CN1131042C - Bee glue prepn for treating stomatocase and its compounding process - Google Patents
Bee glue prepn for treating stomatocase and its compounding process Download PDFInfo
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- CN1131042C CN1131042C CN01107701A CN01107701A CN1131042C CN 1131042 C CN1131042 C CN 1131042C CN 01107701 A CN01107701 A CN 01107701A CN 01107701 A CN01107701 A CN 01107701A CN 1131042 C CN1131042 C CN 1131042C
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- tincture
- propolis
- powder
- mixed solvent
- royal jelly
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Abstract
The present invention relates to an external preparation for treating oral cavity ulcer, which is a tincture prepared by impregnating components of bee glue, dyclonine powder, royal jelly, menthol, etc. in a mixed solvent, and the content of effective bee glue substances in the tincture is from 5 to 15%. The tincture has the advantages of no poison and safe use, recurrent oral cavity ulcer can be recovered in 3 to 7 days after the tincture is spread on an affected point, and a cure rate is 100%. The tincture also has good treatment effect on goose mouth sores of children, periodontitis, toothache caused by decayed teeth, radiation damage glossitis caused by radiotherapy and oral cavity ulcer.
Description
The present invention is relevant with the medicament of treatment oral ulcer, is the medicament about a kind of external curing oral ulcer.
Oral ulcer is a kind of commonly encountered diseases and frequently-occurring disease, and the generation of oral ulcer is normal relevant with systemic disease.Recurrent oral ulceration is characteristics with frequent outbreak, and the spontaneous recovery phase is 7-10 days, and with disease progression, outbreak is frequent, and the ulcer number increases, and is touching continuous.After the morbidity, Chinese medicine preparation commonly used has BINGPENG SAN, XILEI SAN, watermelon crystal powder etc.But from clinical treatment observation, use these medicaments, most of patients all reaches curative effect after the recurrent oral ulceration spontaneous recovery phase, so the true curative effect of said medicine is difficult to differentiate.
The object of the present invention is to provide a kind of therapeutic effect good, curative effect is fast, treatment oral ulcer medicament easy to use.
The medicament of the external curing oral ulcer of the present invention development is to be a kind of propolis tincture that main component is mixed with propolis, mainly form by propolis, dyclonine powder, royal jelly, Mentholum, its constituent content is 25-35 part propolis, 0.5-1.5 part dyclonine powder, 2-6 part royal jelly and 0.2-0.6 part Mentholum, the tincture that said components is made after flooding in mixed solvent.Here said mixed solvent is the mixed solvent that is mixed by 8-15 part glycerol, 8-15 part propylene glycol and 65-85 part 95% ethanol.So the molten system of mixing of preparation can make active component fully leach, and has also improved the serviceability of tincture.The content of effective propolis material is 5-15% in the tincture of making thus.Propolis content is lower than at 5% o'clock, and its film property, narcoticness all reduce, and the curative effect phase prolongs, and the propolis-containing amount surpasses at 15% o'clock, and its narcoticness, film property, anti-inflammatory are basic identical.And the curative effect phase no longer shortens because of the raising of propolis content.
The compound method of this treatment oral ulcer external preparation is to mainly contain following step:
1. the propolis block is placed below-5 ℃, freezing 24 hours, after taking-up was ground into coarse powder, it was standby to place refrigerating chamber to store again.
2. royal jelly and 95% ethanol are mixed well, are ground with 1: 1 ratio by weight, filter standby with 60 mesh sieves;
3. with remaining ethanol, add propylene glycol, glycerol in proportion, stir, make mixed solvent.
4. the dyclonine powder with proportional quantity is dissolved in earlier in the mixed solvent, adds royal jelly dissolve with ethanol thing more in proportion, and propolis powder, mixes, and flood a week under constantly stirring;
5. the elimination residue obtains tincture of the present invention.
Concrete instance of following reuse is described further preparing process of the present invention.Get 1 kilogram of 95% ethanol of royal jelly and mix well, grind with 1 kilogram, standby after filtering with 60 mesh sieves; Getting 13 kilograms of ethanol adds 2 kilograms of propylene glycol and 2 kilograms of glycerol, stirs, make mixed solvent, 0.2 kilogram of dyclonine powder is dissolved in the above-mentioned mixed solvent, add royal jelly dissolve with ethanol thing, and 6 kilograms of propolis powder, mix, and after under agitation flooding a week, the elimination insoluble matter promptly obtains tincture of the present invention.
During use, earlier dry the affected part with a cotton rod, dip in cotton rod immediately and get tincture of the present invention and be applied to wound surface, the mouth breathing several seconds gets final product.Every day, coating was three times.Usually after seven days, all can fully recover.
Experiment shows that tincture of the present invention has multiple functions such as antibiotic property, film property, narcoticness and promotion epithelial cell new life.Use the back on wound surface, can form protecting film and play moment analgesic effect.Most of patients was taken food freely after three hours, no longer included pain.According to clinical observation, cured person reaches 89.9% in three days.All the other all recoveries from illness in 6 days.Recovery period is the traditional treatment medicine at present, obviously shortens, and curative effect is obvious.Tincture of the present invention also has the good curing effect to the toothache that infantile thrush, periodontitis, dental caries cause.Radiation injury glossitis and oral ulcer that radiotherapy is caused also have the good curing effect.
With animal experimental observation preparation of the present invention safety that human body is used.
1. acute toxicity is observed: with 30 adult rat, and body weight 250 ± 20g, 10 every group, male and female half and half pour into tincture of the present invention by stomach.5,10,15 (g/100g) 0.1ml, water was by dilution in 1: 2, and perfusion is after 48 hours, none death of animal, survival rate is 100%.Observed none animal dead still, survival rate 100% 7 days.
2. long term toxicity is observed: with 30 of adult rat, male and female half and half, body weight 250 ± 20g, pour into of the present invention tincture 0.1ml of 15 (g/100gs) by stomach every day, and water was by dilution in 1: 2, observed 28-30 days continuously, the record the weight of animals changes and growing state, weighs weekly three times, after 30 days as a result, animal weight increase 50g/, no abnormal phenomenon.
Above-mentioned experiment shows that the present invention does not have acute to body and the subacute toxicity effect.Amount to the adult (average 50kg calculates), obey 20ml every day and also acute reaction can not occur.Continuous oral the chronic poisoning phenomenon can not occur in 30 days yet.
For showing progressive of the present invention, observed with the therapeutic outcome of tincture of the present invention by No.4 People's Hospital's department of stomatology stochastic sampling, and compared with BINGPENG SAN, XILEI SAN, watermelon crystal powder etc. to 100 routine recurrent oral ulcerations.
Evaluation criteria: cure, ulcer disappears in seven days; Take a turn for the better, ulcer is dwindled pain relief in seven days; Invalid, ulcer does not heal, still pain.Result of the test sees Table 1
Table 1 the present invention is to the recurrent oral ulceration therapeutic outcome
| Use medicine | The treatment number | The healing number | The improvement number | Invalid number | Cure rate % |
| BINGPENG SAN XILEI SAN watermelon crystal powder cydiodine of the present invention | 100 100 100 100 100 | 100 24 30 44 56 | 0 10 12 14 14 | 0 66 58 42 30 | 100 24 30 44 56 |
Above-mentioned experiment shows that the present invention is to the therapeutic effect of recurrent oral ulceration, and compare its cure rate there were significant differences with matched group, obviously is better than matched group.
The several examples of following reuse further specify the present invention.
Component example 1 example 2 examples 3
25 parts 30 parts 35 parts of propolis
8 parts 10 parts 12 parts of glycerol
0.2 part 0.5 part 0.6 part of Mentholum
65 parts 70 parts 80 parts of 95% ethanol
8 parts 10 parts 15 parts of propylene glycol
0.5 part 1 part 1.5 parts in dyclonine powder
2 parts 5 parts 6 parts of royal jelly
The several concrete instances of following reuse further specify effect of the present invention, do the treatment of recurrent oral ulceration by above-mentioned using method.
Yu Zheng, woman, 16 years old, student, first visit on June 16 in 1996.The lower lip inboard has beans size, surface to be canescence ulcer, coating same day, pain relief, recovery from illness after 4 days.
Zhu Li, the woman, 34 years old, the nurse, on May 18th, 1999 went to a doctor.In the right side tongue the big aphtha of two place's grain of rices is arranged, recovery from illness on the 3rd behind the coating.
Zhang Chenghui, the woman, 35 years old, department of stomatology technician, on July 15th, 1999 went to a doctor.There is the big ulcer of a beans at cheek tooth mucosa place in the right side, recovery from illness on the 5th behind the coating.
Tan Qinglan, the woman, 42 years old, the teacher, on July 18th, 1999 went to a doctor, nearly 6 years of former history of repeated attack.In the hypogloeeis and the buccal mucosa place the big two place's ulcer of beans are arranged, behind the coating 6 days the recovery from illness.
Liu Yanjin, the woman, 50 years old, the teacher, on August 12nd, 1999 went to a doctor.In the lip of the tongue the big ulcer of beans is arranged, recovery from illness in 4 days behind the coating.
Qi Feng comes, man, 44 years old, test technician.On August 15th, 1999 went to a doctor, and showed effect repeatedly 5 years.The big dark ulcer of one beans is arranged in the lower lip inboard, and it is yellow that the ulcer center is, recovery from illness after 7 days behind the coating.
Hou Xianzhong, the man, 32 years old, the driver, JIUYUE was gone to a doctor on the 12nd in 1999.Showed effect repeatedly 3 years.The big ulcer of two place's beans is arranged, recovery from illness after 5 days behind the coating in the tongue right side.
Claims (3)
1. external preparation for the treatment of oral ulcer, it is characterized in that said preparation mainly is made up of propolis, dyclonine powder, royal jelly, Mentholum, its constituent content is: 25-35 part propolis, 0.2-0.6 part Mentholum, 0.5-1.5 part dyclonine powder and 2-6 part royal jelly, the tincture that said components is made after flooding in a kind of mixed solvent, said mixed solvent is made up of 8-15 part glycerol, 8-15 part propylene glycol and 65-80 part 95% ethanol.
2. according to the external preparation of the described treatment oral ulcer of claim 1, effective propolis content of material is 5-15% in the tincture that it is characterized in that making.
3. compound method according to the described treatment oral ulcer of claim 1 external preparation is characterized in that comprising following key step:
(1) the propolis block is placed below-5 ℃, freezing 24 hours, after taking-up was ground into coarse powder, it was standby to place refrigerating chamber to store again;
(2) royal jelly and 95% ethanol are mixed well, are ground with 1: 1 ratio by weight, filter standby with 60 mesh sieves;
(3) with remaining ethanol, add propylene glycol, glycerol in proportion, stir, make mixed solvent;
(4) the dyclonine powder with proportional quantities is dissolved in earlier in the mixed solvent, adds royal jelly dissolve with ethanol thing and propolis powder more in proportion, mixes, and flood a week under constantly stirring;
(5) elimination residue obtains tincture of the present invention.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN01107701A CN1131042C (en) | 2001-01-02 | 2001-01-02 | Bee glue prepn for treating stomatocase and its compounding process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN01107701A CN1131042C (en) | 2001-01-02 | 2001-01-02 | Bee glue prepn for treating stomatocase and its compounding process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1362067A CN1362067A (en) | 2002-08-07 |
| CN1131042C true CN1131042C (en) | 2003-12-17 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN01107701A Expired - Lifetime CN1131042C (en) | 2001-01-02 | 2001-01-02 | Bee glue prepn for treating stomatocase and its compounding process |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1131042C (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008208088A (en) * | 2007-02-27 | 2008-09-11 | Ehime Univ | Composition for treatment of stomatitis |
| CN102366426A (en) * | 2011-10-26 | 2012-03-07 | 江苏江大源生态生物科技有限公司 | Propolis tincture for external use and preparation method thereof |
-
2001
- 2001-01-02 CN CN01107701A patent/CN1131042C/en not_active Expired - Lifetime
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| Publication number | Publication date |
|---|---|
| CN1362067A (en) | 2002-08-07 |
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Granted publication date: 20031217 |
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| CX01 | Expiry of patent term |