CN110487638B - Small artificial bionic vascular perfusion fluid pressure testing system and method - Google Patents
Small artificial bionic vascular perfusion fluid pressure testing system and method Download PDFInfo
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- CN110487638B CN110487638B CN201910622024.3A CN201910622024A CN110487638B CN 110487638 B CN110487638 B CN 110487638B CN 201910622024 A CN201910622024 A CN 201910622024A CN 110487638 B CN110487638 B CN 110487638B
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- 239000011664 nicotinic acid Substances 0.000 title claims abstract description 86
- 238000012360 testing method Methods 0.000 title claims abstract description 52
- 239000012530 fluid Substances 0.000 title claims abstract description 38
- 230000010412 perfusion Effects 0.000 title claims abstract description 23
- 238000000034 method Methods 0.000 title abstract description 10
- 230000002792 vascular Effects 0.000 title description 4
- 210000004204 blood vessel Anatomy 0.000 claims abstract description 85
- 239000007788 liquid Substances 0.000 claims abstract description 40
- 238000003860 storage Methods 0.000 claims abstract description 26
- 208000001848 dysentery Diseases 0.000 claims abstract description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 9
- 229910052751 metal Inorganic materials 0.000 claims abstract description 7
- 239000002184 metal Substances 0.000 claims abstract description 7
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 12
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 8
- 235000010413 sodium alginate Nutrition 0.000 claims description 8
- 239000000661 sodium alginate Substances 0.000 claims description 8
- 229940005550 sodium alginate Drugs 0.000 claims description 8
- 239000000243 solution Substances 0.000 claims description 8
- 238000002347 injection Methods 0.000 claims description 6
- 239000007924 injection Substances 0.000 claims description 6
- 239000007921 spray Substances 0.000 claims description 6
- 230000003068 static effect Effects 0.000 claims description 5
- 238000010998 test method Methods 0.000 claims description 4
- 206010018910 Haemolysis Diseases 0.000 claims description 3
- 238000004132 cross linking Methods 0.000 claims description 3
- 230000008588 hemolysis Effects 0.000 claims description 3
- 108010010803 Gelatin Proteins 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 239000008273 gelatin Substances 0.000 claims 1
- 229920000159 gelatin Polymers 0.000 claims 1
- 235000019322 gelatine Nutrition 0.000 claims 1
- 235000011852 gelatine desserts Nutrition 0.000 claims 1
- 230000036772 blood pressure Effects 0.000 description 3
- 239000003292 glue Substances 0.000 description 3
- 238000010146 3D printing Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 1
- 239000002473 artificial blood Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N3/00—Investigating strength properties of solid materials by application of mechanical stress
- G01N3/02—Details
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N3/00—Investigating strength properties of solid materials by application of mechanical stress
- G01N3/08—Investigating strength properties of solid materials by application of mechanical stress by applying steady tensile or compressive forces
- G01N3/10—Investigating strength properties of solid materials by application of mechanical stress by applying steady tensile or compressive forces generated by pneumatic or hydraulic pressure
- G01N3/12—Pressure testing
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Abstract
The invention discloses a system and a method for testing perfusion fluid pressure of a small artificial bionic blood vessel. The test system comprises a liquid storage tank, a perfusion bioreactor and the like; the artificial bionic blood vessel to be tested is arranged in the perfusion bioreactor, and two ends of the artificial bionic blood vessel are respectively connected with a Ruhr joint through metal dispensing needles; the water suction port of the self-priming pump is communicated with a liquid storage bottle, the water outlet is divided into two paths through a first ball valve, one path is communicated with the liquid storage tank through a first pressure transmitter, the other path is communicated with a Ruhr joint at one end of the tested artificial bionic blood vessel through a second ball valve, and the Ruhr joint at the other end of the tested artificial bionic blood vessel is communicated with the liquid storage tank through a second pressure transmitter and a third ball valve. The testing method comprises the steps of setting a liquid pressure as a testing pressure for the testing system, connecting the tested artificial bionic blood vessel to the testing system, testing whether the artificial bionic blood vessel can be kept to be finished under the set pressure, and avoiding the phenomena of damage, leakage and the like.
Description
Technical Field
The invention belongs to the crossing field of mechanical automation, biotechnology and tissue engineering, and particularly relates to a small artificial bionic vascular perfusion fluid pressure testing system and method.
Background
With the development of bio-fabrication and tissue engineering, artificial implantable articles are expected to be used for the replacement and repair of human tissues. Blood pressure, one of the important parameters clinically used to monitor vital signs of a human body, is often used to assess the physical condition of a patient. With the development of biological manufacturing technology and tissue engineering technology, the biological 3D printing artificial hollow bionic blood vessel is expected to be applied to clinic, and the blood vessel of a patient is replaced by transplantation. Therefore, the fluid pressure in the artificial bionic blood vessel needs to be tested by an effective test method to judge whether the pressure is matched with the blood pressure which can be borne by the blood vessel of the human body. However, the inner diameter of the bionic blood vessel structure manufactured by 3D printing is smaller (less than 200-. Although the traditional clinical invasive blood pressure detection method can measure and verify the usability of the artificial bionic blood vessel, the method is not suitable for the rapid test and analysis of the small-sized artificial blood vessel perfusion pressure in the laboratory environment due to the expensive equipment, the large volume, the complex structure and operation and the like.
Disclosure of Invention
In order to solve the problem of testing the artificial bionic blood vessel perfusion pressure in the laboratory, the invention provides a small artificial bionic blood vessel perfusion fluid pressure testing system and method.
The invention is realized by adopting the following technical scheme:
a small artificial bionic blood vessel fluid pressure test system comprises a liquid storage bottle, a self-priming pump, a perfusion bioreactor and a tested artificial bionic blood vessel; wherein,
the artificial bionic blood vessel to be tested is arranged in the perfusion bioreactor, and two ends of the artificial bionic blood vessel are respectively connected with a Ruhr joint through metal dispensing needles; the water suction port of the self-priming pump is communicated with the liquid storage bottle, the water outlet is divided into two paths through the first ball valve, one path is communicated with the liquid storage bottle through the first pressure transmitter, the other path is communicated with the Ruhr joint at one end of the tested artificial bionic blood vessel through the second ball valve, and the Ruhr joint at the other end of the tested artificial bionic blood vessel is communicated with the liquid storage bottle through the second pressure transmitter and the third ball valve.
The invention is further improved in that the perfusion bioreactor adopts a bioreactor of Chinese patent application with publication number CN 201610347545.9.
The invention is further improved in that the two pressure transmitters are digital display pressure transmitters.
The invention has the further improvement that the water outlet of the self-priming pump is divided into two paths through the first ball valve and the three-way joint.
The invention is further improved in that the pipelines in the test system are all transparent/semitransparent hoses.
The invention has the further improvement that the artificial bionic blood vessel to be tested uses the prepared sodium alginate solution with medium viscosity and calcium chloride solution, and the sodium alginate solution and the calcium chloride solution are extruded out by an injection pump and a coaxial nozzle, and the two solutions generate cross-linking reaction to form a hollow gel tube structure; wherein the hemolysis concentration of the sodium alginate is 2-4% (w/v), the concentration of the calcium chloride solution is 4% (w/v), the flow rates of the injection pumps are 1ml/min and 1.5ml/ml respectively, the coaxial spray head is 19G/26G, and the moving speed of the spray head is 10-15 mm/s.
A small artificial bionic blood vessel fluid pressure test method is based on the small artificial bionic blood vessel fluid pressure test system and comprises the following steps:
1) before the test is started, the calcium chloride solution with the concentration of 4% (w/v) is filled in the liquid storage bottle, the calcium chloride solution accounts for 1/2-2/3 of the volume of the liquid storage bottle, the self-priming pump is powered off, the reading displayed on the first pressure transmitter is 0Kpa, the second ball valve is in a closed state, and the first ball valve and the third ball valve are in an open state;
2) when the test is started, the self-priming pump is electrified, the test pressure is adjusted by adjusting the first ball valve, and the adjustment enables the first pressure transmitter to display a reading of 12Kpa corresponding to 90mmHg so as to prevent overlarge hydraulic pressure and directly damage the artificial bionic blood vessel after entering the artificial bionic blood vessel to be tested; after the pressure is set, the second ball valve is opened to enable the liquid to enter the tested artificial bionic blood vessel, and the liquid is closed after flowing through the third ball valve to discharge air in the pipeline; at the moment, the fluid in the artificial bionic blood vessel to be tested is in a static state, wherein the pressure of the static liquid is consistent with the reading displayed by the second pressure transmitter;
3) and continuously adjusting the first ball valve to adjust the pressure of the fluid in the artificial bionic blood vessel to be detected.
The invention has the following beneficial technical effects:
the invention provides a small artificial bionic blood vessel perfusion fluid pressure test system which comprises a liquid storage device, a pressure generation device, a pressure regulation device, a pressure display device, a bionic blood vessel fixing device and a tested artificial bionic blood vessel, wherein the liquid storage device, the pressure generation device, the pressure regulation device, the pressure display device, the bionic blood vessel fixing device and the tested artificial bionic blood vessel are connected through a three-way joint and a transparent/semitransparent hose. The test system has small volume and simple test operation process, and solves the problem that the pressure of the fluid in the manufactured artificial bionic blood vessel is difficult to carry out the test in a laboratory. The outlet fluid of the self-priming pump is used for adjusting the set pressure through a ball valve, and the set pressure is observed through a pressure transmitter.
The invention provides a method for testing perfusion fluid pressure of a small artificial bionic blood vessel, which is characterized in that after the fluid pressure is well adjusted and stabilized, a ball valve in front of the measured artificial bionic blood vessel is switched from a closed state to an open state, and after fluid passes through the artificial bionic blood vessel, the ball valve behind the measured artificial bionic blood vessel is switched from the open state to the closed state, so that a static liquid pressure environment is provided for the measured artificial bionic blood vessel, and the fluid pressure in the measured artificial bionic blood vessel is read by a pressure transmitter. If the artificial bionic blood vessel is not damaged or seeped, the artificial bionic blood vessel can bear the set pressure, and the set fluid pressure can be changed by adjusting the ball valve at the outlet of the self-priming pump. If the artificial bionic blood vessel is damaged or seeps, the artificial bionic blood vessel can not bear the set pressure.
In conclusion, the small artificial bionic vascular perfusion fluid pressure test system and the method provided by the invention have the advantages that the test system is small in size and small in occupied area; by using the test system, whether the artificial bionic blood vessel can bear the regulated stable fluid pressure or not under the set pressure is tested, the test method is simple and easy to operate, the volume of the test system is small, and the problem that the fluid pressure in the manufactured artificial bionic blood vessel is difficult to test in a laboratory is solved.
Drawings
Fig. 1 is a schematic diagram of a small artificial bionic blood vessel pressure testing system.
Fig. 2 is a connection diagram of equipment pipelines adopted by the small artificial bionic blood vessel pressure testing system.
Description of reference numerals:
1. the device comprises a liquid storage bottle, 2 a self-priming pump, 3 a first pressure transmitter, 4 a first ball valve, 5 a second ball valve, 6 a luer connector, 7 a metal dispenser needle, 8 a perfusion bioreactor, 9 a tested artificial bionic blood vessel, 10 a second pressure transmitter, 11 a three-way connector, 12 a third ball valve.
Detailed Description
The present invention will be described in further detail with reference to the accompanying drawings.
As shown in fig. 1 and fig. 2, the small artificial bionic blood vessel fluid pressure testing system provided by the invention comprises a liquid storage bottle 1, a self-priming pump 2, a perfusion bioreactor 8 and a tested artificial bionic blood vessel 9.
In fig. 2, the artificial bionic blood vessel 9 to be tested uses the prepared sodium alginate solution with medium viscosity and calcium chloride solution, and is extruded by an injection pump and a coaxial nozzle, and the two solutions are subjected to a cross-linking reaction to form a hollow gel tube structure. Wherein the hemolysis concentration of the sodium alginate is 2-4% (w/v), the concentration of the calcium chloride solution is 4% (w/v), the flow rates of the injection pumps are 1ml/min and 1.5ml/ml respectively, the coaxial spray head is 19G/26G, and the moving speed of the spray head is 10-15 mm/s.
The tested artificial bionic blood vessel 9 is connected with two 23G metal glue dispenser needle heads 7 and connected with two Ruhr joints 6, and is fixed on a perfusion bioreactor 8 to be connected with a test system. The water suction port of the self-priming pump 2 is communicated with the liquid storage bottle 1, the water outlet is divided into two paths through a first ball valve 4 and a three-way joint 11, one path is communicated with the liquid storage bottle 1 through a first pressure transmitter 3, the other path is communicated with a Ruhr joint 6 at one end of the tested artificial bionic blood vessel 9 through a second ball valve 5, and the Ruhr joint 6 at the other end of the tested artificial bionic blood vessel 9 is communicated with the liquid storage bottle 1 through a second pressure transmitter 10 and a third ball valve 12. All components are placed on an optical flat and are relatively fixed by bolts.
The first ball valve 4 is used for testing whether the artificial bionic blood vessel can not be damaged or leaked under the set pressure or not by setting the fluid pressure at the position of the tested artificial bionic blood vessel. The first pressure transmitter 3 is connected in a pipeline from the first ball valve 4 to the liquid storage bottle 1 and is used for observing the fluid set pressure of the test system. The second ball valve 5 is connected behind the three-way joint 11 connected with the first ball valve 4 and used for preventing fluid from entering the tested artificial bionic blood vessel 9 before the fluid pressure of the test system is set, so that the protection effect is achieved. The tested artificial bionic blood vessel 9 is connected with the two metal glue dispenser needle heads 7, is arranged on the biological perfusion reactor 8, is respectively connected with the two metal glue dispenser needle heads 7 through threads at one end of the two Ruhr connectors 6, and is connected with a hose through transition fit at the other end. One of the two luer connectors 6 is connected with the second ball valve 5 through a hose, and the other luer connector 6 is connected with the second pressure transmitter 10 and the third ball valve 12 through a hose and a three-way connector; wherein the second pressure transmitter 10 is adapted to display the value of the fluid pressure during the test. One end of the third ball valve 12 is connected with the luer connector 6 and the second pressure transmitter 10 through a hose, and the other end of the third ball valve is connected with the liquid storage bottle 1 through a hose, so that after air in the pipeline is exhausted, the fluid is prevented from returning to the liquid storage bottle 1.
The invention provides a method for testing the perfusion fluid pressure of a small artificial bionic blood vessel, which comprises the following steps:
before testing, the first ball valve 4 and the second ball valve 5 are closed and the third ball valve 12 is opened to energize the first pressure transmitter 3 and the second pressure transmitter 10. At the start of the test, the self-priming pump 2 was energized while the first ball valve 4 was adjusted to give a reading of 12KPa (90mmHg) to the first pressure transmitter 3. After the pressure is stabilized, the second ball valve 5 is opened, and after liquid flows through the third ball valve 12, the third ball valve 12 is closed to exhaust the air in the pipeline. At this time, no liquid flows in the pipeline where the second pressure transmitter 10 is located, and the pressure of the pipeline is basically consistent with the reading of the first pressure transmitter 3 and is a set pressure value. And observing whether the tested artificial bionic blood vessel is damaged or leaked under the set pressure value at the moment. Further, if the artificial bionic blood vessel to be tested has no bad state under the pressure, the artificial bionic blood vessel is proved to be capable of bearing the pressure at the moment, and the first ball valve 4 can be continuously adjusted to enable the set pressure to be increased or reduced; if the artificial bionic blood vessel to be tested has the phenomena of damage or leakage and the like under the set pressure, the artificial bionic blood vessel is proved to be incapable of bearing the pressure at the moment. The state of the test system can be restored to the state before testing, a new tested artificial bionic blood vessel is replaced, and the set pressure is adjusted to be small through the first ball valve 4 and then testing is carried out again.
Claims (5)
1. A small artificial bionic blood vessel fluid pressure test system is characterized by comprising a liquid storage bottle (1), a self-priming pump (2), a perfusion bioreactor (8) and a tested artificial bionic blood vessel (9); wherein,
the artificial bionic blood vessel (9) to be tested is arranged in the perfusion bioreactor (8), and two ends of the artificial bionic blood vessel are respectively connected with a Ruhr joint (6) through metal dispensing needles (7); the water suction port of the self-priming pump (2) is communicated with the liquid storage bottle (1), the water outlet is divided into two paths through a first ball valve (4) and a tee joint (11), one path is communicated with the liquid storage bottle (1) through a first pressure transmitter (3), the other path is communicated with a luer joint (6) at one end of the tested artificial bionic blood vessel (9) through a second ball valve (5), the luer joint (6) at the other end of the tested artificial bionic blood vessel (9) is communicated with the liquid storage bottle (1) through a second pressure transmitter (10) and a third ball valve (12), the tested artificial bionic blood vessel (9) uses prepared medium-viscosity sodium alginate solution and calcium chloride solution, the sodium alginate solution and the calcium chloride solution are extruded through an injection pump and a coaxial nozzle, and the two solutions are subjected to a cross-linking reaction to form a hollow gel tube structure; wherein the hemolysis concentration of the sodium alginate is 2-4% (w/v), the concentration of the calcium chloride solution is 4% (w/v), the flow rates of the injection pumps are 1ml/min and 1.5ml/ml respectively, the coaxial spray head is 19G/26G, and the moving speed of the spray head is 10-15 mm/s.
2. The small artificial bionic blood vessel fluid pressure test system according to claim 1, wherein the perfusion bioreactor (8) comprises a liquid inlet needle, a liquid outlet needle, a hollow circular tube, a shell, a first baffle and a second baffle; the upper surface of casing is equipped with first recess, first recess divide into the second recess in proper order through first baffle and second baffle, third recess and fourth recess, the left end of hollow pipe passes first baffle and stretches into in the second recess, the right-hand member of hollow pipe passes the second baffle and stretches into in the fourth recess, the middle part of hollow pipe is located the third recess, the wall that the tip of feed liquor syringe needle passed the casing stretches into in the second recess, and the tip of feed liquor syringe needle cup joints in the left end of hollow pipe, the wall that the tip of play liquid syringe needle passed the casing stretches into in the fourth recess, and the tip of play liquid syringe needle cup joints in the right-hand member of hollow pipe, the second recess, all pour into the mould gelatin in third recess and the fourth recess.
3. The system for testing fluid pressure in small artificial bionic blood vessel according to claim 1, wherein both pressure transmitters are digital display pressure transmitters.
4. The system for testing fluid pressure in small artificial bionic blood vessel according to claim 1, wherein the pipelines in the testing system are all transparent/semitransparent hoses.
5. A small artificial bionic blood vessel fluid pressure test method, which is based on the small artificial bionic blood vessel fluid pressure test system of any one of claims 1 to 4, and comprises the following steps:
1) before the test is started, the concentration of a calcium chloride solution is 4% (w/v) and is filled in a liquid storage bottle (1), the calcium chloride solution accounts for 1/2-2/3 of the volume of the liquid storage bottle (1), a self-sucking pump (2) is powered off, the reading on a first pressure transmitter (3) is 0Kpa, a second ball valve (5) is in a closed state, and a first ball valve (4) and a third ball valve (12) are in an open state;
2) when the test is started, the self-priming pump (2) is electrified, the test pressure is adjusted by adjusting the first ball valve (4), the display reading of the first pressure transmitter (3) is 12Kpa by adjustment, and the first pressure transmitter corresponds to 90mmHg so as to prevent overlarge hydraulic pressure and directly damage the tested artificial bionic blood vessel (9) after entering the artificial bionic blood vessel; after the pressure is set, the second ball valve (5) is opened to enable the liquid to enter the tested artificial bionic blood vessel (9), and the liquid is closed after flowing through the third ball valve (12) to discharge air in the pipeline; at the moment, the fluid in the tested artificial bionic blood vessel (9) is in a static state, wherein the static liquid pressure is consistent with the reading displayed by the second pressure transmitter (10);
3) and continuously adjusting the first ball valve (4) to adjust the fluid pressure in the tested artificial bionic blood vessel (9).
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| CN201724937U (en) * | 2010-05-17 | 2011-01-26 | 郭应强 | Closely circulated perfusion system |
| CN105950468B (en) * | 2016-05-23 | 2018-03-02 | 西安交通大学 | A kind of bioreactor for perfusion and the bioreactor for infiltration |
| CN106264745B (en) * | 2016-08-03 | 2018-06-15 | 苏州大学附属第二医院 | Tumor-microvessel self assembly generating system |
| WO2018159661A1 (en) * | 2017-02-28 | 2018-09-07 | シスメックス株式会社 | Perfusion device and perfusion method |
| CN207435460U (en) * | 2017-10-31 | 2018-06-01 | 广州迈普再生医学科技有限公司 | Dynamic perfusion culture systems |
| CN208752468U (en) * | 2018-09-10 | 2019-04-16 | 江西省医学科学院 | A kind of arterial perfusion pressure control device of myocardium vessel |
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