CN113081886A - 一种烷基多糖苷固体制剂和制备方法及应用 - Google Patents

一种烷基多糖苷固体制剂和制备方法及应用 Download PDF

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CN113081886A
CN113081886A CN202110407845.2A CN202110407845A CN113081886A CN 113081886 A CN113081886 A CN 113081886A CN 202110407845 A CN202110407845 A CN 202110407845A CN 113081886 A CN113081886 A CN 113081886A
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樊媛媛
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Nanjing Fenchem Biological Technology Co ltd
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Abstract

本发明公开了一种烷基多糖苷固体制剂，包括以下重量百分比原料：烷基多糖苷50‑95％、甘油脂肪酸酯1‑10％、黏合剂10‑75％。本发明一种烷基多糖苷的固体形式。有效含量高，流动性好，颗粒分布均匀，吸水性低。可以十分方便地在固体清洁产品中应用；该固体形式中加入了甘油脂肪酸酯和黏合剂，制备方法使用喷雾干燥的方式，该固体形式为颗粒或粉末，具有活性物含量高、不易吸潮、流动性好且粒径分布均匀的优点。可以直接应用于洁颜粉、洗衣粉、清洁片和固体皂中。

Description

一种烷基多糖苷固体制剂和制备方法及应用
技术领域
本发明涉及烷基多糖苷固体制剂技术领域，具体涉及一种烷基多糖苷固体制剂和制备方法及应用。
背景技术
烷基多糖苷(APG)是一种天然来源的绿色环保的非离子表面活性剂。它是由脂肪醇和葡萄糖脱水聚合而成。市场化的烷基多糖苷为C4-C18烷基多糖苷。烷基多糖苷为液体形式，固含量在45-70％。其主要应用于液体产品中，如洗发水、洗面奶、洗车液，餐具清洗液等。其液体物理形式限制了其在固体产品中的应用，如洁颜粉、洗衣粉、固体皂和清洁片等。
专利CN201710752316.X提出用萃取的方法获得高纯度粉末状烷基糖苷。但需要耗费大量有机溶剂，且产品会存在有机溶剂残留的风险，不符合现代追求环保的趋势。市场上现有的APG固体制剂极易吸潮性，且尚未有烷基糖苷含量大于50％的产品。基于此，需提供一种不易吸潮且有效含量高的烷基多糖苷固体制剂。
发明内容
发明目的：为了克服现有技术中存在的不足，本发明提供一种烷基多糖苷固体制剂和制备方法及应用。
技术方案：为实现上述目的，本发明提供如下技术方案：
一种烷基多糖苷固体制剂，包括以下重量百分比原料：烷基多糖苷50-95％、甘油脂肪酸酯1-10％、黏合剂10-75％。
优选地，所述烷基多糖苷为C4-C18的烷基多糖苷。
优选地，所述黏合剂是硅酸钠、糊精和改性淀粉中的一种或多种组合物；在水溶性方面，硅酸钠比水溶性糊精和改性淀粉具有更快的溶解速度且具有价格优势。
优选地，所述油脂肪酸酯包括C8-C16的甘油脂肪酸单酯、二酯的一种或组合物。
优选地，所述烷基多糖苷固体制剂的活性物含量大于50％。
优选地，所述烷基多糖苷固体制剂的颗粒度为200-500μm。
一种烷基多糖苷固体制剂的制备方法，将烷基多糖苷和黏合剂在60-80℃溶解并混合均匀后，加入甘油脂肪酸酯，进行高压均质，均质次数5-10次，均质压力为400～1200bar，将均质所得液体进行喷雾干燥，即可。
一种烷基多糖苷固体制剂的制备方法，所述喷雾干燥的具体温度为：140-200℃，干燥空气通入量400-800米3/小时。
一种烷基多糖苷固体制剂在洁颜粉、洗衣粉、清洁片、固体清洁剂中的应用。
一种APG固体形式在日化产品中的应用：
洁颜粉，APG粉末10-30％、玉米淀粉10-60％、葡萄糖5-30％。将以上粉体充分混合均匀后加入热敏性辅料(香精)即可。
洗衣粉，APG粉末10-70％、洗涤助剂(碳酸钙)10-35％、金红石5-25％。将APG粉末、洗涤助剂、金红石按配方工艺要求直接充分混合后加入热敏性辅料(香精、蛋白酶)即可。
清洁片，取APG粉末70-95％，加入微晶纤维素(MCC)1-8％，润滑剂微粉硅胶3-10％，混合均匀后直接压片即得。
本发明有益效果如下：
本发明提供一种烷基多糖苷的固体形式。该固体形式中加入了甘油脂肪酸酯和黏合剂，制备方法使用喷雾干燥的方式。具有有效含量高，流动性好，颗粒分布均匀，吸水性低的优点。可以直接应用于洁颜粉、洗衣粉、清洁片和固体皂中。
附图说明
图1烷基糖苷粉末的含量测定GC图谱；
图2烷基糖苷粉末实施例5粒径分布图。
具体实施方式
下面结合附图对本发明作更进一步的说明。
实施例1-8：
一种烷基多糖苷固体制剂，包括以下重量百分比原料：烷基多糖苷50-95％、甘油脂肪酸酯1-10％、黏合剂10-75％。
本实施例的烷基多糖苷为C4-C18的烷基多糖苷。
本实施例的黏合剂是硅酸钠、糊精和改性淀粉中的一种或多种组合物。
本实施例的油脂肪酸酯包括C8-C16的甘油脂肪酸单酯、二酯的一种或组合物。
本实施例的烷基多糖苷固体制剂的活性物含量大于50％。
本实施例的烷基多糖苷固体制剂的颗粒度为200-500μm。
本实施例的一种烷基多糖苷固体制剂的制备方法，将烷基多糖苷和黏合剂在60-80℃溶解并混合均匀后，加入甘油脂肪酸酯，进行高压均质，均质次数5-10次，均质压力为400～1200bar，将均质所得液体进行喷雾干燥，即可。
本实施例的一种烷基多糖苷固体制剂的制备方法，所述喷雾干燥的具体温度为：140-200℃，干燥空气通入量400-800米3/小时。
本实施例的一种烷基多糖苷固体制剂在洁颜粉、洗衣粉、清洁片、固体清洁剂中的应用。
本实施例的一种APG固体形式在日化产品中的应用：
洁颜粉，APG粉末10-30％、玉米淀粉10-60％、葡萄糖5-30％。将以上粉体充分混合均匀后加入热敏性辅料(香精)即可。
洗衣粉，APG粉末10-70％、洗涤助剂(碳酸钙)10-35％、金红石5-25％。将APG粉末、洗涤助剂、金红石按配方工艺要求直接充分混合后加入热敏性辅料(香精、蛋白酶)即可。
清洁片，取APG粉末70-95％，加入微晶纤维素(MCC)1-8％，润滑剂微粉硅胶3-10％，混合均匀后直接压片即得。
APG粉末的制备方法如下：
(1)按表1所述的成分配比将APG和黏合剂在60-80℃下融化并混合均匀；
(2)将甘油脂肪酸酯在60-80℃下融化后抽入乳化锅中，进行高压均质，均质次数5-10次，均质压力为400～1200bar。
(3)将步骤(2)所得液体进行喷雾干燥：温度140-200℃，干燥空气通入量400-800米3/小时。即得。
表1：APG粉末的实施例的配方(wt％)
APG 0814 硅酸钠 GMS
实施例1 55 35 10
实施例2 95 4 1
实施例3 65 31 4
实施例4 72 22 6
实施例5 80 15 5
实施例6 85 11.5 3.5
实施例7 90 8 2
实施例8 80 20 0
APG含量测定
检测方法按《GB/T 19464-2014烷基糖苷》中的GC方法进行检测，以已知含量的APG0810，APG 1214作为对照，按外标法计算实施例和对比例中烷基糖苷的含量。结果如表2显示。
表2：APG粉末的含量检测结果(wt％)
含量
实施例1 39
实施例2 90
实施例3 48
实施例4 56
实施例5 67
实施例6 74
实施例7 82
实施例8 67
对比例(Glucopon50) 48
从表2可以看出，通过喷雾干燥方式，可以获得高含量的APG粉末，方便了使用和运输。
吸潮性测试
将APG粉末在RT:25℃，RH:75-85％的高湿环境下放置90天，分别于0，14，28，54，90天测定水分。检测方法为干燥失重法。取2-4g样品均匀平铺于干燥皿上，105℃至恒重。水分检测结果见表3。
表3：APG粉末的吸潮性检测结果(wt％)
Figure BDA0003023016600000041
从表3可以看出，对比例具有很强的吸水性，不利于产品的贮存。APG粉末的吸水性和粉末中APG的含量成正相关。通过调节甘油脂肪酸酯的比例，能够阻止APG和硅酸钠的吸水性。甘油脂肪酸属于亲油型乳化剂，HLB值小于5。它可以包裹在水相液滴外，阻止粉末从环境中吸潮，防止粉末结块。
从表3还可以看出，实施例4和实施例5在有效含量和吸水性参数中，数据优异。
颗粒分布测定
检测设备：Mastersize 2000。检测标准按《GB/T 19077-2016粒度分布激光衍射法》检测。
实施例5的图谱见图2。
APG固体粉末的应用
温和洁颜粉：将APG粉末10-30％、玉米淀粉10-60％、葡萄糖5-30％充分混合均匀后加入热敏性辅料(香精)即得。
环保洗衣粉：APG粉末10-70％、洗涤助剂(碳酸钙)10-35％、金红石5-25％。将APG粉末、洗涤助剂、金红石按配方工艺要求直接充分混合后加入热敏性辅料(香精、蛋白酶)即可。
环保清洁片：取APG粉末70-95％，加入微晶纤维素(MCC)1-8％，润滑剂微粉硅胶3-10％，混合均匀后直接压片即得。
以上所述仅是本发明的优选实施方式，应当指出：对于本技术领域的普通技术人员来说，在不脱离本发明原理的前提下，还可以做出若干改进和润饰，这些改进和润饰也应视为本发明的保护范围。

Claims (9)

1.一种烷基多糖苷固体制剂，其特征在于，包括以下重量百分比原料：烷基多糖苷50-95％、甘油脂肪酸酯1-10％、黏合剂10-75％。
2.根据权利要求1所述的一种烷基多糖苷固体制剂，其特征在于，所述烷基多糖苷为C4-C18的烷基多糖苷。
3.根据权利要求1所述的一种烷基多糖苷固体制剂，其特征在于，所述黏合剂是硅酸钠、糊精和改性淀粉中的一种或多种组合物。
4.根据权利要求1所述的一种烷基多糖苷固体制剂，其特征在于，所述油脂肪酸酯包括C8-C16的甘油脂肪酸单酯、二酯的一种或组合物。
5.根据权利要求1所述的一种烷基多糖苷固体制剂，其特征在于，所述烷基多糖苷固体制剂的烷基糖苷含量大于50％。
6.根据权利要求1所述的一种烷基多糖苷固体制剂，其特征在于，所述烷基多糖苷固体制剂的颗粒度为200-500μm。
7.一种烷基多糖苷固体制剂的制备方法，其特征在于，将烷基多糖苷和黏合剂在60-80℃溶解并混合均匀后，加入甘油脂肪酸酯，进行高压均质，均质次数5-10次，均质压力为400～1200bar，将均质所得液体进行喷雾干燥，即可。
8.一种烷基多糖苷固体制剂的制备方法，其特征在于，所述喷雾干燥的具体温度为：140-200℃，干燥空气通入量400-800米3/小时。
9.一种烷基多糖苷固体制剂在洁颜粉、洗衣粉、清洁片、固体清洁剂中的应用。
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JP2019214519A (ja) * 2018-06-12 2019-12-19 ロレアル 発泡性組成物
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CN1099411A (zh) * 1994-06-24 1995-03-01 黄德丰 无害洗粉
US20040136940A1 (en) * 2002-10-31 2004-07-15 Virginia Lazarowitz Cleaner compositions
CN107184407A (zh) * 2017-05-24 2017-09-22 昆明贝泰妮生物科技有限公司 一种柔滑保湿造粒洁颜粉及其制备方法
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CN111961540A (zh) * 2020-07-14 2020-11-20 广州浪奇日用品有限公司 一种高效去污型洗衣粉的制备工艺

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