CN104435888A - Medicine for treating verruca plana and preparation method of medicine - Google Patents
Medicine for treating verruca plana and preparation method of medicine Download PDFInfo
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Abstract
The invention provides a medicine for treating verruca plana and a preparation method of the medicine. The medicine is prepared from rhizoma cyperi, indigowoad leaves, periostracum cicadae, semen coicis, herba patriniae, flos carthami, steamed polygonatum sibiricum, indigowoad roots, lithospermum erythrorhizon, cyrtomium fortune, equisetum hyemale, plantain and astragalus in a certain proportion compatibly. The semen coicis and the astragalus serve as sovereign drugs, have the functions of preventing ulcers, regenerating tissue and healing wounds, and can treat ulceration of sores and wounds which fail in healing. The lithospermum erythrorhizon, the indigowoad leaves, the herba patriniae, the steamed polygonatum sibiricum, the indigowoad roots, the equisetum hyemale and the plantain serve as ministerial drugs, have the functions of resisting bacteria, eliminating swelling, activating blood and repelling toxicity, and can treat carbuncle swollen boils and heat toxin macular eruption, clear away heat, remove toxicity, dispell wind and heat, remove blood stasis, expel pus, tonify spleen and moisten lung. The rhizoma cyperi, the flos carthami and the cyrtomium fortune are matched with the periostracum cicadae, so that the functions of regulating qi, removing depression, activating blood, clearing and activating the channels and collaterals, eliminating stagnant blood, relieving pain, eliminating sores and ulcers, clearing away heat, removing toxicity, stopping bleeding and killing parasites are achieved. The medicine has a practical curative effect on verruca plana.
Description
Technical field
The present invention relates to a kind of is Chinese medicine composition of crude drug and preparation method thereof by Chinese herbal medicine, relates to a kind of medicine for the treatment of verruca plana and preparation method thereof specifically.
Background technology
Verruca plana is infected by human papillomavirus (HPV) and causes, and is apt to occur in teen-age disease of viral infection.Clinical manifestation is color of the leather or peach flat pimple, and without obvious subjective symptoms, the course of disease is chronic.By direct or indirect contagion.Can onset suddenly, skin lesion is mainly in face, the back of the hand, arm, show as the flat pimple differed in size, slight protuberance, smooth surface, rounded, oval or polygon, boundary is clear, can dense distribution or owing to scratch and in the linear alignment local, general no conscious sympton, the conscious slight pruritus of some patients.The course of disease is chronic process, for many years sustainable.Doctor trained in Western medicine mainly adopts following therapeutic scheme: topical medication: external used medicine adopts the treatments such as Retinoic acid ointment, imiquimod ointment; Physical therapy: comprise freezing and laser therapy; Oral medicine: the oral isotretinoin capsule for treating of severe patient.Existing drug treatment suppresses viral, antitoxin side effect is less; Physiotherapy easily causes recurrence; Some patients leaves the sequela such as cicatrix, pigmentation after treatment, and therapeutic effect is not good enough.
Summary of the invention
The present invention, from clinical treatment medication demand and the dialectical principle of traditional Chinese medical science prescription, proposes a kind of medicine for the treatment of verruca plana and preparation method thereof.It is the medicament be prepared from by the crude drug of following parts by weight proportioning: Rhizoma Cyperi (processed with vinegar) 7-13g, Folium Isatidis 12-18g, Periostracum Cicadae 3-8g, Semen Coicis 27-33g, Herba Patriniae 12-18g, Flos Carthami 7-13g, Rhizoma Polygonati (steamed) 12-18g, Radix Isatidis 12-18g, Radix Arnebiae (Radix Lithospermi) 17-23g, Rhizoma Osmundae 7-13g, Herba Equiseti Hiemalis 12-18g, Herba Plantaginis 12-18g, Radix Astragali 27-33g.Optimum ratio is: Rhizoma Cyperi (processed with vinegar) 10g, Folium Isatidis 15g, Periostracum Cicadae 5g, Semen Coicis 30g, Herba Patriniae 15g, Flos Carthami 10g, Rhizoma Polygonati (steamed) 15g, Radix Isatidis 15g, Radix Arnebiae (Radix Lithospermi) 20g, Rhizoma Osmundae 10g, Herba Equiseti Hiemalis 15g, Herba Plantaginis 15g, Radix Astragali 30g.Described medicament is capsule, tablet or pill.
The preparation method step of described capsule, tablet, pill is as follows:
(1) in the side of getting, screen analysis pulverized by Rhizoma Cyperi (processed with vinegar), Folium Isatidis, Periostracum Cicadae, Semen Coicis, Herba Patriniae, Flos Carthami, Rhizoma Polygonati (steamed), Radix Isatidis, Radix Arnebiae (Radix Lithospermi), Rhizoma Osmundae, Herba Equiseti Hiemalis, Herba Plantaginis, the Radix Astragali;
(2) decocted with water 2-3 time by the mixture of sieve series in step (1), collecting decoction, filtration, worry liquid is condensed into 70-80 when spending, capsule, pill relative density are the thick paste of 1.0-1.6, and tablet relative density is the thick paste of 1.0-1.4;
(3) when making capsule, pill:
By thick paste separation and purification, drying, make dry granule; By dry granule mix homogeneously, in filled capsules, namely make capsule; Dry granule spray is added refined honey, mix homogeneously, makes piller and namely make pill;
When making tablet:
2-4 part starch is mixed homogeneously with the thick paste in step (2), makes granule, drying, make dry granule, dry granule is pressed into tablet, sugar coating, namely makes tablet.
Mixture described in step (2), the preferred number of times decocted with water is 2 times, and first time is 60-80 minute, and second time is 40-60 minute.
crude drug pharmacology of the present invention is as follows:
Rhizoma Cyperi (processed with vinegar): resolving depression of regulating the flow of vital energy, pain relieving regulating menstruation.Treating the liver discomfort in the stomach, depression of QI, breast abdomen distending pain over the hypochondrium, phlegm retention feeling of fullness, menoxenia, bleeding not during menses;
Folium Isatidis: cure mainly pyretic toxicity and send out the diseases such as speckle, erysipelas, laryngopharynx swelling and pain, aphtha of the mouth and tongue, sore and toxic;
Periostracum Cicadae: dispelling wind-heat, rash sore-throat relieving, removing nebula to improve visual acuity, to expelling wind and relieving convulsion;
Semen Coicis: Semen Coicis, Chinese medicine, another name Semen Coicis, NLIUGU, Semen Coicis, the Fructus Sapindi Mukouossi.For the kernel of grass Semen Coicis Coix lacryma-jobi L. var. meyuan (Romen.) Stapf.There is spleen invigorating eliminating dampness by diuresis, eliminating impediment antidiarrheal.For effect that edema, beriberi, dysuria, arthralgia chiefly caused by damp pathogen contracture, diarrhea due to hypofunction of the spleen, carbuncle are not burst.
Herba Patriniae: acrid in the mouth, hardship, have heat-clearing and toxic substances removing, the effects such as removing blood stasis and expelling pus;
Flos Carthami: promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain, contributes to controlling amenorrhea, dysmenorrhea, lochia, obstruction of qi in the chest and cardialgia, the stagnant stomachache of the stasis of blood, the twinge of the breast side of body, traumatic injury, skin infection swells and ache curative effect.Have blood circulation promoting and blood stasis dispelling, wet dissipation goes the effect swollen;
Rhizoma Polygonati (steamed): supplementing QI and nourishing YIN, spleen reinforcing lung moistening kidney tonifying effect strengthen, for the deficiency of YIN cough caused by dryness of lung, weakness of the spleen and stomach is weak, deficiency of kidney essence, dizzy foot are soft;
Radix Isatidis: the effect with heat-clearing and toxic substances removing, preventing cold, sore-throat relieving, bitter in the mouth;
Radix Arnebiae (Radix Lithospermi): Radix Arnebiae (Radix Lithospermi) nature and flavor are sweet, salty, cold.GUIXIN, Liver Channel.There is removing heat from blood, invigorate blood circulation, the function of removing toxic substances rash.Therefore heat in blood poison is contained, measles, macule send out the diseases such as not smooth thoroughly, can apply with the compatibility such as Periostracum Cicadae, Fructus Arctii, Fructus Forsythiae, Herba Schizonepetae.Cure mainly removing heat from blood, invigorate blood circulation, heat clearing away, removing toxic substances, controls warm macule, jaundice due to damp-heat, purpura, tells, is defeated in battle, hematuria, stranguria with turbid discharge, constipation with heat retention, burn, eczema, erysipelas, carbuncle and ulcer;
Rhizoma Osmundae: heat-clearing and toxic substances removing, hemostasis, parasite killing.For anemopyretic cold, encephalitis B, mumps, dysentery, discharging fresh blood stool, metrorrhagia, leukorrhagia, puerperal vim and vigour distending pain, ascarifuge and pinworm, pathopyretic ulcer;
Herba Equiseti Hiemalis: the effect with dispelling wind and heat pathogens, improving acuity of vision and removing nebula, hemostasis;
Herba Plantaginis: herb is medicinal, has effect of diuresis, heat clearing away, improving eyesight;
The Radix Astragali: have another name called continuous stilbene.Perennial herb, high 50-100 centimetre.Main root is plump, wooden, normal branch, canescence.Stem is upright, and top multi-branched, has thin rib, by white pubescence.Perennial herb, high 50-100 centimetre.Originate in the ground such as the Inner Mongol, Shanxi, Gansu, Heilungkiang.The history of medicinal existing more than 2000 year so far of the Radix Astragali, it has enhancing human body immunity function, protects the liver, diuresis, defying age, anti-stress, blood pressure lowering and antibacterial action more widely.Cure mainly: skin infection diabrosis, do not close up for a long time, have the effect of promoting tissue regeneration and wound healing.
The present invention does not burst for monarch drug, carbuncle with Semen Coicis, the Radix Astragali, promoting tissue regeneration and wound healing, and the diabrosis for the treatment of skin infection, does not close up for a long time.
With Radix Arnebiae (Radix Lithospermi), Folium Isatidis, Herba Patriniae, Rhizoma Polygonati (steamed), Radix Isatidis, Herba Equiseti Hiemalis, Herba Plantaginis for ministerial drug, antibacterial detumescence, toxic removing of invigorating blood circulation, controls sore and toxic, pyretic toxicity sends out speckle, heat-clearing and toxic substances removing, dispelling wind and heat pathogens, removing blood stasis and expelling pus, spleen reinforcing lung moistening.
Assistant is with Rhizoma Cyperi (processed with vinegar), Flos Carthami, Rhizoma Osmundae, and make with Periostracum Cicadae, resolving depression of regulating the flow of vital energy, blood stimulates the menstrual flow, eliminating stasis to stop pain, and skin infection swells and ache, heat-clearing and toxic substances removing, hemostasis, parasite killing.Medicine of the present invention holds the marrow of the traditional Chinese medical science, rigorous prescription, and all medicine monarch share, and mends broken combination, brings out the best in each other, meet the principle of traditional Chinese medical science medicine law and determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs.
Medicine for a better understanding of the present invention, clinical trial is as follows:
One, select case: subjects is 193 routine verruca plana patients, wherein male 103 example, women 90 example, the age 12-66 year between, most of patients adopted Western medicine, physiotherapy, but therapeutic effect is not good.
Two, diagnostic criteria:
In face, the back of the hand, arm, show as the flat pimple differed in size, slight protuberance, smooth surface, rounded, oval or polygon, boundary is clear, can dense distribution or owing to scratch and in the linear alignment local, the diabrosis of part skin infection, general no conscious sympton, the conscious slight pruritus of some patients.
Three, therapeutic scheme:
Every day 1 dose, decocting, takes orally at twice, within 6 days, is a course for the treatment of, continuous four courses for the treatment of.
Four, the standard of curative effect evaluation:
Verruca plana variable color peeling, comes off then, affected part preventing from scar after all coming off.
Five, therapeutic effect:
The Chinese medicine composition for the treatment of verruca plana of the present invention, verruca plana size <=1mm2's, one-two course for the treatment of can cure, verruca plana size 1-2 mm2's, three courses for the treatment of can cure, and verruca plana size >=2 mm2, four courses for the treatment of or more can cure.Medicine of the present invention has special efficacy to treatment verruca plana.
Western medicine checks: after treatment, and patient's pathologic finding verruca plana place epidermal thickness is roughly normal, basal layer hyperpigmentation, the visible melanophage of high dermis.
Detailed description of the invention
embodiment 1:a kind of medicine for the treatment of verruca plana and preparation method thereof.It is the medicament be prepared from by the crude drug of following parts by weight proportioning: Rhizoma Cyperi (processed with vinegar) 7-13g, Folium Isatidis 12-18g, Periostracum Cicadae 3-8g, Semen Coicis 27-33g, Herba Patriniae 12-18g, Flos Carthami 7-13g, Rhizoma Polygonati (steamed) 12-18g, Radix Isatidis 12-18g, Radix Arnebiae (Radix Lithospermi) 17-23g, Rhizoma Osmundae 7-13g, Herba Equiseti Hiemalis 12-18g, Herba Plantaginis 12-18g, Radix Astragali 27-33g.Described medicament is capsule, tablet or pill.
According to following portions by weight proportioning weighting raw materials:
Rhizoma Cyperi (processed with vinegar) 7-13g, Folium Isatidis 12-18g, Periostracum Cicadae 3-8g, Semen Coicis 27-33g, Herba Patriniae 12-18g, Flos Carthami 7-13g, Rhizoma Polygonati (steamed) 12-18g, Radix Isatidis 12-18g, Radix Arnebiae (Radix Lithospermi) 17-23g, Rhizoma Osmundae 7-13g, Herba Equiseti Hiemalis 12-18g, Herba Plantaginis 12-18g, Radix Astragali 27-33g.
The preparation method step of described capsule, tablet, pill is as follows:
(1) in the side of getting, screen analysis pulverized by Rhizoma Cyperi (processed with vinegar), Folium Isatidis, Periostracum Cicadae, Semen Coicis, Herba Patriniae, Flos Carthami, Rhizoma Polygonati (steamed), Radix Isatidis, Radix Arnebiae (Radix Lithospermi), Rhizoma Osmundae, Herba Equiseti Hiemalis, Herba Plantaginis, the Radix Astragali;
(2) decocted with water 2-3 time by the mixture of sieve series in step (1), collecting decoction, filtration, worry liquid is condensed into 70-80 when spending, capsule, pill relative density are the thick paste of 1.0-1.6, and tablet relative density is the thick paste of 1.0-1.4;
(3) when making capsule, pill:
By thick paste separation and purification, drying, make dry granule; By dry granule mix homogeneously, in filled capsules, namely make capsule; Dry granule spray is added refined honey, mix homogeneously, makes piller and namely make pill;
When making tablet:
2-4 part starch is mixed homogeneously with the thick paste in step (2), makes granule, drying, make dry granule, dry granule is pressed into tablet, sugar coating, namely makes tablet.
Mixture described in step (2), the preferred number of times decocted with water is 2 times, and first time is 60-80 minute, and second time is 40-60 minute.
embodiment 2:a kind of medicine for the treatment of verruca plana and preparation method thereof.It is the medicament be prepared from by the crude drug of following parts by weight proportioning: Rhizoma Cyperi (processed with vinegar) 10g, Folium Isatidis 15g, Periostracum Cicadae 5g, Semen Coicis 30g, Herba Patriniae 15g, Flos Carthami 10g, Rhizoma Polygonati (steamed) 15g, Radix Isatidis 15g, Radix Arnebiae (Radix Lithospermi) 20g, Rhizoma Osmundae 10g, Herba Equiseti Hiemalis 15g, Herba Plantaginis 15g, Radix Astragali 30g.Described medicament is capsule, tablet or pill.
According to following portions by weight proportioning weighting raw materials:
Rhizoma Cyperi (processed with vinegar) 10g, Folium Isatidis 15g, Periostracum Cicadae 5g, Semen Coicis 30g, Herba Patriniae 15g, Flos Carthami 10g, Rhizoma Polygonati (steamed) 15g, Radix Isatidis 15g, Radix Arnebiae (Radix Lithospermi) 20g, Rhizoma Osmundae 10g, Herba Equiseti Hiemalis 15g, Herba Plantaginis 15g, Radix Astragali 30g.
The preparation method step of described capsule, tablet, pill is as follows:
(1) in the side of getting, screen analysis pulverized by Rhizoma Cyperi (processed with vinegar), Folium Isatidis, Periostracum Cicadae, Semen Coicis, Herba Patriniae, Flos Carthami, Rhizoma Polygonati (steamed), Radix Isatidis, Radix Arnebiae (Radix Lithospermi), Rhizoma Osmundae, Herba Equiseti Hiemalis, Herba Plantaginis, the Radix Astragali;
(2) decocted with water 2-3 time by the mixture of sieve series in step (1), collecting decoction, filtration, worry liquid is condensed into 70-80 when spending, capsule, pill relative density are the thick paste of 1.0-1.6, and tablet relative density is the thick paste of 1.0-1.4;
(3) when making capsule, pill:
By thick paste separation and purification, drying, make dry granule; By dry granule mix homogeneously, in filled capsules, namely make capsule; Dry granule spray is added refined honey, mix homogeneously, makes piller and namely make pill;
When making tablet:
2-4 part starch is mixed homogeneously with the thick paste in step (2), makes granule, drying, make dry granule, dry granule is pressed into tablet, sugar coating, namely makes tablet.
Mixture described in step (2), the preferred number of times decocted with water is 2 times, and first time is 60-80 minute, and second time is 40-60 minute.
Embodiment 3: medicine of the present invention can also be decoction, oral liquid, granule etc.
Claims (5)
1. treat a medicine for verruca plana, it is characterized in that it is the medicament be prepared from by the crude drug of following parts by weight proportioning: Rhizoma Cyperi (processed with vinegar) 7-13g, Folium Isatidis 12-18g, Periostracum Cicadae 3-8g, Semen Coicis 27-33g, Herba Patriniae 12-18g, Flos Carthami 7-13g, Rhizoma Polygonati (steamed) 12-18g, Radix Isatidis 12-18g, Radix Arnebiae (Radix Lithospermi) 17-23g, Rhizoma Osmundae 7-13g, Herba Equiseti Hiemalis 12-18g, Herba Plantaginis 12-18g, Radix Astragali 27-33g.
2. the medicine for the treatment of verruca plana according to claim 1, is characterized in that it is the medicament be prepared from by the crude drug of following parts by weight proportioning: Rhizoma Cyperi (processed with vinegar) 10g, Folium Isatidis 15g, Periostracum Cicadae 5g, Semen Coicis 30g, Herba Patriniae 15g, Flos Carthami 10g, Rhizoma Polygonati (steamed) 15g, Radix Isatidis 15g, Radix Arnebiae (Radix Lithospermi) 20g, Rhizoma Osmundae 10g, Herba Equiseti Hiemalis 15g, Herba Plantaginis 15g, Radix Astragali 30g.
3. the medicine for the treatment of verruca plana according to claim 1 and 2, is characterized in that: described medicament is capsule, tablet or pill.
4. the medicine for the treatment of verruca plana according to claim 3, is characterized in that: the preparation method step of described capsule, tablet, pill is as follows:
(1) in the side of getting, screen analysis pulverized by Rhizoma Cyperi (processed with vinegar), Folium Isatidis, Periostracum Cicadae, Semen Coicis, Herba Patriniae, Flos Carthami, Rhizoma Polygonati (steamed), Radix Isatidis, Radix Arnebiae (Radix Lithospermi), Rhizoma Osmundae, Herba Equiseti Hiemalis, Herba Plantaginis, the Radix Astragali;
(2) decocted with water 2-3 time by the mixture of sieve series in step (1), collecting decoction, filtration, worry liquid is condensed into 70-80 when spending, capsule, pill relative density are the thick paste of 1.0-1.6, and tablet relative density is the thick paste of 1.0-1.4;
(3) when making capsule, pill:
By thick paste separation and purification, drying, make dry granule; By dry granule mix homogeneously, in filled capsules, namely make capsule; Dry granule spray is added refined honey, mix homogeneously, makes piller and namely make pill;
When making tablet:
2-4 part starch is mixed homogeneously with the thick paste in step (2), makes granule, drying, make dry granule, dry granule is pressed into tablet, sugar coating, namely makes tablet.
5. the preparation method of the medicine for the treatment of verruca plana according to claim 4, is characterized in that the mixture described in step (2), and the number of times decocted with water is 2 times, and first time is 60-80 minute, and second time is 40-60 minute.
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