CN113136325A - Inactivation device suitable for viral inactivated vaccine - Google Patents

Inactivation device suitable for viral inactivated vaccine Download PDF

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Publication number
CN113136325A
CN113136325A CN202110487987.4A CN202110487987A CN113136325A CN 113136325 A CN113136325 A CN 113136325A CN 202110487987 A CN202110487987 A CN 202110487987A CN 113136325 A CN113136325 A CN 113136325A
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fixedly connected
frame
gear
test tube
working box
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CN202110487987.4A
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Inventor
赵更凡
吴金凤
王春波
刘卫
晏士杰
徐丽萍
白建秋
王焕焕
韩彦弢
王文成
管境
杨峰
陈雪红
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Shandong Hengye Biotechnology Co ltd
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Shandong Hengye Biotechnology Co ltd
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Priority to CN202110487987.4A priority Critical patent/CN113136325A/en
Publication of CN113136325A publication Critical patent/CN113136325A/en
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    • C12M23/48—Holding appliances; Racks; Supports
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    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/14—Pressurized fluid
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12M37/00—Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination
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    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
    • C12M41/18—Heat exchange systems, e.g. heat jackets or outer envelopes
    • C12M41/22—Heat exchange systems, e.g. heat jackets or outer envelopes in contact with the bioreactor walls
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    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/44—Means for regulation, monitoring, measurement or control, e.g. flow regulation of volume or liquid level
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    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/16—Sterilization

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Abstract

The invention relates to the technical field of vaccine production inactivation, and particularly discloses an inactivation device suitable for viral inactivated vaccines, which comprises a base, a working box, two connecting frames and a top cover, wherein the bottom of the inner wall of the working box is fixedly connected with a heating rod, the bottom of the inner wall of the working box is fixedly connected with a protection frame, the protection frame is sleeved on the surface of the heating rod, the inner part of the connecting frame is slidably connected with a push rod penetrating through the top of the connecting frame, the surface of the connecting frame is fixedly connected with a connecting pipe, the left side and the right side of the top cover top are rotatably connected with first gears, the center of the top cover top is rotatably connected with a second gear, the left side and the right side of the top cover bottom are rotatably connected with rotating rods, the positions of the top cover bottom and the positions close to the left side and the right side are fixedly connected with positioning frames, and test tubes are movably inserted in the positioning frames; the invention can avoid the incomplete condition of chemical reagents for inactivation and is convenient for taking out the inactivated product from the device.

Description

Inactivation device suitable for viral inactivated vaccine
Technical Field
The invention relates to the technical field of vaccine production inactivation, in particular to an inactivation device suitable for virus inactivated vaccines.
Background
The vaccine is an automatic immune preparation for preventing infectious diseases, which is prepared by artificially attenuating, inactivating or utilizing transgenosis and the like pathogenic microorganisms and metabolites thereof, is a common biological product for preventing vaccination, and can be mainly divided into a live vaccine and a dead vaccine.
The inactivated vaccine is a dead vaccine, the inactivated vaccine adopts a non-replicative antigen, so the safety is good, but the immunogenicity is weakened, usually immunity enhancement is needed, when the inactivated vaccine is produced, the virus needs to be inactivated to ensure that the virus loses the activity of infection pathogenicity, a common inactivation method is chemical inactivation, after chemical inactivation, chemical reagents used for inactivation need to be fully hydrolyzed to avoid the influence of the chemical reagents on the inactivated virus antigen, but the existing inactivation device is easy to be heated unevenly, so that the hydrolysis of the chemical reagents used for inactivation is incomplete, the production of the vaccine is seriously influenced, and the existing inactivation device is of a closed structure, and the inactivated product is not convenient to take out of the device.
Disclosure of Invention
Aiming at the defects of the prior art, the invention provides the inactivation device suitable for the virus inactivated vaccine, which has the advantages of avoiding the condition of uneven heating, facilitating the taking out of the inactivated product and the like, and solves the problems that the chemical reagent for inactivation is not thoroughly hydrolyzed and the inactivated product is inconvenient to take out of the device.
The invention relates to an inactivation device suitable for viral inactivated vaccines, which comprises a base, a working box, two connecting frames and a top cover, wherein the bottom of the inner wall of the working box is fixedly connected with a heating rod, the bottom of the inner wall of the working box is fixedly connected with a protective frame which is sleeved on the surface of the heating rod, the two connecting frames are respectively and fixedly connected with the left side and the right side of the working box, the inner part of each connecting frame is slidably connected with a push rod penetrating through the top of the corresponding connecting frame, the surface of each connecting frame is fixedly connected with a connecting pipe, the top cover is movably inserted at the top of the working box, the left side and the right side of the top cover are respectively and rotatably connected with a first gear, the center of the top cover is rotatably connected with a second gear, the left side and the right side of the bottom of the top cover are respectively and rotatably connected with a rotating rod, and the positions of the bottom of the top cover, which are close to the left side and the right side, are respectively and fixedly connected with a positioning frame, the inside activity grafting of locating frame has the test tube.
Through the design of the technical scheme, the virus can be fully heated in the test tube, the test tube can be connected with the top cover through the positioning frame, and when the test tube is required to be taken out from the device, the top cover is only required to be taken down from the top of the working box.
As a further improvement of the invention, the right side of the base is fixedly connected with a power line, the power line is electrically connected with the heating rod, the surface of the protection frame is provided with a plurality of leakage holes, and the leakage holes penetrate through the inner wall of the protection frame and are communicated with the inside of the protection frame.
Through the design of the technical scheme, the heating rod can be protected by the protection frame, and the heating effect of the heating rod can be improved through the leakage hole.
As a further improvement of the invention, the shape and the size of the bottom of the push rod are matched with the shape and the size of the inside of the connecting frame, water used as a heating medium is stored in the connecting frame, the right side of the connecting pipe penetrates through the surface of the working box and is communicated with the inside of the working box, and the connecting frame is communicated with the inside of the working box through the connecting pipe.
Through the design of the technical scheme, the push rod can be utilized to push the water stored in the connecting frame into the working box through the connecting pipe, so that the water stored in the connecting frame can be used as a heating medium.
As a further improvement of the invention, the first gear and the second gear are meshed with each other, and the top of the rotating rod penetrates through the bottom of the top cover and is fixedly connected with the bottom of the first gear.
Through the design of the technical scheme, the second gear can drive the first gear to rotate, and the first gear is utilized to drive the rotating rod to rotate.
As a further improvement of the invention, a fixed frame is fixedly connected to the top of the top cover, the first gear and the second gear are both rotatably connected to the inside of the fixed frame, a working motor is fixedly connected to the center of the top of the fixed frame, and the bottom of an output shaft of the working motor penetrates through the bottom of the fixed frame and is fixedly connected with the top of the second gear.
Through the design of the technical scheme, the second gear can be driven to rotate by the installed working motor.
As a further improvement of the invention, a stirring blade for stirring is fixedly connected to the surface of the rotating rod and the position close to the bottom, a sealing block is fixedly connected to the surface of the rotating rod and the position close to the top, the bottom surface of the sealing block is a smooth plane, the rotating rod is movably inserted into the test tube, and the bottom of the sealing block is attached to the top of the test tube.
Through the design of the technical scheme, the position of the rotary rod and the test tube is limited, so that the rotary rod can rotate in the test tube, the top of the test tube is sealed by the sealing block, and water serving as a heating medium is prevented from entering the test tube.
As a further improvement of the invention, the front surface of the positioning frame is connected with a fixing bolt through threads, and the back surface of the fixing bolt penetrates through the back surface of the positioning frame and is attached to the surface of the test tube.
Through the design of the technical scheme, the test tube in the positioning frame can be fixed under the action of the fixing bolt.
As a further improvement of the invention, a liquid level indicator is fixedly connected to the position close to the left side of the front face of the working box, a thermometer is mounted in the center of the front face of the working box, and the back face of the input end of the thermometer penetrates through the surface of the working box and is positioned inside the working box.
Through the design of the technical scheme, the water level indicator can play the roles of reminding and indicating the amount of water in the working box under the action of the liquid level indicator, and meanwhile, the thermometer is used for monitoring the temperature in the working box in real time.
Compared with the prior art, the invention has the following beneficial effects:
1. in the using process, the water stored in the connecting frame can be pushed into the working box through the push rod, the test tube fixed in the positioning frame is wrapped by the water, the water is heated by the heating rod to be uniformly heated, so that the test tube is heated by the water, the condition that the test tube is not uniformly heated is prevented, a proper reaction hydrolysis temperature is provided for the added beta-propiolactone, the beta-propiolactone can be rapidly hydrolyzed, inactivation is stopped, and the influence on inactivated strains is avoided.
2. According to the invention, through the arrangement of the first gear, the second gear and the working motor, and the matching of the positioning frame, the rotating rod and the sealing block, in the process of heating a test tube by using water in the heating rod and the connecting frame, the rotating rod can be driven by the working motor and can rotate in the test tube under the meshing action of the first gear and the second gear, so that viruses in the test tube can be stirred, the viruses can be fully heated in the test tube, meanwhile, the test tube can be connected with the top cover through the positioning frame under the action of the top cover, the positioning frame and the positioning frame provided with additional fixing bolts, and when the test tube needs to be taken out of the device, the top cover only needs to be taken out of the top of the working box.
Drawings
The accompanying drawings, which are included to provide a further understanding of the application and are incorporated in and constitute a part of this application, illustrate embodiment(s) of the application and together with the description serve to explain the application and not to limit the application. In the drawings:
FIG. 1 is a schematic cross-sectional front view of the present invention;
FIG. 2 is a schematic front view of the present invention;
FIG. 3 is a front view of the protection frame of the present invention;
FIG. 4 is a front view of the top cover and the positioning frame of the present invention;
FIG. 5 is a schematic bottom view of the positioning frame of the present invention.
In the figure: 1. a base; 11. a power line; 2. a work box; 21. a heating rod; 3. a protective frame; 31. a leak hole; 4. a connecting frame; 41. a push rod; 42. a connecting pipe; 5. a top cover; 51. a first gear; 52. a second gear; 6. a fixing frame; 61. a working motor; 7. a rotating rod; 71. a sealing block; 8. a positioning frame; 81. a test tube; 82. fixing the bolt; 9. a liquid level indicator; 91. a thermometer.
Detailed Description
In the following description, for purposes of explanation, numerous implementation details are set forth in order to provide a thorough understanding of the various embodiments of the present invention. It should be understood, however, that these implementation details are not to be interpreted as limiting the invention. That is, in some embodiments of the invention, such implementation details are not necessary. In addition, some conventional structures and components are shown in simplified schematic form in the drawings.
In addition, the descriptions related to the first, the second, etc. in the present invention are only used for description purposes, do not particularly refer to an order or sequence, and do not limit the present invention, but only distinguish components or operations described in the same technical terms, and are not understood to indicate or imply relative importance or implicitly indicate the number of indicated technical features. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one such feature. In addition, technical solutions between various embodiments may be combined with each other, but must be realized by a person skilled in the art, and when the technical solutions are contradictory or cannot be realized, such a combination should not be considered to exist, and is not within the protection scope of the present invention.
Referring to fig. 1 and 3, the inactivation device for viral inactivated vaccines of the invention comprises a base 1, a work box 2, two connection frames 4 and a top cover 5, wherein the bottom of the inner wall of the work box 2 is fixedly connected with a heating rod 21, the bottom of the inner wall of the work box 2 is fixedly connected with a protection frame 3, the protection frame 3 is sleeved on the surface of the heating rod 21, the two connection frames 4 are respectively and fixedly connected with the left side and the right side of the work box 2, the inside of the connection frame 4 is slidably connected with a push rod 41 penetrating the top of the connection frame 4, the surface of the connection frame 4 is fixedly connected with a connection pipe 42, the top cover 5 is movably inserted on the top of the work box 2, the left side and the right side of the top cover 5 are both rotatably connected with a first gear 51, the center of the top cover 5 is rotatably connected with a second gear 52, the left side and the right side of the bottom of the top cover 5 are both rotatably connected with a rotating rod 7, the bottom of the top cover 5 and the positions close to the left side and the right side are both fixedly connected with a positioning frame 8, the inside activity grafting of locating frame 8 has test tube 81, make the virus fully heated in the inside of test tube 81, make test tube 81 can be connected with top cap 5 through locating frame 8 at the same time, when needing to take test tube 81 out of the device, only need to take off top cap 5 from the top of work box 2, the right side of base 1 is fixedly connected with power cord 11, the electrical connection between power cord 11 and heating rod 21, the surface of protective frame 3 is equipped with a plurality of weep holes 31, weep hole 31 runs through the inner wall of protective frame 3 and is linked together with the inside of protective frame 3, when utilizing protective frame 3 to protect heating rod 21, can pass through weep hole 31, the heating effect of heating rod 21 has been improved, the shape size of the bottom of push rod 41 agrees with the shape size of the inside of connecting frame 4, the inside of connecting frame 4 is stored and is used for the water as heating medium, the right side of connecting pipe 42 runs through the surface of work box 2 and is linked together with the inside of work box 2, the connecting frame 4 is communicated with the inside of the working box 2 through the connecting pipe 42, water stored in the connecting frame 4 can be pushed in by the push rod 41 and enters the inside of the working box 2 through the connecting pipe 42, so that the water stored in the connecting frame 4 can be used as a heating medium, the first gear 51 and the second gear 52 are meshed with each other, the top of the rotating rod 7 penetrates through the bottom of the top cover 5 and is fixedly connected with the bottom of the first gear 51, the second gear 52 rotates to drive the first gear to rotate, the rotating rod 7 is driven to rotate by the first gear 51, a stirring blade for stirring is fixedly connected to the surface of the rotating rod 7 at a position close to the bottom, a sealing block 71 is fixedly connected to the surface of the rotating rod 7 at a position close to the top, the bottom surface of the sealing block 71 is a smooth plane, the rotating rod 7 is movably inserted into the inside of the test tube 81, and the bottom of the sealing block 71 is attached to the top of the test tube 81, the positions of the rotary rod 7 and the test tube 81 are defined so that the rotary rod 7 can rotate inside the test tube 81 while the top of the test tube 81 is sealed by the sealing block 71, thereby preventing water as a heating medium from entering the inside of the test tube 81.
Referring to fig. 2, a liquid level indicator 9 is fixedly connected to a position on the front side of the work box 2 and close to the left side of the work box 2, a thermometer 91 is installed in the center of the front side of the work box 2, the back of an input end of the thermometer 91 penetrates through the surface of the work box 2 and is located inside the work box 2, the effect of reminding and indicating the amount of water in the work box 2 can be achieved under the effect of the liquid level indicator 9, and meanwhile the thermometer 91 is used for monitoring the temperature in the work box 2 in real time.
Referring to fig. 4, a fixed frame 6 is fixedly connected to the top of the top cover 5, the first gear 51 and the second gear 52 are both rotatably connected to the inside of the fixed frame 6, a working motor 61 is fixedly connected to the center of the top of the fixed frame 6, and the bottom of the output shaft of the working motor 61 penetrates through the bottom of the fixed frame 6 and is fixedly connected to the top of the second gear 52, so that the second gear 52 can be driven to rotate by the mounted working motor 61.
Referring to fig. 5, the front surface of the positioning frame 8 is connected with a fixing bolt 82 through a thread, and the back surface of the fixing bolt 82 penetrates through the back surface of the positioning frame 8 and is attached to the surface of the test tube 81, so that the test tube 81 in the positioning frame 8 can be fixed under the action of the fixing bolt 82.
In the use of the invention: the power cord 11 that sets up on the device is connected with external power at first, will be equipped with the test tube 81 of concentrated virus liquid again and add concentration and be 1: placing beta-propiolactone of 4000 at 2-8 ℃ for 24 hours, chemically inactivating virus strains by using the beta-propiolactone, then inserting the test tube 81 into the positioning frame 8 from the bottom of the positioning frame 8, inserting the rotating rod 7 into the test tube 81 at the moment, attaching the top of the test tube 81 to the bottom of the sealing block 71, then inserting the top cover 5 at the top of the working box 2, enabling the test tube 81 to be positioned in the working box 2, then pushing the push rod 41, pushing the water stored in the connecting frame 4 into the working box 2 through the push rod 41, wrapping the test tube 81 fixed in the positioning frame 8 by using the water, heating the water through the heating rod 21, enabling the water to be uniformly heated, controlling the water temperature to be stable at 37 ℃ through the thermometer 91, heating the test tube 81 by using the water, hydrolyzing the beta-propiolactone within 2 hours at the reaction temperature of 37 ℃, and providing a stable temperature environment for hydrolyzing the beta-propiolactone, guaranteed that beta-propiolactone can fully hydrolyze, at the in-process that the device utilized the water in heating rod 21 and the connection frame 4 to heat test tube 81 simultaneously, can utilize under the drive of work motor 61, and under the meshing effect of first gear 51 and second gear 52, make bull stick 7 rotate in test tube 81's inside, play the effect of stirring to the virus in the test tube 81, make the virus fully heated in test tube 81's inside, after the inactivation operation is accomplished, when needs take out test tube 81 from the device, only need with top cap 5 from work box 2 top take off can, simultaneously the water in work box 2 can be through the pulling pull rod, with the inside of water follow work box 2 income connection frame 4 once more through connecting pipe 42, so that continue to use next time.
The above description is only an embodiment of the present invention, and is not intended to limit the present invention. Various modifications and alterations to this invention will become apparent to those skilled in the art. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention should be included in the scope of the claims of the present invention.

Claims (8)

1. The utility model provides an inactivation device that is fit for viral inactivated vaccine, includes base (1), work box (2), two connection frame (4) and top cap (5), its characterized in that: the bottom of the inner wall of the working box (2) is fixedly connected with a heating rod (21), the bottom of the inner wall of the working box (2) is fixedly connected with a protection frame (3), and the protection frame (3) is sleeved on the surface of the heating rod (21);
the two connecting frames (4) are respectively and fixedly connected to the left side and the right side of the working box (2), a push rod (41) penetrating through the tops of the connecting frames (4) is connected inside the connecting frames (4) in a sliding mode, and connecting pipes (42) are fixedly connected to the surfaces of the connecting frames (4);
top cap (5) activity is pegged graft in the top of work box (2), the left and right sides at top cap (5) top all rotates and is connected with first gear (51), the central authorities at top cap (5) top rotate and are connected with second gear (52), the left and right sides of top cap (5) bottom all rotates and is connected with bull stick (7), top cap (5) bottom just is close to the equal fixedly connected with locating frame (8) of position department of the left and right sides, the inside activity of locating frame (8) is pegged graft and is had test tube (81).
2. A viral inactivation vaccine adapted as claimed in claim 1 wherein: the right side fixedly connected with power cord (11) of base (1), electric connection between power cord (11) and heating rod (21), a plurality of small openings (31) have been seted up on the surface of bearer bar (3), small opening (31) run through the inner wall of bearer bar (3) and are linked together with the inside of bearer bar (3).
3. A viral inactivation vaccine adapted as claimed in claim 1 wherein: the shape and the size of the bottom of the push rod (41) are matched with the shape and the size of the inside of the connecting frame (4), water used as a heating medium is stored in the connecting frame (4), the right side of the connecting pipe (42) penetrates through the surface of the working box (2) and is communicated with the inside of the working box (2), and the connecting frame (4) is communicated with the inside of the working box (2) through the connecting pipe (42).
4. A viral inactivation vaccine adapted as claimed in claim 1 wherein: the first gear (51) and the second gear (52) are meshed with each other, and the top of the rotating rod (7) penetrates through the bottom of the top cover (5) and is fixedly connected with the bottom of the first gear (51).
5. A viral inactivation vaccine adapted as claimed in claim 1 wherein: the fixed frame (6) of top fixedly connected with of top cap (5), first gear (51) and second gear (52) all rotate to be connected in the inside of fixed frame (6), the central fixedly connected with work motor (61) at fixed frame (6) top, the bottom of work motor (61) output shaft run through the bottom of fixed frame (6) and with the top looks fixed connection of second gear (52).
6. A viral inactivation vaccine adapted as claimed in claim 1 wherein: the stirring leaf that the position department fixedly connected with that bull stick (7) surface just is close to the bottom is used for the stirring, the position department fixedly connected with that the bull stick (7) surface just is close to the top seals piece (71) and the bottom surface of sealed piece (71) is smooth plane, bull stick (7) activity is pegged graft and is laminated each other in the inside of test tube (81) and the bottom of sealed piece (71) and the top of test tube (81).
7. A viral inactivation vaccine adapted as claimed in claim 1 wherein: the front of locating frame (8) has fixing bolt (82) through threaded connection, the back of fixing bolt (82) runs through the back of locating frame (8) and laminates mutually with the surface of test tube (81).
8. A viral inactivation vaccine adapted as claimed in claim 1 wherein: the utility model discloses a temperature measuring device, including work box (2), work box (2) just is close to left position department fixedly connected with liquid level indicator (9) openly, the positive central authorities of work box (2) install thermometer (91) and the back of thermometer (91) input run through the surface of work box (2) and lie in the inside of work box (2).
CN202110487987.4A 2021-04-30 2021-04-30 Inactivation device suitable for viral inactivated vaccine Pending CN113136325A (en)

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Application publication date: 20210720