CN1899302A - Oral sticking plaster preparation for treating oral ulcer and its preparing method - Google Patents
Oral sticking plaster preparation for treating oral ulcer and its preparing method Download PDFInfo
- Publication number
- CN1899302A CN1899302A CN 200610045425 CN200610045425A CN1899302A CN 1899302 A CN1899302 A CN 1899302A CN 200610045425 CN200610045425 CN 200610045425 CN 200610045425 A CN200610045425 A CN 200610045425A CN 1899302 A CN1899302 A CN 1899302A
- Authority
- CN
- China
- Prior art keywords
- montmorillonitum
- preparation
- vanillin
- aspartame
- oral
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
Abstract
The present invention discloses a kind of oral sticking plaster for treating oral ulcer and its preparation process. The oral sticking plaster is prepared with montmorillonite as main medicinal material 500 weight portions, carbomer 15 -35 weight portions, aspartame 0.1-2 weight portions, vanillin 0.1-1.5 weight portions, ethanol solution of 85 % concentration as wetting agent 250-450 weight portions. Compared with available technology, the present invention has the features of long effective duration, high treating effect, simple preparation process, convenient use, etc.
Description
Technical field
The present invention relates to a kind of treatment stomatocace medicine, specifically a kind of mouth paster preparation for the treatment of oral ulcer and preparation method thereof.
Background technology
Existing clinical practice Montmorillonitum looses and directly adds water and make the application mode that paste is applied to the oral ulcer surface, and clinical effectiveness is better.Montmorillonitum is dioctahedron Montmorillonitum [Si8Al4O20 (OH) 4], is the multiple structure of being made up of the octahedra aluminium oxide of two four sides silicon oxide list, and its powder size reaches 1-3 μ m.This material has high stationkeeping ability.But because paste medicament is lower in the ulcer surface concentration, and retention time is short, is diluted by saliva of buccal cavity easily.Can not give full play to the Montmorillonitum drug effect, reach ideal therapeutic effect.
Summary of the invention
Technical assignment of the present invention is to overcome above deficiency, and a kind of mouth paster preparation for the treatment of oral ulcer and preparation method thereof is provided.
The mouth paster preparation of treatment oral ulcer of the present invention comprises major ingredient and adjuvant, and major ingredient is: Montmorillonitum, and adjuvant is: card pool nurse, aspartame and vanillin, wetting agent is: ethanol 85%;
The weight proportion of each raw material is: Montmorillonitum: 500 parts, and card pool nurse: 15-35 part, aspartame: 0.1-2 part, vanillin: 0.1-1.5 part, ethanol 85%:250-450 part.
The optimization weight proportion of each raw material is: Montmorillonitum: 500 parts, and card pool nurse: 20-30 part, aspartame: 0.5-1.5 part, vanillin: 0.2-0.8 part, ethanol 85%:300-400 part.
The optimum weight proportioning of each raw material is: Montmorillonitum: 500 parts, and card pool nurse: 25 parts, aspartame: 1 part, vanillin: 0.5 part, ethanol 85%:350 part.
Above consumption is the raw material weight ratio, and those skilled in the art can be according to producing needs, enlarges arbitrarily or dwindles according to aforementioned proportion, all belongs within protection scope of the present invention.
The preparation process of this mouth paster preparation is: take by weighing Montmorillonitum, and take by weighing in proportion aspartame, vanillin and card pool female with the Montmorillonitum mix homogeneously, add an amount of wetting agent ethanol 85% afterwards, after stirring, system soft material, granulation, tabletting makes Montmorillonitum medicine mouth paster then, at last the packing warehouse-in.
After using mouth paster preparation of the present invention, medicine can cover whole ulcer surface equably, forms skin covering of the surface, and keeps the lasting uninterrupted medicine that discharges.Drug effect is lasting, and the adsorbable multiple pathogen of Montmorillonitum is fixed in the ulcer surface, then excretes with salivation, thereby avoids ulcer wound cell to be damaged by pathogen.Montmorillonitum also has fixation to pathogenic bacterium and toxin, and reducing ulcer surface simultaneously stimulates, and can not reduce patient's sense of taste, thereby guarantees the normal appetite of patient.Helping patient's ulcer surface recovers.In addition, Montmorillonitum can also alleviate the mucosal tissue pathological changes due to the oral ulcer, repairs the intercellular bridge of damaging, and cell is closely connected, and suppresses the pathogen breeding.On the other hand, Montmorillonitum can pass through and the intermolecular interaction of mouth mucus, increases cohesiveness, mucosa elasticity and the life period of mucus gel; thereby enhancing mucus barrier; protection Stomatocyte top and intercellular bridge are avoided damaging, and oral inflammation is disappeared, and make oral ulcer accelerate healing.
The specific embodiment
Embodiment 1:
Each composition proportion: Montmorillonitum: 500g, card pool nurse: 25g, aspartame: 1g, vanillin: 0.5g, ethanol 85%:350g.
Preparation method: take by weighing the 500g Montmorillonitum, and take by weighing aspartame 1g, vanillin 0.5g, the female 25g of card pool and Montmorillonitum mix homogeneously in proportion, add an amount of wetting agent ethanol 85%350g afterwards, after stirring, system soft material, granulation, tabletting makes 1000 of Montmorillonitum medicine mouth pasters then, at last the packing warehouse-in.
Embodiment 2:
Each composition proportion: Montmorillonitum: 500g, card pool nurse: 30g, aspartame: 0.5g, vanillin: 0.8g, ethanol 85%:400g.
Preparation method: take by weighing the 500g Montmorillonitum, and take by weighing aspartame 0.5g, vanillin 0.8g, the female 30g of card pool and Montmorillonitum mix homogeneously in proportion, add an amount of wetting agent ethanol 85%400g afterwards, after stirring, system soft material, granulation, tabletting makes 1000 of Montmorillonitum medicine mouth pasters then, at last the packing warehouse-in.
Embodiment 3:
Each composition proportion: Montmorillonitum: 100g, card pool nurse: 5g, aspartame: 0.2g, vanillin: 0.1g, ethanol 85%:70g.
Preparation method: take by weighing the 100g Montmorillonitum, and take by weighing aspartame 0.2g, vanillin 0.1g, the female 5g of card pool and Montmorillonitum mix homogeneously in proportion, add an amount of wetting agent ethanol 85%70g afterwards, after stirring, system soft material, granulation, tabletting makes 1000 of Montmorillonitum medicine mouth pasters then, at last the packing warehouse-in.
Embodiment 4:
Each composition proportion: Montmorillonitum: 50g, card pool nurse: 2.5g, aspartame: 0.1g, vanillin: 0.05g, ethanol 85%:35g.
Preparation method: take by weighing the 50g Montmorillonitum, and take by weighing aspartame 0.1g, vanillin 0.05g, the female 2.5g of card pool and Montmorillonitum mix homogeneously in proportion, add an amount of wetting agent ethanol 85%35g afterwards, after stirring, system soft material, granulation, tabletting makes 1000 of Montmorillonitum medicine mouth pasters then, at last the packing warehouse-in.
Embodiment 5:
Each composition proportion: Montmorillonitum: 200g, card pool nurse: 8g, aspartame: 0.4g, vanillin: 0.2g, ethanol 85%:130g.
Preparation method: take by weighing the 200g Montmorillonitum, and take by weighing aspartame 0.4g, vanillin 0.2g, the female 8g of card pool and Montmorillonitum mix homogeneously in proportion, add an amount of wetting agent ethanol 85%130g afterwards, after stirring, system soft material, granulation, tabletting makes 1000 of Montmorillonitum medicine mouth pasters then, at last the packing warehouse-in.
Embodiment 6:
Each composition proportion: Montmorillonitum: 400g, card pool nurse: 20g, aspartame: 0.8g, vanillin: 0.4g, ethanol 85%:280g.
Preparation method: take by weighing the 400g Montmorillonitum, and take by weighing aspartame 0.8g, vanillin 0.4g, the female 20g of card pool and Montmorillonitum mix homogeneously in proportion, add an amount of wetting agent ethanol 85%280g afterwards, after stirring, system soft material, granulation, tabletting makes 1000 of Montmorillonitum medicine mouth pasters then, at last the packing warehouse-in.
Case:
Case 1: Zhang Desheng, man 41 years old, Jinan City, Shandong Province Licheng District people.Clinical diagnosis is a stomatitis, and clinical manifestation is the red abnormal pigmentary deposit on the skin in oral cavity, pain, and appetite is poor.With Montmorillonitum mouth paster treatment three days, red abnormal pigmentary deposit on the skin disappeared, and pain disappears; Appetite is recovered.
Case 2: Zhang Haiping, man 6 years old, people from Shanghe County, Jinan City, Shandong Province.Clinical diagnosis is an oral ulcer, and clinical manifestation is oral mucosa hyperemia, and the lingual surface edema has ulcer, the visible canescence thing in ulcer surface.Refusing to eat is not generated heat.With Montmorillonitum mouth paster treatment three days, disappeared in the ulcer surface, and pain disappears; Appetite is recovered.
Case 3: Liu Xiaohui, woman 4 years old, Jinan City, Shandong Province Huaiyin District people.Clinical diagnosis is acute coccus property stomatitis and oral ulcer, and clinical manifestation is oral cavity hyperemia, edema, pain, and there is ulcer in back portion.Appetite is poor, and the heating phenomenon is arranged.With the treatment of Montmorillonitum mouth paster, every day three to five times, treated 3-5 days.Ulcer disappears, and pain disappears; Appetite is recovered.
Case 4: Wang Rui, man 9 years old, Jinan City, Shandong Province Huaiyin District people.Clinical diagnosis is that herpetic stomatitis is accompanied shallow table ulcer, and clinical manifestation is the red abnormal pigmentary deposit on the skin in oral cavity, edema, stomatocace, and the patient has the heating phenomenon, and appetite is poor, influence study.With Montmorillonitum mouth paster treatment 3-5 days, red abnormal pigmentary deposit on the skin, edema extinction, stomatocace pain disappears; Body temperature is normal, and appetite is recovered.
Case 5: Tian Zihao, man, 12 years old, Jinan City, Shandong Province Licheng District people.Clinical diagnosis is a stomatitis and with shallow table ulcer, and clinical manifestation is the red abnormal pigmentary deposit on the skin in oral cavity, pain, and appetite is poor.With Montmorillonitum mouth paster treatment three days, red abnormal pigmentary deposit on the skin disappeared, and pain disappears; Appetite is recovered.
Case 6: Zhang Xiaoxia, woman 10 years old, Jinan City, Shandong Province Changqing District people.Clinical diagnosis is acute coccus property stomatitis and oral ulcer, and clinical manifestation is oral cavity hyperemia, edema, pain, and oral mucosa has ulcer.Patient's appetite is poor, and the heating phenomenon is arranged.With the treatment of Montmorillonitum mouth paster, every day three to five times, treated 3 days.Ulcer disappears, and pain disappears; Appetite is recovered.
Case 7: Sun Zhifei, man 2 years old, Jinan City, Shandong Province Tianqiao District people.Clinical diagnosis is a stomatocace, and clinical manifestation is the red abnormal pigmentary deposit on the skin in oral cavity, pain, and appetite is poor.The visible canescence thing in ulcer surface.Refusing to eat is not generated heat.Montmorillonitum mouth paster treatment three days, red abnormal pigmentary deposit on the skin disappears, and ulcer surface pain disappears; Appetite is recovered.
Case 8: Yan Haifeng, man 4 years old, Jinan City, Shandong Province Pingying County people.Clinical diagnosis is the shallow table ulcer of stomatitis companion's gingiva, and clinical manifestation is the red abnormal pigmentary deposit on the skin in oral cavity, pain, and appetite is poor.The visible canescence thing in ulcer surface, with Montmorillonitum mouth paster treatment three days, red abnormal pigmentary deposit on the skin disappeared, and pain disappears; Appetite is recovered.
Case 9: Shang Yunqing, woman 12 years old, Jinan City, Shandong Province Changqing District people.Clinical diagnosis is acute coccus property stomatitis and oral ulcer, and clinical manifestation is oral cavity hyperemia, edema, pain, and oral mucosa has ulcer.Patient's appetite is poor, and the heating phenomenon is arranged.With the treatment of Montmorillonitum mouth paster, every day five times, treated 3 days.Ulcer disappears, and pain disappears; Appetite is recovered.
Case 10: Wang Xiangrui, man 12 years old, people from Shizhong District, Jinan City, Shandong Province.Clinical diagnosis is that herpetic stomatitis is accompanied shallow table ulcer, and clinical manifestation is the red abnormal pigmentary deposit on the skin in oral cavity, edema, stomatocace, and the patient has the heating phenomenon, and appetite is poor, influence study.With Montmorillonitum mouth paster treatment five days, red abnormal pigmentary deposit on the skin, edema extinction, stomatocace pain disappears; Body temperature is normal, and appetite is recovered.
Claims (5)
1, a kind of mouth paster preparation for the treatment of oral ulcer and preparation method thereof comprises major ingredient and adjuvant, it is characterized in that major ingredient is: Montmorillonitum, and adjuvant is: card pool nurse, aspartame and vanillin, wetting agent is: ethanol 85%;
The weight proportion of each raw material is: Montmorillonitum: 500 parts, and card pool nurse: 15-35 part, aspartame: 0.1-2 part, vanillin: 0.1-1.5 part, ethanol 85%:250-450 part.
2, mouth paster preparation according to claim 1 is characterized in that the weight proportion of each raw material is: Montmorillonitum: 500 parts, and card pool nurse: 20-30 part, aspartame: 0.5-1.5 part, vanillin: 0.2-0.8 part, ethanol 85%:300-400 part.
3, mouth paster preparation according to claim 1 is characterized in that the weight proportion of each raw material is: Montmorillonitum: 500 parts, and card pool nurse: 25 parts, aspartame: 1 part, vanillin: 0.5 part, ethanol 85%:350 part.
4, mouth paster preparation according to claim 1 is characterized in that said preparation is a Formulation.
5, the preparation method of the described mouth paster preparation of claim 1, the preparation process that it is characterized in that this mouth paster preparation is: take by weighing Montmorillonitum, and take by weighing in proportion aspartame, vanillin and card pool female with the Montmorillonitum mix homogeneously, add an amount of wetting agent ethanol 85% afterwards, after stirring, system soft material, granulation, tabletting makes Montmorillonitum medicine mouth paster then, at last the packing warehouse-in.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610045425 CN1899302A (en) | 2006-07-12 | 2006-07-12 | Oral sticking plaster preparation for treating oral ulcer and its preparing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610045425 CN1899302A (en) | 2006-07-12 | 2006-07-12 | Oral sticking plaster preparation for treating oral ulcer and its preparing method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1899302A true CN1899302A (en) | 2007-01-24 |
Family
ID=37655412
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200610045425 Pending CN1899302A (en) | 2006-07-12 | 2006-07-12 | Oral sticking plaster preparation for treating oral ulcer and its preparing method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1899302A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103156825A (en) * | 2013-03-25 | 2013-06-19 | 南京南大药业有限责任公司 | Attapulgite mouth paste and paster |
| CN103948613A (en) * | 2014-04-23 | 2014-07-30 | 林环 | Medicine for oral ulcer and preparation method thereof |
-
2006
- 2006-07-12 CN CN 200610045425 patent/CN1899302A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103156825A (en) * | 2013-03-25 | 2013-06-19 | 南京南大药业有限责任公司 | Attapulgite mouth paste and paster |
| CN103948613A (en) * | 2014-04-23 | 2014-07-30 | 林环 | Medicine for oral ulcer and preparation method thereof |
| CN103948613B (en) * | 2014-04-23 | 2017-08-08 | 林环 | A kind of medicine and preparation method for canker sore |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101062005B (en) | Medical toothpaste including sodium azulene sulfonate | |
| CN101468039B (en) | Method for preparing compound double-layer sustained-release medicinal membrane for treating oral mucosal disease | |
| CN1927160A (en) | Gargle and its preparing process | |
| CN103520049A (en) | Application of compound traditional Chinese medicine extracts in preparation of health care products for oral care | |
| CN102895472B (en) | Topical combination medicament for treating dental ulcer and preparation method thereof | |
| CN102228417A (en) | Chinese herbal medicine toothpaste composition containing sodium gualenate | |
| CN103610817A (en) | Anus lotion | |
| CN1899302A (en) | Oral sticking plaster preparation for treating oral ulcer and its preparing method | |
| CN105213353B (en) | Compound oral film and preparation method containing sodium azulenesulfonate | |
| CN100345542C (en) | Tinizadole dental plaster for treating buccal inflammation | |
| CN1284585C (en) | Medicine for treating acute and chronic pharyogolaryngitis, recurring oral cavity sore and its preparation method | |
| CN101744871B (en) | Propolis Chinese medicinal preparation for treating toothaches and preparation method thereof | |
| CN100384407C (en) | Chinese medicine oral cavity adherent emplastrum and its preparation method | |
| CN1864733A (en) | Chinese proprietary medicine for treating oral cavity inflammation | |
| CN101066399A (en) | Chinese medicine prepn for treating recurrent aphtha | |
| CN104825451A (en) | Vitamin B3 sustained release preparation for whitening and removing freckles | |
| CN1256959C (en) | Rhinitis treating medicinal cream | |
| US3171782A (en) | Oral compositions comprising lysozyme and vitamin b6 | |
| CN104258092A (en) | Gargle for treating recurrent aphthous ulcer and periodontitis and preparation method thereof | |
| CN1720971A (en) | Stomatocace powder | |
| CN1240426C (en) | Prepared Chinese medicine for treating ulcerative stomatitis | |
| CN1296034C (en) | Halitosis removing toothpaste | |
| CN101919799B (en) | Novel sustained-release transdermal medicament delivery system | |
| CN1255174C (en) | Power of pasting on umbilicus for treating dianhea and abdominal pain of infants | |
| CN1263449C (en) | Buccal tablet for treating oral anaerobe infection disease and its manufacturing method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |