CN113121689A - Ctla-4结合分子及其用途 - Google Patents
Ctla-4结合分子及其用途 Download PDFInfo
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- CN113121689A CN113121689A CN202010047300.0A CN202010047300A CN113121689A CN 113121689 A CN113121689 A CN 113121689A CN 202010047300 A CN202010047300 A CN 202010047300A CN 113121689 A CN113121689 A CN 113121689A
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Abstract
Description
原始残基 | 示例性取代 | 优选的取代 |
Ala(A) | Val;Leu;Ile | Val |
Arg(R) | Lys;Gln;Asn | Lys |
Asn(N) | Gln;His;Asp、Lys;Arg | Gln |
Asp(D) | Glu;Asn | Glu |
Cys(C) | Ser;Ala | Ser |
Gln(Q) | Asn;Glu | Asn |
Glu(E) | Asp;Gln | Asp |
Gly(G) | Ala | Ala |
His(H) | Asn;Gln;Lys;Arg | Arg |
Ile(I) | Leu,Val;Met;Ala;Phe;正亮氨酸 | Leu |
Leu(L) | 正亮氨酸;Ile;Val;Met;Ala;Phe | Ile |
Lys(K) | Arg;Gln;Asn | Arg |
Met(M) | Leu;Phe;Ile | Leu |
Phe(F) | Trp;Leu;Val;Ile;Ala;Tyr | Tyr |
Pro(P) | Ala | Ala |
Ser(S) | Thr | Thr |
Thr(T) | Val;Ser | Ser |
Trp(W) | Tyr;Phe | Tyr |
Tyr(Y) | Trp;Phe;Thr;Ser | Phe |
Val(V) | Ile;Leu;Met;Phe;Ala;正亮氨酸 | Leu |
血清稀释倍数 | 阴性血清的OD<sub>450nm</sub> | NSY007羊驼血清的OD<sub>450nm</sub> |
1:200 | 0.348 | 2.268 |
1:400 | 0.219 | 2.306 |
1:800 | 0.186 | 1.93 |
1:1600 | 0.147 | 1.395 |
1:3200 | 0.122 | 1.188 |
1:6400 | 0.103 | 0.788 |
1:12800 | 0.071 | 0.479 |
1:25600 | 0.09 | 0.335 |
反应体系组分 | 单反应体系所需的量 |
2×PrimeSTAR Max DNA聚合酶 | 25μL |
引物-F | 1μL |
引物-R | 1μL |
模板 | 10ng |
ddH<sub>2</sub>O | 补足至50μL |
Claims (26)
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CN202010047300.0A CN113121689B (zh) | 2020-01-16 | 2020-01-16 | Ctla-4结合分子及其用途 |
CN202211175840.2A CN115626956A (zh) | 2020-01-16 | 2020-01-16 | Ctla-4结合分子及其用途 |
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CN202211175840.2A Division CN115626956A (zh) | 2020-01-16 | 2020-01-16 | Ctla-4结合分子及其用途 |
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Publication Number | Publication Date |
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US20170137521A1 (en) * | 2015-11-18 | 2017-05-18 | Juha Punnonen | Ctla4 binders |
US20190233519A1 (en) * | 2016-10-11 | 2019-08-01 | Nanjing Legend Biotech Co., Ltd. | Single-domain antibodies and variants thereof against ctla-4 |
WO2019179388A1 (en) * | 2018-03-19 | 2019-09-26 | Wuxi Biologics (Shanghai) Co., Ltd. | Novel anti-ctla-4 antibody polypeptide |
CN110343180A (zh) * | 2019-07-25 | 2019-10-18 | 北京免疫方舟医药科技有限公司 | 抗ctla-4抗体及其应用 |
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US20170137521A1 (en) * | 2015-11-18 | 2017-05-18 | Juha Punnonen | Ctla4 binders |
US20190233519A1 (en) * | 2016-10-11 | 2019-08-01 | Nanjing Legend Biotech Co., Ltd. | Single-domain antibodies and variants thereof against ctla-4 |
WO2019179388A1 (en) * | 2018-03-19 | 2019-09-26 | Wuxi Biologics (Shanghai) Co., Ltd. | Novel anti-ctla-4 antibody polypeptide |
CN110343180A (zh) * | 2019-07-25 | 2019-10-18 | 北京免疫方舟医药科技有限公司 | 抗ctla-4抗体及其应用 |
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CN115873114A (zh) * | 2021-09-29 | 2023-03-31 | 浙江纳米抗体技术中心有限公司 | Ctla-4结合分子及其应用 |
WO2023051618A1 (zh) * | 2021-09-29 | 2023-04-06 | 浙江纳米抗体技术中心有限公司 | Ctla-4结合分子及其应用 |
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