CN110487638A - A kind of small-sized artificial bionic blood vessel perfusion Fluid pressure test macro and method - Google Patents
A kind of small-sized artificial bionic blood vessel perfusion Fluid pressure test macro and method Download PDFInfo
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- CN110487638A CN110487638A CN201910622024.3A CN201910622024A CN110487638A CN 110487638 A CN110487638 A CN 110487638A CN 201910622024 A CN201910622024 A CN 201910622024A CN 110487638 A CN110487638 A CN 110487638A
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N3/00—Investigating strength properties of solid materials by application of mechanical stress
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N3/00—Investigating strength properties of solid materials by application of mechanical stress
- G01N3/08—Investigating strength properties of solid materials by application of mechanical stress by applying steady tensile or compressive forces
- G01N3/10—Investigating strength properties of solid materials by application of mechanical stress by applying steady tensile or compressive forces generated by pneumatic or hydraulic pressure
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Abstract
The invention discloses a kind of small-sized artificial bionic blood vessel perfusion Fluid pressure test macro and methods.The test macro includes liquid storage tank and perfusion bioreactor etc.；Tested artificial bionic blood vessel is arranged in perfusion bioreactor, and both ends pass through metal dispensing needle head respectively and are connected with a female Luer；The water sucking mouth of self priming pump is connected with liquid storage bottle, water outlet is divided into two-way by the first ball valve, it is connected to all the way by first pressure transmitter with liquid storage tank, another way is connected to by the second ball valve with the female Luer of tested artificial bionic blood vessel one end, and the female Luer of the tested artificial bionic blood vessel other end is connected to by second pressure transmitter and third ball valve with liquid storage tank.The test method is that test macro sets up a fluid pressure as test pressure, by tested artificial bionic blood vessel access system, test is under set pressure, whether artificial bionic blood vessel is able to maintain completion, phenomena such as destroying, leaking does not occur, this test macro is small in size, and test method and easy to operate.
Description
Technical field
The invention belongs to the crossing domains of mechanical automation and biotechnology and organizational project, and in particular to a kind of small-sized people
Make bionical blood vessel perfusion Fluid pressure test macro and method.
Background technique
With the development of biology manufacture and organizational project, artificial implantable is expected to be used for the substitution of tissue and repairs
It is multiple.Blood pressure is usually utilized to the body of assessment patient as one of the important parameter for being clinically used for monitoring human vital sign
Situation.And with the development of Biotechnology and tissue engineering technique, the biological bionical blood vessel of 3D printing artificial hollow is expected to answer
For clinic, the replacement to patient vessel is realized by transplanting.Therefore it needs to test artificial bionic blood by effective test method
The Fluid pressure size that can be born in pipe, the blood pressure for judging that whether it can bear with human body native blood vessel match.However, logical at present
The bionical blood vessel structure internal diameter for crossing 3D printing manufacture is smaller (being less than 200-1000 μm), is difficult to test using common test method
Its liquid perfusion pressure.Although although the invasive blood pressure detection method on traditional clinical can fill the liquid of artificial bionic blood vessel
Flowing pressure measures and verifies the availability of artificial bionic blood vessel, but since its equipment is expensive, bulky, structure and behaviour
Make the reasons such as complexity, be not particularly suited in laboratory environment to the quick test of the artificial blood vessel perfusion pressure of small size and divide
Analysis uses.
Summary of the invention
In order to solve the test problem of artificial bionic blood vessel perfusion pressure in above-mentioned laboratory, the present invention provides a kind of small
Type artificial bionic blood vessel perfusion Fluid pressure test macro and method.
The present invention adopts the following technical scheme that realize:
A kind of small-sized artificial bionic vascular fluid pressure testing system, including liquid storage tank, self priming pump, perfusion bioreactor
With tested artificial bionic blood vessel；Wherein,
Tested artificial bionic blood vessel is arranged in perfusion bioreactor, and both ends pass through metal dispensing needle head and one respectively
Female Luer is connected；The water sucking mouth of self priming pump is connected with liquid storage bottle, and water outlet is divided into two-way, a-road-through by the first ball valve
It crosses first pressure transmitter to be connected to liquid storage tank, another way is connect by the second ball valve and Rule of tested artificial bionic blood vessel one end
Head connection, the female Luer for being tested the artificial bionic blood vessel other end are connected by second pressure transmitter and third ball valve and liquid storage tank
It is logical.
A further improvement of the present invention lies in that perfusion bioreactor uses Chinese patent application, Publication No.
The bioreactor of CN201610347545.9.
A further improvement of the present invention lies in that two pressure transmitters are all made of digital pressure transducer.
A further improvement of the present invention lies in that the water outlet of self priming pump is divided into two by the first ball valve and three-way connection
Road.
A further improvement of the present invention lies in that the pipeline in the test macro is all made of transparent/translucent hose.
A further improvement of the present invention lies in that tested artificial bionic blood vessel uses configured medium viscosity sodium alginate soln
And calcium chloride solution, it is squeezed out by syringe pump and Coaxial nozzle, two solution crosslink reaction, form hollow gel pipe knot
Structure；Wherein sodium alginate hemolytic concentration is 2%-4% (w/v), and calcium chloride solution concentration is 4% (w/v), injection pump discharge difference
For 1ml/min and 1.5ml/ml, Coaxial nozzle 19G/26G, spray head movement speed is 10-15mm/s.
A kind of small-sized artificial bionic vascular fluid method for testing pressure, the test method are based on above-mentioned kind of small-sized artificial bionic
Vascular fluid pressure testing system, comprising the following steps:
1) being filled with calcium chloride solution concentration before starting test, in liquid storage tank is 4% (w/v), and calcium chloride solution accounts for storage
The 1/2-2/3 of liquid pool volume, self priming pump power off, and show that reading is 0Kpa on pressure transmitter, and the second ball valve is in close state,
First ball valve and third ball valve are in the open state；
2) when starting test, self priming pump is powered, and adjusts test pressure by adjusting the first ball valve, adjusting makes pressure transmitter
Display registration is 12Kpa, corresponding 90mmHg, hydraulic excessive to prevent, and is directly broken after entering tested artificial bionic blood vessel
It is bad；After pressure setting, opening the second ball valve makes liquid enter tested artificial bionic blood vessel, and flows through third ball valve in liquid again
After be turned off, to exclude air in pipeline；It is tested the intravascular fluid of artificial bionic at this time to remain static, wherein static
Readings are consistent shown by fluid pressure size and second pressure transmitter；
3) continue to adjust the first ball valve to adjust tested artificial bionic blood vessel fluid pressure.
The present invention has following beneficial technical effect:
A kind of small-sized artificial bionic blood vessel perfusion Fluid pressure test macro provided by the invention, including device for storing liquid, pressure
Force generating apparatus, pressure-regulating device, pressure-display device, bionical blood pipe fixing device and tested artificial bionic blood vessel six
Point, it is connected by using three-way connection with transparent/translucent hose.Small in size, the operating process letter of test of the test macro
It is single, solve the problems, such as that the artificial bionic blood vessel fluid pressure produced is difficult to carry out experiment indoor test.Wherein, self priming pump
Outlet fluid setting pressure is set up by a ball valve, and set pressure is observed by pressure transmitter.
A kind of small-sized artificial bionic blood vessel perfusion Fluid pressure test method provided by the invention, is adjusted in Fluid pressure
And after stablizing, there is closed state to be changed into open state, and fluid warp to be had by the ball valve before tested artificial bionic blood vessel
After crossing artificial bionic blood vessel, it is tested person that the ball valve after making tested artificial bionic blood vessel is in off state by open state transformation
It makes bionical blood vessel and one static fluid pressure environment is provided, and is intravascular to artificial bionic is tested at this time by pressure transmitter
Fluid pressure be read out.If artificial bionic blood vessel proves that artificial bionic is intravascular at this time there is no damaged or seepage flow
This setting pressure can be born, and can be by adjusting self priming pump exit ball valve to change setting Fluid pressure.If artificial bionic
Angiogenesis breakage or seepage flow then prove that artificial bionic is intravascular at this time and are not subject to this setting pressure.
In conclusion a kind of small-sized artificial bionic blood vessel perfusion Fluid pressure test macro provided by the invention and method,
Test macro is small in size, and occupied area is few；Using this test macro, the stable Fluid pressure after overregulating, test is being set
Whether artificial bionic blood vessel can bear under pressure, this test method is simple to operation, and the test macro is small in size, solve
The artificial bionic blood vessel fluid pressure produced is difficult to the problem of carrying out experiment indoor test.
Detailed description of the invention
Fig. 1 is the schematic diagram of small-sized artificial bionic vascular pressure test macro.
Fig. 2 is equipment pipeline connecting figure used by small-sized artificial bionic vascular pressure test macro.
Description of symbols:
1. liquid storage bottle, 2. self priming pumps, 3. first pressure transmitters, 4. first ball valves, 5. second ball valves, 6. female Luers,
7. metal needle head of adhesive dispenser, 8. perfusion bioreactors, 9. tested artificial bionic blood vessels, 10. second pressure transmitters, 11. 3
Pass joint, 12. third ball valves.
Specific embodiment
Below in conjunction with attached drawing, the present invention is further described in detail.
As depicted in figs. 1 and 2, a kind of small-sized artificial bionic vascular fluid pressure testing system provided by the invention, including
Liquid storage tank 1, self priming pump 2, perfusion bioreactor 8 and tested artificial bionic blood vessel 9.
In Fig. 2, it is tested artificial bionic blood vessel 9 and uses configured medium viscosity sodium alginate soln and calcium chloride solution,
It is squeezed out by syringe pump and Coaxial nozzle, two solution crosslink reaction, form hollow gel pipe structure.Wherein sodium alginate is molten
Blood concentration is 2%-4% (w/v), and calcium chloride solution concentration is 4% (w/v), and injection pump discharge is respectively 1ml/min and 1.5ml/
Ml, Coaxial nozzle 19G/26G, spray head movement speed are 10-15mm/s.
Tested artificial bionic blood vessel 9 is connected using two 23G metal needle head of adhesive dispenser 7, and is connected with two female Luers 6
It connects, is fixed on perfusion bioreactor 8 and accesses test macro.The water sucking mouth of self priming pump 2 is connected with liquid storage bottle 1, water outlet
Divided by the first ball valve 4 and three-way connection 11 for two-way, is connected to all the way by first pressure transmitter 3 with liquid storage tank 1, it is another
Road is connected to by the second ball valve 5 with the female Luer 6 of tested 9 one end of artificial bionic blood vessel, and 9 other end of artificial bionic blood vessel is tested
Female Luer 6 be connected to by second pressure transmitter 10 and third ball valve 12 with liquid storage tank 1.All components are placed on a light
It learns on plate, keeps its relatively fixed by bolt.
Wherein, the first ball valve 4 is by setting up the Fluid pressure at tested artificial bionic blood vessel, and then tests artificial bionic blood
Whether pipe can not occur to destroy, leak etc. under the pressure of setting.First pressure transmitter 3 be connected to the first ball valve 4 to
Among the pipeline of liquid storage bottle 1, for observing test macro fluid set pressure.Second ball valve 5 is connected to the first ball valve 4 and is connected
Three-way connection 11 after, for preventing fluid from entering tested artificial bionic blood vessel before the setting of test macro Fluid pressure
9, it plays a protective role.Tested artificial bionic blood vessel 9 is connected to two metal needle head of adhesive dispenser 7, and it is anti-to be mounted on biological perfusion
It answers on device 8, and is connect respectively with two metal needle head of adhesive dispenser 7, separately by one end of two female Luers 6 by screw thread
One end is connect by transition fit with hose.One of those is connected by hose with the second ball valve 5 for two female Luers 6, separately
One female Luer 6 is connected by hose and three-way connection with second pressure transmitter 10 and third ball valve 12；Wherein second
Pressure transmitter 10 is used to show the fluid pressure value in test process.12 one end of third ball valve passes through hose and female Luer 6
And second pressure transmitter 10 connects, and the other end is connected by hose with liquid storage bottle 1, for draining in pipeline after air,
Fluid is prevented to return to liquid storage bottle 1.
A kind of small-sized artificial bionic blood vessel perfusion Fluid pressure test method provided by the invention, including the following contents:
Before test, the first ball valve 4 and the second ball valve 5 are closed, third ball valve 12 is opened, and first pressure transmitter 3 is given
It is powered with second pressure transmitter 10.When starting test, self priming pump 2 is powered, while adjusting the first ball valve 4, makes first pressure
The registration of transmitter 3 is 12KPa (90mmHg).It is after pressure stabilisation, the second ball valve 5 is opened, seeing has liquid to flow through third ball valve
After 12, third ball valve 12 is closed, to drain the air in pipeline.Pipeline no liquid stream locating for second pressure transmitter 10 at this time
Dynamic, pressure and the registration of first pressure transmitter 3 are almost the same, for the pressure value of setting.Observe set pressure value at this moment
Under, whether tested artificial bionic blood vessel occurs phenomena such as destroying or leaking.Further, if being tested artificial bionic blood under this pressure
Pipe then proves that artificial bionic blood vessel can bear pressure at this time without defective mode, can continue to adjust the first ball valve 4, make to adjust
Constant-pressure is raised and lowered；If being tested artificial bionic blood vessel under set pressure phenomena such as damaged or leakage occurs, prove
Artificial bionic blood vessel cannot bear pressure at this time.Before test macro state reduction can extremely being tested, and the quilt more renewed
Artificial bionic blood vessel is surveyed, after setting pressure is turned down by the first ball valve 4, re-starts test.
Claims (7)
1. a kind of small-sized artificial bionic vascular fluid pressure testing system, which is characterized in that including liquid storage tank (1), self priming pump
(2), perfusion bioreactor (8) and tested artificial bionic blood vessel (9)；Wherein,
In perfusion bioreactor (8), both ends pass through metal dispensing needle head (7) respectively for tested artificial bionic blood vessel (9) setting
It is connected with a female Luer (6)；The water sucking mouth of self priming pump (2) is connected with liquid storage bottle (1), and water outlet passes through the first ball valve
(4) be divided into two-way, be connected to liquid storage tank (1) by first pressure transmitter (3) all the way, another way pass through the second ball valve (5) and
Female Luer (6) connection of tested artificial bionic blood vessel (9) one end, is tested the female Luer of artificial bionic blood vessel (9) other end
(6) it is connected to by second pressure transmitter (10) and third ball valve (12) with liquid storage tank (1).
2. a kind of small-sized artificial bionic vascular fluid pressure testing system according to claim 1, which is characterized in that perfusion
Bioreactor (8) uses Chinese patent application, the bioreactor of Publication No. CN201610347545.9.
3. a kind of small-sized artificial bionic vascular fluid pressure testing system according to claim 1, which is characterized in that two
Pressure transmitter is all made of digital pressure transducer.
4. a kind of small-sized artificial bionic vascular fluid pressure testing system according to claim 1, which is characterized in that self-priming
The water outlet of pump (2) is divided into two-way by the first ball valve (4) and three-way connection (11).
5. a kind of small-sized artificial bionic vascular fluid pressure testing system according to claim 1, which is characterized in that the survey
Pipeline in test system is all made of transparent/translucent hose.
6. a kind of small-sized artificial bionic vascular fluid pressure testing system according to claim 1, which is characterized in that tested
Artificial bionic blood vessel (9) uses configured medium viscosity sodium alginate soln and calcium chloride solution, by syringe pump and coaxially
Spray head squeezes out, and two solution crosslink reaction, forms hollow gel pipe structure；Wherein sodium alginate hemolytic concentration is 2%-4%
(w/v), calcium chloride solution concentration is 4% (w/v), and injection pump discharge is respectively 1ml/min and 1.5ml/ml, and Coaxial nozzle is
19G/26G, spray head movement speed are 10-15mm/s.
7. a kind of small-sized artificial bionic vascular fluid method for testing pressure, which is characterized in that the test method is based on claim 1
To a kind of small-sized artificial bionic vascular fluid pressure testing system described in any one of 6, comprising the following steps:
1) being filled with calcium chloride solution concentration before starting test, in liquid storage tank (1) is 4% (w/v), and calcium chloride solution accounts for liquid storage
The 1/2-2/3 of pond (1) volume, self priming pump (2) power off, and reading is shown on pressure transmitter (3) for 0Kpa, at the second ball valve (5)
In closed state, the first ball valve (4) and third ball valve (12) are in the open state；
2) when starting test, self priming pump (2) is powered, and adjusts test pressure by adjusting the first ball valve (4), adjusting makes pressure inverting
Device (3) shows that registration is 12Kpa, and corresponding 90mmHg is hydraulic excessive to prevent, straight afterwards entering tested artificial bionic blood vessel (9)
It connects and is destroyed；After pressure setting, opening the second ball valve (5) enters liquid tested artificial bionic blood vessel (9), and in liquid again
Body is turned off after flowing through third ball valve (12), to exclude air in pipeline；It is tested at artificial bionic blood vessel (9) interior fluid at this time
In stationary state, wherein readings are consistent shown by static fluid pressure size and second pressure transmitter (10)；
3) continue to adjust the first ball valve (4) to adjust tested artificial bionic blood vessel (9) fluid pressure.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113008509A (en) * | 2019-12-20 | 2021-06-22 | 天津大学 | Blood vessel loading device |
| US11109973B2 (en) | 2020-01-15 | 2021-09-07 | Biomedical Device Consultants and Laboratories of Colorado, LLC | System for evaluation of prosthetic heart valves under steady hydrodynamic conditions |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113008509A (en) * | 2019-12-20 | 2021-06-22 | 天津大学 | Blood vessel loading device |
| US11109973B2 (en) | 2020-01-15 | 2021-09-07 | Biomedical Device Consultants and Laboratories of Colorado, LLC | System for evaluation of prosthetic heart valves under steady hydrodynamic conditions |
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