CN113144148A - Oral and external traditional Chinese medicine for treating liver depression, phlegm dampness and blood stasis type hyperplasia of mammary glands and preparation method thereof - Google Patents

Abstract

An oral and external traditional Chinese medicine for treating liver depression, phlegm dampness and blood stasis type hyperplasia of mammary glands comprises the following raw material medicines in parts by weight: 10-20 parts of rhizoma cyperi; 20-25 parts of raw oysters; 10-20 parts of cowherb seed; 10-20 parts of tangerine seeds; 15-20 parts of spina gleditsiae; 20-30 parts of fructus trichosanthis; 10-20 of trigone; 10-2 of curcuma zedoary; 15-30 parts of seaweed; 10-20 parts of dried orange peel; 10-20 parts of selfheal; 10-20 parts of cassia twig; 10-20 parts of angelica; 10-20 parts of astragalus membranaceus; 10-20 parts of fried bighead atractylodes rhizome; 2-5 parts of liquorice; the traditional Chinese medicine has the effects of enriching blood, promoting blood circulation, regulating menstruation, relieving pain and lubricating intestines, and has the effects of enriching blood, promoting blood circulation and promoting qi circulation to relieve pain; the number of the white blood cells and the multi-core white blood cells is obviously increased, the phagocytic percentage and the phagocytic index of macrophages are obviously increased, the Chinese medicinal composition has the effects of promoting humoral immunity and cellular immunity, and has obvious and durable diuretic effects, and the dampness eliminating and diuresis inducing effects of the Chinese medicinal composition are related to the diuretic effect.

Description

Oral and external traditional Chinese medicine for treating liver depression, phlegm dampness and blood stasis type hyperplasia of mammary glands and preparation method thereof

Technical Field

The invention relates to an oral and external traditional Chinese medicine for treating liver depression, phlegm dampness and blood stasis type hyperplasia of mammary glands, in particular to an oral and external traditional Chinese medicine for treating liver depression, phlegm dampness and blood stasis type hyperplasia of mammary glands and a preparation method thereof.

Background

Hyperplasia of mammary glands, also known as "mammary gland dysplasia", is a benign disease of mammary glands that is neither tumor nor inflammation, mainly manifested as pain and mass, mostly on one side, and affecting both sides. The hyperplasia of mammary glands belongs to the range of the mammary nodules in the traditional Chinese medicine, most doctors think that the hyperplasia of mammary glands belongs to liver depression and phlegm coagulation and is caused by the imbalance of Chong and conception channels, and the treatment mainly comprises soothing the liver, regulating the flow of qi, strengthening the spleen and eliminating dampness. The traditional Chinese medicine formula mainly comprises medicines for soothing liver, regulating qi, strengthening spleen and eliminating dampness, such as Xiaoyao powder, Erchen decoction and the like, and a person who uses penmans clinically finds that phlegm, qi and blood stasis are formed at breast parts along with stagnation of liver qi and phlegm-dampness coagulation, and the internal stagnation of blood stasis is easy to cause, and the disease condition can be temporarily relieved and easily recurs although some patients are treated by soothing liver, regulating qi, strengthening spleen and eliminating dampness, so that the traditional Chinese medicine for treating liver-phlegm-dampness-stagnation and blood-stasis type hyperplasia of mammary glands by oral administration and external application and the preparation method thereof are specially designed.

Disclosure of Invention

In order to overcome the defects, the invention provides an oral and external traditional Chinese medicine for treating liver depression, phlegm dampness and blood stasis type hyperplasia of mammary glands and a preparation method thereof.

The technical scheme adopted by the invention for solving the technical problems is as follows: an oral and external traditional Chinese medicine for treating liver depression, phlegm dampness and blood stasis type hyperplasia of mammary glands is characterized by comprising the following raw material medicines in parts by weight:

the traditional Chinese medicine formula disclosed by the invention has the effects of soothing the liver, eliminating dampness, activating blood circulation and dissipating stagnation, is mainly used for treating liver depression, phlegm dampness and stasis type hyperplasia of mammary glands, clinically shows pain and lumps on one side or two sides of a breast, aggravates before and after a menstrual period or a menstrual period, and has the disadvantages of chest distress, vexation, pale tongue, thick or greasy fur, sublingual stasis and wiry and smooth pulse.

The flavor of the accessory ingredient is pungent, slightly bitter and even; it enters liver and triple energizer meridians. Has the efficacies of soothing liver, regulating qi, regulating menstruation and relieving pain, and is mainly used for treating hyperplasia of mammary glands caused by stagnation of liver qi. Modern pharmacology considers that the rhizoma cyperi has the effects of relieving fever, easing pain, resisting inflammation and the like.

Oyster is salty in nature and taste and slightly cold; entering liver and kidney meridians, they have the actions of pacifying liver and subduing yang, softening and resolving hard mass, astringing and arresting discharge, and in this recipe, they have the actions of softening and resolving hard mass of breast mass. Modern pharmacology considers that the oyster has the effects of calming, softening hard masses, relieving fever, protecting the liver, enhancing immunity and the like.

The cowherb seed is bitter and mild in taste; it enters liver and stomach meridians. Has the efficacies of activating blood and dredging channels, promoting lactation and reducing swelling, and inducing diuresis and treating stranguria, and the main indications of the formula are hyperplasia of mammary glands caused by blood stasis and stagnation. Modern pharmacology considers that the cowherb seed has the effects of resisting early pregnancy, resisting implantation, exciting uterus, easing pain and resisting tumor.

The tangerine seeds are bitter and mild in nature; it enters liver and kidney meridians. Has the effects of regulating qi, dissipating stagnation and relieving pain, and has direct treatment effect on hyperplasia of mammary glands due to stagnation of liver qi. Modern pharmacology considers that tangerine seeds have the effects of relieving fever, inhibiting bacteria, relieving pain and the like.

Spina Gleditsiae is pungent and warm in flavor; it enters liver and stomach meridians. Has the efficacies of relieving swelling, expelling toxin, expelling pus and killing parasites, has the functions of relieving swelling, resolving masses and treating hyperplasia of mammary glands caused by internal retention of phlegm, dampness and stasis. Modern pharmacology has suggested that spina gleditsiae has inhibitory effects on staphylococcus aureus and alpha-beta-coccus.

The snakegourd fruit is sweet in nature and taste and cold; it enters lung, stomach and large intestine meridians. Has the effects of clearing lung and eliminating phlegm, promoting qi circulation and relieving chest stuffiness, and lubricating the intestines and relaxing bowels, and is used for treating the hyperplasia of mammary glands caused by stagnation of phlegm and dampness. Modern pharmacology considers that the snakegourd fruit has the effects of expanding arterial coronary, resisting myocardial ischemia, improving microcirculation, inhibiting platelet aggregation, resisting anoxia, arrhythmia, ulcer, bacteria, cancer, aging and the like.

The rhizoma sparganii is bitter in nature and moderate in taste; it enters liver and spleen meridians. Has the functions of breaking blood and dissolving stasis, and promoting qi circulation and relieving pain, and the blood is broken and the stasis is removed in the formula to treat the hyperplasia of mammary glands with blood stasis and stagnation. Modern pharmacology considers that the rhizoma sparganii has the effects of resisting external thrombosis, resisting tumors, reducing oxygen consumption of myocardial cells, reducing coronary resistance, increasing coronary flow, improving myocardial anoxia tolerance and the like.

The zedoary is pungent, bitter and warm in nature; it enters liver and spleen meridians. Has the functions of breaking blood and dissolving stasis, and promoting qi circulation and relieving pain, and the blood is broken and removed in the formula to treat the hyperplasia of mammary glands with blood stasis stagnation. Modern pharmacology considers that the curcuma zedoary has the effects of resisting tumors, resisting bacteria, increasing white blood cells, promoting blood circulation and removing blood stasis and the like.

The nature and taste of the seaweed are salty and cold; it enters liver, stomach and kidney meridians. Has the functions of resolving phlegm and softening hard masses and inducing diuresis, and the phlegm-resolving and hard masses in the recipe are used for treating hyperplasia of mammary glands caused by phlegm-damp stagnation. Modern pharmacology considers that the seaweed has the effects of resisting tumor, endotoxin, virus, immunity, radiation and blood pressure.

The dried orange peel is pungent, bitter and warm in nature; it enters spleen and lung meridians. Has the efficacies of regulating qi, eliminating dampness and resolving phlegm, and has the treatment effect on the hyperplasia of mammary glands caused by internal retention of phlegm and dampness. Modern pharmacology considers that the dried orange peel has the effects of relieving asthma, eliminating phlegm, enhancing immune function, resisting inflammation, shortening bleeding and blood coagulation time and the like.

The selfheal is bitter, pungent and cold in property and taste; it enters liver meridian. Has the functions of clearing liver-fire, removing toxicity and dissipating stagnation, and can be used for treating hyperplasia of mammary glands with phlegm-damp stagnation. Modern pharmacology considers that the selfheal has the effects of reducing blood pressure, resisting arrhythmia, resisting inflammation, suppressing immunity, reducing blood sugar, resisting bacteria, viruses and resisting cell toxicity.

The cassia twig is pungent, sweet and warm in flavor; it enters heart, kidney and bladder meridians. Has the efficacies of inducing sweat to relieve exterior syndrome, warming meridians to activate yang and warming and invigorating yang qi, and has the effects of stimulating yang qi and dissipating stagnated heat in the recipe against spleen deficiency. Modern pharmacology considers that cassia twig has the effects of relieving fever, easing pain, resisting inflammation, resisting allergy, resisting pathogenic microorganisms and the like, and the cassia twig volatile oil has the effect of inhibiting acute inflammation caused by various inflammatory substances.

Chinese angelica root, radix Angelicae sinensis is sweet, pungent and warm in nature and flavor; it enters liver, heart and spleen meridians. Has the functions of enriching blood, promoting blood circulation, regulating menstruation, relieving pain and moistening intestines, and has the functions of enriching blood, promoting blood circulation and promoting qi circulation to relieve pain. Modern pharmacology considers that angelica has the effects of promoting the hematopoietic function of organisms, inhibiting platelet aggregation, resisting thrombus and the like.

Radix astragali is sweet in nature and taste, and is slightly warm; it enters spleen and lung meridians. Has the functions of invigorating qi and raising yang, protecting and consolidating superficial resistance, expelling toxin and promoting tissue regeneration, and inducing diuresis and relieving edema, and can expel toxin and promote tissue regeneration by invigorating qi and blood in the recipe. Modern pharmacology considers that astragalus can enhance the phagocytic function of a reticuloendothelial system, obviously increase the number of white blood cells and multinuclear white blood cells, obviously increase the phagocytic percentage and the phagocytic index of macrophages, and promote humoral immunity and cellular immunity.

Bighead atractylodes rhizome is bitter and sweet in taste and warm; it enters spleen and stomach meridians. Has the functions of tonifying qi and strengthening spleen, eliminating dampness and inducing diuresis, strengthening superficies and arresting sweating and preventing miscarriage, and the atractylodes rhizome in the formula not only is a medicine for tonifying qi and strengthening spleen, but also can effectively eliminate damp turbidity stagnating in the body due to spleen deficiency by eliminating dampness and inducing diuresis. Modern pharmacology considers that the white atractylodes rhizome can obviously enhance the capability of white blood cells to phagocytose staphylococcus aureus and enhance the immune function of an organism; has obvious and lasting diuretic effect, and the efficacy of eliminating dampness and inducing diuresis is related to the diuretic effect.

Licorice root, radix Glycyrrhizae is sweet and neutral in nature; it enters heart, lung, spleen and stomach meridians. Has the efficacies of tonifying heart and spleen qi, expelling phlegm to arrest cough, relieving spasm and pain, detoxifying and harmonizing drug properties, and the phlegm-eliminating in the recipe plays a role in treating the hyperplasia of mammary glands caused by internal retention of phlegm and dampness and has the efficacy of harmonizing various drugs. Modern pharmacology considers that the liquorice has the effects of adrenocortical hormone-like action, peptic ulcer resistance, liver protection, phlegm elimination, cough relief and the like.

The preparation method comprises the following steps:

1. decoction: the preparation method comprises the following steps of putting qualified traditional Chinese medicinal materials of 10 parts of rhizoma cyperi, 20 parts of raw oyster, 10 parts of cowherb seed, 10 parts of tangerine seed, 15 parts of spina gleditsiae, 20 parts of fructus trichosanthis, 10 parts of rhizoma sparganii, 10 parts of curcuma zedoary, 15 parts of seaweed, 10 parts of dried orange peel, 10 parts of selfheal, 10 parts of cassia twig, 10 parts of angelica, 10 parts of astragalus membranaceus, 10 parts of fried bighead atractylodes rhizome and 5 parts of liquorice in a casserole, adding 600 milliliters of water into the casserole, soaking for half an hour, then decocting the mixture with soft fire to about 300 milliliters of water after boiling with big fire, and decanting the medicine juice for later use; adding 500 ml of water into the second decoction, boiling with strong fire, decocting with slow fire to about 250 ml of water, decanting the decoction, mixing the decoctions, and taking twice each day in the morning and evening.

External use: the above materials are made into topical plaster, and the affected part is cleaned before sleeping every night, applied and taken off in the second morning.

2. And (3) particle: concentrating the decoction to 20-30%, drying, spray drying at the actual temperature of 35-50 deg.C for several seconds or tens of seconds, and packaging with aluminum-plastic composite bag for sterilization.

3. And (3) capsule preparation: grinding the granular medicine prepared by the above granule processing method, making into powder, uniformly packaging, and making into hard capsule.

4. Oral liquid: extracting effective components from the decoction, adding additives, and making into oral liquid by injection process.

5. And (3) tablet preparation: the granules prepared by the granule processing method are mixed with the lubricant evenly and then put into a tablet machine for tabletting, thus preparing the tablets.

6. Bag soaking agent: the granular medicine prepared by the above granule processing method is filled into a small nontoxic filter bag, and the mouth is sealed, and then the medicine is packaged with an outer packaging bag.

Clinical cases

The following cases are all used to verify the curative effects of the oral and external traditional Chinese medicine prepared in example 1 for treating liver depression, phlegm dampness and blood stasis type hyperplasia of mammary glands.

General data 2018 and 2019 written patients clinically treat 60 patients with liver depression, phlegm dampness and blood stasis type mammary gland hyperplasia, wherein the patients are 21 years old at the minimum age, 50 years old at the maximum age and 35.5 years old on average; 24 cases on one side and 36 cases on both sides; the shortest disease course is 2 months, and the longest disease course is 8 years.

The diagnosis basis is according to the diagnosis standard of the traditional Chinese medicine disease diagnosis curative effect

1. Most of them have a flat lump in the upper quadrant of the breast, and some palpable hard nodules with bean size. The lump boundary is not clear and does not adhere to surrounding tissues.

2. Breast distending pain usually worsens before and remits after menstruation, and the sensation of weakness and growing in accordance with anger.

3. This disease is commonly seen in women aged 20-40 years.

4. The diagnosis of hyperplasia of mammary glands is confirmed by molybdenum target X-ray or B-ultrasonic examination.

Liver depression, phlegm dampness and stasis type mammary gland hyperplasia clinical symptoms: pain and lumps on one side or both sides of the breast, aggravation during or before the menstrual period, chest distress, vexation, pale, moist and thick or greasy tongue coating, sublingual stasis, wiry and smooth pulse, and liver depression, phlegm dampness and stasis type hyperplasia of mammary glands.

Method of treatment

The prescription is self-prepared for oral administration: rhizoma cyperi 10 oyster 20 cowherb seed 10 tangerine seed 10 spina gleditsiae 15

20 parts of fructus trichosanthis, 10 parts of rhizoma sparganii, 10 parts of curcuma zedoary, 15 parts of seaweed, 10 parts of dried orange peel, 10 parts of prunella vulgaris, 10 parts of cassia twig, 10 parts of angelica, 10 parts of astragalus, 10 parts of fried bighead atractylodes rhizome and 10 parts of liquorice for 5 days 1 dose, the medicinal materials are put into a casserole, 600 milliliters of water is added for soaking for half an hour, then the medicinal materials are boiled with big fire and decocted with small fire to about 300 milliliters of water, and medicinal liquid is decanted for later use; adding 500 ml of water into the second decoction, boiling with strong fire, decocting with slow fire to about 250 ml of water, decanting the decoction, mixing the decoctions, and taking twice each day in the morning and at night, wherein one month is a treatment course, and three treatment courses (disease severity increasing treatment courses) are generally performed.

The external preparation of the external traditional Chinese medicine for oral administration is applied by a pasting method, the affected part is cleaned and externally applied every night, and the affected part is taken off the next day, one month is taken as a treatment course, and three treatment courses (the treatment course is increased) are generally taken.

The application period can reduce pungent diet such as spicy and cold food, avoid drinking, and avoid overwork and mental stress.

Observation of therapeutic effects

The judgment of the curative effect is that the judgment of the curative effect is standard in the diagnosis of the traditional Chinese medicine diseases: the hard and tough and fat areas of the mammary gland of the patient disappear, the gland becomes soft and painless, and the clinical cure (obvious effect) is realized; the hard, tough and thick parts of the mammary gland gradually fade away, but the gland does not become soft completely, so that the pain is relieved and relieved (effective); the treatment is unchanged, namely after 3 courses of treatment, the hard, tough and thick areas of the mammary gland still exist, and the pain is as early as before and is ineffective.

Treatment results 60 clearly diagnosed patients with hyperplasia of mammary glands were treated, of which 46 clinical cures account for 76.67%; 11 cases of remission, accounting for 18.33; the total effective rate of the treatment is 95%. 3 cases are invalid, accounting for 5%. No adverse reaction in the whole treatment process. No toxic or side effect is found.

Examples of medical cases

Case one: 2019. 4, 8 flood a certain woman 46. The bilateral breast distending pain is obvious before menstrual period, the B-ultrasonic left breast 6mmx8mm and the right breast 12mmx9mmm are unclear in boundary, the B-ultrasonic left breast is scattered in a flaky and cord-shaped second echo area, the appearance is irregular, 4 types of bilateral breast hyperplasia are diagnosed, insomnia is caused for many years, and the bilateral breast hyperplasia is easy to wake up, bitter taste in mouth, dry mouth, dark palm color, dark lip, constipation, red and swollen tongue, sublingual stasis and blockage, and deep and smooth pulse. The traditional Chinese medicine is used for treating breast nodules (liver depression, phlegm dampness and stasis syndrome) by a self-prepared formula, and the formula comprises the following components: 10 parts of rhizoma cyperi, 20 parts of oyster, 10 parts of cowherb seed, 10 parts of tangerine seed, 10 parts of spina gleditsiae, 20 parts of fructus trichosanthis, 10 parts of rhizoma sparganii, 10 parts of curcuma zedoary, 15 parts of seaweed, 10 parts of dried orange peel, 10 parts of selfheal, 10 parts of cassia twig, 30 parts of raw bighead atractylodes rhizome, 10 parts of radix rehmanniae and 5 parts of liquorice. One dose per day, decocting with water, and applying topically, and checking the hyperplasia of mammary glands to 1 class after two months.

Case two: 2019. 5, 13 old a certain woman 32. The patient looks up 29mmx13mm residues of right mammary gland and 15 mmx9mm in 6-month and 15-month B-ultrasonography in 2019, diagnoses 3 types of bilateral mammary gland hyperplasia, and the hospital recommends operations, has insufficient sleep, chest distress, short breath, dark menstrual blood, small blood clot, pale-red tongue, sublingual stasis and weak pulse. The traditional Chinese medicine is used for treating breast nodules (liver depression, phlegm dampness and blood stasis type) by a self-prepared formula, and the formula comprises the following components: 10 parts of rhizoma cyperi, 20 parts of oyster, 10 parts of cowherb seed, 10 parts of tangerine seed, 10 parts of spina gleditsiae, 20 parts of fructus trichosanthis, 10 parts of rhizoma sparganii, 10 parts of curcuma zedoary, 15 parts of seaweed, 10 parts of pericarpium citri reticulatae, 10 parts of selfheal, 10 parts of cassia twig, 10 parts of astragalus membranaceus, 10 parts of angelica sinensis and 5 parts of liquorice. One dose of the medicine is taken after decoction and external application, and after four months, the hyperplasia of mammary glands is checked to be 1 type without operation.

Case three: 2018. 10, 23 Guo, woman, 54. 2018. 10, 11 certain hospitals can detect a plurality of nodules on the left mammary gland by B ultrasonic diagnosis, the large nodules are 3.1mmx3.4mm, the rest bilateral mammary gland structures are hierarchical and are not clear, the interior of the mammary gland structures is scattered in a flaky and strip-shaped hypoechoic area, the appearances are irregular and are mutually continued, and 3 types of hyperplasia of the left mammary glands, lassitude, loose stool, fat tongue, greasy fur, sublingual stasis and wiry and smooth pulse are diagnosed. The traditional Chinese medicine is used for treating breast nodules (liver depression, phlegm dampness and blood stasis type) by a self-prepared formula, and the formula comprises the following components: 10 parts of rhizoma cyperi, 20 parts of oyster, 10 parts of cowherb seed, 10 parts of tangerine seed, 10 parts of spina gleditsiae, 20 parts of fructus trichosanthis, 10 parts of rhizoma sparganii, 10 parts of curcuma zedoary, 15 parts of seaweed, 10 parts of pericarpium citri reticulatae, 10 parts of selfheal, 10 parts of cassia twig, 10 parts of poria cocos, 10 parts of fried bighead atractylodes rhizome and 5 parts of liquorice. One dose of the medicine is taken after decoction in water and externally applied, and no hyperplasia of mammary glands is detected after four months.

Clinical application shows that the traditional Chinese medicine can obviously relieve the clinical symptoms of liver depression, phlegm dampness and blood stasis type hyperplasia of mammary glands, has obvious effect, is safe and has no toxic or side effect, and is suitable for being developed and developed into granules, oral liquid, capsules, tablets, bagged steeping drugs and the like which are convenient to carry and take by applying modern pharmaceutical technology.

Claims (2)

1. An oral and external traditional Chinese medicine for treating liver depression, phlegm dampness and blood stasis type hyperplasia of mammary glands is characterized in that: the medicine is composed of the following raw material medicines in parts by weight:

10-20 parts of rhizoma cyperi;

20-25 parts of raw oysters;

10-20 parts of cowherb seed;

10-20 parts of tangerine seeds;

15-20 parts of spina gleditsiae;

20-30 parts of fructus trichosanthis;

10-20 of trigone;

10-2 of curcuma zedoary;

15-30 parts of seaweed;

10-20 parts of dried orange peel;

10-20 parts of selfheal;

10-20 parts of cassia twig;

10-20 parts of angelica;

10-20 parts of astragalus membranaceus;

10-20 parts of fried bighead atractylodes rhizome;

2-5 parts of liquorice.

2. The preparation method of the oral and external traditional Chinese medicine for treating liver depression, phlegm dampness and blood stasis type hyperplasia of mammary glands according to claim 1, which is characterized by comprising the following steps: the method comprises the following steps:

1. decoction: the preparation method comprises the following steps of putting qualified traditional Chinese medicinal materials of 10 parts of rhizoma cyperi, 20 parts of raw oyster, 10 parts of cowherb seed, 10 parts of tangerine seed, 15 parts of spina gleditsiae, 20 parts of fructus trichosanthis, 10 parts of rhizoma sparganii, 10 parts of curcuma zedoary, 15 parts of seaweed, 10 parts of dried orange peel, 10 parts of selfheal, 10 parts of cassia twig, 10 parts of angelica, 10 parts of astragalus membranaceus, 10 parts of fried bighead atractylodes rhizome and 5 parts of liquorice in a casserole, adding 600 milliliters of water into the casserole, soaking for half an hour, then decocting the mixture with soft fire to about 300 milliliters of water after boiling with big fire, and decanting the medicine juice for later use; adding 500 ml of water into the second decoction, boiling with strong fire, decocting with slow fire to about 250 ml of water, decanting the decoction, mixing the decoctions, taking twice each day in the morning and at night, and externally applying: making the above materials into topical plaster, cleaning affected part before sleeping every night, applying, and taking off in the second morning;

2. and (3) particle: concentrating the decoction to 20-30%, drying, spray drying at the actual temperature of 35-50 deg.C for several or tens of seconds, and packaging with aluminum-plastic composite bag for sterilization;

3. and (3) capsule preparation: grinding the granular medicine prepared by the above granule processing method to obtain powder, uniformly packaging and making into hard capsule;

4. oral liquid: extracting effective components from the decoction, adding additives, and making into oral liquid by injection process;

5. and (3) tablet preparation: mixing the granules and the lubricant, and tabletting to obtain tablet;

6. bag soaking agent: the granular medicine prepared by the above granule processing method is filled into a small nontoxic filter bag, and the mouth is sealed, and then the medicine is packaged with an outer packaging bag.