CN113017370A - Medicinal pillow and preparation and use method thereof - Google Patents
Medicinal pillow and preparation and use method thereof Download PDFInfo
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- CN113017370A CN113017370A CN202110297979.3A CN202110297979A CN113017370A CN 113017370 A CN113017370 A CN 113017370A CN 202110297979 A CN202110297979 A CN 202110297979A CN 113017370 A CN113017370 A CN 113017370A
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- 238000000034 method Methods 0.000 title claims abstract description 24
- 238000002360 preparation method Methods 0.000 title abstract description 13
- 230000008859 change Effects 0.000 claims abstract description 46
- 239000004480 active ingredient Substances 0.000 claims abstract description 45
- 230000000694 effects Effects 0.000 claims abstract description 17
- 238000007789 sealing Methods 0.000 claims abstract description 11
- 239000000047 product Substances 0.000 claims description 80
- 239000000463 material Substances 0.000 claims description 49
- 239000000178 monomer Substances 0.000 claims description 24
- 238000001035 drying Methods 0.000 claims description 23
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims description 21
- 150000001875 compounds Chemical class 0.000 claims description 18
- 238000006116 polymerization reaction Methods 0.000 claims description 18
- 239000002131 composite material Substances 0.000 claims description 17
- 229920000742 Cotton Polymers 0.000 claims description 12
- 239000012467 final product Substances 0.000 claims description 11
- 238000004806 packaging method and process Methods 0.000 claims description 11
- 230000002441 reversible effect Effects 0.000 claims description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 239000000243 solution Substances 0.000 claims description 8
- 239000007864 aqueous solution Substances 0.000 claims description 6
- 238000002844 melting Methods 0.000 claims description 6
- 230000008018 melting Effects 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- 230000004048 modification Effects 0.000 claims description 6
- 238000012986 modification Methods 0.000 claims description 6
- 239000002245 particle Substances 0.000 claims description 6
- 230000001699 photocatalysis Effects 0.000 claims description 6
- 230000035484 reaction time Effects 0.000 claims description 6
- 238000012216 screening Methods 0.000 claims description 6
- 238000002791 soaking Methods 0.000 claims description 6
- 238000010025 steaming Methods 0.000 claims description 6
- 239000004094 surface-active agent Substances 0.000 claims description 6
- 238000009835 boiling Methods 0.000 claims description 5
- 239000012188 paraffin wax Substances 0.000 claims description 5
- 102000004190 Enzymes Human genes 0.000 claims description 4
- 108090000790 Enzymes Proteins 0.000 claims description 4
- 239000000470 constituent Substances 0.000 claims description 3
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- 239000000945 filler Substances 0.000 claims description 2
- 239000007795 chemical reaction product Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 abstract description 23
- 230000000857 drug effect Effects 0.000 abstract description 11
- 208000019901 Anxiety disease Diseases 0.000 abstract description 8
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- 230000036772 blood pressure Effects 0.000 abstract description 8
- 230000008451 emotion Effects 0.000 abstract description 5
- 241000157352 Uncaria Species 0.000 description 11
- 230000000052 comparative effect Effects 0.000 description 10
- 229940079593 drug Drugs 0.000 description 9
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- 238000011049 filling Methods 0.000 description 4
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 3
- 241000411851 herbal medicine Species 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 235000008495 Chrysanthemum leucanthemum Nutrition 0.000 description 2
- 244000035851 Chrysanthemum leucanthemum Species 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 238000009098 adjuvant therapy Methods 0.000 description 2
- 230000001914 calming effect Effects 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 206010010904 Convulsion Diseases 0.000 description 1
- 241000628997 Flos Species 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 208000012902 Nervous system disease Diseases 0.000 description 1
- 206010033557 Palpitations Diseases 0.000 description 1
- 241001107098 Rubiaceae Species 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 description 1
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- 208000002173 dizziness Diseases 0.000 description 1
- 208000002296 eclampsia Diseases 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 208000018997 giddiness Diseases 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- MUVGVMUWMAGNSY-HLKYYGKDSA-N isocorynoxeine Natural products O=C(OC)/C(=C\OC)/[C@@H]1[C@@H](C=C)CN2[C@H]([C@]3(C(=O)Nc4c3cccc4)CC2)C1 MUVGVMUWMAGNSY-HLKYYGKDSA-N 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000007721 medicinal effect Effects 0.000 description 1
- MUVGVMUWMAGNSY-VKCGGMIFSA-N methyl (e)-2-[(3s,6'r,7's,8'as)-6'-ethenyl-2-oxospiro[1h-indole-3,1'-3,5,6,7,8,8a-hexahydro-2h-indolizine]-7'-yl]-3-methoxyprop-2-enoate Chemical compound O=C1NC2=CC=CC=C2[C@@]21CCN1[C@H]2C[C@H](\C(=C/OC)C(=O)OC)[C@@H](C=C)C1 MUVGVMUWMAGNSY-VKCGGMIFSA-N 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
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- 238000004088 simulation Methods 0.000 description 1
- 229940013618 stevioside Drugs 0.000 description 1
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 description 1
- 235000019202 steviosides Nutrition 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A47—FURNITURE; DOMESTIC ARTICLES OR APPLIANCES; COFFEE MILLS; SPICE MILLS; SUCTION CLEANERS IN GENERAL
- A47G—HOUSEHOLD OR TABLE EQUIPMENT
- A47G9/00—Bed-covers; Counterpanes; Travelling rugs; Sleeping rugs; Sleeping bags; Pillows
- A47G9/10—Pillows
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention provides a medicine pillow and a preparation and use method thereof, belonging to the technical field of medicine. The medicated pillow comprises pressure sensitive layer, heat sensitive layer and effective component core; when the pressure sensitive layer and the heat sensitive layer are not subjected to external condition change, the pressure sensitive layer and the heat sensitive layer have a sealing effect on the core of the effective components to prevent the effective components from being lost; when the pressure sensitive layer is subjected to external pressure change, a first gap channel is generated on the pressure sensitive layer; when the temperature of the outside changes, the thermosensitive layer generates a second gap channel; only when external pressure and ambient temperature change simultaneously, the active ingredient through UNICOM the gap passageway one with the release is accomplished to gap passageway two, has solved ordinary medicine pillow drug effect time weak point, short service life problem, changes the problem that frequent use cost is high, has low in use cost, drug effect cycle length, reliable and stable and convenient to carry's characteristics simultaneously, can step down the blood pressure simultaneously, promotes sleep, alleviates bad emotions such as anxiety, fear, depression, has extensive application prospect.
Description
Technical Field
The invention relates to a drug pillow and a preparation and use method thereof, belonging to the technical field of medicine.
Background
Ramulus Uncariae cum uncis is dry stem and branch with hooks of Uncariae cum uncis (Mip. Jacks.) of Rubiaceae, also known as ramulus Uncariae cum uncis and radix Zanthoxyli Avicennae, has effects of clearing heat, calming liver, calming wind and arresting convulsion, and can be used for treating cardiovascular and cerebrovascular and nervous system diseases such as headache, giddiness, hypertension, palpitation, tetany, eclampsia gravidarum, and general numbness, and is proposed as the top product by physicians of all ages. The main effective component of the uncaria is isodehydrorhynchophylline (isocorynoxeine), and the chemical components and the content of representative components of uncaria leaves are monitored and analyzed in recent years, and the uncaria leaves and stem branches with hooks of the uncaria are found to have similar functional components.
Therefore, the uncaria leaves have the similar blood pressure reducing function of uncaria medicinal materials, and the medicine pillow with convenient carrying is prepared for assisting psychological rehabilitation. The inventor finds that the existing medicinal pillow containing uncaria or other medicinal materials has the problems of short medicinal effect time, short service life and high replacement frequency and use cost in the use process.
Disclosure of Invention
In order to solve one or more of the above problems, the present invention provides a medical pillow and a method for preparing and using the same, wherein the medical pillow comprises a filling containing a pressure-sensitive layer, a heat-sensitive layer and an active ingredient core; when the active ingredient core is not subjected to external condition change, the pressure-sensitive layer and the heat-sensitive layer have a sealing effect on the active ingredient core, so that the active ingredient is prevented from being lost; when the pressure sensitive layer is subjected to external pressure change, a first gap channel is generated on the pressure sensitive layer; when the temperature of the outside changes, the heat-sensitive layer generates a second gap channel; and the effective components are released through the communicated first gap channel and the second gap channel only when the external pressure and the external temperature change simultaneously.
The pressure-sensitive layer constituent material includes an acrylate-based compound.
The acrylate-based compound synthetic monomer comprises an acrylate-based monomer; and/or the polymerization mode of the acrylate-based compound is photocatalytic polymerization; and/or the polymerization degree of the acrylate-based compound is 200-5000.
The pressure-sensitive layer generates a gap channel I which is not reversible; the ambient pressure change comprises a pressure increase.
The melting point range of the heat-sensitive layer composition material is 30-40 ℃; and/or the heat-sensitive layer comprises one or more of water-based PEG, paraffin and derivatives thereof and esters.
The temperature-sensitive layer generates a gap channel II which is reversible reaction; the external temperature change comprises temperature rise and temperature drop; when the external temperature rises, the second gap channel appears; when the external temperature is reduced, the second gap channel disappears, and meanwhile, the heat-sensitive layer material is solidified and limited in the range of the pressure-sensitive layer and the effective component core.
A preparation method of a medicated pillow comprises the following steps:
(1) collecting the cut leaves when collecting the medicinal materials, drying in the sun, crushing, screening and selecting 50-200 mesh particles to obtain a product I;
(2) steaming and boiling the first product at the temperature of 100-120 ℃ for 10-20 minutes to remove the enzyme, and drying or airing the first product at the temperature of 50-70 ℃ to obtain a second product;
(3) adding a proper surfactant into the product II in an aqueous solution for modification treatment, wherein the temperature is 50-70 ℃, and the reaction time is 10-20min, so as to obtain a mixed system I of a product III and water;
(4) adding a thermosensitive layer composition material into the mixed system I, fully mixing and reacting, and drying or drying in the sun at 50-70 ℃ to obtain a product IV with the surface covered with the thermosensitive layer composition material;
(5) fully soaking the product IV in 0.01-0.1mol/L pressure-sensitive material monomer dilute solution, taking out the product and placing the product at 500-3000uw/cm2Rotating the ultraviolet lamp to ensure that the pressure-sensitive material monomers on the four outer surfaces of the product are fully reacted to obtain a fifth product;
(6) and bagging the product V in a clean environment to obtain a final product.
The packaging bag comprises a strip shape; and/or the packaging bag material comprises pure cotton gauze.
The preferable size of the long strip shape is 30 cm, 20 cm and 3 cm.
The final product further includes an outer face, the outer face material comprising a conventional cotton pillow towel material.
A medicated pillow can be used alone or in combination with a household common pillow.
The beneficial effects are that:
a medicated pillow and its preparation method solve the problem of short drug action time, short service life, frequent replacement and high cost of use of common medicated pillow, and has the advantages of low cost, long drug action cycle, good stability and reliability, and convenient carrying, and can be used for lowering blood pressure, promoting sleep, and relieving anxiety, fear, depression, etc., and can be used as psychological adjuvant therapy tool.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be described in detail below. It is to be understood that the described embodiments are merely exemplary of the invention, and not restrictive of the full scope of the invention. All other embodiments, which can be derived by a person skilled in the art from the examples given herein without making any creative effort, shall fall within the scope of protection of the present disclosure.
Disclosed herein are a medical pillow and a method for preparing and using the same, wherein the medical pillow has a filling comprising a pressure-sensitive layer, a heat-sensitive layer and an active ingredient core; when the active ingredient core is not subjected to external condition change, the pressure-sensitive layer and the heat-sensitive layer have a sealing effect on the active ingredient core, so that the active ingredient is prevented from being lost; when the pressure sensitive layer is subjected to external pressure change, a first gap channel is generated on the pressure sensitive layer; when the temperature of the outside changes, the heat-sensitive layer generates a second gap channel; and the effective components are released through the communicated first gap channel and the second gap channel only when the external pressure and the external temperature change simultaneously.
The pressure-sensitive layer constituent material includes an acrylate-based compound.
The acrylate-based compound synthetic monomer comprises an acrylate-based monomer; and/or the polymerization mode of the acrylate-based compound is photocatalytic polymerization; and/or the polymerization degree of the acrylate-based compound is 200-5000.
The pressure-sensitive layer generates a gap channel I which is not reversible; the ambient pressure change comprises a pressure increase.
The melting point range of the heat-sensitive layer composition material is 30-40 ℃; and/or the heat-sensitive layer comprises one or more of water-based PEG, paraffin and derivatives thereof and esters.
The temperature-sensitive layer generates a gap channel II which is reversible reaction; the external temperature change comprises temperature rise and temperature drop; when the external temperature rises, the second gap channel appears; and when the external temperature is reduced, the second gap channel disappears.
A preparation method of a medicated pillow comprises the following steps:
(1) collecting the cut leaves when collecting the medicinal materials, drying in the sun, crushing, screening and selecting 50-200 mesh particles to obtain a product I;
(2) steaming and boiling the first product at the temperature of 100-120 ℃ for 10-20 minutes to remove the enzyme, and drying or airing the first product at the temperature of 50-70 ℃ to obtain a second product;
(3) adding a proper surfactant into the product II in an aqueous solution for modification treatment, wherein the temperature is 50-70 ℃, and the reaction time is 10-20min, so as to obtain a mixed system I of a product III and water;
(4) adding a thermosensitive layer composition material into the mixed system I, fully mixing and reacting, and drying or drying in the sun at 50-70 ℃ to obtain a product IV with the surface covered with the thermosensitive layer composition material;
(5) fully soaking the product IV in 0.01-0.1mol/L pressure-sensitive material monomer dilute solution, taking out the product and placing the product at 500-3000uw/cm2Irradiating for 5-100s under a rotating ultraviolet lamp to ensure that the pressure-sensitive material monomers on the four outer surfaces of the product are fully reacted to obtain a fifth product;
(6) and bagging the product V in a clean environment to obtain a final product.
The packaging bag comprises a strip shape; and/or the packaging bag material comprises pure cotton gauze.
The preferable size of the long strip shape is 30 cm, 20 cm and 3 cm.
The final product further includes an outer face, the outer face material comprising a conventional cotton pillow towel material.
A medicated pillow can be used alone or in combination with a household common pillow.
In some alternative embodiments, the filler adopts a three-layer structure of a pressure-sensitive layer, a heat-sensitive layer and an active ingredient core; when the active ingredient core is not subjected to external condition change, the pressure-sensitive layer and the heat-sensitive layer have a sealing effect on the active ingredient core, so that the active ingredient is prevented from being lost; when the pressure sensitive layer is subjected to external pressure change, a first gap channel is generated on the pressure sensitive layer; when the temperature of the outside changes, the heat-sensitive layer generates a second gap channel; and the effective components are released through the communicated first gap channel and the second gap channel only when the external pressure and the external temperature change simultaneously. When a user has a rest, the neck and the head generate pressure on the medicine pillow, and the pressure-sensitive layer generates a first gap channel; meanwhile, the body temperature of a person is conducted to the thermosensitive layer, the thermosensitive material is heated to deform or even melt, and the active ingredient core emits active ingredients. After the human body leaves from contacting the drug pillow, the thermosensitive material is gradually solidified at room temperature, the gap channel II disappears, the effective components of the effective component core are sealed, and meanwhile, the pressure-sensitive layer structure is fixed in the range of the pressure-sensitive layer and the effective component core, so that the next use period can play a role conveniently. The structure and the implementation method ensure that the effective components of the medical pillow are released when a person uses the medical pillow at rest, and avoid the diffusion of the effective components when the medical pillow is not used, thereby prolonging the effective use time and the stability, and solving the problems of short drug effect time, short service life and high replacement frequency and use cost of the common medical pillow.
In some optional embodiments, the medical pillow can be made into a pillow shape, has small volume, has the total weight of not more than 1kg, and is convenient to carry.
In some optional embodiments, the medical pillow disclosed herein can simultaneously reduce blood pressure, promote sleep, relieve anxiety, fear, depression and other adverse emotions in population experiments, and serve as a psychological adjuvant therapy tool.
In order to better prove the beneficial effects, the method for detecting the effective time of the medicine pillow is also disclosed for determining the content change of the effective components in the medicine pillow and further determining the actual use effective period, the used equipment is a high performance liquid chromatography detector, and the content change of the effective substances in the medicine pillow after different time passes is calculated through integration. The specific method is that the filling sample obtained by the medical pillow with the same mass or volume under different conditions is extracted by corresponding organic solvent, and the content is analyzed by a liquid chromatograph after dilution.
Also disclosed is a filled traditional Chinese medicine having similar functions to uncaria, namely wild chrysanthemum flower, the main effective component of which is stevioside, and the medicinal pillow also has the effects of reducing blood pressure, promoting sleep, relieving anxiety, fear and depression, and the like, and has synergistic effect with uncaria.
In some optional embodiments, the drug pillow disclosed herein has advantages of long drug effect time and long service life compared with the similar products without the three-layer structure of the pressure-sensitive layer, the heat-sensitive layer and the effective component core in the detection experiment of the effective time of the drug pillow.
In some alternative embodiments, the medical pillow described herein can have the beneficial effects described above for a variety of herbal remedies and combinations thereof.
Example 1
On the basis of the disclosed embodiments, a medical pillow and a preparation and use method thereof are preferably disclosed, wherein the medical pillow comprises a pressure-sensitive layer, a heat-sensitive layer and an effective component core; when the active ingredient core is not subjected to external condition change, the pressure-sensitive layer and the heat-sensitive layer have a sealing effect on the active ingredient core, so that the active ingredient is prevented from being lost; when the pressure sensitive layer is subjected to external pressure change, a first gap channel is generated on the pressure sensitive layer; when the temperature of the outside changes, the heat-sensitive layer generates a second gap channel; and the effective components are released through the communicated first gap channel and the second gap channel only when the external pressure and the external temperature change simultaneously.
The pressure-sensitive layer is made of methacrylate.
The acrylate-based compound synthetic monomer comprises a methacrylate monomer; and/or the methacrylate polymerization mode is photocatalytic polymerization; and/or, the acrylate-based compound has a polymerization degree of 1000-.
The pressure-sensitive layer generates a gap channel I which is not reversible; the ambient pressure change comprises a pressure increase.
The melting point of the heat-sensitive layer composition material is 35-40 ℃; and/or the thermosensitive layer is made of water-based PEG.
The temperature-sensitive layer generates a gap channel II which is reversible reaction; the external temperature change comprises temperature rise and temperature drop; when the external temperature rises, the second gap channel appears; and when the external temperature is reduced, the second gap channel disappears.
A preparation method of a medicated pillow comprises the following steps:
(1) collecting the cut leaves when collecting the medicinal materials, drying, crushing, screening and selecting 100-mesh and 200-mesh particles to obtain a product I;
(2) steaming and boiling the product I at the high temperature of 100 ℃ for 10 minutes to remove green, and drying or airing at the temperature of 50 ℃ to obtain a product II;
(3) adding a proper surfactant into the product II in an aqueous solution for modification treatment, wherein the temperature is 50 ℃, and the reaction time is 10min, so as to obtain a mixed system I of a product III and water;
(4) adding a thermosensitive layer composition material into the mixed system I, fully mixing and reacting, and drying or drying in the sun at 50 ℃ to obtain a product IV with the surface covered with the thermosensitive layer composition material;
(5) fully soaking the product IV in 0.01mol/L pressure-sensitive material monomer dilute solution, taking out the product and placing the product at 1000uw/cm2Irradiating for 50s under a rotating ultraviolet lamp to ensure that the pressure-sensitive material monomers on the four outer surfaces of the product are fully reacted to obtain a fifth product;
(6) and bagging the product V in a clean environment to obtain a final product.
The packaging bag comprises a strip shape; and/or the packaging bag is made of pure cotton gauze.
The preferable size of the long strip shape is 30 cm, 20 cm and 3 cm.
The final product further includes an outer face, the outer face material comprising a conventional cotton pillow towel material.
A medicated pillow can be used alone or in combination with a household common pillow.
The embodiment adopts a three-layer structure of a pressure-sensitive layer, a heat-sensitive layer and an effective component core; when the active ingredient core is not subjected to external condition change, the pressure-sensitive layer and the heat-sensitive layer have a sealing effect on the active ingredient core, so that the active ingredient is prevented from being lost; when the pressure sensitive layer is subjected to external pressure change, a first gap channel is generated on the pressure sensitive layer; when the temperature of the outside changes, the heat-sensitive layer generates a second gap channel; and the effective components are released through the communicated first gap channel and the second gap channel only when the external pressure and the external temperature change simultaneously. When a user has a rest, the neck and the head generate pressure on the medicine pillow, and the pressure-sensitive layer generates a first gap channel; meanwhile, the body temperature of a person is conducted to the thermosensitive layer, the thermosensitive material is heated to deform or even melt, and the active ingredient core emits active ingredients. After the human body leaves from contacting the drug pillow, the thermosensitive material is gradually solidified at room temperature, the gap channel II disappears, the effective components of the effective component core are sealed, and meanwhile, the pressure-sensitive layer structure is fixed in the range of the pressure-sensitive layer and the effective component core, so that the next use period can play a role conveniently. The structure and the implementation method ensure that the effective components of the medical pillow are released when a person uses the medical pillow at rest, and avoid the diffusion of the effective components when the medical pillow is not used, thereby prolonging the effective use time and the stability, and solving the problems of short drug effect time, short service life and high replacement frequency and use cost of the common medical pillow.
The medical pillow adopts uncaria as an effective component.
The medical pillow can be made into a pillow shape, has small volume, has the total weight of not more than 1kg, and is convenient to carry.
In population experiments, the medical pillow can reduce blood pressure, promote sleep, relieve anxiety, fear, depression and other bad emotions, and is used as a psychological auxiliary treatment tool.
The detection experiment of the effective time of the medical pillow proves that the medical pillow has the advantages of long drug effect time and long service life compared with the similar product without a three-layer structure of a pressure-sensitive layer, a heat-sensitive layer and an effective component core.
The medical pillow has the beneficial effects on various Chinese herbal medicines with treatment effects and combinations thereof.
Example 2
On the basis of the disclosed embodiments, a medical pillow and a preparation and use method thereof are preferably disclosed, wherein the medical pillow comprises a pressure-sensitive layer, a heat-sensitive layer and an effective component core; when the active ingredient core is not subjected to external condition change, the pressure-sensitive layer and the heat-sensitive layer have a sealing effect on the active ingredient core, so that the active ingredient is prevented from being lost; when the pressure sensitive layer is subjected to external pressure change, a first gap channel is generated on the pressure sensitive layer; when the temperature of the outside changes, the heat-sensitive layer generates a second gap channel; and the effective components are released through the communicated first gap channel and the second gap channel only when the external pressure and the external temperature change simultaneously.
The pressure-sensitive layer is made of methacrylic acid acetate.
The acrylate-based compound synthetic monomer comprises a methacrylate acetate monomer; and/or the polymerization mode of the methacrylic acid acetate is photocatalytic polymerization; and/or, the degree of polymerization of the acrylate-based compound is 2000-.
The pressure-sensitive layer generates a gap channel I which is not reversible; the change in ambient pressure is a pressure increase.
The melting point of the heat-sensitive layer composition material is 32-38 ℃; and/or the heat-sensitive layer is made of paraffin.
The temperature-sensitive layer generates a gap channel II which is reversible reaction; the external temperature change comprises temperature rise and temperature drop; when the external temperature rises, the second gap channel appears; and when the external temperature is reduced, the second gap channel disappears.
The medicinal pillow adopts flos Chrysanthemi Indici as effective component.
A preparation method of a medicated pillow comprises the following steps:
(1) collecting the cut leaves when collecting the medicinal materials, drying, crushing, screening and selecting 150-mesh and 200-mesh particles to obtain a product I;
(2) steaming the product I at the high temperature of 120 ℃ for 20 minutes to remove enzyme, and drying or airing at the temperature of 70 ℃ to obtain a product II;
(3) adding a proper surfactant into the product II in an aqueous solution for modification treatment, wherein the temperature is 70 ℃, and the reaction time is 20min to obtain a mixed system I of a product III and water;
(4) adding a thermosensitive layer composition material into the mixed system I, fully mixing and reacting, and drying or drying in the sun at 70 ℃ to obtain a product IV with the surface covered with the thermosensitive layer composition material;
(5) fully soaking the product IV in 0.1mol/L pressure-sensitive material monomer dilute solution, taking out the product and placing the product at 2000uw/cm2Irradiating for 100s under a rotating ultraviolet lamp to ensure that the pressure-sensitive material monomers on the four outer surfaces of the product are fully reacted to obtain a fifth product;
(6) and bagging the product V in a clean environment to obtain a final product.
The packaging bag comprises a strip shape; and/or the packaging bag is made of pure cotton gauze.
The preferable size of the long strip shape is 30 cm, 20 cm and 3 cm.
The final product further includes an outer face, the outer face material comprising a conventional cotton pillow towel material.
A medicated pillow can be used alone or in combination with a household common pillow.
The embodiment adopts a three-layer structure of a pressure-sensitive layer, a heat-sensitive layer and an effective component core; when the active ingredient core is not subjected to external condition change, the pressure-sensitive layer and the heat-sensitive layer have a sealing effect on the active ingredient core, so that the active ingredient is prevented from being lost; when the pressure sensitive layer is subjected to external pressure change, a first gap channel is generated on the pressure sensitive layer; when the temperature of the outside changes, the heat-sensitive layer generates a second gap channel; and the effective components are released through the communicated first gap channel and the second gap channel only when the external pressure and the external temperature change simultaneously. When a user has a rest, the neck and the head generate pressure on the medicine pillow, and the pressure-sensitive layer generates a first gap channel; meanwhile, the body temperature of a person is conducted to the thermosensitive layer, the thermosensitive material is heated to deform or even melt, and the active ingredient core emits active ingredients. After the human body leaves from contacting the drug pillow, the thermosensitive material is gradually solidified at room temperature, the gap channel II disappears, the effective components of the effective component core are sealed, and meanwhile, the pressure-sensitive layer structure is fixed in the range of the pressure-sensitive layer and the effective component core, so that the next use period can play a role conveniently. The structure and the implementation method ensure that the effective components of the medical pillow are released when a person uses the medical pillow at rest, and avoid the diffusion of the effective components when the medical pillow is not used, thereby prolonging the effective use time and the stability, and solving the problems of short drug effect time, short service life and high replacement frequency and use cost of the common medical pillow.
The medical pillow can be made into a pillow shape, has small volume, has the total weight of not more than 1kg, and is convenient to carry.
In population experiments, the medical pillow can reduce blood pressure, promote sleep, relieve anxiety, fear, depression and other bad emotions, and is used as a psychological auxiliary treatment tool.
The detection experiment of the effective time of the medical pillow proves that the medical pillow has the advantages of long drug effect time and long service life compared with the similar product without a three-layer structure of a pressure-sensitive layer, a heat-sensitive layer and an effective component core.
The medical pillow has the beneficial effects on various Chinese herbal medicines with treatment effects and combinations thereof.
Example 3
On the basis of the disclosed embodiments, a medical pillow and a preparation and use method thereof are preferably disclosed, wherein the medical pillow comprises a pressure-sensitive layer, a heat-sensitive layer and an effective component core; when the active ingredient core is not subjected to external condition change, the pressure-sensitive layer and the heat-sensitive layer have a sealing effect on the active ingredient core, so that the active ingredient is prevented from being lost; when the pressure sensitive layer is subjected to external pressure change, a first gap channel is generated on the pressure sensitive layer; when the temperature of the outside changes, the heat-sensitive layer generates a second gap channel; and the effective components are released through the communicated first gap channel and the second gap channel only when the external pressure and the external temperature change simultaneously.
The pressure-sensitive layer is made of methacrylic acid acetate.
The acrylate-based compound synthetic monomer comprises a methacrylate acetate monomer; and/or the polymerization mode of the methacrylic acid acetate is photocatalytic polymerization; and/or, the degree of polymerization of the acrylate-based compound is 2000-3000.
The pressure-sensitive layer generates a gap channel I which is not reversible; the change in ambient pressure is a pressure increase.
The melting point of the heat-sensitive layer composition material is 35-38 ℃; and/or the heat-sensitive layer is made of paraffin.
The temperature-sensitive layer generates a gap channel II which is reversible reaction; the external temperature change comprises temperature rise and temperature drop; when the external temperature rises, the second gap channel appears; and when the external temperature is reduced, the second gap channel disappears.
The medical pillow adopts the mixture of uncaria and wild chrysanthemum as the effective component.
A preparation method of a medicated pillow comprises the following steps:
(1) collecting the cut leaves when collecting the medicinal materials, drying, crushing, screening and selecting 150-mesh and 200-mesh particles to obtain a product I;
(2) steaming and boiling the first product at 110 ℃ for 30 minutes to remove green, and drying or airing at 60 ℃ to obtain a second product;
(3) adding a proper surfactant into the product II in an aqueous solution for modification treatment, wherein the temperature is 70 ℃, and the reaction time is 15min, so as to obtain a mixed system I of a product III and water;
(4) adding a thermosensitive layer composition material into the mixed system I, fully mixing and reacting, and drying or airing at 60 ℃ to obtain a product IV with the surface covered with the thermosensitive layer composition material;
(5) fully soaking the product IV in 0.05mol/L pressure-sensitive material monomer dilute solution, taking out the product and placing the product at 3000uw/cm2Irradiating for 50s under a rotating ultraviolet lamp to ensure that the pressure-sensitive material monomers on the four outer surfaces of the product are fully reacted to obtain a fifth product;
(6) and bagging the product V in a clean environment to obtain a final product.
The packaging bag comprises a strip shape; and/or the packaging bag is made of pure cotton gauze.
The preferable size of the long strip shape is 30 cm, 20 cm and 3 cm.
The final product further includes an outer face, the outer face material comprising a conventional cotton pillow towel material.
A medicated pillow can be used alone or in combination with a household common pillow.
The embodiment adopts a three-layer structure of a pressure-sensitive layer, a heat-sensitive layer and an effective component core; when the active ingredient core is not subjected to external condition change, the pressure-sensitive layer and the heat-sensitive layer have a sealing effect on the active ingredient core, so that the active ingredient is prevented from being lost; when the pressure sensitive layer is subjected to external pressure change, a first gap channel is generated on the pressure sensitive layer; when the temperature of the outside changes, the heat-sensitive layer generates a second gap channel; and the effective components are released through the communicated first gap channel and the second gap channel only when the external pressure and the external temperature change simultaneously. When a user has a rest, the neck and the head generate pressure on the medicine pillow, and the pressure-sensitive layer generates a first gap channel; meanwhile, the body temperature of a person is conducted to the thermosensitive layer, the thermosensitive material is heated to deform or even melt, and the active ingredient core emits active ingredients. After the human body leaves from contacting the drug pillow, the thermosensitive material is gradually solidified at room temperature, the gap channel II disappears, the effective components of the effective component core are sealed, and meanwhile, the pressure-sensitive layer structure is fixed in the range of the pressure-sensitive layer and the effective component core, so that the next use period can play a role conveniently. The structure and the implementation method ensure that the effective components of the medical pillow are released when a person uses the medical pillow at rest, and avoid the diffusion of the effective components when the medical pillow is not used, thereby prolonging the effective use time and the stability, and solving the problems of short drug effect time, short service life and high replacement frequency and use cost of the common medical pillow.
The medical pillow can be made into a pillow shape, has small volume, has the total weight of not more than 1kg, and is convenient to carry.
In population experiments, the medical pillow can reduce blood pressure, promote sleep, relieve anxiety, fear, depression and other bad emotions, and is used as a psychological auxiliary treatment tool.
The detection experiment of the effective time of the medical pillow proves that the medical pillow has the advantages of long drug effect time and long service life compared with the similar product without a three-layer structure of a pressure-sensitive layer, a heat-sensitive layer and an effective component core.
The medical pillow has the beneficial effects on various Chinese herbal medicines with treatment effects and combinations thereof.
Comparative example 1
A medical pillow was prepared by any of the methods disclosed in examples 1-3, wherein ramulus Uncariae cum uncis was used as the effective ingredient, and the outer pressure-sensitive layer and heat-sensitive layer were not prepared, and the rest was the same as in examples 1-3.
Comparative example 2
A medical pillow was prepared by any of the methods disclosed in examples 1-3, wherein ramulus Uncariae cum uncis was used as the effective ingredient, and the outer pressure-sensitive layer was not prepared, and the rest was the same as in examples 1-3.
Comparative example 3
A medical pillow was prepared by any of the methods disclosed in examples 1-3, wherein ramulus Uncariae cum uncis was used as the effective ingredient, and the outer heat-sensitive layer was not prepared, and the rest was the same as in examples 1-3.
Experimental example 1
Selecting the filling components of the medical pillow prepared by the method disclosed in the embodiment 1 and the comparative examples 1-3 to carry out a simulation experiment, and respectively carrying out 8h use and 16h standing for simulating the real use condition of a human; wherein the application method comprises applying 250N external pressure to simulate human head, and heating the pillow at stable temperature of 35 deg.C; removing external pressure during standing, placing at a stable temperature of 25 ℃, and simulating the condition of non-use during standing; the content of the effective components is detected by sampling at 10d, 20d and 30d by using the disclosed detection means, and the final experimental result is as follows:
test results show that the core of the effective component in the comparative example 1 has no external pressure-sensitive layer and heat-sensitive layer, so that the effective substance is quickly dissipated, and most of the medicine pillow is not used and is ineffectively dissipated; comparative example 2 the effective component is lost because the core of the effective component is not supported by the external pressure-sensitive layer, the structure of the heat-sensitive layer flows after being thermally deformed, and the original structure can not be recovered when the heat-sensitive layer is not used, and the function of preventing the effective component from being lost when the heat-sensitive layer is not used can not be realized; comparative example 3 the effective component is lost because the core of the effective component has no external heat-sensitive layer, and the gap channel generated after the external pressure-sensitive layer is used for the first time can not be closed by itself; example 1 the concentration of the active ingredient decreased because the active ingredient was effectively lost in normal use and the rate of decrease was much lower than in comparative examples 1-3, demonstrating that the outer pressure-sensitive and heat-sensitive layers served as effective protection, demonstrating the beneficial effects described above.
Experimental example two
25 volunteers with different degrees of anxiety and insomnia symptoms were selected from example 1 and comparative examples 1 to 3, and were continuously used for 1 month to count the improvement.
The test result shows that the improvement effect of the example 1 is obviously better than that of the comparative examples 1-3, because the sample of the example 1 can be slowly, stably and effectively released, can continuously and effectively exert the drug effect, has the characteristics of stability and high efficiency, and proves the beneficial effect.
It will be understood by those of ordinary skill in the art that the foregoing embodiments are specific examples for carrying out the invention, and that various changes in form and details may be made therein without departing from the spirit and scope of the invention in practice.
Claims (10)
1. A medicated pillow is characterized in that the filler contains a pressure-sensitive layer, a heat-sensitive layer and an active ingredient core; when the active ingredient core is not subjected to external condition change, the pressure-sensitive layer and the heat-sensitive layer have a sealing effect on the active ingredient core, so that the active ingredient is prevented from being lost; when the pressure sensitive layer is subjected to external pressure change, a first gap channel is generated on the pressure sensitive layer; when the temperature of the outside changes, the heat-sensitive layer generates a second gap channel; and the effective components are released through the communicated first gap channel and the second gap channel only when the external pressure and the external temperature change simultaneously.
2. The medical pillow of claim 1, wherein the pressure sensitive layer forming material comprises an acrylate based compound.
3. A medical pillow as recited in claim 2, wherein said acrylate-based compound synthetic monomer comprises an acrylate-based monomer; and/or the polymerization mode of the acrylate-based compound is photocatalytic polymerization; and/or the polymerization degree of the acrylate-based compound is 200-5000.
4. The medical pillow of claim 1, wherein the pressure sensitive layer creates a first non-reversible change in the gap path.
5. The medical pillow of claim 1, wherein the heat sensitive layer constituent material has a melting point in the range of 30-40 ℃; and/or the heat-sensitive layer comprises one or more of water-based PEG, paraffin and derivatives thereof and esters.
6. The medical pillow of claim 1, wherein the second heat sensitive layer is reversibly responsive to the second heat sensitive layer, further comprising: when the external temperature is reduced, the second gap channel disappears, and meanwhile, the heat-sensitive layer material is solidified and limited in the range of the pressure-sensitive layer and the effective component core.
7. A method for preparing the medical pillow of claims 1-6, comprising the steps of:
(1) collecting the cut leaves when collecting the medicinal materials, drying in the sun, crushing, screening and selecting 50-200 mesh particles to obtain a product I;
(2) steaming and boiling the first product at the temperature of 100-120 ℃ for 10-20 minutes to remove the enzyme, and drying or airing the first product at the temperature of 50-70 ℃ to obtain a second product;
(3) adding a proper surfactant into the product II in an aqueous solution for modification treatment, wherein the temperature is 50-70 ℃, and the reaction time is 10-20min, so as to obtain a mixed system I of a product III and water;
(4) adding a thermosensitive layer composition material into the mixed system I, fully mixing and reacting, and drying or drying in the sun at 50-70 ℃ to obtain a product IV with the surface covered with the thermosensitive layer composition material;
(5) fully soaking the product IV in 0.01-0.1mol/L pressure-sensitive material monomer dilute solution, taking out the product and placing the product at 500-3000uw/cm2Rotating the ultraviolet lamp to ensure that the pressure-sensitive material monomers on the four outer surfaces of the product are fully reacted to obtain a fifth product;
(6) and bagging the product V in a clean environment to obtain a final product.
8. The method of making a medical pillow of claim 7, wherein said package comprises a strip shape; and/or the packaging bag material comprises pure cotton gauze; and/or, the end product further comprises an outer face, the outer face material comprising a conventional cotton pillow towel material.
9. The method for preparing the medical pillow as claimed in claim 8, wherein the preferable size of the long strip shape is 30 cm long, 20 cm wide and 3 cm thick.
10. The method of using a medical pillow of claim 1, comprising using the pillow as a pillow alone or in a home pillow.
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Cited By (1)
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| CN116898908A (en) * | 2023-05-10 | 2023-10-20 | 南方医科大学 | Sleep-aiding pillow using Chinese herbal medicine as pillow core filler |
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