CN216647635U - Arteriovenous blood vessel circulation simulating system - Google Patents
Arteriovenous blood vessel circulation simulating system Download PDFInfo
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- CN216647635U CN216647635U CN202123168398.4U CN202123168398U CN216647635U CN 216647635 U CN216647635 U CN 216647635U CN 202123168398 U CN202123168398 U CN 202123168398U CN 216647635 U CN216647635 U CN 216647635U
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- hose
- arteriovenous
- peristaltic pump
- circulatory system
- thrombus
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Abstract
The utility model discloses an arteriovenous blood vessel circulation simulating system, which comprises: one end of the hose is communicated with the liquid inlet end of the peristaltic pump, and the other end of the hose is communicated with the liquid outlet end of the peristaltic pump; at least one tee fitting connected in series with the hose; a one-way valve connected in series to the hose; the constant-temperature water bath box is internally preset with physiological saline so as to soak the hose; and the inside of the hose is preset with the bovine whole blood thrombus and the bionic blood. The system can simulate a human body static/arterial system, can visually implement absorption, dissolution, filtration, capture test and demonstration of thrombus, is extremely close to the real situation of a living body, and greatly facilitates scientific research and teaching.
Description
Technical Field
The utility model relates to the technical field of medical instruments, in particular to an arteriovenous blood vessel circulation simulating system.
Background
French patent document FR3086089a1 describes an artificial thrombus device composed of agar and xanthan gum that mimics the physical properties of a human thrombus that can be used to simulate the operation of a medical thrombectomy device. But the composition ratio and preparation mode of agar and xanthan gum are lacked, and the artificial thrombus is far away from the physical, chemical and biological characteristics of real thrombus in human body or animal body, and the aim is to establish a container for simply containing the artificial thrombus.
The isolated thrombolysis simulator discussed in taiwan patent document TWM272507U uses thrombofibrin and natto extract as a thrombus simulator in a channel. The characteristics of the simulant are relatively close to those of a real thrombus, but the simulant is lack of a preparation method, and the mixed natto extract deviates from the real components of a human body and cannot be dissolved by the thrombolytic agent, so that the simulant can deviate from the experimental results of a model.
In particular, the expected design environment of many nerve and peripheral vessel interventional products is the environment with salt at about 37 ℃ of human body temperature, and the design characteristics of many materials all play a role in the environment, for example, the physical characteristics of nickel-titanium alloy materials are very different at 37 ℃ and 20 ℃, including the friction and flexibility of some high polymer materials are very different. Therefore, the simulated thrombus and environment in vitro should be as close as possible to the real environment and characteristics in vivo.
Therefore, it is necessary to provide a simulated arteriovenous thrombosis and vascular circulatory system to solve the above problems.
SUMMERY OF THE UTILITY MODEL
In order to achieve the purpose, the utility model provides the following technical scheme: an arteriovenous thrombosis and vascular circulatory system mimicking comprising:
one end of the hose is communicated with the liquid inlet end of the peristaltic pump, and the other end of the hose is communicated with the liquid outlet end of the peristaltic pump;
at least one tee fitting connected in series with the hose;
a one-way valve connected in series to the hose; and
the constant-temperature water bath box is internally preset with physiological saline so as to soak the hose;
and the inside of the hose is preset with the bovine whole blood thrombus and the bionic blood.
Further, preferably, the hose is used for simulating a blood vessel and is made of a polymer material.
Further, preferably, the polymer material includes PTFE, FEP, and silicone rubber.
Further, preferably, the inner diameter of the hose is 0.5 to 20mm, and the wall thickness is 0.1 to 3 mm.
Further, preferably, the hose is composed of a plurality of segments, each segment being connected by a hose connector.
Further, it is preferable that the check valve allows a one-way flow after the fluid reaches a rated pressure, and the pressure of the fluid flowing into the check valve is adjusted by adjusting the pump speed of the peristaltic pump.
Further, preferably, an artificial vascular valve is also placed in the flexible tube to mimic the condition of a vein in a living body.
Further, preferably, the flexible tube is provided with a plurality of branches connected in series or in parallel from the peristaltic pump to the one-way valve so as to simulate the arterial system of the human body.
Further, preferably, the hose is provided with a plurality of branches connected in series or in parallel from the one-way valve to the peristaltic pump so as to simulate the venous system of a human body.
Further, preferably, the constant temperature water bath tank can maintain a constant temperature of 37 ℃.
Compared with the prior art, the utility model provides an arteriovenous thrombosis and vascular circulatory system simulation agent, which has the following beneficial effects:
1. the embodiment of the utility model provides a preparation method and a process of in-vitro simulated thrombus, and the preparation method and the process have the characteristics of low operation difficulty, convenient acquisition of raw materials and instrument equipment, simple operation, low cost and the like;
2. in the embodiment of the utility model, in the thrombus preparation method, bovine blood is selected, the thrombus model is highly matched with the biochemical characteristics of the real thrombus, the influence on the data of the absorption, dissolution, filtration, capture and other tests of the thrombus is extremely small, and the data is highly close to the real condition of a living body during the test;
3. in the embodiment of the utility model, the preparation method of the bovine thrombus can be carried out to the conditions of human beings, simians, sheep, rabbits and the like by analogy, and in-vitro thrombus experimental models of other mammals are established;
4. the embodiment of the utility model provides an arteriovenous thrombus and blood vessel circulatory system simulation device, which can simulate a human body venous/arterial system, can visually implement thrombus absorption, dissolution, filtration, capture test and demonstration, is extremely close to the real situation of a living body, and greatly facilitates scientific research and teaching.
Drawings
FIG. 1 is a schematic overall view of an arteriovenous vascular-like circulatory system;
FIG. 2 is a schematic diagram of the preparation of fresh anticoagulated bovine whole blood;
FIG. 3 is a schematic illustration of the preparation of a bovine whole blood thrombus;
FIG. 4 is a schematic diagram of the preparation of frozen fresh anticoagulated bovine whole blood plasma;
in the figure: 1. bovine whole blood thrombus; 2. a three-way joint; 3. a hose; 4. simulating blood and flow direction thereof; 5. a peristaltic pump; 6. a one-way valve; 7.7% physiological saline; 8. a constant temperature water bath tank; 9. the inlet of the three-way joint.
Detailed Description
The first embodiment is as follows: referring to fig. 1, the present invention provides an arteriovenous vascular-simulated circulatory system, comprising:
one end of the hose 3 is communicated with the liquid inlet end of the peristaltic pump 5, and the other end of the hose is communicated with the liquid outlet end of the peristaltic pump 5;
at least one three-way joint 2 connected in series to the flexible tube 3, providing an inlet for the thrombus;
a one-way valve 6 connected in series to the hose 3; and
a constant temperature water bath tank 8, in which a physiological saline 7 is preset so as to soak the hose 3;
and, the inside of the hose 3 is preset with the bovine whole blood thrombus and the bionic blood which can be 0.7% physiological saline or a mixed solution of 0.7% physiological saline and fresh anticoagulated bovine whole blood plasma.
In this embodiment, the flexible tube 3 is used for simulating a blood vessel and is made of a polymer material, and the polymer material includes PTFE, FEP, and silica gel; the inner diameter of the hose 3 is 0.5-20mm, and the wall thickness is 0.1-3 mm; the hose 3 is made up of multiple sections, each section being connected by a hose connector.
As a preferred embodiment, the check valve 6 allows the fluid to flow in one direction after reaching a rated pressure, and adjusts the pressure of the fluid flowing into the check valve by adjusting the pumping speed of the peristaltic pump, and when reaching the rated pressure, the check valve opens to allow the fluid to flow through the check valve, and the addition of the check valve can further enable the system to approach the venous/arterial circulation system in the human body, i.e. the peristaltic pump flows to the check valve with a high pressure section at a section, and approaches the artery of the human body, and the check valve flows back to the peristaltic pump with a low pressure section, and has a slow flow rate, and approaches the vein of the human body.
As a preferred embodiment, an artificial blood vessel valve is further placed in the flexible tube 3 for simulating the situation of veins in a living body, and the artificial blood vessel valve is an existing medical device and will not be described herein again.
In this embodiment, a plurality of branches are connected in series or in parallel in the hose 3 from the peristaltic pump to the one-way valve to simulate the arterial system of a human body; a plurality of branches are connected in series or in parallel in the hose 3 from the one-way valve to the peristaltic pump so as to simulate the venous system of a human body; the constant temperature water bath box 8 can keep constant temperature of 37 ℃.
During the experiment, can be through the three way connection entry 9 leading-in apparatus that is close to the thrombus, absorb, dissolve, filter, catch thrombus/bionical blood, also can carry out the experiment operation to thrombus/bionical blood outside the hose.
Example two: referring to fig. 2 to 4, for the preparation of in vitro simulated thrombus:
1. preparation of blood preservation solution: is prepared from 0.8% citric acid, 2.2% sodium citrate, 2.45% glucose and sterilized water.
2. Preparation of fresh anticoagulated bovine whole blood: as shown in figure 2 of the drawings, in which,
mixing fresh bovine whole blood and blood preservation solution, wherein the ratio of the fresh bovine whole blood to the blood preservation solution is 86:14 (V/V), uniformly mixing, and storing in a refrigerator at 4 ℃ at the amount of 50 ml/test tube for refrigeration.
3. Preparing the bovine whole blood thrombus: as shown in the figure 3 of the drawings,
a clean 2.0ml centrifuge tube is added with 33ul of 5% calcium chloride solution (equivalent to 1.11mg of calcium chloride), then fresh anticoagulated bovine whole blood stored in a refrigerator at 4 ℃ is taken out and gently mixed, 1ml of blood sample is sucked by a pipette and added into the centrifuge tube, and the mixture is gently blown and beaten to be mixed evenly. Meanwhile, a soft spring can be placed in the centrifuge tube, the soft spring needs to be completely immersed in blood, and then the centrifuge tube is placed in a 37 ℃ constant temperature water bath for 3 hours to prepare the bovine whole blood thrombus.
The soft spring can be made of 3 series stainless steel round wires or nickel-titanium alloy round wires, the wire diameter is 0.05-0.2mm, and the spring pitch is 0.1-5 mm. The outer diameter of the spring is similar to the inner diameter of the hose in the vein/artery blood vessel circulation simulating system during the test, so that the spring can conveniently drive the thrombus to be supported on the vessel wall for fixation.
And when the thrombus is implanted, the whole bovine blood thrombus can enter the cavity of the hose through the inlet 9 of the three-way joint, and is pushed to a target position by the spring in the thrombus supported by the round-head guide wire and supported on the wall of the hose.
4. Preparation of fresh anticoagulated bovine whole blood frozen plasma: as shown in fig. 4
Fresh anticoagulated bovine whole blood is subjected to low-temperature low-speed centrifugation (1000g,15min) within 6h after blood collection to obtain blood plasma, the blood plasma is rapidly frozen at the temperature below minus 30 ℃, and then the blood plasma is stored at the temperature of minus 20 ℃ for refrigeration.
Preparing a mixed solution of 0.7% physiological saline and fresh anticoagulated bovine whole blood plasma: adding fresh frozen plasma of anticoagulated cattle and normal saline in a ratio of 1:1 into a container, and preserving in a water bath at the constant temperature of 37 ℃.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered as the technical solutions and the inventive concepts of the present invention within the technical scope of the present invention.
Claims (10)
1. An arteriovenous blood vessel circulation simulating system is characterized in that: the method comprises the following steps:
one end of the hose (3) is communicated with the liquid inlet end of the peristaltic pump (5), and the other end of the hose is communicated with the liquid outlet end of the peristaltic pump (5);
at least one tee coupling (2) connected in series to the hose (3);
a one-way valve (6) connected in series to the hose (3); and
a constant temperature water bath tank (8) which is internally preset with physiological saline (7) so as to soak the hose (3);
and the soft tube (3) is internally preset with the bovine whole blood thrombus and the bionic blood.
2. The arteriovenous vascular circulatory system of claim 1, wherein: the hose (3) is used for simulating blood vessels and is made of high polymer materials.
3. The arteriovenous vascular circulatory system of claim 2 wherein: the high polymer material comprises PTFE, FEP and silica gel.
4. The arteriovenous vascular circulatory system of claim 1, wherein: the inner diameter of the hose (3) is 0.5-20mm, and the wall thickness is 0.1-3 mm.
5. The arteriovenous vascular circulatory system of claim 1, wherein: the hose (3) is composed of a plurality of sections, and each section is connected by a hose connector.
6. The arteriovenous vascular circulatory system of claim 1, wherein: the one-way valve (6) allows one-way flow after the fluid reaches the rated pressure, and the pressure of the fluid flowing into the one-way valve is adjusted by adjusting the pump speed of the peristaltic pump.
7. The arteriovenous vascular circulatory system of claim 1, wherein: an artificial vascular valve is also placed in the flexible tube (3) and is used for simulating the condition of veins in a living body.
8. The arteriovenous vascular circulatory system of claim 1, wherein: a plurality of branches are connected in series or in parallel in the hose (3) from the peristaltic pump to the one-way valve so as to simulate the arterial system of a human body.
9. The arteriovenous vascular circulatory system of claim 1, wherein: a plurality of branches are connected in series or in parallel in the hose (3) from the one-way valve to the peristaltic pump so as to simulate the venous system of a human body.
10. The arteriovenous vascular circulation-like system of claim 1, wherein: the constant-temperature water bath box (8) can keep a constant temperature of 37 ℃.
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| CN202123168398.4U CN216647635U (en) | 2021-12-16 | 2021-12-16 | Arteriovenous blood vessel circulation simulating system |
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| CN202123168398.4U CN216647635U (en) | 2021-12-16 | 2021-12-16 | Arteriovenous blood vessel circulation simulating system |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115672431A (en) * | 2022-10-18 | 2023-02-03 | 哈尔滨工业大学（威海） | Extracorporeal circulation and intraluminal intervention isolated blood vessel constant temperature auxiliary device |
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2021
- 2021-12-16 CN CN202123168398.4U patent/CN216647635U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115672431A (en) * | 2022-10-18 | 2023-02-03 | 哈尔滨工业大学（威海） | Extracorporeal circulation and intraluminal intervention isolated blood vessel constant temperature auxiliary device |
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