CN1306842A - Preparation of shaolin plaster for rheumatism and wound - Google Patents
Preparation of shaolin plaster for rheumatism and wound Download PDFInfo
- Publication number
- CN1306842A CN1306842A CN 00110090 CN00110090A CN1306842A CN 1306842 A CN1306842 A CN 1306842A CN 00110090 CN00110090 CN 00110090 CN 00110090 A CN00110090 A CN 00110090A CN 1306842 A CN1306842 A CN 1306842A
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- China
- Prior art keywords
- radix
- mentholum
- rhizoma
- borneolum syntheticum
- methyl salicylate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Abstract
Disclosed is a plaster prepared through preparation of matrix; preparation of medicine paste with 23 kinds of Chinese medicinal materials including Radix aconiti, Radixlinderae, aconite, rhubarb, etc. by crushing, alcohol extraction, decoction, filtering, concentration, mixing and other steps; mixing matrix and medicinie paste through stirring.
Description
The invention belongs to field of pharmaceutical technology, a kind of specifically Chinese medicine class medicine for external use is the succedaneum of shaolin plaster for rheumatism and wound rubber emplastrum, is the up-to-date dosage form of external plaster.
External-use drug form is mainly based on rubber emplastrum at present.The preparation method of rubber emplastrum generally is:
Rubber is cleaned, 50-60 ℃ of heat drying or dry, be cut into bulk, mastication reticulates thin slice in rubber mixing machine, eliminates static 18-24 hour, be dipped in an amount of gasoline, treat to stir in the rearmounted adhesive supplier of swelling, the back gradation that stirs adds vaseline, lanoline, zinc oxide and Colophonium, add medicine again and stir evenly, be coated with cream.
There are many deficiencies aborning in rubber emplastrum:
1, the high temperature in the production process makes the effective ingredient loss in the mastic bigger, need 100 ℃ of temperature about agent in process of production, so that coating is produced, the Borneolum Syntheticum in the mastic, Mentholum, methyl salicylate and volatile ingredient are lost in about 30-40% behind high temperature after testing.
2, human body skin is easily produced stimulation, cause red swelling of the skin and scratchy, because rubber emplastrum adds viscosifier such as Colophonium in process of production, hold still residual about 6 ‰ the gasoline of rubber emplastrum that the agent method is produced, rosin acid and gasoline can cause stimulation to human body skin, cause allergy, because rubber emplastrum viscosity is stronger, easily cause physical property to pull simultaneously human body skin.
The present invention seeks to disclose a kind of preparation of shaolin plaster for rheumatism and wound.Adopt temperature production, water-soluble high-molecular substance is a substrate, thereby has preserved the biological activity of active substance, and skin is not had any stimulation, owing to added transdermal agent, medicine releasability and transdermal characteristic is strengthened greatly.
Manufacture method of the present invention comprises:
One. modulation substrate: (weight ratio)
Sodium polyacrylate 273g polyvinyl alcohol 50g sodium carboxymethyl cellulose 45g
Gelatin 91g kaolin 364g glycerol 1365g
Oleum Ricini 50g sorbitol 500g Purified Water is an amount of
Two. make up a prescription:
1. write out a prescription: (weight ratio)
Radix Aconiti 16g Radix Linderae 16g Radix Aconiti Kusnezoffii 16g Pseudobulbus Bletillae (Rhizoma Bletillae) 16g
Radix Angelicae Dahuricae 16g Radix Ampelopsis 16g Eupolyphaga Seu Steleophaga 16g Fructus Chaenomelis 16g
Rhizoma sparganic 16g Rhizoma Curcumae 16g Radix Angelicae Sinensis 16g Radix Paeoniae Rubra
Cortex Cinnamomi 16g Radix Et Rhizoma Rhei 32g Fructus Forsythiae 32g Sanguis Draxonis 10g
Olibanum (stir-fry) 6g Myrrha (stir-fry) 6g Radix Notoginseng 6g catechu 6g
Mentholum 8g Borneolum Syntheticum 8g methyl salicylate 8g
2. above 23 flavors, except that Borneolum Syntheticum, Mentholum, methyl salicylate, Sanguis Draxonis, Olibanum, Myrrha, Radix Notoginseng, catechu are ground into coarse powder, and making relative density with 90% ethanol is 1.05 fluid extract,
3. ten five tastes such as all the other Radix Aconiti decoct with water three times, first and second time each 3 hours, and 2 hours for the third time, collecting decoction filtered, and filtrate is concentrated into the thick paste that relative density is 1.25-1.30 (80 ℃).
4. above-mentioned fluid extract merges, and adds Borneolum Syntheticum, Mentholum, methyl salicylate after cooling, and mixing adds in the substrate, stirs, and filters.
5. be coated with cream lid lining, section.
The substrate of shaolin plaster for rheumatism and wound of the present invention is the hydrophilic plaster that a kind of polyethylene oxide and polyacrylic acid slaine are formed, polyethylene oxide and polypropylene have constituted its skeleton, form by certain multistage alcohol in the side, have stable characteristics such as long preservation and combating microorganisms decomposition, chafe not, can prevent the skin alligatoring, because the steam of multistage alcohol forces down, can make lubricant, the flexibility and the stability that have kept plaster, polyacrylic acid slaine and genuine milk fiber derivative have the effect that prevents effective ingredient and moisture evaporation, can improve simultaneously the thermostability of cataplasma, the effect of mouldability and oil preparation dispersibility, hydrophilic polymeies such as polyacrylic acid polymeric metal salt and carboxymethyl cellulose, make the good adhesive performance of its tool, conformality, water-retaining property and guarantor's oiliness, also have and the good characteristics of various ingredient intermiscibilities, can make the effective ingredient of medicine enter subcutaneous tissue slowly, brought into play long lasting effect.
This product is erythroid lamellar water soluble plaster, gas fragrance.The every 100cm paste containing amount of paste containing amount is more than the 4g.
Check:
Get 5 of this product, add the moistening 20ml of the adding diethyl ether supersound process of 60ml ammonia solution 30 minutes, inclining ether extracted liquid, and evaporate to dryness, residue add dehydrated alcohol makes dissolving in right amount, and standardize solution is in the 5ml volumetric flask, as need testing solution.Other gets the aconitine reference substance, adds dehydrated alcohol and makes the solution that every 1ml contains 1mg, in contrast product solution.According to the thin layer chromatography test, draw need testing solution 1ul, reference substance solution 5ul puts respectively on same silica gel g thin-layer plate, is developing solvent with benzene one ethyl acetate, one diethylamine (7: 2: 0.5), launches, and takes out, and dries, and spray is with rare bismuth potassium iodide test solution.In the test sample chromatograph, with reference substance chromatograph relevant position on the speckle that occurs should be less than the speckle of reference substance.
Get 10 of this product, put in the 250ml boiling flask, add water 150ml, connect the volatilization determinator.Add water makes and is full of the scale part from determinator upper end, and overflow is gone into till the flask, add ethyl acetate 5ml again, connect reflux condensing tube, reflux 40 minutes moves to separatory funnel with the liquid in the volatile oil determination apparatus, divides and gets the ethyl acetate layer, filter with the funnel that is covered with anhydrous sodium sulfate, filtrate is product solution in contrast.Other gets Mentholum 8mg and Borneolum Syntheticum 8mg and methyl salicylate 8mg, adds ethanol 10ml solution.According to the gas chromatography test, column length is 2m, is fixative with Polyethylene Glycol (PEG)-20M, and coating concentration is 10%, and column temperature is 130 ℃.Get reference substance solution respectively and need testing solution is an amount of, inject gas chromatograph.Test sample presents the chromatographic peak identical with the reference substance retention time.
Effect of the present invention:
Removing blood stasis and activating blood flow, muscles and tendons relaxing to alleviate pain, expelling wind and cold.Be used for traumatic injury, waist is tingle, abdomen inner accumulated, rheumatalgia.
It is substrate that the present invention all adopts the water-soluble natural macromolecular material, have good cohesiveness, moisture retention and flexibility, these polymer substances are through the chemical reaction of a series of complexity, formed the strong skeleton of a kind of flexible adhesion strength, long-acting is played in release to medicine, low molecule multivalence alcohol wherein is as plasticizer and wetting agent, strengthened affinity to skin, pasting more comfortable, the percutaneous introduction agent that adds, the release property and the transdermal characteristic of medicine are strengthened greatly, reduced stimulation, help the patient and use skin.
Claims (5)
1. preparation of shaolin plaster for rheumatism and wound comprises:
One. modulation substrate: (weight ratio) sodium polyacrylate 273g polyvinyl alcohol 50g sodium carboxymethyl cellulose 45g gelatin 91g kaolin 364g glycerol 1365g Oleum Ricini 50g sorbitol 500g Purified Water is an amount of
Two. make up a prescription:
1. write out a prescription:, (weight ratio) Radix Aconiti 16g Radix Linderae 16g Radix Aconiti Kusnezoffii 16g Pseudobulbus Bletillae (Rhizoma Bletillae) 16g Radix Angelicae Dahuricae 16g Radix Ampelopsis 16g Eupolyphaga Seu Steleophaga 16g Fructus Chaenomelis 16g rhizoma sparganic 16g Rhizoma Curcumae 16g Radix Angelicae Sinensis 16g Radix Paeoniae Rubra Cortex Cinnamomi 16g Radix Et Rhizoma Rhei 32g Fructus Forsythiae 32g Sanguis Draxonis 10g Olibanum, (stir-fry) 6g Myrrha, (stir-fry) 6g Radix Notoginseng 6g catechu 6g Mentholum 8g Borneolum Syntheticum 8g methyl salicylate 8
2. above 23 flavors, except that Borneolum Syntheticum, Mentholum, methyl salicylate, Sanguis Draxonis, Olibanum, Myrrha, Radix Notoginseng, catechu are ground into coarse powder, and making relative density with 90% ethanol is 1.05 fluid extract,
3. ten five tastes such as all the other Radix Aconiti decoct with water three times, first and second time each 3 hours, and 2 hours for the third time, collecting decoction filtered, and filtrate is concentrated into the thick paste that relative density is 1.25-1.30 (80 ℃).
4. above-mentioned fluid extract merges, and adds Borneolum Syntheticum, Mentholum, methyl salicylate after cooling, and mixing adds in the substrate, stirs, and filters.
5. be coated with cream lid lining, section
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 00110090 CN1306842A (en) | 2000-01-27 | 2000-01-27 | Preparation of shaolin plaster for rheumatism and wound |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 00110090 CN1306842A (en) | 2000-01-27 | 2000-01-27 | Preparation of shaolin plaster for rheumatism and wound |
Publications (1)
Publication Number | Publication Date |
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CN1306842A true CN1306842A (en) | 2001-08-08 |
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CN 00110090 Pending CN1306842A (en) | 2000-01-27 | 2000-01-27 | Preparation of shaolin plaster for rheumatism and wound |
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Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100333720C (en) * | 2005-01-11 | 2007-08-29 | 中国人民解放军第二军医大学 | Compound analgesic agent |
CN100387276C (en) * | 2005-12-08 | 2008-05-14 | 高飞 | Bone-activating ointment |
CN100486451C (en) * | 2006-08-18 | 2009-05-13 | 山东师范大学 | Ground beetle sauce and its producing method |
CN103356893A (en) * | 2012-03-27 | 2013-10-23 | 上海卫生材料厂有限公司 | Method for extracting traditional Chinese medicines such as frankincense, myrrh and rhizoma bletillae |
CN104258067A (en) * | 2014-09-12 | 2015-01-07 | 皖南医学院 | Pharmaceutical composition for cataplasm, cataplasm and preparation process of pharmaceutical composition |
CN107737311A (en) * | 2017-12-04 | 2018-02-27 | 安徽金马药业有限公司 | A kind of shaolin plaster for rheumatism and wound medicinal extract extraction production technology code |
CN107952035A (en) * | 2017-12-04 | 2018-04-24 | 安徽金马药业有限公司 | A kind of shaolin plaster for rheumatism and wound and production technology code |
CN116036218A (en) * | 2023-01-06 | 2023-05-02 | 山东省药学科学院 | Shaolin ointment for treating rheumatism and traumatic injury |
CN116196381A (en) * | 2023-01-06 | 2023-06-02 | 山东省药学科学院 | Emulsion for treating rheumatism and traumatic injuries |
-
2000
- 2000-01-27 CN CN 00110090 patent/CN1306842A/en active Pending
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100333720C (en) * | 2005-01-11 | 2007-08-29 | 中国人民解放军第二军医大学 | Compound analgesic agent |
CN100387276C (en) * | 2005-12-08 | 2008-05-14 | 高飞 | Bone-activating ointment |
CN100486451C (en) * | 2006-08-18 | 2009-05-13 | 山东师范大学 | Ground beetle sauce and its producing method |
CN103356893A (en) * | 2012-03-27 | 2013-10-23 | 上海卫生材料厂有限公司 | Method for extracting traditional Chinese medicines such as frankincense, myrrh and rhizoma bletillae |
CN104258067A (en) * | 2014-09-12 | 2015-01-07 | 皖南医学院 | Pharmaceutical composition for cataplasm, cataplasm and preparation process of pharmaceutical composition |
CN104258067B (en) * | 2014-09-12 | 2017-08-29 | 皖南医学院 | It is a kind of for the pharmaceutical composition of cataplasm, cataplasm and its preparation technology |
CN107737311A (en) * | 2017-12-04 | 2018-02-27 | 安徽金马药业有限公司 | A kind of shaolin plaster for rheumatism and wound medicinal extract extraction production technology code |
CN107952035A (en) * | 2017-12-04 | 2018-04-24 | 安徽金马药业有限公司 | A kind of shaolin plaster for rheumatism and wound and production technology code |
CN116036218A (en) * | 2023-01-06 | 2023-05-02 | 山东省药学科学院 | Shaolin ointment for treating rheumatism and traumatic injury |
CN116196381A (en) * | 2023-01-06 | 2023-06-02 | 山东省药学科学院 | Emulsion for treating rheumatism and traumatic injuries |
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