CN113164507A - 由多个寡核苷酸构成的通过与靶标的互补相互作用调控基因表达的多靶向核酸构建体 - Google Patents
由多个寡核苷酸构成的通过与靶标的互补相互作用调控基因表达的多靶向核酸构建体 Download PDFInfo
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- CN113164507A CN113164507A CN201980063688.9A CN201980063688A CN113164507A CN 113164507 A CN113164507 A CN 113164507A CN 201980063688 A CN201980063688 A CN 201980063688A CN 113164507 A CN113164507 A CN 113164507A
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- C12N2310/321—2'-O-R Modification
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/322—2'-R Modification
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/51—Physical structure in polymeric form, e.g. multimers, concatemers
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2330/00—Production
- C12N2330/30—Production chemically synthesised
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862738222P | 2018-09-28 | 2018-09-28 | |
| US62/738,222 | 2018-09-28 | ||
| PCT/IB2019/058221 WO2020065602A2 (en) | 2018-09-28 | 2019-09-27 | Products and compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN113164507A true CN113164507A (zh) | 2021-07-23 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201980063688.9A Pending CN113164507A (zh) | 2018-09-28 | 2019-09-27 | 由多个寡核苷酸构成的通过与靶标的互补相互作用调控基因表达的多靶向核酸构建体 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20210371861A1 (https=) |
| EP (1) | EP3856200A4 (https=) |
| JP (1) | JP2022503850A (https=) |
| KR (1) | KR20210093851A (https=) |
| CN (1) | CN113164507A (https=) |
| AU (1) | AU2019346148A1 (https=) |
| BR (1) | BR112021005777A2 (https=) |
| CA (1) | CA3110300A1 (https=) |
| IL (1) | IL281684A (https=) |
| WO (1) | WO2020065602A2 (https=) |
| ZA (1) | ZA202101298B (https=) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US20250000892A1 (en) * | 2021-10-14 | 2025-01-02 | Arizona Board Of Regents On Behalf Of Arizona State University | Programmable delivery platforms for rna structures |
| WO2023069707A2 (en) * | 2021-10-22 | 2023-04-27 | Sirnaomics, Inc. | Products and compositions |
| WO2023240249A1 (en) * | 2022-06-11 | 2023-12-14 | Sirnaomics, Inc. | Products and compositions |
| WO2024059873A2 (en) * | 2022-09-16 | 2024-03-21 | Sirnaomics, Inc. | Products and compositions |
| WO2024081922A1 (en) * | 2022-10-14 | 2024-04-18 | Arizona Board Of Regents On Behalf Of Arizona State University | Modular rna delivery platforms and methods of their use |
| WO2024164001A2 (en) * | 2023-02-03 | 2024-08-08 | Sirnaomics, Inc. | Products and compositions |
| WO2024216267A2 (en) * | 2023-04-14 | 2024-10-17 | Sirnaomics, Inc. | Products and compositions |
| WO2024229229A2 (en) * | 2023-05-02 | 2024-11-07 | Sirnaomics, Inc. | Products and compositions |
| TW202526017A (zh) | 2023-09-14 | 2025-07-01 | 美商Ionis製藥公司 | 用於減少ａｐｏｃｉｉｉ表現的化合物及方法 |
| WO2025064821A2 (en) | 2023-09-21 | 2025-03-27 | Ionis Pharmaceuticals, Inc. | Compounds and methods for inhibiting lpa |
| WO2025259875A1 (en) * | 2024-06-12 | 2025-12-18 | Sirnaomics, Inc. | Novel antibody oligonucleotide drug conjugates containing gemcitibine for pharmaceutical compositions and related methods of use and treatment |
Citations (6)
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| WO2007091269A2 (en) * | 2006-02-08 | 2007-08-16 | Quark Pharmaceuticals, Inc. | NOVEL TANDEM siRNAS |
| US20080269474A1 (en) * | 2006-11-09 | 2008-10-30 | Donald Rao | Novel shRNA molecules and methods of use thereof |
| US20120016007A1 (en) * | 2009-02-04 | 2012-01-19 | Dong Ki Lee | Small interference rna complex with increased intracellular transmission capacity |
| US20180105815A1 (en) * | 2016-10-18 | 2018-04-19 | Augusta University Research lnstitute, lnc. | Bivalent siRNA Chimeras and Methods of Use Thereof |
| CN108026527A (zh) * | 2015-06-15 | 2018-05-11 | Mpeg La有限责任公司 | 确定的多偶联寡核苷酸 |
| CN108342386A (zh) * | 2017-01-22 | 2018-07-31 | 广州市锐博生物科技有限公司 | 一种多聚寡核酸分子及其在多靶标干扰中的应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2318528A1 (en) * | 2008-07-24 | 2011-05-11 | Rxi Pharmaceuticals Corporation | Rnai constructs and uses therof |
| ES2804764T3 (es) * | 2009-06-01 | 2021-02-09 | Halo Bio Rnai Therapeutics Inc | Polinucleótidos para la interferencia de ARN multivalente, composiciones y métodos de uso de los mismos |
| WO2015164818A1 (en) * | 2014-04-25 | 2015-10-29 | Strike Bio, Inc. | Multiple targeted rnai for the treatment of cancers |
| EP4365291A3 (en) * | 2015-06-12 | 2024-08-14 | Alnylam Pharmaceuticals, Inc. | Complement component c5 irna compositions and methods of use thereof |
| WO2020014948A1 (zh) * | 2018-07-20 | 2020-01-23 | 广州市锐博生物科技有限公司 | 核酸单元及其聚合核酸与应用 |
-
2019
- 2019-09-27 CN CN201980063688.9A patent/CN113164507A/zh active Pending
- 2019-09-27 CA CA3110300A patent/CA3110300A1/en active Pending
- 2019-09-27 EP EP19866965.7A patent/EP3856200A4/en active Pending
- 2019-09-27 AU AU2019346148A patent/AU2019346148A1/en not_active Abandoned
- 2019-09-27 WO PCT/IB2019/058221 patent/WO2020065602A2/en not_active Ceased
- 2019-09-27 JP JP2021517420A patent/JP2022503850A/ja active Pending
- 2019-09-27 KR KR1020217009902A patent/KR20210093851A/ko not_active Withdrawn
- 2019-09-27 BR BR112021005777A patent/BR112021005777A2/pt not_active IP Right Cessation
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2021
- 2021-02-25 ZA ZA2021/01298A patent/ZA202101298B/en unknown
- 2021-03-21 IL IL281684A patent/IL281684A/en unknown
- 2021-03-29 US US17/215,964 patent/US20210371861A1/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007091269A2 (en) * | 2006-02-08 | 2007-08-16 | Quark Pharmaceuticals, Inc. | NOVEL TANDEM siRNAS |
| US20080293655A1 (en) * | 2006-02-08 | 2008-11-27 | Huseyin Aygun | Novel tandem siRNAS |
| US20080269474A1 (en) * | 2006-11-09 | 2008-10-30 | Donald Rao | Novel shRNA molecules and methods of use thereof |
| US20130078719A1 (en) * | 2006-11-09 | 2013-03-28 | Gradalis, Inc. | Novel shrna molecules and methods of use thereof |
| US20120016007A1 (en) * | 2009-02-04 | 2012-01-19 | Dong Ki Lee | Small interference rna complex with increased intracellular transmission capacity |
| CN108026527A (zh) * | 2015-06-15 | 2018-05-11 | Mpeg La有限责任公司 | 确定的多偶联寡核苷酸 |
| US20180105815A1 (en) * | 2016-10-18 | 2018-04-19 | Augusta University Research lnstitute, lnc. | Bivalent siRNA Chimeras and Methods of Use Thereof |
| CN108342386A (zh) * | 2017-01-22 | 2018-07-31 | 广州市锐博生物科技有限公司 | 一种多聚寡核酸分子及其在多靶标干扰中的应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2020065602A2 (en) | 2020-04-02 |
| BR112021005777A2 (pt) | 2022-04-19 |
| JP2022503850A (ja) | 2022-01-12 |
| ZA202101298B (en) | 2024-06-26 |
| EP3856200A4 (en) | 2022-07-20 |
| IL281684A (en) | 2021-05-31 |
| CA3110300A1 (en) | 2020-04-02 |
| KR20210093851A (ko) | 2021-07-28 |
| US20210371861A1 (en) | 2021-12-02 |
| WO2020065602A3 (en) | 2020-06-25 |
| AU2019346148A1 (en) | 2021-05-27 |
| EP3856200A2 (en) | 2021-08-04 |
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