KR20210093851A - 표적과의 상보적 상호 작용을 통해 유전자 발현을 조절하는 다수의 올리고뉴클레오티드로 구성된 다중-표적화 핵산 구조체 - Google Patents
표적과의 상보적 상호 작용을 통해 유전자 발현을 조절하는 다수의 올리고뉴클레오티드로 구성된 다중-표적화 핵산 구조체 Download PDFInfo
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- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
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- A61K48/0041—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being polymeric
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- C12N2310/00—Structure or type of the nucleic acid
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| WO2023240249A1 (en) * | 2022-06-11 | 2023-12-14 | Sirnaomics, Inc. | Products and compositions |
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| WO2024081922A1 (en) * | 2022-10-14 | 2024-04-18 | Arizona Board Of Regents On Behalf Of Arizona State University | Modular rna delivery platforms and methods of their use |
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| WO2024216267A2 (en) * | 2023-04-14 | 2024-10-17 | Sirnaomics, Inc. | Products and compositions |
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| TW202526017A (zh) | 2023-09-14 | 2025-07-01 | 美商Ionis製藥公司 | 用於減少ａｐｏｃｉｉｉ表現的化合物及方法 |
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| WO2025259875A1 (en) * | 2024-06-12 | 2025-12-18 | Sirnaomics, Inc. | Novel antibody oligonucleotide drug conjugates containing gemcitibine for pharmaceutical compositions and related methods of use and treatment |
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| US8252526B2 (en) * | 2006-11-09 | 2012-08-28 | Gradalis, Inc. | ShRNA molecules and methods of use thereof |
| EP2318528A1 (en) * | 2008-07-24 | 2011-05-11 | Rxi Pharmaceuticals Corporation | Rnai constructs and uses therof |
| EP2395085B1 (en) * | 2009-02-04 | 2015-06-10 | Sungkyunkwan University Foundation for Corporate Collaboration | Small interference rna complex with increased intracellular transmission capacity |
| ES2804764T3 (es) * | 2009-06-01 | 2021-02-09 | Halo Bio Rnai Therapeutics Inc | Polinucleótidos para la interferencia de ARN multivalente, composiciones y métodos de uso de los mismos |
| WO2015164818A1 (en) * | 2014-04-25 | 2015-10-29 | Strike Bio, Inc. | Multiple targeted rnai for the treatment of cancers |
| EP4365291A3 (en) * | 2015-06-12 | 2024-08-14 | Alnylam Pharmaceuticals, Inc. | Complement component c5 irna compositions and methods of use thereof |
| IL316159A (en) * | 2015-06-15 | 2024-12-01 | Mpeg La Llc | Defined Oligonucleotide Multimers and Methods for Manufacture Thereof |
| US10689654B2 (en) * | 2016-10-18 | 2020-06-23 | Augusta University Research Institute, Inc. | Bivalent siRNA chimeras and methods of use thereof |
| CN108342386B (zh) * | 2017-01-22 | 2022-04-15 | 广州市锐博生物科技有限公司 | 一种多聚寡核酸分子及其在多靶标干扰中的应用 |
| WO2020014948A1 (zh) * | 2018-07-20 | 2020-01-23 | 广州市锐博生物科技有限公司 | 核酸单元及其聚合核酸与应用 |
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