CN113101260B - Composition for repairing skin after medical and artistic treatment and preparation method and application thereof - Google Patents
Composition for repairing skin after medical and artistic treatment and preparation method and application thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9706—Algae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The application relates to the field of cosmetics, and particularly discloses a composition for repairing skin after medical arts and a preparation method and application thereof. The composition for repairing skin after medical arts comprises the following components in parts by weight: 0.5-3 parts of lactobacillus fermentation lysate; 3-5 parts of leuconostoc/radish root fermentation product filtrate; 0.3-1 part of Europe aspen bark extract; 0.01-0.5 part of Enteromorpha prolifera extract; 0.1-0.4 parts of silybum marianum fruit extract; 0.1-0.3 parts of holy basil leaf extract; 0.1-0.5 part of citric acid; 2-5 parts of a solvent; the preparation method comprises the following steps: and uniformly mixing the components of the composition for repairing skin after medical and artistic treatment to obtain the composition for repairing skin after medical and artistic treatment. The composition can be used in various cosmetics, and has the advantages of mildness, no stimulation, and relieving dry skin, itching, redness and swelling and allergy; in addition, the preparation method has the advantages of simple and convenient preparation and easy industrialized production.
Description
Technical Field
The present application relates to the field of cosmetics, and more particularly, to a composition for repairing skin after medical arts, a preparation method and applications thereof.
Background
Medical cosmetology is a series of treatments by medical means including medicines, instruments, operations and the like, so as to achieve the purposes of changing the external form and color of the human body, partially improving the physiological functions of the human body and enhancing the external aesthetic feeling of the human body.
Most of the medical and cosmetic operations at present basically leave wounds and take a certain time to repair. In order to accelerate wound repair after medical cosmetic surgery, some skin care products with the function of repairing wounds are generally adopted.
Aiming at the related technology, the inventor considers that in the repairing process after medical arts, a clean sterile environment is needed to be created for the wound surface, so that the risk of infection can be reduced, and the accelerating healing of the wound surface can be facilitated. Meanwhile, in the medical and aesthetic operation process, the skin is damaged due to the action of external force (light and electricity), so that the skin becomes sensitive temporarily, and the skin can release inflammatory factors due to the stimulation of the external force, so that the skin has side effects of red, swelling, itching and the like, but the components with itching relieving functions at present comprise the following components: peppermint, camphene, borneol and the like have certain irritation, and the itching relieving effect is achieved mainly by making skin feel cool, and the irritation components cannot be added into products for medical and artistic post-repair, so that secondary injury is easily caused to the wound surface after operation, and therefore, the functions of eliminating redness and swelling, especially itching in the current products for medical and artistic post-repair are weaker, and therefore, the improvement still has room.
Disclosure of Invention
In order to accelerate the process of repairing wounds after medical arts and reduce symptoms such as inflammation, redness and itching of skin in the repairing process, the application provides a composition for repairing the skin after medical arts and a preparation method and application thereof.
In a first aspect, the present application provides a composition for repairing skin after medical arts, which adopts the following technical scheme:
the composition for repairing skin after medical arts comprises the following components in parts by mass:
0.5-3 parts of lactobacillus fermentation lysate;
3-5 parts of leuconostoc/radish root fermentation product filtrate;
0.3-1 part of Europe aspen bark extract;
0.01-0.5 part of Enteromorpha prolifera extract;
0.1-0.4 parts of silybum marianum fruit extract;
0.1-0.3 parts of holy basil leaf extract;
0.1-0.5 part of citric acid;
2-5 parts of solvent.
Preferably, the composition for repairing skin after medical arts comprises the following components in parts by mass:
1-2 parts of lactobacillus fermentation lysate;
3.5-4.5 parts of Leuconostoc mesenteroides/radish root fermentation product filtrate;
0.6-0.8 part of Europe aspen bark extract;
0.05-0.2 part of enteromorpha extract;
0.15-0.25 parts of silybum marianum fruit extract;
0.05-0.2 parts of holy basil leaf extract;
0.3-0.4 part of citric acid;
2.5-3 parts of solvent.
By adopting the technical scheme, the lactobacillus fermentation lysate, the leuconostoc mesenteroides/radish root fermentation product filtrate and the Europe aspen bark extract are added to be matched in a synergistic way, so that the proliferation of fiber cells is promoted, the healing speed of wounds after operation is accelerated, the wound repairing effect of the composition is better, meanwhile, the skin irritation is relieved, the problems of skin allergy, redness and swelling and the like are solved, and skin redness is reduced; the composition also contains heat shock protein, which is beneficial to reducing skin inflammation for external use; meanwhile, the Leuconostoc mesenteroides/radix Raphani fermentation product filtrate is also beneficial to improving the antibacterial performance and mildness of the composition, so that wound wounds after medical and artistic treatment are not easy to be infected, in addition, the skin density is also beneficial to better increase, the loss of water is reduced, and the moisturizing effect of the composition is better improved.
Through the addition of the Enteromorpha prolifera extract, the Silybum marianum fruit extract, the holy basil leaf extract and the citric acid which are mutually matched, the collagen of the dermis layer type I and the collagen of the dermis layer type III are favorably increased, the smoothness and the compactness of the skin are favorably improved, the wound healing process after medical arts is favorably accelerated, and the repairing effect after medical arts is better; meanwhile, the composition is favorable for inhibiting inflammatory mediators of skin, and can relieve dry itching, redness and swelling and allergy of the skin; in addition, the composition can be used for repairing damaged skin affected by mechanical external force, and has mild and durable effect.
The inventor also found in the research process that the lactobacillus fermentation lysate and the holy basil leaf extract are mutually cooperated to be beneficial to improving the permeability of the composition, meanwhile, the composition can effectively relieve the problem of skin itch, and the components are natural, mild and non-irritating, so that the postoperative wound is not easily damaged secondarily when the itch is not easy to occur in the process of repairing and curing, and the patient is not easy to scratch the wound due to the fact that the itch is not easy to be held, and the healing speed of the postoperative wound is better accelerated.
The main reasons for the itching of the postoperative wound in the repair process are as follows: when medical cosmetic surgery is performed, the dermis layer is mainly composed of protein, blood vessels, glands and rich nerve endings, the wound healing process is that the original damaged wound grows new connective tissue to fill the damaged place, the skin nerve, blood vessels and the like which are originally broken because of damage also grow into the new connective tissue again, and the nerve endings which are newly generated are easily stimulated in the healing process, so that the itching feeling occurs, and therefore, the itching of the wound in the healing process mainly occurs in the dermis layer; in the process of repairing skin, the repairing agent can continuously promote the generation of fiber cells, so that the skin on the surface of the skin can better and faster reform a new skin barrier, and the skin barrier can prevent the active ingredients from penetrating into the dermis layer of the skin to play a role.
Based on the technical effects, the inventor believes that the lactobacillus fermentation lysate has better skin penetration performance, is favorable for the synergistic holy basil leaf extract to better penetrate through the epidermis skin barrier and penetrate into the dermis layer, and in addition, the lactobacillus fermentation lysate and the holy basil leaf extract can generate a component for inhibiting the perception sensitivity of nerve endings after being mixed, or the lactobacillus fermentation lysate and the holy basil leaf extract can contain a component for inhibiting the sensitivity of nerve endings, so that the skin is not easy to be itchy in the healing process of healing wounds after medical arts, and simultaneously, the skin is not easy to be stimulated.
The inventor also discovers in the research that after lactobacillus fermentation lysate, holy basil leaf extract and enteromorpha extract are added to be mutually matched, the scar-remaining problem can be effectively relieved, melanin of skin is not easy to precipitate, scar is not easy to be left on the repaired skin, and the scar-removing time of the skin after complete repair is shortened.
Preferably, the solvent comprises one or more of propylene glycol, ethanol, water, and butylene glycol.
By adopting the technical scheme, the composition prepared by adopting one or more substances as the solvent is milder and has no stimulation, is beneficial to inhibiting the activity of inflammatory mediators better, and ensures that the skin is less prone to inflammation in the repair process after operation.
Preferably, the solvent is formed by mixing water and propylene glycol in a mass ratio of 7-9:1.
By adopting the technical scheme, the water and the propylene glycol in a specific proportion are cooperatively matched to serve as the solvent, so that the solubility of each component of the composition is better improved, the components are better mutually cooperatively matched and exert actions, the water supplementing effect of the skin is better improved, the drying problem of the skin in the repairing process can be effectively relieved, and the water supplementing effect is mild and durable.
In a second aspect, the present application provides a method for preparing a composition for repairing skin after medical arts, which adopts the following technical scheme:
a preparation method of a composition for repairing skin after medical arts comprises uniformly mixing the components of the composition for repairing skin after medical arts to obtain the composition for repairing skin after medical arts.
By adopting the technical scheme, the composition can be obtained by uniformly mixing the components of the composition, the production is simple and convenient, and the industrial production is easy.
In a third aspect, the present application provides an application of the composition for repairing skin after medical arts, which adopts the following technical scheme:
the application of the composition for repairing skin after medical arts is that the composition for repairing skin after medical arts is directly added into skin care water, essence, emulsion, cream and facial mask.
By adopting the technical scheme, the composition is directly added into various skin care products, so that the skin care products have the function of repairing skin after medical arts and craft, and the application range is wide.
In a fourth aspect, the present application provides an essence containing the composition for repairing skin after medical arts, which adopts the following technical scheme:
an essence containing the composition for repairing skin after medical arts is characterized in that: comprises the following components in parts by mass:
phase A:
3-6 parts of butanediol;
0.1-0.3 part of sodium hyaluronate;
and B phase:
5-10 parts of the composition for repairing skin after medical and artistic treatment;
the total mass part of the essence containing the composition for repairing skin after medical and artistic treatment is 100 parts, and the balance is water.
By adopting the technical scheme, the composition is added into the essence, so that the composition is better and uniformly blended with the essence, the composition can better play a role in the essence, and the skin effect of the essence after medical and artistic repairing is better.
In summary, the present application has the following beneficial effects:
1. the components adopted by the application are natural, mild, harmless and non-irritating, are favorable for relieving irritation, effectively relieve skin allergy, redness, itching and other phenomena, reduce skin redness and are not easy to cause secondary injury to skin wounds.
2. The composition is beneficial to promoting the proliferation of the fibroblasts, ensuring that skin wounds are repaired faster after medical arts, simultaneously relieving itching of the skin in the repairing and healing process, increasing collagen of the skin, ensuring that the original collagen structure of the skin is not easily damaged, increasing the density of the skin, ensuring that moisture in the skin is not easily lost, and ensuring that the repairing effect of the skin is better.
3. The composition can be obtained by uniformly mixing the components, is simple and convenient to prepare, and is beneficial to industrial production.
Detailed Description
The present application is described in further detail below with reference to examples.
The sources of the respective raw material components of the following examples, comparative examples and experimental examples are shown in table 1.
TABLE 1
Example 1
A composition for repairing skin after medical arts, comprising the following components by mass:
0.5kg of lactobacillus fermentation lysate; 5kg of Leuconostoc mesenteroides/radish root fermentation product filtrate; 0.3kg of Europe aspen bark extract; 0.01kg of Enteromorpha prolifera extract; 0.1kg of silybum marianum fruit extract; 0.1kg of holy basil leaf extract; 0.1kg of citric acid; 5kg of isopropanol.
A preparation method of a composition for repairing skin after medical arts comprises the following steps:
the components are added into a stirring kettle one by one in sequence, and are fully and uniformly stirred at normal temperature until the components are completely dissolved, so that the composition for repairing skin after medical arts is obtained.
Example 2
A composition for repairing skin after medical arts, comprising the following components by mass:
3kg of lactobacillus fermentation lysate; 3kg of Leuconostoc mesenteroides/radish root fermentation product filtrate; 1kg of Populus tremula bark extract; 0.5kg of Enteromorpha prolifera extract; 0.4kg of silybum marianum fruit extract; 0.3kg of holy basil leaf extract; 0.5kg of citric acid; propylene glycol 2kg.
A preparation method of a composition for repairing skin after medical arts comprises the following steps:
the components are added into a stirring kettle one by one in sequence, and are fully and uniformly stirred at normal temperature until the components are completely dissolved, so that the composition for repairing skin after medical arts is obtained.
Example 3
A composition for repairing skin after medical arts, comprising the following components by mass:
1kg of lactobacillus fermentation lysate; 4.5kg of Leuconostoc mesenteroides/radish root fermentation product filtrate; 0.6kg of Europe aspen bark extract; 0.2kg of Enteromorpha prolifera extract; 0.15kg of silybum marianum fruit extract; 0.05kg of holy basil leaf extract; 0.3kg of citric acid; 3kg of solvent.
In this example, the solvent was homogeneously mixed with propylene glycol and water in a mass ratio of 10:1.
A preparation method of a composition for repairing skin after medical arts comprises the following steps:
the components are added into a stirring kettle one by one in sequence, and are fully and uniformly stirred at normal temperature until the components are completely dissolved, so that the composition for repairing skin after medical arts is obtained.
Example 4
A composition for repairing skin after medical arts, comprising the following components by mass:
2kg of lactobacillus fermentation lysate; 3.5kg of Leuconostoc mesenteroides/radish root fermentation product filtrate; 0.8kg of Europe aspen bark extract; 0.05kg of Enteromorpha prolifera extract; 0.25kg of silybum marianum fruit extract; 0.2kg of holy basil leaf extract; 0.4kg of citric acid; solvent 2.5kg.
In this example, the solvent was homogeneously mixed with propylene glycol and water in a mass ratio of 9:1.
A preparation method of a composition for repairing skin after medical arts comprises the following steps:
the components are added into a stirring kettle one by one in sequence, and are fully and uniformly stirred at normal temperature until the components are completely dissolved, so that the composition for repairing skin after medical arts is obtained.
Example 5
A composition for repairing skin after medical arts, comprising the following components by mass:
1.5kg of lactobacillus fermentation lysate; 4kg of Leuconostoc mesenteroides/radish root fermentation product filtrate; 0.7kg of Europe aspen bark extract; 0.1kg of Enteromorpha prolifera extract; 0.2kg of silybum marianum fruit extract; 0.1kg of holy basil leaf extract; 0.4kg of citric acid; solvent 2.7kg.
In this example, the solvent was homogeneously mixed with propylene glycol and water in a mass ratio of 8:1.
A preparation method of a composition for repairing skin after medical arts comprises the following steps:
the components are added into a stirring kettle one by one in sequence, and are fully and uniformly stirred at normal temperature until the components are completely dissolved, so that the composition for repairing skin after medical arts is obtained.
Comparative example 1
The difference from example 1 is that: equivalent isopropanol was used to replace lactobacillus fermentation lysate, leuconostoc mesenteroides/radish root fermentation product filtrate, and aspen bark extract.
Comparative example 2
The difference from example 1 is that: the equal amount of isopropanol is used for replacing the enteromorpha extract, the silybum marianum fruit extract, the holy basil leaf extract and the citric acid.
Comparative example 3
The difference from example 1 is that: equivalent amounts of isopropanol were used to replace lactobacillus fermentation lysate and holy basil leaf extract.
Comparative example 4
The difference from example 1 is that: the lactobacillus fermentation lysate was replaced with an equal amount of isopropanol.
Comparative example 5
The difference from example 1 is that: the holy basil leaf extract was replaced with an equal amount of isopropanol.
Comparative example 6
The difference from example 1 is that: the enteromorpha extract is replaced by equal amount of isopropanol.
Comparative example 7
The difference from example 1 is that: the lactobacillus fermentation lysate and the holy basil leaf extract were replaced with equal amounts of borneol.
Application examples 1 to 12
An essence containing a composition for medical and artistic skin repair, comprising the following components in mass:
phase A:
5kg of butanediol; 0.1kg of high molecular sodium hyaluronate; 0.05kg of low molecular sodium hyaluronate;
and B phase:
7kg of a composition for repairing skin after medical arts;
87.85kg of water.
Wherein the compositions for post-medical-treatment skin restoration in application examples 1 to 12 are the compositions for post-medical-treatment skin restoration prepared in examples 1 to 5 and comparative examples 1 to 7, respectively.
A process for the preparation of an essence containing a composition for medical post-art skin repair comprising the steps of:
step (1), mixing the components in the phase A and water, and fully stirring uniformly at normal temperature until the components are completely dissolved to form a mixture A;
and (2) adding the B phase into the mixture A, and fully stirring until the B phase is completely dissolved, thus obtaining the essence containing the composition for repairing the skin after medical arts.
Experiment 1
The method comprises the steps of randomly selecting 65 mice, wherein weights are similar, the sex is unlimited, randomly dividing the mice into 13 groups, 5 mice in each group are shaved, the hair removal positions are disinfected, the skin is cut by a disinfectant scalpel in a "#" shape, the incision length is 4cm, the incision interval is 1.5m, the incision depth reaches the muscle layer, then 12 groups are respectively smeared with essence containing the composition for skin repair after medical art, prepared in the application examples 1-12, at the wound position, once daily, the smearing amount is 2g, the stimulus response of the products to the damaged skin is observed, the rest groups are not smeared with any medicine as blank control groups, and the skin conditions of the mice after 24 hours, 48 hours and 72 hours of skin damage are recorded.
The experimental detection data are shown in Table 2.
Experiment 2
The method comprises the steps of taking a white mouse in experiment 1 to shave the back of the right foot, respectively and correspondingly smearing the essence containing the composition for skin repair after medical arts prepared in application examples 1-12 on the shaved parts 10 days before the experiment, and respectively abrading the shaved parts of the back of the right foot of the white mouse with coarse sand paper on the day of the experiment to obtain the hair removing composition with the area of 1cm 2 Until the wound is slightly oozed, the essence containing the composition for skin repair after medical arts prepared in application examples 1-12 is respectively and correspondingly coated on the wound, a blank control group is not coated with any substance, 0.01mg/L of phosphoric acid tissue solution is dripped on the wound surface of the right hind foot of each group of mice after 10min of coating, each mouse is dripped with 0.05mL, the histamine concentration (0.01 mg/L, 0.02mg/L, 0.03mg/L and 0.04mg/L … …) is sequentially increased every 3min, and the total amount (mug/L) of histamine administered by each mouse is recorded until the mice have the head and foot of licking, and the total amount of histamine is taken as a itching threshold.
The experimental detection data are shown in Table 2.
Experiment 3
60 female volunteers with similar wound sizes, just completed the double eyelid-cutting micro plastic surgery, were randomly selected, and the ages of the female volunteers were 18-25 years.
The 60 female volunteers were randomly divided into 12 groups each corresponding to 5 persons, and each group corresponding to the time (day) for complete repair of wound of each group of volunteers using the essence containing the composition for post-medical-art skin repair prepared in application examples 1 to 12 in the morning and evening, 2 times a day, 1g each time.
After the volunteers completely healed, melanin and heme test probes (Mexameter MX 18) of a germany CK functional skin tester MPA9 were used to test the skin normal to the face of the volunteers and the MI value of the sum pigment content of the skin at the wound repair site repaired after medical arts, respectively, wherein the higher the MI value is, the higher the melanin content is.
The experimental detection data are shown in Table 3.
Experiment 4
According to GB/T4256-2011 (cosmetic moisturizing efficacy evaluation guidelines), the moisturizing effect of essence of the composition for repairing skin after medical and artistic treatment, which is prepared correspondingly in application examples 1-12, is detected by the following specific detection method:
the cheek on both sides of the nose wing is selected as a tested area, the moisture content of the skin in the tested area is tested by adopting a skin moisture content tester Corneometer CM825, then 2g of essence containing the composition for repairing skin after medical arts prepared by using application examples 1-12 is respectively and uniformly smeared on the tested area, and the skin moisture content in the tested area after 10min, 30min, 1h, 2h and 4h of the smeared sample is respectively tested.
In order to ensure the accuracy of test data, during the test, the tested area of a tester is required to be incapable of using other skin care products, the ambient temperature is controlled to be 20+/-2 ℃, the ambient humidity is controlled to be 40-60%, and meanwhile, the tester is required to enter a test room to have a rest for 10-20min and then enter the test. The test values are all averages of data for all volunteers in each panel.
The experimental detection data are shown in Table 4.
TABLE 2
Wherein "++" in Table 2 indicates that the damage of the mice is more obvious than congestion and red swelling when the operation is just completed originally; "+" indicates congestion and redness at the broken part of the mice; "+ -" indicates congestion and redness, but the area is smaller than before, and "-" indicates no congestion and redness.
TABLE 3 Table 3
TABLE 4 Table 4
According to the data comparison of application examples 1 and 6 in tables 2, 3 and 4, the lactobacillus fermentation lysate, the leuconostoc mesenteroides/radish root fermentation product filtrate and the Europe populus bark extract are adopted to cooperate with each other, so that the proliferation of fiber cells is better promoted, the skin repair speed is accelerated, and the time for completely repairing and recovering the postoperative wound of a patient is shorter; meanwhile, the mildness of the composition is improved better, so that the wound of a mouse is less prone to congestion and redness; in addition, the moisturizing effect of the composition is better improved, and the skin is better in instant moisturizing and long-acting moisturizing.
According to the data comparison of application examples 1 and 7 in tables 2, 3 and 4, the enteromorpha extract, the silybum marianum extract, the holy basil leaf extract and the citric acid are adopted to cooperatively cooperate, so that the collagen of the skin is better increased, the compactness and smoothness of the skin are improved, the water content of the skin is better improved, and the skin is more moist and elastic; meanwhile, the skin itching relieving composition is beneficial to better relieving dry itching, redness and swelling and allergy of the skin, reducing the irritation of the composition to the skin and better relieving itching, so that the effect of repairing the skin is better realized.
According to the data comparison of application examples 1 and 8-10 in tables 2, 3 and 4, only by employing lactobacillus fermentation lysate and holy basil leaf extract in a specific ratio in cooperation with each other, the antipruritic effect of the composition can be improved better, and the absence of any substance easily has a great influence on the antipruritic effect of the composition. In addition, by combining the data comparison of examples 6-7, the synergy of lactobacillus fermentation lysate, leuconostoc mesenteroides/radix raphani fermentation product filtrate and Europe populus bark extract lacks any component, and the synergistic effect of the lactobacillus fermentation lysate, leuconostoc mesenteroides/radix raphani fermentation product filtrate and Europe populus bark extract is easy to have great influence on the skin repair promotion speed, the mild bacteriostasis and the water supplementing effect of the composition; any substance is absent in the synergism of the Enteromorpha prolifera extract, the Silybum marianum fruit extract and the holy basil leaf extract with citric acid, and the effects of relieving dry itching, redness and swelling and allergy of the composition are also greatly influenced.
According to the MI data comparison of application example 1 and application example 11 in Table 3, the addition of Enteromorpha prolifera extract is beneficial to better reducing melanin of skin, so that scar is less likely to be left after the postoperative wound is completely repaired and healed.
As can be seen from the comparison of the data in Table 2 for application example 1 and application example 12, the antipruritic effect of borneol is superior to that of the composition formed by the synergistic combination of the lactobacillus fermentation lysate and the holy basil leaf extract, but the borneol is liable to cause a relatively large irritation to the skin.
According to the data comparison of application examples 1-5 in tables 2, 3, 4, it is advantageous to improve the mildness of the composition by using propylene glycol as solvent; by adopting the propylene glycol and water to be matched with a specific proportion as the solvent, the solubility of each component in the composition is improved, and the components are better matched with each other, so that the effects of supplementing water, mildly inhibiting bacteria, relieving dry skin, itching, redness, swelling, allergy and the like of the composition are better improved.
The foregoing are all preferred embodiments of the present application, and are not intended to limit the scope of the present application in any way, therefore: all equivalent changes in structure, shape and principle of this application should be covered in the protection scope of this application.
Claims (5)
1. A composition for repairing skin after medical arts, characterized in that: comprises the following components in parts by mass:
1-2 parts of lactobacillus fermentation lysate;
3.5-4.5 parts of Leuconostoc mesenteroides/radish root fermentation product filtrate;
0.6-0.8 part of Europe aspen bark extract;
0.05-0.2 part of enteromorpha extract;
0.15-0.25 parts of silybum marianum fruit extract;
0.05-0.2 parts of holy basil leaf extract;
0.3-0.4 part of citric acid;
2.5-3 parts of solvent;
the solvent is formed by mixing water and propylene glycol in a mass ratio of 7-9:1.
2. A method of preparing the composition for post-medical and artistic skin repair according to claim 1, wherein: and uniformly mixing the components of the composition for repairing skin after medical and artistic treatment to obtain the composition for repairing skin after medical and artistic treatment.
3. Use of a composition for the post-medical-art skin repair according to claim 1, characterized in that: the composition for repairing skin after medical arts is directly added into skin care lotion, essence, emulsion, cream and facial mask.
4. An essence containing the composition for medical and artistic skin repair according to claim 1, characterized in that: comprises the following components in parts by mass:
phase A:
3-6 parts of butanediol;
0.05-0.2 part of high molecular sodium hyaluronate;
0.01-0.1 part of low molecular sodium hyaluronate;
and B phase:
5-10 parts of a composition for repairing skin after medical arts;
the total mass part of the essence containing the composition for repairing skin after medical and artistic treatment is 100 parts, and the balance is water.
5. The essence containing a composition for repairing skin after medical arts according to claim 4, characterized in that: the preparation method of the essence containing the composition for repairing skin after medical arts comprises the following steps:
step (1), mixing the components of the phase A and water, uniformly stirring and completely dissolving to form a phase A composition;
and (2) adding the components of the phase B into the phase A composition, uniformly mixing and completely dissolving to obtain the essence containing the composition for repairing skin after medical and artistic treatment.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109381352A (en) * | 2018-11-15 | 2019-02-26 | 乳源南岭好山好水化妆品有限公司 | A kind of cosmetic composition, preparation method and its spraying |
| CN110893160A (en) * | 2019-12-14 | 2020-03-20 | 广州尚妆优品生物科技有限公司 | Repair composition |
| CN112043667A (en) * | 2020-09-12 | 2020-12-08 | 广州市爱百伊生物技术有限公司 | Composition for moisturizing and maintaining skin barrier, and preparation method and application thereof |
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| CN108210442A (en) * | 2018-02-09 | 2018-06-29 | 广州英格信电子商务有限公司 | Skin care compositions of mild high nutrition and its preparation method and application |
| US11241376B2 (en) * | 2019-07-11 | 2022-02-08 | Zhejiang Kangmanjia Daily Necessities Co., Ltd | Skincare composition containing plant extracts and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109381352A (en) * | 2018-11-15 | 2019-02-26 | 乳源南岭好山好水化妆品有限公司 | A kind of cosmetic composition, preparation method and its spraying |
| CN110893160A (en) * | 2019-12-14 | 2020-03-20 | 广州尚妆优品生物科技有限公司 | Repair composition |
| CN112043667A (en) * | 2020-09-12 | 2020-12-08 | 广州市爱百伊生物技术有限公司 | Composition for moisturizing and maintaining skin barrier, and preparation method and application thereof |
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