101158695A (zh) * 2002-12-04 2008-04-09 斯宾克斯公司 流体的可程控微量控制用方法
US20080212643A1 (en) * 2007-03-02 2008-09-04 Mcgahhey D David Temperature monitoring device
CN101712926A (zh) * 2008-09-23 2010-05-26 米利波尔公司 用于微生物分析的装置
CN102465093A (zh) * 2010-11-12 2012-05-23 索尼公司 反应处理装置与反应处理方法
CN102917796A (zh) * 2010-04-20 2013-02-06 科贝特研究私人有限公司 温度控制方法和设备
US20150328633A1 (en) * 2012-12-27 2015-11-19 Research Business Foundation Sungkyunkwan University Nucleic acid amplification disk apparatus using temperature sensitive polymer synthesis and the analysis method using the same
WO2017127570A1 (en) * 2016-01-20 2017-07-27 Triv Tech, Llc Point-of-care nucleic acid amplification and detection
CN107921399A (zh) * 2015-07-30 2018-04-17 加利福尼亚大学董事会 光腔pcr

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US5786182A (en) 1997-05-02 1998-07-28 Biomerieux Vitek, Inc. Dual chamber disposable reaction vessel for amplification reactions, reaction processing station therefor, and methods of use
FR2941960B1 (fr) * 2009-02-11 2013-11-01 Inst Nat De La Rech Agronomique Inra Procede pour tester la regulation thermique d'un thermocycleur pour pcr, et moyens pour sa mise en oeuvre
JP2013113679A (ja) 2011-11-28 2013-06-10 Sony Corp マイクロチップ及びマイクロチップの製造方法
JP2014032153A (ja) * 2012-08-06 2014-02-20 Hitachi High-Technologies Corp 温度計測装置及び化学分析装置
WO2016145360A1 (en) * 2015-03-11 2016-09-15 Hexna Corp. Portable dna analysis machine
ES2871861T3 (es) 2016-03-10 2021-11-02 Pioneer Hi Bred Int Sistema de amplificación por reacción en cadena de la polimerasa mediada por luz y de detección de productos y métodos de uso
JP2022504858A (ja) 2018-10-16 2022-01-13 クリプトス バイオテクノロジーズ，インコーポレイテッド 生化学反応容器の温度監視のための方法およびシステム

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US7081226B1 (en) * 1996-06-04 2006-07-25 University Of Utah Research Foundation System and method for fluorescence monitoring
US6210882B1 (en) * 1998-01-29 2001-04-03 Mayo Foundation For Medical Education And Reseach Rapid thermocycling for sample analysis
CN101158695A (zh) * 2002-12-04 2008-04-09 斯宾克斯公司 流体的可程控微量控制用方法
CN101002322A (zh) * 2004-06-07 2007-07-18 先锋生物科技股份有限公司 用于微流体器件的光学透镜系统和方法
US20080212643A1 (en) * 2007-03-02 2008-09-04 Mcgahhey D David Temperature monitoring device
CN101712926A (zh) * 2008-09-23 2010-05-26 米利波尔公司 用于微生物分析的装置
CN102917796A (zh) * 2010-04-20 2013-02-06 科贝特研究私人有限公司 温度控制方法和设备
CN102465093A (zh) * 2010-11-12 2012-05-23 索尼公司 反应处理装置与反应处理方法
US20150328633A1 (en) * 2012-12-27 2015-11-19 Research Business Foundation Sungkyunkwan University Nucleic acid amplification disk apparatus using temperature sensitive polymer synthesis and the analysis method using the same
CN107921399A (zh) * 2015-07-30 2018-04-17 加利福尼亚大学董事会 光腔pcr
WO2017127570A1 (en) * 2016-01-20 2017-07-27 Triv Tech, Llc Point-of-care nucleic acid amplification and detection

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114634869A (zh) * 2022-03-21 2022-06-17 诺美纳瑞(广州)医疗技术有限公司 一种pcr的检测系统
CN114672405A (zh) * 2022-03-21 2022-06-28 诺美纳瑞(广州)医疗技术有限公司 一种pcr扩增检测集成系统及其pcr反应控制方法

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Publication number Publication date
EP3866976A4 (en) 2022-07-06
WO2020081700A1 (en) 2020-04-23
US20200114363A1 (en) 2020-04-16
US20220072556A1 (en) 2022-03-10
US20200114362A1 (en) 2020-04-16
US11628442B2 (en) 2023-04-18
US11896977B2 (en) 2024-02-13
EP3866976A1 (en) 2021-08-25
US11203019B2 (en) 2021-12-21
JP2022504858A (ja) 2022-01-13

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