CN214781828U - Integrated device for rapidly detecting pathogenic microorganisms - Google Patents
Integrated device for rapidly detecting pathogenic microorganisms Download PDFInfo
- Publication number
- CN214781828U CN214781828U CN202120024957.5U CN202120024957U CN214781828U CN 214781828 U CN214781828 U CN 214781828U CN 202120024957 U CN202120024957 U CN 202120024957U CN 214781828 U CN214781828 U CN 214781828U
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- cavity
- amplification reaction
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- buffer solution
- solution storage
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- 238000012360 testing method Methods 0.000 claims abstract description 62
- 238000001514 detection method Methods 0.000 claims abstract description 60
- 238000006243 chemical reaction Methods 0.000 claims abstract description 48
- 238000007789 sealing Methods 0.000 claims abstract description 45
- 230000003321 amplification Effects 0.000 claims abstract description 40
- 238000003199 nucleic acid amplification method Methods 0.000 claims abstract description 40
- 239000007853 buffer solution Substances 0.000 claims abstract description 34
- 239000000443 aerosol Substances 0.000 claims abstract description 5
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims abstract description 4
- 238000011901 isothermal amplification Methods 0.000 claims description 11
- 230000000149 penetrating effect Effects 0.000 claims description 6
- 239000000243 solution Substances 0.000 claims description 6
- 239000000047 product Substances 0.000 claims description 3
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- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
The utility model relates to an integrated device for rapidly detecting pathogenic microorganisms, which belongs to the field of clinical microorganism detection. The device includes box body and lid, is provided with constant temperature amplification reaction chamber, buffer solution storage chamber in the box body and is used for the test paper strip detection chamber of splendid attire colloidal gold test paper, and box body upper portion is provided with two draw-in grooves and places the sealing washer for sealed reaction chamber. In addition, sealing films are arranged between the test strip detection cavity and the buffer solution storage cavity and between the test strip detection cavity and the constant-temperature amplification reaction cavity; the box cover is detachably connected to one end, provided with an opening, of the box cover, two puncture needles for puncturing the sealing film are arranged on one side, close to the opening, of the box cover, and the two puncture needles correspond to the buffer solution storage cavity and the constant-temperature amplification reaction cavity respectively. The utility model discloses simple structure detects swiftly, low in production cost, and no aerosol pollutes, is suitable for large-scale production and application.
Description
Technical Field
The utility model belongs to clinical microbiological examination field relates to an integrated device for rapidly detecting pathogenic microorganism.
Background
Microorganisms that are pathogenic to humans and animals are called pathogenic microorganisms, and mainly include viruses, bacteria, fungi, rickettsia, mycoplasma, chlamydia, spirochetes, actinomycetes, prions, and the like. These pathogenic microorganisms can cause diseases such as infection, allergy, tumor, dementia and the like, and are also one of the main factors harming food safety. In recent decades, new and virulent infectious diseases such as tuberculosis, plague bacillus, anthrax, cholera, SARS coronavirus, Ebola virus, highly pathogenic avian influenza H7N9, SARS-CoV-2 coronavirus and the like have appeared in succession, which seriously affect human health. The new and virulent infectious diseases have the characteristics of strong infectivity, high transmission speed, wide transmission range and the like, and are easy to cause epidemic outbreaks and pandemics in the world. Therefore, detection of pathogens must be rapid, accurate and aerosol-free. The traditional real-time fluorescent quantitative detection method has the disadvantages of complex operation, long detection period, higher requirement on the technical level of operators, need of integrating huge, expensive and precise optical equipment, and is not beneficial to the miniaturization development and the on-site rapid detection of the device. The requirements of the emerging non-optical detection methods such as an electrochemical method, an HNB colorimetric method and a turbidimetric method on the device are greatly simplified, but the methods still have the problems of cover opening operation, aerosol pollution, low detection sensitivity, difficult interpretation of results and the like. Therefore, it is more and more important to develop a closed, miniaturized, and portable nucleic acid detection device, and combine it with the existing isothermal amplification detection method.
The isothermal amplification colloidal gold test strip method has attracted much attention due to its detection specificity, high sensitivity, simplicity and convenience. However, the current commercialized test paper strip detection device is complex in design and not beneficial to reducing the cost. Therefore, there is a need for developing a isothermal amplification integrated detection device that is simple in operation, low in cost, simple in design, and free of aerosol contamination.
SUMMERY OF THE UTILITY MODEL
In view of this, the present invention provides an integrated device for rapidly detecting pathogenic microorganisms, which can accelerate the process of identifying pathogenic microorganisms and increase the detection rate.
In order to achieve the above purpose, the utility model provides a following technical scheme: the integrated device for rapidly detecting the pathogenic microorganisms comprises a box body and a box cover, wherein a constant-temperature amplification reaction cavity, a buffer solution storage cavity and a test strip detection cavity for containing detection test paper are arranged in the box body, and the test strip detection cavity is respectively communicated with the buffer solution storage cavity and the constant-temperature amplification reaction cavity; sealing films are respectively arranged between the test strip detection cavity and the buffer solution storage cavity and between the test strip detection cavity and the constant-temperature amplification reaction cavity, and the test strip detection cavity is respectively sealed and isolated from the buffer solution storage cavity and the constant-temperature amplification reaction cavity through the sealing films; openings are respectively arranged on the mutually close sides of the buffer solution storage cavity and the constant-temperature amplification reaction cavity in a penetrating way, the openings are far away from the sealing film, and a test paper inlet for detecting the inlet and outlet of test paper is arranged on the side of the test paper strip detection cavity close to the box cover in a penetrating way; the box cover is detachably connected to one end of the box body, which is provided with the opening, and a puncture needle for puncturing the sealing film is arranged on one side of the box cover, which is close to the opening; the number of the puncture needles is two, and the two puncture needles are respectively arranged corresponding to the buffer solution storage cavity and the constant-temperature amplification reaction cavity.
Optionally, the test strip detection cavity, the buffer storage cavity and the isothermal amplification reaction cavity are arranged in parallel.
Optionally, the box cover is connected with the box body in a sealing manner, and the opening of the buffer solution storage cavity, the opening of the constant-temperature amplification reaction cavity and the test paper opening are all located in the sealing range of the box cover.
Optionally, the box body with be provided with the sealing washer on the outside of lid complex one end, the inboard of lid corresponds be provided with the draw-in groove on the position of sealing washer, the box body reaches the lid passes through the draw-in groove with the sealing washer can realize sealing, can not lead to the aerosol pollution of surrounding environment.
Optionally, the number of the clamping grooves and the number of the sealing rings are two, and the two clamping grooves and the two sealing rings are sequentially arranged along the puncture direction of the puncture needle.
Optionally, the cartridge is transparent.
Optionally, an observation window is arranged at a position of the box body corresponding to the test strip detection cavity, and the wall thickness of the box body at the observation window is smaller than the wall thickness of the rest positions on the box body.
Optionally, the volumes of the buffer storage chamber and the isothermal amplification reaction chamber satisfy the volume of the isothermal amplification reaction.
Optionally, the test strip detection cavity is filled with a colloidal gold test strip for detecting a constant-temperature amplification reaction product, the constant-temperature amplification reaction cavity is filled with a constant-temperature amplification reaction solution, the buffer solution storage cavity is filled with a buffer solution for diluting an amplification product, and the rapid detection of pathogenic microorganisms can be realized by the integrated device only by adding nucleic acid of the detected pathogenic microorganisms into the reaction cavity.
The beneficial effects of the utility model reside in that: a buffer solution storage cavity and a constant temperature amplification reaction cavity are arranged in the box body and respectively contain buffer solution and reaction liquid. The buffer solution storage cavity and the constant-temperature amplification reaction cavity are respectively communicated with the test strip detection cavity, and sealing films are respectively arranged between the test strip detection cavity and the buffer solution storage cavity and between the test strip detection cavity and the constant-temperature amplification reaction cavity. The box cover is provided with two puncture needles, after the box cover is buckled on the box body, the two puncture needles respectively puncture the sealing film, the buffer solution and the reaction solution are mixed after entering the test strip detection cavity and are contacted with the test paper, and the quality control line and the detection line of the test paper change color to be positive. The box body is transparent to be provided with the observation window, can directly read test paper through the box body, convenient and fast. The utility model discloses simple structure detects swiftly, and low in production cost is suitable for large-scale production and application.
Additional advantages, objects, and features of the invention will be set forth in part in the description which follows and in part will become apparent to those having ordinary skill in the art upon examination of the following or may be learned from practice of the invention. The objectives and other advantages of the invention may be realized and attained by the means of the instrumentalities and/or combinations particularly pointed out in the appended claims.
Drawings
For the purposes of promoting a better understanding of the objects, features and advantages of the invention, reference will now be made to the following detailed description taken in conjunction with the accompanying drawings in which:
FIG. 1 is a schematic view of the puncture state of the integrated device;
FIG. 2 is a schematic structural diagram of a cartridge;
fig. 3 is a schematic structural view of the box cover.
Reference numerals: the kit comprises a kit cover 1, a kit body 2, a constant-temperature amplification reaction cavity 3, a buffer solution storage cavity 4, a puncture needle 5, a test strip detection cavity 6, a sealing film 7, a sealing ring 8, a clamping groove 9 and an observation window 10.
Detailed Description
The following description of the embodiments of the present invention is provided for illustrative purposes, and other advantages and effects of the present invention will be readily apparent to those skilled in the art from the disclosure herein. The present invention can also be implemented or applied through other different specific embodiments, and various details in the present specification can be modified or changed based on different viewpoints and applications without departing from the spirit of the present invention. It should be noted that the drawings provided in the following embodiments are only for illustrating the basic idea of the present invention, and the features in the following embodiments and examples may be combined with each other without conflict.
Wherein the showings are for the purpose of illustrating the invention only and not for the purpose of limiting the same, and in which there is shown by way of illustration only and not in any way limiting the scope of the invention; for a better understanding of the embodiments of the present invention, some parts of the drawings may be omitted, enlarged or reduced, and do not represent the size of an actual product; it will be understood by those skilled in the art that certain well-known structures in the drawings and descriptions thereof may be omitted.
The same or similar reference numerals in the drawings of the embodiments of the present invention correspond to the same or similar parts; in the description of the present invention, it should be understood that if there are terms such as "upper", "lower", "left", "right", "front", "back", etc., indicating directions or positional relationships based on the directions or positional relationships shown in the drawings, it is only for convenience of description and simplification of description, but it is not intended to indicate or imply that the device or element referred to must have a specific direction, be constructed and operated in a specific direction, and therefore, the terms describing the positional relationships in the drawings are only used for illustrative purposes and are not to be construed as limiting the present invention, and those skilled in the art can understand the specific meanings of the terms according to specific situations.
Referring to fig. 1 to 3, an integrated device for rapidly detecting pathogenic microorganisms includes a box body 2 and a box cover 1, wherein a constant temperature amplification reaction chamber 3, a buffer storage chamber 4 and a test strip detection chamber 6 for containing test paper are arranged in the box body 2, and the buffer storage chamber 4 and the constant temperature amplification reaction chamber 3 are respectively communicated with the test strip detection chamber 6; sealing films 7 are respectively arranged between the test strip detection cavity 6 and the buffer solution storage cavity 4 and between the test strip detection cavity 6 and the constant-temperature amplification reaction cavity 3, and the test strip detection cavity 6 is respectively sealed and isolated from the buffer solution storage cavity 4 and the constant-temperature amplification reaction cavity 3 through the sealing films 7; openings are respectively arranged on the mutually close sides of the buffer solution storage cavity 4 and the constant-temperature amplification reaction cavity 3 in a penetrating way, the openings are far away from the sealing film 7, and a test paper inlet for detecting the inlet and the outlet of test paper is arranged on the side of the test paper detection cavity 6 close to the box cover 1 in a penetrating way; the box cover 1 is detachably connected to one end of the box body 2 provided with an opening, and a puncture needle 5 for puncturing the sealing film 7 is arranged on one side of the box cover 1 close to the opening; the number of the puncture needles 5 is two, and the two puncture needles 5 are respectively arranged corresponding to the buffer solution storage cavity 4 and the constant temperature amplification reaction cavity 3.
In this embodiment, the test strip detection chamber 6, the buffer storage chamber 4 and the isothermal amplification reaction chamber 3 are disposed in parallel. The box cover 1 is connected with the box body 2 in a sealing way, and the opening of the buffer solution storage cavity 4, the opening of the constant temperature amplification reaction cavity 3 and the test paper port are all positioned in the sealing range of the box cover 1. A sealing ring 8 is arranged on the outer side of one end, matched with the box cover 1, of the box body 2, a clamping groove 9 is arranged on the position, corresponding to the sealing ring 8, of the inner side of the box cover 1, and the box body 2 and the box cover 1 are detachably connected with the sealing ring 8 through the clamping groove 9. The number of the clamping grooves 9 and the number of the sealing rings 8 are two, and the two sealing rings 8 and the two clamping grooves 9 are sequentially arranged along the puncture direction of the puncture needle 5. The clamping groove 9 and the sealing ring 8 can prevent reaction liquid from overflowing in the process of puncturing the sealing film 7 by the puncture needle 5, meanwhile, the position of the box cover 1 is convenient to limit to a certain extent, and the puncture needle 5 is prevented from accidentally puncturing the sealing film 7 when not detected. The case 2 is transparent. The position of the box body 2 corresponding to the test strip detection cavity 6 is provided with the observation window 10, the wall thickness of the observation window 10 is smaller than the wall thickness of the rest positions on the box body 2, the detection test strip can be read more clearly through the observation window 10, and convenience and rapidness are achieved. In this embodiment, the volumes of the buffer storage chamber and the isothermal amplification reaction chamber satisfy the volume of the isothermal amplification reaction.
During actual use, the constant-temperature amplification reaction cavity 3 is filled with reaction liquid, the buffer storage cavity 4 is filled with buffer, and the test strip detection cavity 6 is filled with detection test paper. After a sample is injected into the constant-temperature amplification reaction cavity 3, the box cover 1 is buckled on the box body 2, and the sample reacts in the constant-temperature amplification reaction cavity 3. After the reaction is finished, the box cover 1 is further pushed, the puncture needle 5 punctures the sealing film 7, the reaction liquid and the buffer liquid enter the test strip detection cavity 6 and then are mixed, and the test strip in the test strip detection cavity 6 is immersed. The quality control line and the detection line of the detection test are both changed into positive color, and an operator reads the detection result of the detection test paper through the observation window 10.
Finally, the above embodiments are only used for illustrating the technical solutions of the present invention and not for limiting, and although the present invention has been described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions may be made to the technical solutions of the present invention without departing from the spirit and scope of the technical solutions, and all of them should be covered by the scope of the claims of the present invention.
Claims (9)
1. Integrated device for rapidly detecting pathogenic microorganisms, which is characterized in that: the kit comprises a kit body and a kit cover, wherein a constant-temperature amplification reaction cavity, a buffer solution storage cavity and a test strip detection cavity for containing test paper are arranged in the kit body, and the test strip detection cavity is respectively communicated with the buffer solution storage cavity and the constant-temperature amplification reaction cavity;
sealing films are respectively arranged between the test strip detection cavity and the buffer solution storage cavity and between the test strip detection cavity and the constant-temperature amplification reaction cavity, and the test strip detection cavity is respectively sealed and isolated from the buffer solution storage cavity and the constant-temperature amplification reaction cavity through the sealing films;
openings are respectively arranged on the mutually close sides of the buffer solution storage cavity and the constant-temperature amplification reaction cavity in a penetrating way, the openings are far away from the sealing film, and a test paper inlet for detecting the inlet and outlet of test paper is arranged on the side of the test paper strip detection cavity close to the box cover in a penetrating way;
the box cover is detachably connected to one end of the box body, which is provided with the opening, and a puncture needle for puncturing the sealing film is arranged on one side of the box cover, which is close to the opening;
the number of the puncture needles is two, and the two puncture needles are respectively arranged corresponding to the buffer solution storage cavity and the constant-temperature amplification reaction cavity.
2. The integrated device for rapidly detecting pathogenic microorganisms according to claim 1, which is characterized in that: the test strip detection cavity, the buffer solution storage cavity and the constant-temperature amplification reaction cavity are arranged in parallel.
3. The integrated device for rapidly detecting pathogenic microorganisms according to claim 1, which is characterized in that: the lid with sealing connection between the box body, the opening in buffer solution storage chamber, the opening in constant temperature amplification reaction chamber and the test paper mouth all are located the sealed within range of lid.
4. The integrated device for rapidly detecting pathogenic microorganisms according to claim 1, which is characterized in that: the box body with be provided with the sealing washer on the outside of lid complex one end, the inboard of lid corresponds be provided with the draw-in groove on the position of sealing washer, the box body reaches the lid passes through the draw-in groove with the sealing washer can realize sealing, can not lead to the aerosol pollution of surrounding environment.
5. The integrated device for rapidly detecting pathogenic microorganisms according to claim 4, wherein: the number of the clamping grooves and the number of the sealing rings are two, and the two clamping grooves and the two sealing rings are sequentially arranged along the puncture direction of the puncture needle.
6. The integrated device for rapidly detecting pathogenic microorganisms according to claim 1, which is characterized in that: the box body is transparent.
7. The integrated device for rapidly detecting pathogenic microorganisms according to claim 6, wherein: an observation window is arranged at the position, corresponding to the test strip detection cavity, of the box body, and the wall thickness of the box body at the position of the observation window is smaller than that of the rest positions on the box body.
8. The integrated device for rapidly detecting pathogenic microorganisms according to claim 1, which is characterized in that: the volumes of the buffer solution storage cavity and the isothermal amplification reaction cavity meet the volume of the isothermal amplification reaction.
9. An integrated apparatus for rapid detection of pathogenic microorganisms according to any one of claims 1 to 8, characterized in that: the test strip detection cavity is filled with a colloidal gold test strip for detecting a constant-temperature amplification reaction product, the constant-temperature amplification reaction cavity is filled with a constant-temperature amplification reaction solution, and the buffer solution storage cavity is filled with a buffer solution for diluting the amplification product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202120024957.5U CN214781828U (en) | 2021-01-06 | 2021-01-06 | Integrated device for rapidly detecting pathogenic microorganisms |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202120024957.5U CN214781828U (en) | 2021-01-06 | 2021-01-06 | Integrated device for rapidly detecting pathogenic microorganisms |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN214781828U true CN214781828U (en) | 2021-11-19 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202120024957.5U Expired - Fee Related CN214781828U (en) | 2021-01-06 | 2021-01-06 | Integrated device for rapidly detecting pathogenic microorganisms |
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| Country | Link |
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| CN (1) | CN214781828U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114196519A (en) * | 2021-12-10 | 2022-03-18 | 中国检验认证集团辽宁有限公司 | Disease marker detection chip general structure utilizing body temperature reaction and use method thereof |
-
2021
- 2021-01-06 CN CN202120024957.5U patent/CN214781828U/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114196519A (en) * | 2021-12-10 | 2022-03-18 | 中国检验认证集团辽宁有限公司 | Disease marker detection chip general structure utilizing body temperature reaction and use method thereof |
| CN114196519B (en) * | 2021-12-10 | 2023-11-07 | 中国检验认证集团辽宁有限公司 | Universal structure of disease marker detection chip by utilizing body temperature reaction and application method thereof |
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| CF01 | Termination of patent right due to non-payment of annual fee |