CN113056274A - 具有降低的毒性的杂化两性霉素b衍生物 - Google Patents

具有降低的毒性的杂化两性霉素b衍生物 Download PDF

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Publication number
CN113056274A
CN113056274A CN201980072996.8A CN201980072996A CN113056274A CN 113056274 A CN113056274 A CN 113056274A CN 201980072996 A CN201980072996 A CN 201980072996A CN 113056274 A CN113056274 A CN 113056274A
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China
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compound
alkyl
cycloalkyl
heterocyclyl
group
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Pending
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CN201980072996.8A
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English (en)
Chinese (zh)
Inventor
M·D·伯克
J·张
A·罕德尔瓦尔
A·桑塔马里亚
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University of Illinois System
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University of Illinois System
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Publication of CN113056274A publication Critical patent/CN113056274A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
CN201980072996.8A 2018-09-07 2019-09-06 具有降低的毒性的杂化两性霉素b衍生物 Pending CN113056274A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862728203P 2018-09-07 2018-09-07
US62/728203 2018-09-07
PCT/US2019/049971 WO2020051465A1 (en) 2018-09-07 2019-09-06 Hybrid amphotericin b derivatives with reduced toxicity

Publications (1)

Publication Number Publication Date
CN113056274A true CN113056274A (zh) 2021-06-29

Family

ID=69719049

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980072996.8A Pending CN113056274A (zh) 2018-09-07 2019-09-06 具有降低的毒性的杂化两性霉素b衍生物

Country Status (8)

Country Link
US (1) US11198705B2 (enExample)
EP (1) EP3846823A4 (enExample)
JP (1) JP7477177B2 (enExample)
KR (1) KR102893040B1 (enExample)
CN (1) CN113056274A (enExample)
AU (1) AU2019335409B2 (enExample)
CA (1) CA3111565A1 (enExample)
WO (1) WO2020051465A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113056274A (zh) 2018-09-07 2021-06-29 伊利诺伊大学评议会 具有降低的毒性的杂化两性霉素b衍生物
EP4009984A4 (en) * 2019-08-08 2023-09-06 The Board Of Trustees Of The University Of Illinois HYBRID AMPHOTERICIN B DERIVATIVES WITH REDUCED TOXICITY
AU2021325676A1 (en) * 2020-08-10 2023-03-30 The Board Of Trustees Of The University Of Illinois Hybrid amide derivatives of amphotericin B

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105848721A (zh) * 2013-10-07 2016-08-10 伊利诺伊大学评议会 具有提高的治疗指数的两性霉素b衍生物
WO2016168568A1 (en) * 2015-04-15 2016-10-20 Revolution Medicines, Inc. Derivatives of amphotericin b
CN106414473A (zh) * 2014-06-12 2017-02-15 盐野义制药株式会社 多烯大环内酯衍生物
WO2017100171A1 (en) * 2015-12-08 2017-06-15 Kalyra Pharmaceuticals, Inc. Antifungal compounds and methods

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6543272B2 (ja) 2014-05-16 2019-07-10 ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティ オブ イリノイＴｈｅ Ｂｏａｒｄ Ｏｆ Ｔｒｕｓｔｅｅｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｉｌｌｉｎｏｉｓ 低減された毒性を有するアンホテリシンｂ誘導体
CN113056274A (zh) 2018-09-07 2021-06-29 伊利诺伊大学评议会 具有降低的毒性的杂化两性霉素b衍生物

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105848721A (zh) * 2013-10-07 2016-08-10 伊利诺伊大学评议会 具有提高的治疗指数的两性霉素b衍生物
CN106414473A (zh) * 2014-06-12 2017-02-15 盐野义制药株式会社 多烯大环内酯衍生物
WO2016168568A1 (en) * 2015-04-15 2016-10-20 Revolution Medicines, Inc. Derivatives of amphotericin b
WO2017100171A1 (en) * 2015-12-08 2017-06-15 Kalyra Pharmaceuticals, Inc. Antifungal compounds and methods

Also Published As

Publication number Publication date
AU2019335409B2 (en) 2025-06-05
EP3846823A4 (en) 2022-04-20
EP3846823A1 (en) 2021-07-14
WO2020051465A1 (en) 2020-03-12
JP2021536462A (ja) 2021-12-27
US20200079811A1 (en) 2020-03-12
KR20210064247A (ko) 2021-06-02
US11198705B2 (en) 2021-12-14
CA3111565A1 (en) 2020-03-12
JP7477177B2 (ja) 2024-05-01
AU2019335409A1 (en) 2021-05-06
KR102893040B1 (ko) 2025-11-27

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Application publication date: 20210629

RJ01 Rejection of invention patent application after publication