CN113008509A - Blood vessel loading device - Google Patents
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- CN113008509A CN113008509A CN201911328215.5A CN201911328215A CN113008509A CN 113008509 A CN113008509 A CN 113008509A CN 201911328215 A CN201911328215 A CN 201911328215A CN 113008509 A CN113008509 A CN 113008509A
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- G—PHYSICS
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- G01M—TESTING STATIC OR DYNAMIC BALANCE OF MACHINES OR STRUCTURES; TESTING OF STRUCTURES OR APPARATUS, NOT OTHERWISE PROVIDED FOR
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- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
A blood vessel loading device comprises a liquid pump, a liquid storage tank, an electromagnetic valve, a blood vessel loading assembly and a pressure sensor, wherein liquid in the liquid storage tank is pumped by the liquid pump to a blood vessel loaded on the blood vessel loading assembly through the electromagnetic valve and then flows back to the liquid storage tank, and the pressure sensor is arranged at an inlet and an outlet of the blood vessel loading assembly to measure the pressure of the liquid flowing into and out of the blood vessel respectively.
Description
Technical Field
The invention belongs to the field of human organ testing, and particularly relates to a blood vessel loading device.
Background
With the improvement of living standard of people, Cardiovascular and cerebrovascular diseases (CVD) become one of the diseases with the highest death rate all over the world. The pathogenesis of CVD can be clarified by studying the mechanical characteristics of in vivo blood vessels to provide help for diagnosis and treatment of CVD, but at present, no better method is available for realizing in vivo measurement. Therefore, it is desirable to simulate the in-vivo environment by an experimental device, simulate the relevant loading on the mechanical properties of the blood vessel and the blood vessel phantom, and further realize the measurement of the loaded blood vessel and the blood vessel phantom. Furthermore, such a loading device needs to have certain flexibility, mobility and stability, so that the loaded blood vessel sample or the blood vessel phantom simulating the real condition can be placed in a microscope or other testing equipment environment together with the loading device for measurement and characterization.
At present, research methods of tissue engineering blood vessels (also called as artificial blood vessels, which are one kind of blood vessel imitations) and blood vessels placed in stents and the like are underway, and how to simulate the loading conditions of the heart and blood in a human body more truly in an in vitro environment is achieved, so that the development of related research is also a problem in the field of tissue engineering blood vessel research at present.
Disclosure of Invention
In order to solve at least part of the technical problems to a certain extent, the invention provides a blood vessel loading device.
In one aspect, the blood vessel loading device of this application includes liquid pump, reservoir, solenoid valve, blood vessel loading subassembly, pressure sensor, the liquid pump with the liquid in the reservoir flow back to behind the solenoid valve pump sending to the blood vessel of loading in the blood vessel loading subassembly the reservoir, pressure sensor set up in the entry and the export of blood vessel loading subassembly are in order to measure the pressure of the liquid that flows in and flow out the blood vessel respectively.
Optionally, the blood vessel loading device is configured with a main base, the liquid pump, the liquid storage tank and the electromagnetic valve are all detachably and fixedly arranged on the main base, the blood vessel loading device is further configured with a movable base which can be separated from the main base, and the blood vessel loading assembly and the pressure sensor are all detachably and fixedly arranged on the movable base.
Optionally, the device further comprises a hose for connecting the liquid pump, the liquid storage tank, the electromagnetic valve, the blood vessel loading assembly and the pressure sensor, so that the liquid in the liquid storage tank sequentially enters the liquid pump, the electromagnetic valve and the blood vessel loading assembly which are connected by the hose and then flows back to the liquid storage tank.
Optionally, the hose is a transparent fine hose.
Optionally, the bottom of the main base and/or the movable base is provided with a fixing part for installation and fixation.
Optionally, the blood vessel loading assembly comprises a liquid tank and two loading parts, the loading parts are respectively symmetrically sealed and penetrated on two opposite side walls of the liquid tank, the loading parts are provided with a fluid passage, a blood vessel loading part and a hose connecting end, the blood vessel loading part is used for tightly connecting two ends of a blood vessel, so that the excited liquid can be introduced from the outside of the liquid tank to the blood vessel immersed in the liquid tank through the fluid passage of the loading part through the hose connecting end.
Optionally, the loading part comprises a cylindrical loading main body, a cylindrical boss formed at one end of the loading main body, an installation part formed at the top end of the boss, a fastening ring sleeved outside the extension part, and a pressing cap pressing the fastening ring and fastening to the boss, so that blood vessels with different calibers can be sleeved outside the installation part and pressed on the boss by the fastening ring and the pressing cap outside the circumference of the installation part, and the loading part is communicated with the blood vessels in a sealing manner.
In another aspect, the present application also discloses a vessel loading slot comprising:
the tank body is a rectangular solid square tank with an opening at the upper end and a top view section, and is provided with a bottom surface and four vertical side walls, wherein two opposite side walls with smaller area are provided with two coaxial mounting holes with the same aperture,
two cylindrical holders movably inserted into and partially fixed in the mounting holes are formed to include a cylindrical body, a hose connector extending vertically outward along the center of one end face of the body, a blood vessel connector extending vertically outward along the center of the other end face of the body, the cylindrical body having an annular groove on a circumferential surface thereof, an O-ring being disposed in the groove, and a fluid passage extending through the body of the holder, the hose connector, and the blood vessel connector.
Optionally, the vascular access tip is formed as a tapered tip with a taper angle of 0.2 to 0.6.
Optionally, the blood vessel joint is externally sleeved with a tapered rubber ring and a clamping cap for clamping the blood vessel and the rubber ring, and the clamping cap fixes the blood vessel to the blood vessel joint through a buckle, a magnet and/or a thread.
In view of the above, possible benefits of the present application include, but are not limited to: the loading device and the related loading slot can load and load blood vessels with different lengths and calibers in a wider range and realize more reliable loading and loading effects, and the loading device has better mobility and flexibility, can be better installed or fixed on other test equipment or devices, is more convenient for testing after loading and the like.
Drawings
In order to more clearly illustrate the embodiments and/or related technical solutions in the prior art according to the present invention, the following briefly describes the drawings needed to be used in the embodiments and/or related technical solutions in the prior art description, obviously, the drawings in the following description are only some embodiments described in the embodiments according to the present invention, and other drawings can be obtained by those skilled in the art according to the drawings and other possible embodiments without departing from the spirit of the present invention, wherein:
FIG. 1 is a top view of a vascular loading device according to the present invention, showing the main configuration of the vascular loading device according to the present invention;
FIG. 2 is a perspective view of a vascular loading device according to the present invention, showing the main configuration and arrangement and positional relationship of the main components of the vascular loading device according to the present invention;
figure 3 illustrates an assembled perspective view of a vascular loading assembly of a vascular loading device according to the present invention;
FIG. 4 illustrates a block diagram of a loading member of a vascular loading assembly of a vascular loading device in accordance with the present invention;
figures 5A and 5B illustrate a variant embodiment of a loading member of a vascular loading assembly of a vascular loading device in accordance with the present invention;
fig. 6 schematically shows a connection relationship of a blood vessel loading device having a blood vessel three-way joint through which a fiberscope connected to an intravascular OCT system is inserted into a blood vessel to be measured, thereby measuring characteristics of the blood vessel in a loaded state.
Detailed Description
The technical solution of the present invention will be described in detail with reference to the following embodiments and accompanying drawings. The examples set forth herein are specific embodiments of the present invention and are presented only for the purpose of illustrating the concepts of the present invention, and are intended to be illustrative and exemplary and should not be construed as limiting the scope of the invention and the embodiments thereof. In addition to the embodiments described herein, those skilled in the art will be able to employ other alternative embodiments that are obvious based on the disclosure of the claims and their description, including those that employ any obvious substitutions and modifications to the embodiments described herein, all of which are within the scope of the present disclosure. It should be understood that, unless otherwise specified, the following description of the embodiments of the present invention is made for the convenience of understanding, and the description is made in a natural state where the relevant devices, apparatuses, components, etc. are originally still and no external control signal or driving force is given.
Throughout the present disclosure, it should be understood that "blood vessel" refers to blood vessel-like bodies such as real physiological tissues of human body, artificial blood vessels (also called tissue engineering blood vessels) or other animal blood vessels, and its meaning is not limited to the blood vessels of human body; the vascular loading device 10 according to the present invention shown in fig. 1 is similar to a simulated artificial heart, and delivers "blood" carrying pulse waves to the blood vessel to be tested by simulating the operation of the real heart, and the blood or liquid in the present disclosure may be real human blood, animal blood, serum, artificial blood and/or physiological saline and other liquids and mixtures thereof.
Specifically, as shown in fig. 1 and 2, the vascular loading device 10 according to the present invention includes: the blood vessel loading device comprises a liquid pump 101, a liquid storage tank 102, a solenoid valve 103, a blood vessel loading assembly 201, a first pressure sensor 202 and a second pressure sensor 203, wherein the liquid pump 101 conveys liquid in the liquid storage tank 102 to a blood vessel loaded in the blood vessel loading assembly 201 through the solenoid valve 103 and then flows back to the liquid storage tank 102, and the first pressure sensor 202 and the second pressure sensor 203 are connected to a liquid inlet and a liquid outlet at two ends of the blood vessel loading assembly 201 to measure the pressure of the liquid flowing into and out of the blood vessel respectively.
In practice, the liquid pump 101 is connected to the reservoir 102 by means of a transparent fine hose (not shown) commonly used by those skilled in the art to draw the liquid in the reservoir 102 and pump it to the solenoid valve 103 at a certain speed and pressure, the solenoid valve 103 is controlled to be switched on and off at a certain frequency so that the liquid flows out in a pulse flow similar to arterial blood, flows into the first pressure sensor 202 for measuring the inlet pressure of the blood vessel via the transparent fine hose, then flows into the blood vessel loaded in the blood vessel loading assembly 201 via the transparent fine hose for connection to apply pulse wave loading to the blood vessel, flows out of the blood vessel loading assembly 201 after flowing through and loading the blood vessel, then flows into the second pressure sensor 203 for measuring the outlet pressure of the blood vessel via the hose, and then flows back to the reservoir 102 via the hose, the dynamic circulation is carried out, so that the circulative closed-loop continuous loading is realized.
In the present disclosure, the transparent fine flexible tube, also referred to as a "soft thin tube", may be formed of a fine silicone rubber tube, as a medical rubber tube, generally made of two materials, i.e., medical rubber and silicone rubber containing barium sulfate, extruded by a co-extruder, and has better medical properties, so that it is used as a substitute for a capillary vessel in a cardiovascular system for transporting blood or liquid; the advantage of using such transparent tubes is that it facilitates the task of viewing or detecting by optical detection instruments, those devices or components, such as balloons, stents, microscopes, etc., that may be inserted into the tube.
The blood vessel loading device 10 further comprises an industrial control unit (not shown) for controlling the electromagnetic valve 103 and/or the liquid pump 101, wherein the industrial control unit comprises an upper computer and/or a data interface component such as bluetooth, WiFi, USB and the like which can exchange data with external electronic equipment, so that the industrial control unit is connected with the external equipment to realize the operation control of the blood vessel loading device; furthermore, a singlechip can be used as an upper computer, the singlechip is connected with an external mobile phone through a Bluetooth module in the industrial control unit, and application software installed in the mobile phone is used for controlling the liquid pump 101 and the electromagnetic valve 103 and further controlling the frequency of the switch of the electromagnetic valve 103; in order to simulate blood supply to human heart, the switching frequency of the solenoid valve 103 can be controlled at 40 to 180 times/min, preferably 60 to 120 times/min.
Preferably, the liquid pump 101 may be a peristaltic pump, a variable pump or a fixed displacement pump, and the peristaltic pump mainly includes three parts, namely a driver, a pump head and a hose; when the peristaltic pump works, the hose is squeezed by controlling the rotation of the motor, so that liquid flows in the hose at a certain flow rate. The peristaltic pump is like a finger, and the tube cavity is filled with blood by squeezing the air in the hose; and then the blood/fluid is squeezed to have a certain flow rate. In the blood vessel loading device, the liquid pump 101 is similar to the left atrium in a cardiovascular system, provides kinetic energy for the whole loading device, enables blood to circulate in the whole system, can select a peristaltic pump with a fixed range of 30-200 ml/min, and preferably adopts a peristaltic pump with a fixed range of 50-180 ml/min; alternatively, a variable range peristaltic pump, micro-fluid pump, or the like may be used. Since adult systolic pressure is generally 90-139mmHg (12-17kPa) and diastolic pressure is 60-89mmHg (8-11.9kPa), the first pressure sensor 202 of the vascular loading device 10 according to the present invention preferably employs a 5-step accuracy hydraulic pressure sensor with a range of 0-100kPa, which outputs a voltage signal of 0V-12V, preferably a voltage signal of 0V-3.3V.
The reservoir 102 is mainly used for enabling the vascular loading device 10 to realize fluid circulation loading, a fluid pump 101 serving as a power device and an electromagnetic valve 103 serving as one of control devices are connected to two ends or two sides of the vascular loading device through hoses respectively, and the reservoir 102 can be regarded as veins in a cardiovascular system of a human body. In the cardiovascular system, the ventricular blood supply is realized by the opening and closing of an aortic valve and an atrioventricular valve. Thus, the vascular loading device 10 according to the present invention employs the solenoid valve 103 to alternatively simulate an arterial valve and an atrioventricular valve. When the electromagnetic valve 103 is not energized, the valve of the electromagnetic valve 103 is closed, and since the liquid pump 101 is always in the operating state, the pressure of the liquid stored in the hose increases; when the electromagnetic valve 103 is powered on, the valve of the electromagnetic valve 103 is opened, the liquid stored in the hose is released, a pressure fluid with a high flow rate is formed, flows through the hose and loads the pulse wave of the loaded blood vessel to be tested, and a KVE electromagnetic valve (KVE21PS24N2N651) can be selected for controlling the supply flow of the liquid pump 101 to simulate the cardiovascular ejection circulation process.
Further, in order to increase the movability and separability of the blood vessel loading device 10 according to the present invention, thereby facilitating the placement thereof in different measuring devices or under a measuring lens/sensor, the blood vessel loading device 10 is configured with a main base 100 such that a liquid pump 101, a reservoir 102, a solenoid valve 103 are all detachably and fixedly provided on the main base 100, and the blood vessel loading device 10 is further configured with a moving base 200 which is separable from the main base 100; the blood vessel loading assembly 201, the first pressure sensor 202 and the second pressure sensor 203 are all detachably and fixedly arranged on the movable base 200; the main base 100 and the moving base 200 are each made of an aluminum, aluminum alloy and/or stainless material having a small relative magnetic permeability, thereby increasing the weight of the base to reduce the influence of the vibration generated from the liquid pump on the blood vessel and reducing the interference, such as induced eddy current, which the base may generate on the measurement signal, thereby facilitating more accurate measurement of the stent, balloon, etc. built-in other components, which may be made of metal, which may be disposed in the blood vessel by an external measurement apparatus.
As shown in fig. 3, the blood vessel loading assembly 201 of the blood vessel loading device 10 according to the present invention is composed of a loading tank 2011 and two loading components 2022A and 2022B, the reservoir 102 and the loading tank 2011 of the blood vessel loading device 10 are both made of plastic such as polymethyl methacrylate, and the inner wall surfaces of the reservoir 102 and the loading tank 2011 may be coated with a layer of hydrophobic material or hydrophilic material such as teflon, preferably, a layer of super-hydrophilic material or super-hydrophobic material; further, in order to increase the stability and the like of the reservoir 102 and the loading well 2011, the thickness of the side wall thereof should be not less than 2mm, and preferably not less than 10 mm.
Further, the liquid storage tank 102 and the loading tank 2011 are provided with fixing members such as a magnetic suction cup, a vacuum suction cup, a clamping jaw, a fixing wing 2001, and the like at the bottom or the side thereof, so as to increase the fixing reliability, convenience and stability thereof and facilitate the fixing of the blood vessel loading device 10 on other testing devices, test benches or object benches.
In addition, as shown in fig. 3, in order to make the blood vessel loading device 10 according to the present invention have general applicability, so that it can load blood vessels of different forms, different sizes, different materials, different lengths, or the like, the blood vessel loading assembly 201 may be formed to be composed of a loading slot 2011 and two loading parts 2022A and 2022B, the loading assembly 201 is formed as a rectangular square slot with an upper opening as the loading slot 2011, two opposite side walls of the rectangular loading slot 2011 are penetratingly formed with two through holes 2023A and 2023B having substantially the same or similar diameters and facing each other, and the two through holes are preferably coaxially arranged; further, to facilitate loading of the blood vessel, two through holes 2023A and 2023B are formed on two opposite side walls 2011A and 2011B of the loading groove 2011 having a smaller area. The loading part 2022A is inserted and fixed in the through hole 2023A by a frictional force of interference fit and adjusts the insertion distance, and the loading part 2022B is also inserted and fixed in the through hole 2023B by a frictional force of interference fit and adjusts the insertion distance; the thickness of the two side walls 2011A and 2011B should therefore be not less than 2mm, and preferably not less than 10 mm; alternatively, as shown in fig. 3, extensions 228A and 228B for fixing the snap loading parts 2022A and 2022B, respectively, may be provided on the side walls 2011A and 2011B to enhance the fixation between the side walls and the loading parts and to increase the stability and reliability of the distance adjustment between the loading parts.
Further, as shown in fig. 4, the loading part 2022A is formed to include a cylindrical main body 222A, an inner central passage 223A penetrating the entire loading part 2022A along the central axis of the cylindrical main body, a hose connector 224A, a blood vessel connector 225A, an annular seal groove 226A, and an O-ring (not shown) fitted to the annular seal groove 226A; wherein, the outer diameter of the main body 222A and the inner diameter of the through hole 2023A are formed into an interference fit relationship so as to be convenient for being inserted and fixed in the through hole 2023A, and because the main bodies 222A and 222B of the two loading components 2022A and 2022B with the same structure and construction are inserted into the loading groove 2011 through the through holes 2023A and 2023B respectively, the distance between the two opposite vascular connectors 225A and 225B is different, thereby realizing that blood vessels with different lengths can be loaded or clamped and fixed. Although not shown, as a modification of the loading parts 2022A and 2022B of the vascular loading device according to the present invention, two or more parallel annular grooves 226 may be provided on the cylindrical body 222A and/or 222B and two or more corresponding O-rings may be provided, so as to increase the adjustability, stability and sealing property of the distance between the vascular joints 225A and 225B, and so that when the body 222A and/or 222B is fixed in the sidewall of the loading groove 2011, the sealing rings are also located in the sidewall of the loading groove 2011 so as to prevent the liquid in the loading groove 2011 from flowing out through the assembly gap between the loading part 2011 and the through hole 2023, and the surface thereof is textured and the surface roughness of the surface thereof is greater than ra0.2mm. Preferably, the vascular joints 225A and 225B are formed in a tapered or reverse tapered shape, have a taper angle of 0.2 to 0.6, a length of 3mm to 12mm, and have a surface formed with a texture and a surface roughness of more than ra0.2mm.
To facilitate secure mounting of the hose to the hose coupler 224A, the circumferential outer surface of the cylindrical hose coupler 224A is formed with an annular projection 228A to facilitate gripping of the hose tightly to the outer circumferential wall of the hose coupler 224A; similarly, the outer surface of the cylindrical hose coupler 224A is formed with at least one ring of annular protrusions 228A to facilitate a tight snap-fit attachment of the blood vessel to the hose coupler 224A by an interference fit. Preferably, the height of the annular protrusion 228A is 0.1mm to 0.3 mm, and the height of the annular protrusion 228A is 0.1mm to 0.3 mm; further, two or more rings of annular protrusions 228A parallel to each other and having different heights may be provided to accommodate hoses of different calibers, in view of the fact that the protruding length of the hose connector 224A is about 10mm to 20mm and the inner diameter of the hose is 0.5mm to 1.5mm, the distance between the different annular protrusions is preferably 3mm to 10mm, and the height of the protrusion near the cylindrical body 222A is at least 0.5mm, preferably 1mm greater than the annular protrusion near the end of the hose connector 224A.
As a variation of the loading member of the loading unit 201 of the blood vessel loading device 10, the loading member may also be formed as the loading member 30 shown in fig. 5A and 5B, which includes a cylindrical loading body 301, an annular groove 302 formed on the outer surface of the loading body 301, an O-ring (not shown) sleeved on the groove 302, a step-shaped overhanging boss 3011 formed on the insertion end of the loading body 301 for clamping the blood vessel and having screw threads on the outer surface of the boss 3011, a step-shaped overhanging extension port 3012 formed on the end surface of the boss 3011 for engaging with the blood vessel to assist in fixation, an annular tapered rubber ring 3013 sleeved on the periphery of the extension port 3012, the inner wall of the tapered cylindrical rubber ring 3013 being in a shape of a cone and fitting the outer wall of the extension port 3012, the rubber ring 3013 being sleeved on the outer side of the extension port 3012 and then inserted into the blood vessel, since the rubber ring 3013 has a certain elasticity and the rubber ring 3013 is formed to have a diameter at its bottom end which is 1.2 to 2 times as large as the diameter at its top end and thus is sufficient to accommodate insertion of blood vessels of different calibers, the diameter at the top end of the rubber ring 3013 is 2mm to 9mm to accommodate loading of most common blood vessels, preferably 5mm or 6 mm; a pressing cap 303 made of a plastic material is sleeved on the outer side of the upper part of the rubber ring 3013, the surface of the pressing cap is formed to be provided with a fixing conical surface matched with the outer surface of the rubber ring 3013, and an inner thread matched with the outer thread of the boss 3011 is formed on the inner surface of the bottom end of the pressing cap close to the opening; it is easily conceivable that the loading body 301 is internally formed with a through hole along its central axis, so that the blood is fed from the outside of the loading groove 2011 and/or the blood vessel loaded therein via the loading body 301 of the loading assembly 201 to load the blood vessel with carrier liquid. Preferably, the taper angle of the rubber ring is 0.2 to 0.6, the outer surface of the rubber ring is formed with texture structures and/or convex structures, and the surface roughness is more than Ra0.2mm so as to tightly clamp the blood vessel.
Preferably, the main substances known to date to influence the vascular mechanical behaviour are elastin, lipoprotein fibres and smooth muscle. The young's modulus of elastin fiber is small, about 3-6 x 10-dyn/cm, tensile strength is low, the area of stress-strain curve hysteresis loop is small, stress relaxation is not obvious, and it is very close to complete elastomer. The elasticity of blood vessels is mainly provided by elastin fibers. The elastic modulus of the collagen fiber is very high, which can reach 10dyn/cm, and the tensile strength is very high. The hysteresis loop and stress relaxation phenomena are more pronounced than with elastin fibres. Therefore, in order to better fix blood vessels of different types and taken from different living body samples and satisfy safety requirements, it is preferable to prepare the rubber ring 3013 using a perfluoroether rubber (FFKM), and to avoid the influence of permeation, it is preferable to coat a parylene coating on the entire surface of the rubber ring 3013 and to coat a parylene coating, which may have a thickness of 0.5 μm to 2 μm, on the surface or the entire surface of the compression cap 303 pressed against the rubber ring 3013.
As shown in fig. 6, a blood vessel three-way joint 501 may be provided at one end of one of the loading parts, thereby facilitating insertion of a wire, an optical fiber, a lens, a balloon, etc. connected to an external device such as an intravascular OCT system into a blood vessel to measure the performance of the blood vessel under the action of a pulse wave, etc., however, the blood vessel three-way joint 501 may occupy a certain space and have problems of affecting propagation of the pulse wave, time consuming connection, easy leakage of fluid, etc. Although not shown in the drawings, a through inclined hole extending into the inner central passage 223A of the loading part 2022A shown in fig. 4 may be provided on the side wall surface or the outer wall surface of the main body of the loading part 2022A, and a hole plug for blocking the inclined hole may be provided, so as to facilitate insertion of an optical fiber, a lens, a balloon, or the like into the blood vessel to be measured through the inclined hole, thereby saving the space occupied by the blood vessel three-way connector 501, and also facilitating carrying and moving, and increasing the reliability of the whole device.
The drawings in the present specification are schematic views to assist in explaining the concept of the present invention, and schematically show the shapes of respective portions and their mutual relationships. It should be understood that the drawings are not necessarily to scale, the same reference numerals being used to identify the same elements in the drawings in order to clearly show the structure of the elements of the embodiments of the invention. In the description herein, references to the description of the term "one embodiment," "some embodiments," "an illustrative embodiment," "an example," "a specific example," or "some examples" or the like mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples. While embodiments of the invention have been shown and described, it will be understood by those of ordinary skill in the art that: various changes, modifications, substitutions and alterations can be made to the embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the claims and their equivalents.
Claims (10)
1. A blood vessel loading device comprises a liquid pump, a liquid storage tank, an electromagnetic valve, a blood vessel loading assembly and a pressure sensor, wherein liquid in the liquid storage tank is pumped by the liquid pump to a blood vessel loaded on the blood vessel loading assembly through the electromagnetic valve and then flows back to the liquid storage tank, and the pressure sensor is arranged at an inlet and an outlet of the blood vessel loading assembly to measure the pressure of the liquid flowing into and out of the blood vessel respectively.
2. The vascular loading device of claim 1, wherein the vascular loading device is configured with a main base on which the fluid pump, the fluid reservoir, and the solenoid valve are removably secured, and a removable base that is separable from the main base on which the vascular loading assembly and the pressure sensor are removably secured.
3. The vascular loading device of claim 1, further comprising a hose for connecting the fluid pump, the fluid reservoir, the solenoid valve, the vascular loading assembly, and the pressure sensor, such that fluid in the fluid reservoir flows into the fluid pump, the solenoid valve, and the vascular loading assembly connected by the hose in sequence and then flows back to the fluid reservoir.
4. The vascular loading device of claim 3, wherein the flexible tube is a clear fine flexible tube.
5. The vascular loading device of claim 2, wherein the main base and/or the mobile base are provided at the bottom with a fixing portion for mounting and fixing.
6. The vascular loading device of claim 1, wherein the vascular loading assembly comprises a liquid tank and two loading members symmetrically sealed through two opposite side walls of the liquid tank, respectively, the loading members having a fluid passage, a vascular loading portion, and a hose connection end, the vascular loading portion being adapted to tightly engage both ends of a blood vessel such that an energized liquid can be passed from outside the liquid tank through the fluid passage of the loading member via the hose connection end to the blood vessel immersed in the liquid tank.
7. The vessel loading device according to claim 1, wherein the loading member comprises a cylindrical loading body, a cylindrical boss formed at one end of the loading body, an installation part formed at the top end of the boss, a fastening ring sleeved on the outside of the extension part, and a pressing cap pressing the fastening ring and fastening to the boss, so that vessels with different calibers can be sleeved on the outside of the installation part and pressed on the boss by the fastening ring and the pressing cap on the outside of the circumference thereof, thereby realizing sealed communication with the vessels through the loading member.
8. A vessel loading slot comprising: the groove body is a rectangular three-dimensional square groove with an opening at the upper end, and is provided with a bottom surface and four vertical side walls, wherein two opposite side walls with smaller areas are provided with two coaxial mounting holes with the same aperture, two cylindrical clamping pieces which are movably inserted into and partially fixed in the mounting holes are formed to comprise a cylindrical main body, a hose connector and a blood vessel connector, the hose connector extends vertically and outwards along the center of one end face of the main body, the blood vessel connector extends vertically and outwards along the center of the other end face of the main body, the circumferential surface of the cylindrical main body is provided with an annular groove, an O-shaped sealing ring is arranged in the annular groove, and a fluid channel penetrates through the main body, the hose connector and the blood vessel connector of the clamping piece.
9. The loading well of claim 8 wherein said vascular access port is formed as a tapered port having a taper angle of 0.2 to 0.6.
10. The loading slot of claim 8, wherein a tapered rubber ring and a clamping cap for clamping the blood vessel and the rubber ring are sleeved outside the blood vessel joint, and the clamping cap fixes the blood vessel to the blood vessel joint through a buckle, a magnetic attraction and/or a thread.
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| CN201911328215.5A CN113008509A (en) | 2019-12-20 | 2019-12-20 | Blood vessel loading device |
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Citations (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6517354B1 (en) * | 2000-11-17 | 2003-02-11 | David Levy | Medical simulation apparatus and related method |
| JP2005337758A (en) * | 2004-05-24 | 2005-12-08 | Tissue Engineering Initiative Co Ltd | Method and instrument for evaluating compliance of artificial blood vessel |
| US20090123993A1 (en) * | 2005-03-31 | 2009-05-14 | Medtrain Technologies, Llc | Bioreactor for development of blood vessels |
| JP2009254777A (en) * | 2007-07-19 | 2009-11-05 | National Cardiovascular Center | Connection unit and connection construction of artificial blood vessel or blood passage tube |
| US20110080076A1 (en) * | 2009-10-01 | 2011-04-07 | Dvorak Steven G | Drawer containing a sink |
| JP2011177428A (en) * | 2010-03-03 | 2011-09-15 | Mitsubishi Heavy Ind Ltd | Blood vessel connection device of artificial heart pump and artificial heart pump provided with the same |
| CN205822364U (en) * | 2016-06-29 | 2016-12-21 | 朱智仁 | A kind of scalable downcomer |
| US20170000934A1 (en) * | 2013-12-27 | 2017-01-05 | Sun Medical Technology Research Corporation | Artificial-blood-vessel connector and artificial-blood-vessel unit |
| CN206450657U (en) * | 2017-01-13 | 2017-08-29 | 南通纺织丝绸产业技术研究院 | A kind of artificial blood vessel's vivo environment analogue means |
| CN107748128A (en) * | 2017-11-27 | 2018-03-02 | 郑州大学 | The biomechanical property test device and method of a kind of scaffold for vascular tissue engineering |
| CN108051141A (en) * | 2017-12-29 | 2018-05-18 | 四川大学华西医院 | A kind of imitative body of adjustable-pressure ultrasound |
| CN208670112U (en) * | 2018-09-20 | 2019-03-29 | 台州市台升金属制品有限公司 | A kind of pressure-control valve |
| CN110487638A (en) * | 2019-07-10 | 2019-11-22 | 西安交通大学 | A kind of small-sized artificial bionic blood vessel perfusion Fluid pressure test macro and method |
| CN211740557U (en) * | 2019-12-20 | 2020-10-23 | 天津大学 | Blood vessel loading device and blood vessel loading groove |
-
2019
- 2019-12-20 CN CN201911328215.5A patent/CN113008509A/en active Pending
Patent Citations (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6517354B1 (en) * | 2000-11-17 | 2003-02-11 | David Levy | Medical simulation apparatus and related method |
| JP2005337758A (en) * | 2004-05-24 | 2005-12-08 | Tissue Engineering Initiative Co Ltd | Method and instrument for evaluating compliance of artificial blood vessel |
| US20090123993A1 (en) * | 2005-03-31 | 2009-05-14 | Medtrain Technologies, Llc | Bioreactor for development of blood vessels |
| JP2009254777A (en) * | 2007-07-19 | 2009-11-05 | National Cardiovascular Center | Connection unit and connection construction of artificial blood vessel or blood passage tube |
| US20110080076A1 (en) * | 2009-10-01 | 2011-04-07 | Dvorak Steven G | Drawer containing a sink |
| JP2011177428A (en) * | 2010-03-03 | 2011-09-15 | Mitsubishi Heavy Ind Ltd | Blood vessel connection device of artificial heart pump and artificial heart pump provided with the same |
| US20170000934A1 (en) * | 2013-12-27 | 2017-01-05 | Sun Medical Technology Research Corporation | Artificial-blood-vessel connector and artificial-blood-vessel unit |
| CN205822364U (en) * | 2016-06-29 | 2016-12-21 | 朱智仁 | A kind of scalable downcomer |
| CN206450657U (en) * | 2017-01-13 | 2017-08-29 | 南通纺织丝绸产业技术研究院 | A kind of artificial blood vessel's vivo environment analogue means |
| CN107748128A (en) * | 2017-11-27 | 2018-03-02 | 郑州大学 | The biomechanical property test device and method of a kind of scaffold for vascular tissue engineering |
| CN108051141A (en) * | 2017-12-29 | 2018-05-18 | 四川大学华西医院 | A kind of imitative body of adjustable-pressure ultrasound |
| CN208670112U (en) * | 2018-09-20 | 2019-03-29 | 台州市台升金属制品有限公司 | A kind of pressure-control valve |
| CN110487638A (en) * | 2019-07-10 | 2019-11-22 | 西安交通大学 | A kind of small-sized artificial bionic blood vessel perfusion Fluid pressure test macro and method |
| CN211740557U (en) * | 2019-12-20 | 2020-10-23 | 天津大学 | Blood vessel loading device and blood vessel loading groove |
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