CN104042875B - Traditional Chinese medicine composition as well as preparation method and application thereof - Google Patents
Traditional Chinese medicine composition as well as preparation method and application thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition as well as a preparation method and application thereof. The traditional Chinese medicine composition is prepared from panax notoginseng, daemonorops draco, gypsum, liquorice, myrrh, black radix scrophulariae, safflowers, medicinal cyathula roots, N. franchetii Boiss, ligusticum wallichii, fritillary bulbs, musk and plum slices in a special weight ratio. The traditional Chinese medicine composition has a good curative effect on common gynecological diseases, traumas, surgical diseases and the like.
Description
Technical field
The present invention relates to field of medicaments, be specifically related to Chinese medicine composition and its production and use.
Background technology
Common gynaecopathia, as irregular menstruation, abdominal pain in menstruation, amenorrhea, leucorrhea with red and white discharge, cold uterus, fail to be impregnated for a long time, cervical erosion, mastalgia breast carcinoma etc., for the women suffering from these diseases brings a lot of health problem, them are made to endure health or mental suffering to the fullest extent.
Wherein, irregular menstruation shows as the exception of menstrual cycle or amount of bleeding, or the moon is premenstrual, menstrual period time stomachache and General Symptoms.
Wound refers to and comprises bullet, Jin Ren, traumatic injury, injury by overexertion, burn and scald, cold injury and insect-animal injury etc. by the outer damage that health or object cause due to the erosion etc. of the strike of external object, collision or chemical substance.For various wound, no matter wound size, the depth, all to carry out process correct in time, if deal with improperly, wound bleeding, infection, suppuration can be caused, seriously can obtain tetanus, severed limb, even life-threatening.Treatment of wounds is correct, and it can be made to heal rapidly; Otherwise possible suppurative infection, does not prolongedly heal, even because of threat to life such as concurrent systemic infection, gas gangrene, tetanus.Process wound generally comprises sterilization, hemostasis and wrapping.
For the surgical diseases except wound, as anal fistula proctoptosis etc., be main mainly with operative treatment clinically at present.
For common gynecological disease, wound or surgery diseases etc., there is no the external application Chinese medicine all can effectively treated.
Summary of the invention
The object of the invention is to a kind of external medicine composition, it is made up of the Radix Notoginseng of specified weight proportioning, Sanguis Draxonis, Gypsum Fibrosum, Radix Glycyrrhizae, Myrrha, black element ginseng, Flos Carthami, river Niu Xi, angelica, Rhizoma Chuanxiong, Bulbus Fritillariae Thunbergii, Moschus and borneol, can effectively treat Common Gynecologic Diseases, wound and surgical diseases, apply ointment or plaster conveniently, therapeutic effect is good.
The invention provides following technical scheme:
1. an external medicine composition, it is made up of the crude drug comprising following weight proportion:
radix Notoginseng 10 parts, Sanguis Draxonis 5-15 part, Gypsum Fibrosum 2-5 part, Radix Glycyrrhizae 12-16 part, Myrrha 7-9 part, black element ginseng 5-8 part, Flos Carthami 5-15 part, river cattle sunset 6-12 part, angelica 6-12 part, Rhizoma Chuanxiong 5-15 part, Bulbus Fritillariae Thunbergii 6-14 part, Moschus 4-8 part, borneol 5-15 part
This Chinese medicine composition is made by the following method:
(1) take the crude drug of above-mentioned weight proportion, and wear into fine powder respectively;
(2) take 500-600 weight portion Oleum sesami and put into heating container, during temperature with 300-330 at a simmer DEG C, under agitation add adjuvant Plumbum preparatium 40-60 part, continue to stir after 10-30 minute and add Colophonium 40-60 part, add Aerugo 40-50 part after stirring 10-30 minute again, then add Hydrocerussitum (Ceruse) 30-40 part after stirring 10-30 minute, Keep agitation is until form plaster mother, form plaster imperial mother and remove fire, Temperature fall;
(3) when the female temperature of plaster is reduced to the temperature of 70-90 DEG C, each crude drug powder of above-mentioned (1) is added, stirs, be cooled to room temperature.
2. external medicine composition as above, it is made up of the crude drug comprising following weight proportion:
radix Notoginseng 10 parts, Sanguis Draxonis 8-1 2 parts, Gypsum Fibrosum 3-4 parts, Radix Glycyrrhizae 12-1 4 parts, Myrrha 7-9 part, black element ginseng 6-8 parts, Flos Carthami 8-1 2 parts, river cattle sunset 8-1 0 parts, angelica 8-1 0 parts, Rhizoma Chuanxiong 8-1 2 parts, Bulbus Fritillariae Thunbergii 9-1 3 parts, 6-8 parts, Moschus, borneol 8-1 0 parts.
3. external medicine composition as above, it is made up of the crude drug comprising following weight proportion:
radix Notoginseng 10 parts, Sanguis Draxonis 10 parts, Gypsum Fibrosum 4 parts, 12 parts, Radix Glycyrrhizae, Myrrha 8 parts, black element ginseng 8 parts, Flos Carthami 11 parts, river cattle sunset 10 parts, angelica 10 parts, Rhizoma Chuanxiong 10 parts, Bulbus Fritillariae Thunbergii 11 parts, 8 parts, Moschus, borneol 8 parts.
4. prepare the method for above-mentioned external medicine composition, the method comprises:
(1) take the crude drug of above-mentioned weight proportion, and wear into fine powder respectively;
(2) take 500-600 weight portion Oleum sesami and put into heating container, during temperature with 300-330 at a simmer DEG C, under agitation add adjuvant Plumbum preparatium 40-60 part, continue to stir after 10-30 minute and add Colophonium 40-60 part, add Aerugo 40-50 part after stirring 10-30 minute again, then add Hydrocerussitum (Ceruse) 30-40 part after stirring 10-30 minute, Keep agitation is until form plaster mother, form plaster imperial mother and remove fire, Temperature fall;
(3) when the female temperature of plaster is reduced to the temperature of 70-90 DEG C, each crude drug powder obtained is added, stirs, be cooled to room temperature, form plaster in above-mentioned (1).
5. method as above, the method also comprises:
(4) get plaster agglomerate and be placed in container, water-bath or slow fire are melted, get appropriate plaster and adhere on kraft paper or plaster cloth.
6. above-mentioned external medicine composition is for the preparation of the purposes in the gynopathic medicine for the treatment of, and described gynaecopathia comprises irregular menstruation, abdominal pain in menstruation, amenorrhea, leucorrhea with red and white discharge, cold uterus, fails to be impregnated for a long time, cervical erosion and mastalgia breast carcinoma etc.
7. the purposes of above-mentioned external medicine composition in the medicine for the preparation for the treatment of wound, described wound comprises traumatic injury, knife injury is bled, adult's hernia, muscles and bones numbness and the cold pain of waist lower limb etc.
8. the purposes of above-mentioned external medicine composition in the medicine for the preparation for the treatment of surgical diseases, described surgical diseases comprises cellulitis carbuncle on the back, Canis familiaris L. stings that scorpion stings, innominate toxic swelling, scrofula scrofula disease, lymphogranuloma inguinale inguinal bubo, step boil on the nape opposite the mouth, inclined head toothache, beriberi chilblain, children's's infantile spleen malnutrition, inside and outside hemorrhoid, anal fistula proctoptosis and psoriasis etc.
External medicine composition provided by the invention, can be prepared as external type plaster easily, have good therapeutic effect for common gynaecopathia, wound and surgical diseases, and easy to use, lasting medicine.
Detailed description of the invention
Below engage detailed description of the invention and further describe the present invention, the features and advantages of the invention will become more clear, clear and definite along with these descriptions.
The present inventor is through large quantity research and experiment, drug matching is passed through in discovery, the crude drug Radix Notoginseng of specified weight proportioning, Sanguis Draxonis, Gypsum Fibrosum, Radix Glycyrrhizae, Myrrha, black element ginseng, Flos Carthami, river Niu Xi, angelica, Rhizoma Chuanxiong, Bulbus Fritillariae Thunbergii, Moschus and borneol are made medicine for external use, as plaster, significant analgesic effect can be played, to gynaecopathia, wound and surgical diseases, there is remarkable therapeutic effect.
In the present invention, each crude drug used is all Chinese herbal medicine, can buy at pharmacy.
Wherein, Radix Notoginseng also referred to as Radix Notoginseng, have dissipating blood stasis hemostasis, calm the nerves analgesic effect.
Sanguis Draxonis has the effect of promoting blood circulation to remove blood stasis, analgesic therapy and hemostasia and promoting granulation.In the present invention, based on 10 weight portion Radix Notoginsengs, the consumption of Sanguis Draxonis is 5-15 part, preferred 8-12 part, more preferably 10 parts.
Gypsum Fibrosum has clearing away heat-fire, relieving restlessness is quenched the thirst and restrain the effect of granulation promoting.In the present invention, based on 10 weight portion Radix Notoginsengs, the consumption of Gypsum Fibrosum is 2-5 part, preferred 3-4 part, more preferably 4 parts.
Radix Glycyrrhizae has the effects such as QI invigorating invigorating middle warmer, relieving spasm to stop pain, eliminating fire and detoxication, coordinating the actions of various ingredients in a prescription.In the present invention, based on 10 weight portion Radix Notoginsengs, the consumption of Radix Glycyrrhizae is 12-16 part, preferred 12-14 part, more preferably 12 parts.
Myrrha has the effect such as promoting blood circulation and stopping pain, detumescence and promoting granulation.In the present invention, based on 10 weight portion Radix Notoginsengs, the consumption of Myrrha is 7-9 part, preferably 8 parts.
Black element ginseng, also referred to as black ginseng or Radix Scrophulariae, has the effects such as clearing away heat and cooling blood, replenishing YIN and removing heat, eliminating fire and detoxication and hard masses softening and resolving.In the present invention, based on 10 weight portion Radix Notoginsengs, the consumption of black element ginseng is 5-8 part, preferred 6-8 part, more preferably 8 parts.
Flos Carthami, also referred to as Flos Carthami, has the effect such as promoting blood circulation to restore menstrual flow, blood stasis removing pain relieving.In the present invention, based on 10 weight portion Radix Notoginsengs, the consumption of Flos Carthami is 5-15 part, preferred 8-12 part, more preferably 11 parts.
River Niu Xi, also referred to as Radix Cyathulae, has the effects such as promoting blood circulation to restore menstrual flow, invigorating the liver and kidney, bone and muscle strengthening.In the present invention, based on 10 weight portion Radix Notoginsengs, the consumption of river Niu Xi is 6-12 part, preferred 8-10 part, more preferably 10 parts.
Angelica has the effect of channels sootheing and network vessel quickening.In the present invention, based on 10 weight portion Radix Notoginsengs, the consumption of angelica is 6-12 part, preferred 8-10 part, more preferably 10 parts.
Rhizoma Chuanxiong has the effect such as blood circulation promoting and blood stasis dispelling, wind-expelling pain-stopping.In the present invention, based on 10 weight portion Radix Notoginsengs, the consumption of Rhizoma Chuanxiong is 5-15 part, preferred 8-12 part, more preferably 10 parts.
Bulbus Fritillariae Thunbergii, also referred to as Bulbus Fritillariae Thunbergii, has the effect of dissipating depression of QI eliminating stagnation.In the present invention, based on 10 weight portion Radix Notoginsengs, the consumption of Bulbus Fritillariae Thunbergii is 6-14 part, preferred 9-13 part, more preferably 11 parts.
Moschus has the effect of having one's ideas straightened out, warding off dirty, dredging collateral, scattered silt, analgesia, detumescence.In the present invention, based on 10 weight portion Radix Notoginsengs, the consumption of Moschus is 4-8 part, preferred 6-8 part, more preferably 8 parts.
Borneol, also referred to as Borneolum Syntheticum, has the effect of logical all keys, loose stagnated fire, reducing swelling and alleviating pain, removing nebula improving eyesight.In the present invention, based on 10 weight portion Radix Notoginsengs, the consumption of borneol is 5-15 part, preferred 8-10 part, more preferably 8 parts.
External medicine composition of the present invention, suitable dosage forms is unguentum, preferred plaster.
When preparing external medicine composition of the present invention, first preparing plaster mother, adding each crude drug powder, make plaster.
When preparing plaster and being female, use Oleum sesami as medicine oil, and add Plumbum preparatium (also referred to as Plumbum preparatium), Colophonium, Aerugo and Hydrocerussitum (Ceruse) successively.
Specifically, take 500-600 weight portion Oleum sesami and put into heating container, with 300-330 DEG C at a simmer, preferably during the temperature of about 320 DEG C, under agitation add adjuvant Plumbum preparatium 40-60 part, preferably 50 parts, continue to stir 10-30 minute, preferably after 30 minutes, add Colophonium 40-60 part, preferably 50 parts, stir 10-30 minute again, preferably after 30 minutes, add Aerugo 40-50 part, preferably 40 parts, stir 10-30 minute again, preferably after 30 minutes, add Hydrocerussitum (Ceruse) 30-40 part, preferably 30 parts, Keep agitation is until form plaster mother.
Treat that the female temperature of plaster is reduced to 70-90 DEG C, during the temperature of preferred 70-80 DEG C, each crude drug powder is added, stirs, be cooled to room temperature, namely form plaster.
Further, plaster agglomerate can be got and be placed in container, water-bath or slow fire are melted, get appropriate plaster and adhere on kraft paper or plaster cloth.
Embodiment
Further illustrate the present invention below by way of instantiation, but these examples are only to exemplary explanation of the present invention, do not form any restriction to protection scope of the present invention.
Embodiment 1
Take the crude drug of following weight:
radix Notoginseng 100g, Sanguis Draxonis 100g, Gypsum Fibrosum 40g, Radix Glycyrrhizae 120g, Myrrha 80g, black element ginseng 80g, Flos Carthami 110g, river cattle sunset 100g, angelica 100g, Rhizoma Chuanxiong 100g, Bulbus Fritillariae Thunbergii 110g, Moschus 80g, borneol 80g.
Prepare plaster by the following method:
(1) above-mentioned raw materials drug mill is become fine powder;
(2) take 6000g Oleum sesami and put into pot, by the temperature of 320 DEG C at a simmer, under agitation add adjuvant Plumbum preparatium 500g, continue stirring and add Colophonium 500g after 30 minutes, add Aerugo 400g after stirring 30 minutes again, then add Hydrocerussitum (Ceruse) 300g after stirring 30 minutes, Keep agitation is until the plaster forming even thickness is female, remove fire, Temperature fall;
(3) when the female temperature of plaster is reduced to the temperature of 80 DEG C, each crude drug powder obtained is added, stir, be cooled to room temperature in above-mentioned (1).
Embodiment 2
Prepare plaster with method similar to Example 1, difference is, raw materials used medicine weight is as follows:
radix Notoginseng 100g, Sanguis Draxonis 80g, Gypsum Fibrosum 30g, Radix Glycyrrhizae 120g, Myrrha 70g, black element ginseng 60g, Flos Carthami 80g, river cattle sunset 80g, angelica 80g, Rhizoma Chuanxiong 80g, Bulbus Fritillariae Thunbergii 90g, Moschus 60g, borneol 80g.
Embodiment 3
Prepare plaster with method similar to Example 1, difference is, raw materials used medicine weight is as follows:
Radix Notoginseng 100g, Sanguis Draxonis 120g, Gypsum Fibrosum 40g, Radix Glycyrrhizae 140g, Myrrha 90g, black element ginseng 80g, Flos Carthami 120g, river cattle sunset 100g, angelica 100g, Rhizoma Chuanxiong 120g, Bulbus Fritillariae Thunbergii 130g, Moschus 80g, borneol 100g.
Embodiment 4
Prepare plaster with method similar to Example 1, difference is, raw materials used medicine weight is as follows:
radix Notoginseng 100g, Sanguis Draxonis 50g, Gypsum Fibrosum 20g, Radix Glycyrrhizae 120g, Myrrha 70g, black element ginseng 50g, Flos Carthami 50g, river cattle sunset 60g, angelica 60g, Rhizoma Chuanxiong 50g, Bulbus Fritillariae Thunbergii 60g, Moschus 40g, borneol 50g.
Embodiment 5
Prepare plaster with method similar to Example 1, difference is, raw materials used medicine weight is as follows:
radix Notoginseng 100g, Sanguis Draxonis 150g, Gypsum Fibrosum 50g, Radix Glycyrrhizae 160g, Myrrha 90g, black element ginseng 80g, Flos Carthami 150g, river cattle sunset 120g, angelica 120g, Rhizoma Chuanxiong 150g, Bulbus Fritillariae Thunbergii 140g, Moschus 80g, borneol 150g.
test example
Treatment gynaecopathia: totally 109 routine female patients, wherein 55 examples show as irregular menstruation, abdominal pain in menstruation, and 54 examples show as leucorrhea with red and white discharge, cold uterus.
Therapeutic Method: the plaster in embodiment of applying ointment or plaster continuously 1, in umbilical part, is changed once for every three days.
Therapeutic outcome: apply ointment or plaster continuously more than 30 days, patients symptomatic all has obvious alleviation, wherein, 55 examples show as irregular menstruation, abdominal pain in menstruation patient after treatment, suffer from abdominal pain in menstrual period and obviously alleviate, 38 examples are not almost suffered from abdominal pain sensation, and menstrual period rule, normochromic; 54 examples show as leucorrhea with red and white discharge, cold uterus patient after treatment, leucorrhea with red and white discharge symptom obviously alleviates, and leucorrhea color is normal, does not have specific peculiar smell.
Treatment wound: totally 77 routine patients, wherein traumatic injury 59 example, knife injury 18 example.
Therapeutic Method: the plaster in embodiment of applying ointment or plaster continuously 1, in injury, is changed once for every three days.
Therapeutic outcome: apply ointment or plaster continuously more than 3 days, traumatic injury patient pain feels and obviously alleviating, and apply ointment or plaster continuously more than 7 days, traumatic injury patient no longer experiences pain.
Apply ointment or plaster continuously more than 1 day, knife injury patient wound pain almost disappears, and the plaster in embodiment of applying ointment or plaster continuously 1 more than 3 days, knife injury patient wound heal substantially.
Treatment surgical diseases: totally 137 routine hemorrhoid patients, wherein hemorrhoid patients 103 example, wherein internal hemorrhoid 46 example, external hemorrhoid 34 example, mixed hemorrhoid 23 example, anal fissure patient 17 example, perianal hemorroids patient 13 example, proctoptosis patient 4 example.In patient, max age 65 years old, minimal ages 28 years old, the course of disease is the shortest 10 months, and the course of disease is the longest 26 years, male 108 example, women 29 example.
Diagnostic criteria: State Administration of Traditional Chinese Medicine, disease of tcm Standardization of diagnosis and curative effect, [M] Nanjing: publishing house of Nanjing University, 1994,132
Therapeutic Method: the plaster in embodiment of applying ointment or plaster 1 is in affected part, and every block plaster can be applied ointment or plaster 72 hours continuously.Treatments period is avoided pungent.
Treatment standard: " traditional Chinese medical science anorectum department Illnesses Diagnoses criterion of therapeutical effect " of promulgating with reference to State Administration of Traditional Chinese Medicine
Cure: without symptoms such as having blood in stool, deviate from, blood stasis disappears or atrophy completely
Effective: without having blood in stool, the symptom such as to deviate from, blood stasis reduce or atrophy to original 1/3
Effective: to have and have blood in stool on a small quantity or even to have blood in stool, slightly deviate from blood stasis, core reduce or atrophy to original 2/3
Invalid: disease and sign are without improvement or aggravation
Therapeutic outcome:
Plaster in embodiment of applying ointment or plaster continuously 1 more than 3 days, all patient pain feel and obviously alleviating, and have blood in stool and significantly reduce, reach significant degree;
Plaster in embodiment of applying ointment or plaster continuously 1 more than 7 days, 134 routine patients are almost without having blood in stool, and blood stasis obviously reduces or atrophy, reach effective degree;
Plaster in embodiment of applying ointment or plaster continuously 1 more than 14 days, 132 routine patients do not have blood in stool, and affected part is shunk completely, reach healing degree.
Claims (8)
1. an external medicine composition, it is made up of the crude drug of following weight proportion:
Radix Notoginseng 10 parts, Sanguis Draxonis 5-15 part, Gypsum Fibrosum 2-5 part, Radix Glycyrrhizae 12-16 part, Myrrha 7-9 part, black element ginseng 5-8 part, Flos Carthami 5-15 part, river cattle sunset 6-12 part, angelica 6-12 part, Rhizoma Chuanxiong 5-15 part, Bulbus Fritillariae Thunbergii 6-14 part, Moschus 4-8 part, borneol 5-15 part
This Chinese medicine composition is made by the following method:
(1) take the crude drug of above-mentioned weight proportion, and wear into fine powder respectively;
(2) take 500-600 weight portion Oleum sesami and put into heating container, during temperature with 300-330 at a simmer DEG C, under agitation add adjuvant Plumbum preparatium 40-60 part, continue to stir after 10-30 minute and add Colophonium 40-60 part, add Aerugo 40-50 part after stirring 10-30 minute again, then add Hydrocerussitum (Ceruse) 30-40 part after stirring 10-30 minute, Keep agitation is until form plaster mother, form plaster imperial mother and remove fire, Temperature fall;
(3) when the female temperature of plaster is reduced to the temperature of 70-90 DEG C, each crude drug powder of above-mentioned (1) is added, stirs, be cooled to room temperature.
2. external medicine composition as claimed in claim 1, it is made up of the crude drug of following weight proportion:
Radix Notoginseng 10 parts, Sanguis Draxonis 8-12 part, Gypsum Fibrosum 3-4 part, Radix Glycyrrhizae 12-14 part, Myrrha 7-9 part, black element ginseng 6-8 part, Flos Carthami 8-12 part, river cattle sunset 8-10 part, angelica 8-10 part, Rhizoma Chuanxiong 8-12 part, Bulbus Fritillariae Thunbergii 9-13 part, Moschus 6-8 part, borneol 8-10 part.
3. external medicine composition as claimed in claim 1, it is made up of the crude drug of following weight proportion:
Radix Notoginseng 10 parts, Sanguis Draxonis 10 parts, Gypsum Fibrosum 4 parts, 12 parts, Radix Glycyrrhizae, Myrrha 8 parts, black element ginseng 8 parts, Flos Carthami 11 parts, river cattle sunset 10 parts, angelica 10 parts, Rhizoma Chuanxiong 10 parts, Bulbus Fritillariae Thunbergii 11 parts, 8 parts, Moschus, borneol 8 parts.
4. prepare the method for external medicine composition according to any one of claim 1-3, the method comprises:
(1) take the crude drug of above-mentioned weight proportion, and wear into fine powder respectively;
(2) take 500-600 weight portion Oleum sesami and put into heating container, during temperature with 300-330 at a simmer DEG C, under agitation add adjuvant Plumbum preparatium 40-60 part, continue to stir after 10-30 minute and add Colophonium 40-60 part, add Aerugo 40-50 part after stirring 10-30 minute again, then add Hydrocerussitum (Ceruse) 30-40 part after stirring 10-30 minute, Keep agitation is until form plaster mother, form plaster imperial mother and remove fire, Temperature fall;
(3) when the female temperature of plaster is reduced to the temperature of 70-90 DEG C, each crude drug powder obtained is added, stirs, be cooled to room temperature, form plaster in above-mentioned (1).
5. method according to claim 4, the method also comprises:
(4) get plaster agglomerate and be placed in container, water-bath or slow fire are melted, get appropriate plaster and adhere on kraft paper or plaster cloth.
6. external medicine composition according to any one of claim 1-3 for the preparation for the treatment of gynopathic medicine in purposes, described gynaecopathia is irregular menstruation, abdominal pain in menstruation, leucorrhea with red and white discharge and cold uterus.
7. the purposes of external medicine composition according to any one of claim 1-3 in the medicine for the preparation for the treatment of wound, described wound is that traumatic injury and knife injury are bled.
8. the purposes of external medicine composition according to any one of claim 1-3 in the medicine for the preparation for the treatment of surgical diseases, described surgical diseases is hemorrhoid, anal fistula and proctoptosis.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101077403A (en) * | 2007-05-05 | 2007-11-28 | 赵启坤 | Plaster for treating retention of food and dysmenorrhea |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101077403A (en) * | 2007-05-05 | 2007-11-28 | 赵启坤 | Plaster for treating retention of food and dysmenorrhea |
Non-Patent Citations (1)
| Title |
|---|
| 王婷婷,等.《痛经中医辨证治疗》.《辽宁中医药大学学报》.2013,第15卷(第7期),104-107. * |
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