CN113144098A - A Chinese medicinal composition for treating rheumatic arthritis and arthralgia and myalgia - Google Patents
A Chinese medicinal composition for treating rheumatic arthritis and arthralgia and myalgia Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A61K36/804—Rehmannia
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/35—Extraction with lipophilic solvents, e.g. Hexane or petrol ether
Abstract
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating rheumatic arthritis and arthralgia and myalgia. The traditional Chinese medicine composition for treating rheumatoid arthritis and arthralgia and myalgia comprises the following raw materials: bletilla striata, ampelopsis japonica, monkshood, kusnezoff monkshood root, ephedra herb, dried rehmannia root, pawpaw, clematis root, edestan, peach kernel, cinnamon bark, honeycomb, sesame oil and yellow lead. The traditional Chinese medicine composition for treating the rheumatic arthritis and the arthralgia and myalgia has good treatment effect and safety and no obvious toxic or side effect.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating rheumatic arthritis and arthralgia and myalgia.
Background
Rheumatoid arthritis (rheumatoid arthritis) is a common acute or chronic inflammation of connective tissue. Generally, the rheumatic arthritis is one of the main manifestations of rheumatic fever, and is clinically characterized by joint and muscle wandering soreness, red swelling and pain. It is associated with group A type B hemolytic streptococcal infection, and cold, dampness and other factors can induce the disease. The large joints of the lower limbs such as the knee joints and the ankle joints are most frequently affected.
The arthralgia and myalgia refers to the six excesses of the whole muscle and joint affected by wind, cold, summer heat, dampness, dryness and fire, or the six toxicities caused by trauma and chronic strain and the six toxicities caused by percutaneous bone penetration, which is commonly called as the bone toxicities. The bone poison exists on bones and periosteum for a long time to form the foreign poison. The toxin retention causes repeated congestion, edema, adhesion and contracture of soft tissues around bones and joints, thereby causing local blood circulation disorder, generating a large amount of acidic substances to stimulate blood vessels and damage muscle tissues, which are manifested as soreness, numbness, swelling and even red swelling and deformation of muscles, bones and joints of joints, and the serious patients can cause damage of joint sclerotin, joint deformation and incapability of self-care in life. The arthralgia and myalgia is an important clinical manifestation of the rheumatic bone disease and is treated with great importance.
The record of rheumatism bone disease in the four classic departments and the great Tibetan meridians includes that the heterozygosis of cold-dampness pseudo-ginseng is called arthralgia, and the rheumatism is mostly caused by the defects of joints, so the term of rheumatism is used up to now, and the rheumatism disease is a short term of the rheumatism disease in the modern medical concept, and the broad fingers influence a large group of diseases of bones, joints, muscles and surrounding soft tissues, such as bursa, tendons, fascia, blood vessels, nerves and the like.
The common drugs for treating rheumatoid arthritis in the prior art comprise non-steroidal anti-inflammatory drugs (NSAID), glucocorticoids, immunosuppressant and other chemical drugs, and the drugs have definite curative effects in clinical application, but have many adverse reactions, such as gastrointestinal reaction, liver and kidney function damage, bone marrow suppression, gonadal suppression and the like. In addition, prolonged or improper use of immunosuppressive agents can reduce the body's resistance, which can lead to severe infections, especially infectious pneumonia, and can even induce malignancies. Oral administration of Chinese herbs, external application of Chinese herbs, acupuncture and moxibustion and tuina are also commonly used therapeutic methods, but the therapeutic effects are all to be improved. Taking traditional Chinese medicine application as an example, the application is to apply the traditional Chinese medicine prepared into paste or powder to an affected part so that the effective components of the medicine can exert corresponding drug effect through skin. The plaster for treating rheumatism and ostealgia, hibiscus cream and the like have certain curative effects. However, when the Chinese medicine is applied, the medicine often needs to be combined with other treatment methods such as oral administration of the Chinese medicine and the like to exert better efficacy.
Disclosure of Invention
The invention provides a traditional Chinese medicine composition for treating rheumatic arthritis and arthralgia and myalgia, which can be applied to treat the rheumatic arthritis and the arthralgia and myalgia without combining other therapies.
The invention also provides a preparation method of the traditional Chinese medicine composition for treating rheumatoid arthritis and arthralgia and myalgia.
The traditional Chinese medicine composition for treating rheumatoid arthritis and arthralgia and myalgia adopts the following technical scheme: a traditional Chinese medicine composition for treating rheumatoid arthritis and arthralgia and myalgia comprises the following raw materials: bletilla striata, ampelopsis japonica, monkshood, kusnezoff monkshood root, ephedra herb, dried rehmannia root, pawpaw, clematis root, edestan, peach kernel, cinnamon bark, honeycomb, sesame oil and yellow lead.
As a further preferred technical scheme, the raw materials of the traditional Chinese medicine composition comprise: 40-50 parts of bletilla striata, 45-55 parts of ampelopsis japonica, 10-15 parts of monkshood, 10-15 parts of kusnezoff monkshood root, 10-15 parts of ephedra, 50-60 parts of radix rehmanniae, 50-65 parts of pawpaw, 40-50 parts of clematis root, 50-60 parts of edestan, 45-60 parts of peach kernel, 50-60 parts of cinnamomum micranthum, 30-40 parts of honeycomb, 1000 parts of sesame oil and 500 parts of yellow lead 300-.
As a further preferred technical scheme, the raw materials of the traditional Chinese medicine composition comprise: 45 parts of bletilla striata, 50 parts of ampelopsis japonica, 12 parts of monkshood, 12 parts of kusnezoff monkshood root, 12 parts of ephedra herb, 55 parts of dried rehmannia root, 60 parts of pawpaw, 45 parts of clematis root, 55 parts of edestan, 50 parts of peach seed, 55 parts of cinnamon bark, 35 parts of honeycomb, 900 parts of sesame oil and 350 parts of yellow lead.
As a further preferable technical scheme, the dosage form of the traditional Chinese medicine composition is a patch.
As a further preferred technical solution, the paste is prepared according to a method comprising the following steps: (1) frying rhizoma Bletillae, radix Ampelopsis, radix Aconiti Kusnezoffii, herba Ephedrae, radix rehmanniae, fructus Chaenomelis, radix Clematidis, fructus Cannabis, semen Persicae, cortex Cinnamomi and nidus Vespae in oleum Sesami; (2) filtering to remove residues, adding Plumbum Preparatium into the filtrate, and mixing to obtain paste; (3) cooling, dripping the paste obtained in the step (2) on cotton cloth, covering an anti-sticking film, and packaging to obtain the patch.
As a further preferable technical scheme, the temperature of the sesame oil during frying is 320 ℃.
The preparation method of the traditional Chinese medicine composition for treating rheumatoid arthritis and arthralgia and myalgia adopts the following technical scheme: the Chinese medicinal composition for treating the rheumatoid arthritis and the arthralgia and myalgia is prepared according to the steps defined in any one of the Chinese medicinal compositions for treating the rheumatoid arthritis and the arthralgia and myalgia.
The traditional Chinese medicine raw materials used in the traditional Chinese medicine composition for treating rheumatoid arthritis and arthralgia and myalgia respectively have the following effects:
bletilla striata: astringe to stop bleeding, resolve swelling and promote granulation (for hemoptysis, hematemesis, traumatic hemorrhage, pyocutaneous disease, pyogenic infection, and chapped skin).
Ampelopsis japonica: clearing away heat and toxic material, resolving carbuncle and dissipating binds, healing sore and promoting granulation (used for carbuncle, cellulitis, furuncle, scrofula, burn and scald).
Radix aconiti: the unprocessed radix aconite tincture can stimulate the skin after being generally orally taken after being processed and can produce numbness and pain after being externally used, so the unprocessed radix aconite tincture is externally used as an analgesic for certain neuralgia and rheumatism.
Kusnezoff monkshood root: dispelling wind and removing dampness, warming channels and relieving pain (arthralgia due to wind-cold-dampness)
Squama Manis: detumescence, ulcer, abscess, wind-dispelling collateral flow, meridian dredging, and lactation promotion (for carbuncle, cellulitis, sore, arthralgia due to wind-cold-dampness, amenorrhea, galactostasis, and hematochezia).
Herba ephedrae: inducing sweat and relieving exterior syndrome, dispersing lung qi and relieving asthma, and inducing diuresis to alleviate edema (exterior syndrome due to wind-cold, chest distress, cough and asthma, edema due to wind-cold, rheumatalgia, dorsal furuncle).
Radix rehmanniae: clear heat and cool blood, nourish yin, promote the production of body fluid (dark-red tongue with polydipsia, yin deficiency and internal heat, bone steaming, fatigue heat, internal heat, diabetes, hematemesis, epistaxis, macula and eruption).
Pawpaw: pacify liver, relax tendons, harmonize stomach and resolve dampness (wind-damp-dispelling and tendon and bone-strengthening herbs belonging to the category of the damp-dispelling herbs).
Clematis root: has the functions of dispelling wind-damp and dredging the channels and collaterals (wind-damp arthralgia, numbness of limbs, spasm of muscles and tendons and difficulty in flexion and extension).
Fructus cannabis: moisten intestines to relieve constipation (indicated for constipation due to blood deficiency and fluid deficiency with intestinal dryness).
Peach kernel: promoting blood circulation and removing blood stasis (traumatic injury).
The official cinnamon: strengthen tendons and bones, unblock blood vessels.
Honeycomb: counteract toxic pathogen and kill parasites, dispel wind and alleviate pain (pyocutaneous disease, acute mastitis, scrofula, intractable tinea, fungal infection of hand and foot, toothache, rheumatalgia).
Sesame oil: for external use as ointment and plaster base; for external application, such as scald, burn, sore, etc., sesame oil and (mixed) medicine (powder) are applied to the affected part without dryness and cracking, and the effect is good.
Yellow lead: has effects in relieving fever, removing toxic substance, promoting granulation, and removing blood stasis (it is mainly used in powder and plaster, can be combined with vegetable oil, and is used as base agent for preparing plaster, and has good effects in removing toxic substance and astringing).
The invention has the beneficial effects that: the traditional Chinese medicine composition for treating the rheumatic arthritis and the arthralgia and myalgia has the effects of dredging collaterals, relieving pain, dispelling cold, activating blood circulation, clearing damp, dredging collaterals, clearing heat and dispelling wind, and can obviously improve the clinical symptoms of the rheumatic arthritis, neck, shoulder, waist and leg pain and sciatica.
The traditional Chinese medicine composition for treating rheumatoid arthritis and arthralgia and myalgia adopts the dosage form of the external patch, can treat both symptoms and root causes in clinical use under the condition of effectively treating diseases, and has the advantages of good curative effect, easy operation, low price, no toxic or side effect and no treatment pain for patients.
Detailed Description
The technical solutions of the present invention will be described clearly and completely with reference to specific embodiments, and it should be understood that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1A Chinese medicinal composition for treating rheumatic arthritis and arthralgia and myalgia, and its preparation method
The traditional Chinese medicine composition comprises the following raw materials: 45 parts of bletilla striata, 50 parts of ampelopsis japonica, 12 parts of monkshood, 12 parts of kusnezoff monkshood root, 12 parts of ephedra herb, 55 parts of dried rehmannia root, 60 parts of pawpaw, 45 parts of clematis root, 55 parts of edestan, 50 parts of peach seed, 55 parts of cinnamon bark, 35 parts of honeycomb, 900 parts of sesame oil and 350 parts of yellow lead.
The preparation method comprises the following steps: (1) frying rhizoma Bletillae, radix Ampelopsis, radix Aconiti Kusnezoffii, herba Ephedrae, radix rehmanniae, fructus Chaenomelis, radix Clematidis, fructus Cannabis, semen Persicae, cortex Cinnamomi and nidus Vespae (cut) in oleum Sesami; (2) filtering to remove residues, adding Plumbum Preparatium into the filtrate, and mixing to obtain paste; (3) cooling, dripping the paste obtained in the step (2) on cotton cloth, covering an anti-sticking film, and packaging to obtain the patch.
In particular, the following scheme is referred to in the preparation process of the patch:
1 to take and note: the first pill and the second pill are thick, the plaster is thick, the third and the fourth are lower, the mixture is decocted to be dry and deslagged, the mixture is dripped into water to form beads, the pills are discharged from fire, the pills are cooked and melted, the shape of the pills is black like paint under the ground with cold water, the pills are soft when being hot and hard when being cold, the pills are stuck and the pills are pulled out.
Detailed procedures
The black plaster is a lead plaster prepared by frying edible oil to obtain medicinal materials, removing residues, and reacting with Plumbum Preparatium at high temperature.
Selection of matrix raw material and treatment of medicinal material
Vegetable oil: preferably pure sesame oil. Its advantages are less foam and easy operation. The prepared plaster has bright color, sticky property and good quality.
Yellow lead: also called as Plumbum preparatium, red lead, Clay lead, orange, heavy, powdery, mainly made into lead tetraoxide, purity requirement is above 95%, and contains no moisture (available in large pharmacy or chemical shop).
Treatment of the medicine materials: the raw materials are taken according to the prescription and are ground properly to prepare for decocting to dry and removing slag.
Conventional manufacturing process
2.2.1 extraction of the medicinal materials (dregs removal by decoction): placing vegetable oil in a pot, slightly heating, adding the medicinal materials, heating, and stirring until the medicinal materials are fried to dark brown surface and brown inside. The temperature can reach 220 ℃, the dregs of a decoction can be removed by an iron wire sieve after frying, and the oil after removing the dregs is the medicinal oil. (copper pan is preferably used as pan, special thermometer can be used for controlling temperature, medical apparatus and instruments are sold in market)
2.2.2 oil refining: decocting the above medicinal oil, and using middle fire when the oil temperature rises to 320 deg.C (which is critical). Duration of oil refining: firstly, a thermometer is seen to reach a specified temperature; second, the oil smoke starts to be light cyan, gradually becomes black and dense, and then becomes white dense smoke, and the white smoke is directly upward when no wind exists; thirdly, oil flower observation: when boiling begins, the oil bloom is mostly near the periphery of the pot wall, and the oil bloom is concentrated towards the center of the pot; fourthly, dripping into beads: dripping a little of the medicine oil into water, and not dispersing to form a bead shape (oil refining is required until the dripping water becomes a bead, fire prevention is required to be paid attention to, and the temperature is too high).
Preparing paste by using the following components: after the medicinal oil is refined, the pill is taken out of the fire and is added, and the yellow pill is dried and sieved by a 100-mesh sieve before being added. Adding small amount of lead while stirring, and stirring in the same direction. Stirring into viscous paste, which is not sticky, and has good wiredrawing effect, too hard to make the paste old, and too viscous to make the paste soft.
Fire toxin removal: the plaster is prepared by soaking in cold water once a day and then making plaster ten days later.
Placing the paste mass in a container, melting in water bath or with slow fire, adding the fine materials, stirring, and spreading a certain amount of paste on kraft paper or plaster cloth with bamboo stick.
Example 2A Chinese medicinal composition for treating rheumatic arthritis and arthralgia and myalgia, and its preparation method
The traditional Chinese medicine composition comprises the following raw materials: 40 parts of bletilla striata, 45 parts of ampelopsis japonica, 10 parts of monkshood, 10 parts of kusnezoff monkshood root, 10 parts of ephedra herb, 50 parts of dried rehmannia root, 50 parts of pawpaw, 40 parts of clematis root, 50 parts of edestan, 45 parts of peach seed, 50 parts of cinnamon bark, 30 parts of honeycomb, 800 parts of sesame oil and 300 parts of yellow lead.
The preparation method comprises the following steps: (1) frying rhizoma Bletillae, radix Ampelopsis, radix Aconiti Kusnezoffii, herba Ephedrae, radix rehmanniae, fructus Chaenomelis, radix Clematidis, fructus Cannabis, semen Persicae, cortex Cinnamomi and nidus Vespae (cut) in oleum Sesami; (2) filtering to remove residues, adding Plumbum Preparatium into the filtrate, and mixing to obtain paste; (3) cooling, dripping the paste obtained in step (2) on cotton cloth, covering with an anti-sticking film, and packaging to obtain patch (see example 1 for detailed steps).
Example 3A Chinese medicinal composition for treating rheumatic arthritis and arthralgia and myalgia, and its preparation method
The traditional Chinese medicine composition comprises the following raw materials: 50 parts of bletilla striata, 55 parts of ampelopsis japonica, 15 parts of monkshood, 15 parts of kusnezoff monkshood root, 15 parts of ephedra herb, 60 parts of dried rehmannia root, 65 parts of pawpaw, 50 parts of clematis root, 60 parts of edestan, 60 parts of peach seed, 60 parts of cinnamon bark, 40 parts of honeycomb, 1000 parts of sesame oil and 400 parts of yellow lead.
The preparation method comprises the following steps: (1) frying rhizoma Bletillae, radix Ampelopsis, radix Aconiti Kusnezoffii, herba Ephedrae, radix rehmanniae, fructus Chaenomelis, radix Clematidis, fructus Cannabis, semen Persicae, cortex Cinnamomi and nidus Vespae (cut) in oleum Sesami; (2) filtering to remove residues, adding Plumbum Preparatium into the filtrate, and mixing to obtain paste; (3) cooling, dripping the paste obtained in step (2) on cotton cloth, covering with an anti-sticking film, and packaging to obtain patch (see example 1 for detailed steps).
Example 4 efficacy test of the Chinese medicinal composition for treating rheumatoid arthritis and arthralgia and myalgia of the present invention
The experimental scheme is as follows: the traditional Chinese medicine composition and the hydroxychloroquine sulfate are respectively adopted to treat patients with rheumatoid arthritis; the specific treatment scheme of the traditional Chinese medicine composition (examples 1-3) is as follows: the patch is attached to the joint, and the patch of the invention is replaced every 2 days; the treatment scheme of the hydroxychloroquine sulfate is as follows: the preparation is administered at a dose of 200mg 2 times daily; every 2 weeks is a course of treatment, and 2 courses of treatment are observed.
The test was included in the standard: the activity of RA is evaluated by adopting the international universal disease activity degree comprising 28 joints, patients with DAS28 of 2.6-5.1 are included in the experiment (meeting the diagnosis standard of Western medicine), and an informed consent is signed; after screening, a total of 80 persons entered the experiment and were randomly and evenly divided into 3 experimental groups (treated with the patches prepared in examples 1-3) and 1 control group (treated with hydroxychloroquine sulfate), each group containing 20 persons; each group was tested at age. The time of onset, the time of diagnosis, the history of medication and the like have no significant difference; the experimental result is evaluated by taking DAS28 score as a standard (delta DAS28 is more than 1.2 curative effect, delta DAS28 is more than 0.6 and less than 1.2 curative effect, and delta DAS28 is less than or equal to 0.6 curative effect).
The specific experimental results are shown in table 1 below:
TABLE 1
As can be seen from the above table 1, the Chinese medicinal composition for treating rheumatic arthritis and arthralgia and myalgia, prepared into a patch, has a treatment effect on the rheumatic arthritis which is remarkably superior to that of hydroxychloroquine sulfate, and has the effective rate of over 90 percent; particularly, the patch prepared in the embodiment 1 has the best treatment effect, and the effective rate can reach 100%.
In addition, no obvious adverse reaction occurs in the treatment process and the follow-up process in the later period by adopting the patch, and the traditional Chinese medicine composition for treating the rheumatoid arthritis and the arthralgia and myalgia has good safety.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.
Claims (7)
1. A traditional Chinese medicine composition for treating rheumatoid arthritis and arthralgia and myalgia is characterized by comprising the following raw materials: bletilla striata, ampelopsis japonica, monkshood, kusnezoff monkshood root, ephedra herb, dried rehmannia root, pawpaw, clematis root, edestan, peach kernel, cinnamon bark, honeycomb, sesame oil and yellow lead.
2. The traditional Chinese medicine composition for treating rheumatoid arthritis and arthralgia and myalgia as claimed in claim 1, wherein the raw materials of the traditional Chinese medicine composition comprise: 40-50 parts of bletilla striata, 45-55 parts of ampelopsis japonica, 10-15 parts of monkshood, 10-15 parts of kusnezoff monkshood root, 10-15 parts of ephedra, 50-60 parts of radix rehmanniae, 50-65 parts of pawpaw, 40-50 parts of clematis root, 50-60 parts of edestan, 45-60 parts of peach kernel, 50-60 parts of cinnamomum micranthum, 30-40 parts of honeycomb, 1000 parts of sesame oil and 500 parts of yellow lead 300-.
3. The traditional Chinese medicine composition for treating rheumatoid arthritis and arthralgia and myalgia as claimed in claim 2, wherein the raw materials of the traditional Chinese medicine composition comprise: 45 parts of bletilla striata, 50 parts of ampelopsis japonica, 12 parts of monkshood, 12 parts of kusnezoff monkshood root, 12 parts of ephedra herb, 55 parts of dried rehmannia root, 60 parts of pawpaw, 45 parts of clematis root, 55 parts of edestan, 50 parts of peach seed, 55 parts of cinnamon bark, 35 parts of honeycomb, 900 parts of sesame oil and 350 parts of yellow lead.
4. The Chinese medicinal composition for treating rheumatoid arthritis and arthralgia and myalgia as claimed in any one of claims 1 to 3, wherein the dosage form of the Chinese medicinal composition is a patch.
5. The Chinese medicinal composition for treating rheumatoid arthritis and arthralgia and myalgia as claimed in claim 4, wherein the patch is prepared by a method comprising the following steps: (1) frying rhizoma Bletillae, radix Ampelopsis, radix Aconiti Kusnezoffii, herba Ephedrae, radix rehmanniae, fructus Chaenomelis, radix Clematidis, fructus Cannabis, semen Persicae, cortex Cinnamomi and nidus Vespae in oleum Sesami; (2) filtering to remove residues, adding Plumbum Preparatium into the filtrate, and mixing to obtain paste; (3) cooling, dripping the paste obtained in the step (2) on cotton cloth, covering an anti-sticking film, and packaging to obtain the patch.
6. The Chinese medicinal composition for treating rheumatoid arthritis and arthralgia and myalgia as claimed in claim 4, wherein the temperature of the sesame oil during frying is 320 ℃.
7. The method for preparing a Chinese medicinal composition according to any one of claims 1-6 for treating rheumatic arthritis and arthralgia and myalgia.
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Non-Patent Citations (1)
Title |
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王光清等: "《中国膏药学》", 31 October 1981, 陕西科学技术出版社 * |
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