CN112999100B - Anti-allergy polishing paste containing calcium potassium phosphosilicate bioglass - Google Patents
Anti-allergy polishing paste containing calcium potassium phosphosilicate bioglass Download PDFInfo
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Abstract
An anti-allergy polishing paste containing calcium potassium phosphosilicate bioglass comprises the following components in parts by weight: 2.5-7.5 parts of calcium potassium phosphosilicate bioglass, 5-15 parts of silicon dioxide, 30-50 parts of humectant, 2-4 parts of thickener, 3-5 parts of amino acid surfactant and 2-4 parts of betaine. According to the anti-sensitivity polishing paste containing the potassium calcium phosphosilicate bioglass, the potassium calcium phosphosilicate bioglass is added, so that the anti-sensitivity polishing paste is free of toxic and side effects and high in biological safety, the effect of promoting remineralization of the potassium calcium phosphosilicate bioglass is good, caries bacteria and dental plaque bacteria can be inhibited, dental enamel is firm, and compared with traditional anti-sensitivity components such as potassium nitrate and sodium fluoride, the potassium calcium phosphosilicate bioglass is higher in safety and has a remarkable effect on dentin sensitivity; meanwhile, the calcium potassium phosphosilicate bioglass, the amino acid surfactant and the betaine act together, so that the durability and the stability of the anti-sensitivity effect of the anti-sensitivity polishing paste are improved.
Description
Technical Field
The application relates to a dental polishing technology, in particular to an anti-allergy polishing paste containing calcium potassium phosphosilicate bioglass.
Background
Residues of substances such as tobacco, tea, coffee, colored foods and the like in daily life are easy to deposit on tooth surfaces through saliva protein organic films on the surfaces of the teeth, if the teeth are not cleaned timely and effectively, the teeth can be gradually yellow or even black after long-time accumulation, exogenous stains and stains on the teeth are formed, and the oral hygiene and the tooth attractiveness are influenced. In recent years, with the economic development and the improvement of the living standard of people, people have higher and higher requirements on oral hygiene and health.
Traditional oral cleaning and nursing products (such as toothpaste, mouthwash and the like) cannot meet the requirements of consumers on oral health care. Regular tooth cleaning is an important means of protecting teeth, and long-term non-cleaning of teeth causes numerous oral health problems. Meanwhile, dentin hypersensitivity is one of common diseases and frequently encountered diseases in oral diseases, and can cause sharp pain of patients under the conditions of cold, heat, mechanical or chemical stimulation, so that the life quality of the patients is directly influenced. At present, the tooth polishing paste commonly used in oral clinics is calcium carbonate matrix, and because the calcium carbonate matrix particles are large, certain damage can be caused to enamel, and teeth are sensitive and feel sore.
Potassium nitrate and sodium fluoride which are used as traditional anti-sensitivity agents can improve the anti-sensitivity effect to a certain degree, but are harmful. Wherein potassium nitrate has irritation to respiratory tract, strong irritation to skin and eyes, even burn, and can cause methemoglobinemia due to large contact, and skin dryness, chapping and rash due to repeated contact; the sodium fluoride dust and steam have irritation effect on skin and can cause dermatitis, acute poisoning can be caused by mistaken intake of sodium fluoride, severe nausea, vomit, abdominal pain and diarrhea can be caused immediately after the sodium fluoride is taken, and chronic fluorosis can be caused by the use of sodium fluoride.
The patent CN106539697A discloses an anti-caries and anti-sensitivity polishing paste and a preparation method thereof, ammonium hexafluorosilicate is added into the polishing paste, the anti-sensitivity effect is remarkable, and the anti-caries and anti-sensitivity polishing paste has the functions of caries prevention and sterilization, but the ammonium hexafluorosilicate is fluoride and has certain toxic and side effects, the overdose use of the fluoride can cause dental fluorosis and fluoroossium, the remineralization of early caries is limited to a lesion surface layer, and the fluoride prevents the remineralization of deep demineralized tissues of teeth, so that the anti-sensitivity effect is not persistent.
Disclosure of Invention
In order to solve the problem that the anti-sensitive effect is not durable, the application provides the anti-sensitive polishing paste containing the calcium potassium phosphosilicate bioglass.
In a first aspect, the application provides an anti-sensitive polishing paste containing calcium potassium phosphosilicate bioglass, which is realized by adopting the following technical scheme:
the anti-sensitive polishing paste containing the potassium calcium phosphosilicate bioglass comprises the following raw materials in parts by weight: 2.5-7.5 parts of calcium potassium phosphosilicate bioglass, 5-15 parts of silicon dioxide, 30-50 parts of humectant, 2-4 parts of thickener, 3-5 parts of amino acid surfactant and 2-4 parts of betaine.
By adopting the technical scheme, the potassium calcium phosphosilicate bioglass is adopted, so that the biological glass is free from toxic and side effects and high in biological safety, and the potassium calcium phosphosilicate bioglass has a good remineralization promoting effect, can inhibit caries bacteria and dental plaque bacteria, and can solidify enamel. Compared with traditional anti-sensitivity components such as potassium nitrate, sodium fluoride and the like, the potassium calcium phosphosilicate bioglass has higher safety and has obvious effect of resisting dentin sensitivity. Meanwhile, the calcium potassium phosphosilicate bioglass, the amino acid surfactant and the betaine act together, so that the sensitivity relieving effect, the durability and the stability of the anti-sensitivity effect of the anti-sensitivity polishing paste are improved, and the tooth cleaning irritation of the anti-sensitivity polishing paste is reduced. On one hand, the potassium calcium phosphosilicate bioglass has the function of releasing ions and can supplement the concentration of silicon calcium and phosphorus ions, and the stability of the concentration of the silicon calcium and phosphorus ions can be improved by adding the amino acid surfactant and the betaine, so that the sensitivity relieving effect and the durability of the anti-sensitive polishing paste are improved, and the remineralization effect is promoted. On the other hand, the silicon hydroxyl layer of the calcium potassium phosphosilicate bioglass is a hydrated Si-OH layer and has high pH value and negative potential, and the addition of the amino acid surfactant and the betaine further improves the bacteriostatic and bactericidal action and the storage stability of the anti-sensitive polishing paste. In addition, the HCA mineralized layer of the calcium potassium phosphosilicate bioglass has high surface area and strong adsorption force, and the calcium potassium phosphosilicate bioglass, the amino acid surfactant and the betaine act together, so that the sedimentation of silicon dioxide is reduced, and the stability of the system is effectively improved.
In addition, the calcium potassium phosphosilicate bioglass has water insolubility, which not only greatly improves the polishing and tooth cleaning effect, but also greatly reduces the allergic condition of teeth after tooth cleaning due to the remineralization and anti-sensitivity effect of the bioglass. After tooth cleaning, the anti-sensitive polishing containing calcium potassium phosphosilicate bioglass is used, the calcium phosphosilicate bioglass can repair bone tissues and soft tissues, is favorable for repairing gum, gingival sulcus or other soft tissue injuries caused by sand blasting tooth cleaning, has a good antibacterial effect and can well prevent dental plaque bacteria.
Preferably, the silicon dioxide is selected from one or more of SJ-105, SJ-165 and SJ-26; more preferably, the silica is a mixture of SJ-105 and SJ-26.
By adopting the technical scheme, the whitening effect of the anti-allergy polishing paste can be improved by adopting SJ-105 and SJ-165 with larger friction coefficients, and the taste of the anti-allergy polishing paste can be reduced by adopting an SJ-165 with an overlarge friction coefficient; when the anti-allergy polishing paste is compounded by SJ-105 and SJ-26, the whitening effect and the taste of the anti-allergy polishing paste are obviously improved, and the sedimentation of silicon dioxide can be obviously reduced, so that the stability of the anti-allergy polishing paste is improved.
Preferably, the silicon dioxide consists of SJ-105 and SJ-26 in a mass ratio of (5-15): 1, mixing; more preferably, the silicon dioxide is prepared by mixing SJ-105 and SJ-26 in a mass ratio of 10:1 are mixed.
By adopting the technical scheme, the whitening effect, the taste and the stability of the anti-allergy polishing paste can be adjusted by regulating and controlling the mass ratio of SJ-105 to SJ-26. In the research process, the applicant finds that the whitening effect of the anti-allergy polishing paste is reduced when the content of SJ-26 is too high, the mouthfeel and the stability of the anti-allergy polishing paste are reduced when the content of SJ-105 is too high, and when the mass ratio of SJ-105 to SJ-26 is (5-15): 1. in particular 10:1, the whitening effect of the anti-allergy polishing paste is improved, and meanwhile, the mouthfeel and the stability of the anti-allergy polishing paste are improved.
Preferably, the amino acid surfactant is potassium lauroyl glutamate and/or sodium lauroyl glutamate; more preferably, the amino acid surfactant is potassium lauroyl glutamate.
By adopting the technical scheme, the anti-allergy effect of the anti-allergy polishing paste can be further improved by adopting the potassium lauroyl glutamate, and the potassium lauroyl glutamate, the thickening agent, the humectant and the betaine act together, so that the compatibility of a system can be improved, the whitening effect and the taste of the anti-allergy polishing paste are improved, and the irritation of the anti-allergy polishing paste is reduced.
Preferably, the betaine is cocamidopropyl betaine and/or lauramidopropyl hydroxysultaine betaine; more preferably, the betaine is lauramidopropyl hydroxysultaine betaine.
By adopting the technical scheme, the lauramide propyl hydroxysulfonic acid betaine and the lauroyl potassium glutamate have the combined action, so that the anti-allergy polishing paste can be prevented from being dissolved into a liquid state at high temperature, the stability of a system can be improved, the whitening effect of the anti-allergy polishing paste can be improved, and the tooth cleaning irritation of the anti-allergy polishing paste can be reduced.
Preferably, the thickening agent is selected from one or more of sodium alginate, carbomer and xanthan gum; more preferably, the thickener is a mixture of carbomer and xanthan gum.
By adopting the technical scheme, the carbomer and xanthan gum are compounded as the thickening agent, so that the taste of the anti-allergy polishing paste can be greatly improved, and the tooth cleaning irritation of the anti-allergy polishing paste is further reduced.
Preferably, the thickening agent is prepared from carbomer and xanthan gum according to a mass ratio (0.8-1.2): 1, mixing; more preferably, the thickening agent is prepared from carbomer and xanthan gum according to the mass ratio of 1:1 are mixed.
By adopting the technical scheme, the mass ratio of carbomer to xanthan gum is controlled to be (0.8-1.2): 1, especially when the two mass ratios are 1:1, the mouth feel of the anti-allergy polishing paste can be greatly improved, the whitening effect is better, and the tooth cleaning irritation of the anti-allergy polishing paste can be further reduced.
Preferably, the humectant is prepared from glycerol and sorbitol in a mass ratio of 1: (0.6-0.8) by mixing.
By adopting the technical scheme, the glycerin and sorbitol are compounded to serve as the humectant, and the mass ratio of the glycerin and sorbitol is controlled, so that the whitening effect of the anti-allergy polishing paste can be further improved, and the tooth cleaning irritation can be reduced.
Preferably, the preparation raw material also comprises 0.2-0.4 weight part of fluoride.
By adopting the technical scheme, the fluoride is added and compounded with the calcium potassium phosphosilicate bioglass, so that the polishing time of the anti-allergy polishing paste can be obviously shortened, and the anti-allergy and tooth firmness are further enhanced. The weight part of the fluoride is controlled to be 0.2-0.4, the content of the fluoride is much lower than that of the fluoride in the imported polishing paste, the toxic and side effects of the fluoride are reduced, calcium and phosphorus released by the calcium phosphosilicate bioglass can improve the absorption of the fluoride on the surface of teeth, the pH value of the system is improved, and the remineralization effect of enamel is improved.
In summary, the present application has the following beneficial effects:
1. the potassium calcium phosphosilicate bioglass is added, so that the toxic and side effects are avoided, the biological safety is high, the effect of promoting remineralization of the potassium calcium phosphosilicate bioglass is good, cariogenic bacteria and dental plaque bacteria can be inhibited, and enamel is firm; compared with traditional anti-sensitivity components such as potassium nitrate, sodium fluoride and the like, the potassium calcium phosphosilicate bioglass has higher safety and has obvious effect of resisting dentin sensitivity; meanwhile, the calcium potassium phosphosilicate bioglass, the amino acid surfactant and the betaine act together, so that the sensitivity relieving effect, the durability and the stability of the anti-sensitivity effect of the anti-sensitivity polishing paste are improved, and the tooth cleaning irritation of the anti-sensitivity polishing paste is reduced.
2. When SJ-105 and SJ-26 are compounded, the whitening effect and the taste of the anti-allergy polishing paste are obviously improved, and the sedimentation of silicon dioxide can be obviously reduced, so that the stability of the anti-allergy polishing paste is improved.
3. According to the application, the lauramide propyl hydroxysulfonic acid betaine and the lauroyl potassium glutamate have the combined action, so that the anti-allergy polishing paste can be prevented from being dissolved into a liquid state at high temperature, the stability of a system can be improved, the whitening effect of the anti-allergy polishing paste can be improved, and the tooth cleaning irritation of the anti-allergy polishing paste is reduced.
4. According to the application, carbomer and xanthan gum are compounded to serve as a thickening agent, and the mass ratio of carbomer to xanthan gum is controlled to be (0.8-1.2): 1, the mouth feel of the anti-allergy polishing paste can be greatly improved, and the tooth cleaning irritation of the anti-allergy polishing paste is further reduced.
5. The application adopts the potassium calcium phosphosilicate bioglass to be compounded with the fluoride, and the weight part of the fluoride is controlled to be 0.2-0.4, which is much lower than the content of the fluoride in the imported polishing paste, thereby reducing the toxic and side effect of the fluoride and improving the remineralization effect of enamel; the calcium potassium phosphosilicate bioglass can more easily remove pigment on the surface of teeth, polish the uneven columnar enamel surface, prevent the pigment from being easily deposited, seal dentinal tubules, simultaneously lighten the sensitivity of dental nerves and achieve double curative effects.
Detailed Description
In order to improve the anti-allergy effect of the polishing paste, the applicant finds through a large number of experiments that the characteristics of the calcium potassium phosphosilicate bioglass material, namely water-insoluble and irregular crystals, enable the tooth glaze surface to be smoother and smoother compared with water-soluble polishing materials of other polishing pastes, and meanwhile, the dentin is repaired to play an anti-allergy role.
The present application will be described in further detail below with reference to preparation examples, examples and comparative examples.
The raw materials used in the present application are commercially available, and unless otherwise specified, the raw materials used in the respective preparation examples, examples and comparative examples of the present application are derived from table 1 below, and the raw materials not mentioned in table 1 are all purchased from pharmaceutical industry group chemical agents ltd.
TABLE 1
Preparation example
Preparation example 1 provides a calcium potassium phosphosilicate bioglass, which is prepared by the following steps:
mixing 50g of nano silicon dioxide, 20g of monopotassium phosphate, 10g of potassium carbonate and 30g of calcium oxide, uniformly stirring, putting into a high-temperature smelting furnace, heating to 1550 ℃ for high-temperature liquid-phase chemical reaction for 6 hours to obtain potassium calcium phosphosilicate, cooling the potassium calcium phosphosilicate to 25 ℃, and then crushing the cooled potassium calcium phosphosilicate into particles of 5 mu m by using an ultrafine crusher to obtain the potassium calcium phosphosilicate bioglass;
the chemical reaction formula for synthesizing potassium calcium phosphosilicate by using the nano silicon dioxide, the monopotassium phosphate, the potassium carbonate and the calcium oxide is as follows:
SiO 2 +KH 2 PO 4 +K 2 CO 3 +CaO＝KCaPSiO 6 +CO 2 ↑+K 2 O↑+H 2 O↑；
the high-temperature smelting furnace is purchased from Shanghai optical precision machinery research institute of national academy of sciences;
the ultrafine grinder is purchased from Shandong Dingkun mechanical Co Ltd;
the nano-silica is purchased from Shanghai Yixiu chemical Co., ltd.
Examples
Examples 1-26 provide an anti-sensitivity polishing paste containing a potassium calcium phosphosilicate bioglass, which is illustrated below by way of example 1.
Example 1 provides an anti-sensitivity polishing paste containing calcium potassium phosphosilicate bioglass, which is prepared by the steps of:
uniformly stirring 30g of humectant, 2g of thickener, 3g of amino acid surfactant and 2g of betaine, adding 2.5g of potassium calcium phosphosilicate bioglass and 5g of silicon dioxide, uniformly stirring, grinding and kneading until the mixture is fully and uniformly mixed, vacuumizing until the vacuum degree reaches 0.096MPa, and finally aging for 180min to obtain the anti-sensitive polishing paste containing the potassium calcium phosphosilicate bioglass;
wherein the humectant is food grade glycerin;
the thickening agent is food-grade carbomer;
the amino acid surfactant is sodium cocoyl glutamate (CAS number is 68187-32-6);
the betaine is monohydrate betaine (CAS number is 17146-86-0);
the potassium calcium phosphosilicate bioglass is the potassium calcium phosphosilicate bioglass prepared in preparation example 1;
the model of the silicon dioxide is SJ-65.
Examples 2-5, like example 1, differ only in that: the quality of the raw materials for preparing the anti-allergy polishing paste containing the calcium potassium phosphosilicate bioglass is different, and the quality is shown in table 2.
TABLE 2
| Components | Example 1 | Example 2 | Example 3 | Example 4 | Example 5 |
| Moisture retention agent | 30g | 50g | 40g | 40g | 40g |
| Thickening agent | 2g | 4g | 3g | 3g | 3g |
| Amino acid surfactants | 3g | 5g | 4g | 4g | 4g |
| Betaine | 2g | 4g | 3g | 3g | 3g |
| Calcium potassium phosphosilicate bioglass | 2.5g | 7.5g | 5g | 4g | 5g |
| Silicon dioxide | 5g | 15g | 10g | 8g | 12g |
Example 6, like example 3, differs only in that: the silica was replaced by SJ-65 to SJ-105.
Example 7, like example 3, differs only in that: the silica was replaced by SJ-65 to SJ-165.
Example 8, like example 3, differs only in that: the silica was replaced with SJ-26 from SJ-65.
Example 9, like example 3, differs only in that: the silicon dioxide is replaced by SJ-65 to SJ-105 and SJ-26 according to the mass ratio of 5:1, and mixing the components.
Example 10, like example 3, differs only in that: the silicon dioxide is replaced by SJ-65 to SJ-105 and SJ-26 according to the mass ratio of 15:1, and mixing the components.
Example 11, like example 3, differs only in that: the silicon dioxide is replaced by SJ-65 to SJ-105 and SJ-26 according to the mass ratio of 10:1, and mixing the components.
Example 12, like example 3, differs only in that: the silicon dioxide is replaced by SJ-65 to SJ-105 and SJ-26 according to the mass ratio of 1:5 mixing the components to obtain a mixture.
Example 13, like example 11, differs only in that: the sodium cocoyl glutamate is replaced by potassium lauroyl glutamate (CAS number 89187-78-0).
Example 14, like example 11, differs only in that: the cocoyl sodium glutamate is replaced by sodium lauroyl glutamate (CAS No. 29923-31-7).
Example 15, like example 13, differs only in that: the betaine monohydrate is replaced by cocamidopropyl betaine and the mark is Dehyton PK 45.
Example 16, like example 13, differs only in that: the betaine monohydrate is replaced by lauramidopropyl hydroxysulfonic acid betaine, and the mark is LHSB-35.
Example 17, like example 16, differs only in that: the food grade carbomer is replaced by food grade xanthan gum.
Example 18, like example 16, differed only in that: the food-grade carbomer is replaced by the food-grade carbomer and the food-grade xanthan gum according to the mass ratio of 0.8:1, and mixing the components.
Example 19, like example 16, differs only in that: the food-grade carbomer is replaced by food-grade carbomer and food-grade xanthan gum according to the mass ratio of 1.2:1, and mixing the components.
Example 20, like example 16, differs only in that: the food-grade carbomer is replaced by food-grade carbomer and food-grade xanthan gum according to the mass ratio of 1:1, and mixing the components.
Example 21, like example 20, differs only in that: the food-grade glycerin is replaced by food-grade glycerin and food-grade sorbitol according to the mass ratio of 1:0.6 of the mixture.
Example 22, like example 20, differs only in that: the food-grade glycerin is replaced by food-grade glycerin and food-grade sorbitol according to the mass ratio of 1:0.8 of a mixture.
Example 23, like example 20, differs only in that: the food grade glycerin is replaced with food grade sorbitol.
Example 24, the same as example 3, only differs: the raw materials for preparing the anti-allergy polishing paste containing the calcium potassium phosphosilicate bioglass also comprise 0.2g of food-grade sodium fluoride (CAS No. 7681-49-4), and the purity is 99%;
the preparation steps of the anti-allergy polishing paste containing the calcium potassium phosphosilicate bioglass are as follows:
uniformly stirring 40g of humectant, 3g of thickener, 4g of amino acid surfactant and 3g of betaine, adding 5g of potassium calcium phosphosilicate bioglass, 0.2g of food-grade sodium fluoride and 10g of silicon dioxide, uniformly stirring, grinding and kneading until the mixture is fully and uniformly mixed, then vacuumizing until the vacuum degree reaches 0.096MPa, and finally aging for 180min to obtain the anti-sensitivity polishing paste containing the potassium calcium phosphosilicate bioglass.
Example 25, like example 24, differs only in that: the mass of the food-grade sodium fluoride is changed from 0.2g to 0.4g.
Example 26, like example 24, differs only in that: the mass of the food-grade sodium fluoride is changed from 0.2g to 0.3g.
Comparative example
Comparative example 1, like example 1, differs only in that: the calcium potassium phosphosilicate bioglass is replaced by food-grade calcium carbonate.
Comparative example 2, like example 1, differs only in that: the calcium potassium phosphosilicate bioglass is replaced by food-grade sodium fluoride.
Comparative example 3, like example 1, differs only in that: the potassium calcium phosphosilicate bioglass is replaced by potassium nitrate.
Comparative example 4, like example 1, differs only in that: the potassium calcium phosphosilicate bioglass is replaced by ammonium hexafluorosilicate (CAS number 16919-19-0), and the purity is 98%.
Comparative example 5, like example 1, differs only in that: the amino acid surfactant was replaced with PEG-400.
Comparative example 6, like example 1, differs only in that: the betaine is replaced by PEG-400.
Performance test
The following property tests were performed on the anti-sensitive polishing pastes provided in examples 1 to 26 of the present application and comparative examples 1 to 6.
1. Sensitive relief effect: 320 volunteers with dentin hypersensitivity were screened, randomly divided into 32 groups, 10 persons in each group, each group used the anti-hypersensitivity polishing cream described in examples 1-26 and comparative examples 1-6, respectively, used 1 time every morning, continuously used for 30 days, and used 0.2g each time, each volunteer evaluated the hypersensitivity relieving effect according to the effect after use (compared with before use on day 1 on day 30) when used for 30 days, and divided into 10 grades according to the hypersensitivity relieving effect, wherein grade 1 represents no relief, grade 10 represents that relief is very obvious (no pain when used for 30 days), the larger the grade is, the better the hypersensitivity relieving effect is, each volunteer rated, the average value of 10 persons in each group is taken, and the test results are shown in table 3.
2. Durability of anti-sensitivity effect: 320 volunteers suffering from dentinal hypersensitivity were screened, randomly divided into 32 groups, 10 persons in each group, each group used the anti-sensitivity polishing creams described in examples 1-26 and comparative examples 1-6, 1 time per morning, continuously used for 30 days, 0.2g each time, and then stopped using for 30 days, each volunteer was allowed to evaluate the sensitivity relief effect according to the effect after the stoppage of use for 30 days (compared with before the use on day 1 when the stoppage of use for day 30), the sensitivity relief effect was divided into 10 grades according to which no relief is shown on grade 1, the relief is very obvious on grade 10 (no pain when the stoppage of use for day 30), the larger the grade is the better, that is, the longer the grade is the longer the durability of the sensitivity relief is better, each volunteer is rated and scored, the average value of 10 persons in each group is taken, and the test results are shown in table 3.
3. Stimulating tooth cleaning: 320 persons who were sensitive to teeth after cleaning teeth were selected and randomly divided into 32 groups of 10 persons, each group was treated with the anti-sensitivity polishing paste described in examples 1 to 26 and comparative examples 1 to 6, respectively, after cleaning teeth, the anti-sensitivity polishing paste was divided into 10 grades according to the stimulus sensation, the 1 grade represents significant stimulus, the 10 grade represents no stimulus, the larger the grade, the lower the stimulus sensation, the rating of each person was scored, the average value of 10 persons per group was taken, and the test results are shown in table 3.
4. The mouthfeel is as follows: 320 volunteers sensitive to teeth after cleaning teeth were screened and randomly divided into 32 groups of 10 persons, the anti-sensitivity polishing pastes of examples 1-26 and comparative examples 1-6 were used in each group after cleaning teeth, the number of persons who used the anti-sensitivity polishing paste in each group and were willing to continue using the anti-sensitivity polishing paste was recorded, and the test results are shown in table 3.
5. Whitening effect: 320 volunteers with exogenous dental stains are screened out and randomly divided into 32 groups, each group comprises 10 persons, each group uses the anti-sensitivity polishing paste described in examples 1-26 and comparative examples 1-6 respectively, the anti-sensitivity polishing paste is used for 1 time every morning and is continuously used for 30 days, 0.2g of the anti-sensitivity polishing paste is used for each time, each volunteer evaluates the whitening effect according to the effect after use when using for 30 days (compared with the effect before using for 1 day when using for 30 days), the anti-sensitivity polishing paste is divided into 10 grades according to the whitening effect, the 1 grade represents no whitening, the 10 grade represents whitening to be obvious, the larger the grade is the better the whitening effect, the average value of 10 persons in each group is taken, and the test result is shown in table 3.
TABLE 3
| Anti-allergy polishing paste | Sensitivity relieving effect | Durability of anti-sensitivity Effect | Irritation of tooth cleaning | Taste of food | Whitening effect |
| Example 1 | 8.3 | 7.8 | 6.7 | 6 | 6.9 |
| Example 2 | 8.9 | 8.4 | 7.4 | 5 | 7.6 |
| Example 3 | 8.8 | 8.7 | 7.6 | 6 | 7.5 |
| Example 4 | 8.4 | 8 | 6.9 | 6 | 7.3 |
| Example 5 | 8.6 | 8.3 | 7.2 | 5 | 7.6 |
| Example 6 | 9.1 | 8.9 | 7.9 | 7 | 8.4 |
| Example 7 | 9 | 8.9 | 7.7 | 5 | 8.7 |
| Example 8 | 9 | 8.8 | 8.1 | 7 | 7.1 |
| Example 9 | 9.2 | 9 | 8.3 | 8 | 8.6 |
| Example 10 | 9.2 | 9.1 | 8.4 | 8 | 8.9 |
| Example 11 | 9.3 | 9.2 | 8.5 | 8 | 8.9 |
| Example 12 | 9.1 | 8.9 | 8.2 | 8 | 7.4 |
| Example 13 | 9.5 | 9.3 | 8.8 | 9 | 9.2 |
| Example 14 | 9.3 | 9.2 | 8.7 | 9 | 9.1 |
| Example 15 | 9.5 | 9.4 | 9.1 | 9 | 9.2 |
| Example 16 | 9.6 | 9.4 | 9.3 | 9 | 9.3 |
| Example 17 | 9.7 | 9.5 | 9.5 | 9 | 9.6 |
| Example 18 | 9.8 | 9.5 | 9.7 | 10 | 9.8 |
| Example 19 | 9.7 | 9.6 | 9.6 | 10 | 9.7 |
| Example 20 | 9.8 | 9.6 | 9.8 | 10 | 9.8 |
| Example 21 | 9.9 | 9.7 | 10 | 10 | 9.9 |
| Example 22 | 9.9 | 9.7 | 10 | 10 | 10 |
| Example 23 | 9.8 | 9.6 | 9.9 | 10 | 9.8 |
| Example 24 | 9.2 | 9.1 | 8.3 | 7 | 7.8 |
| Example 25 | 9.4 | 9.1 | 8.1 | 6 | 7.9 |
| Example 26 | 9.3 | 9.2 | 8.2 | 7 | 7.9 |
| Comparative example 1 | 3.2 | 1.8 | 1.2 | 0 | 3.3 |
| Comparative example 2 | 5.8 | 3.4 | 3.8 | 1 | 4.2 |
| Comparative example 3 | 5.8 | 3.4 | 3.8 | 1 | 4.2 |
| Comparative example 4 | 7.3 | 3.9 | 4.2 | 2 | 4.5 |
| Comparative example 5 | 6.4 | 6.1 | 5.8 | 3 | 5.8 |
| Comparative example 6 | 6.6 | 6.2 | 5.3 | 3 | 5.4 |
6. Storage stability: the anti-sensitive polishing pastes of examples 1-26 and comparative examples 1-6 were left at 50 ℃ for 6 months, and the presence or absence of liquid or sedimentation of the anti-sensitive polishing paste was observed after 6 months, and the test results are shown in Table 4.
TABLE 4
The present application is described in detail below with reference to the test data provided in tables 3 and 4.
From examples 1 to 5 of the present application, it can be seen that the quality of the raw materials and components for preparing the anti-sensitivity polishing paste affects not only the sensitivity alleviation effect, the durability of the anti-sensitivity effect and the tooth cleaning irritation of the anti-sensitivity polishing paste, but also the taste, the whitening effect and the storage stability of the anti-sensitivity polishing paste, wherein the whitening effect of the anti-sensitivity polishing paste can be improved by increasing the quality of the silica, but the stability of the anti-sensitivity polishing paste can be reduced and the taste of the anti-sensitivity polishing paste can be reduced when the quality of the silica is high and the calcium potassium phosphosilicate bioglass is low. Taken together, example 3 is a preferred embodiment of examples 1-5.
From the application example 1 and the comparative example 2, compared with sodium fluoride, the potassium calcium phosphosilicate bioglass is higher in safety, effectively avoids irritation of the sodium fluoride, osteofluorosis and the like, has a remarkable effect on resisting dentin sensitivity, and has the effects of inhibiting dental plaque formation, relieving gingivitis and improving gum health.
From the application example 1 and the comparative example 3, compared with potassium nitrate, the potassium calcium phosphosilicate bioglass is higher in safety, effectively avoids irritation and other hazards of potassium nitrate, has a remarkable effect on dentin sensitivity resistance, is good in biocompatibility, and has the effects of promoting soft tissue wound repair and the like.
As can be seen from the example 1 and the comparative examples 1 and 4, the potassium calcium phosphosilicate bioglass adopted in the application has no toxic or side effect and high biological safety, and the potassium calcium phosphosilicate bioglass has a good effect of promoting remineralization, can inhibit cariogenic bacteria and dental plaque bacteria and can strengthen dental enamel. Compared with ammonium hexafluorosilicate, the potassium calcium phosphosilicate bioglass has higher safety, and the characteristics of water-insoluble and irregular crystals of the potassium calcium phosphosilicate bioglass material enable the tooth glaze surface to be smoother and smoother, repair dentin, have obvious effect on dentin sensitivity resistance and better durability of anti-sensitivity effect, improve the stability and taste of the anti-sensitivity polishing paste and reduce the irritation of tooth cleaning. The potassium calcium phosphosilicate bioglass can repair bone tissues and soft tissues, can well play a role in preventing and repairing side effects of tooth cleaning, and has a good antibacterial effect.
From the application example 1 and the comparative examples 5 to 6, the application adopts the combined action of the amino acid surfactant, the betaine and the calcium potassium phosphosilicate bioglass, so that the stability, the mouthfeel and the anti-sensitivity effect of the anti-sensitivity polishing paste are further improved, the dispersibility of the silicon dioxide is also improved, the mouthfeel of the anti-sensitivity polishing paste is further improved, and the tooth cleaning irritation of the anti-sensitivity polishing paste is reduced.
As can be seen from examples 3 and 6 to 12 of the application, SJ-105 and SJ-165 with larger friction coefficients are adopted in the application, so that the whitening effect of the anti-allergy polishing paste can be improved, and the mouthfeel of the anti-allergy polishing paste can be reduced due to the fact that the friction coefficient of the SJ-165 is too large; when SJ-105 and SJ-26 are compounded, the whitening effect, the mouthfeel and the stability of the anti-allergy polishing paste can be adjusted by regulating and controlling the mass ratio of SJ-105 to SJ-26. In the research process, the applicant finds that the whitening effect of the anti-allergy polishing paste is reduced when the content of SJ-26 is too high, the mouthfeel and the stability of the anti-allergy polishing paste are reduced when the content of SJ-105 is too high, and when the mass ratio of SJ-105 to SJ-26 is (5-15): 1. in particular 10:1, the whitening effect of the anti-allergy polishing paste is improved, and the mouthfeel and stability of the anti-allergy polishing paste are improved. Taken together, example 11 is a preferred example of examples 6-12.
From examples 11 and 13 to 14 of the present application, it is known that potassium lauroyl glutamate and sodium lauroyl glutamate can improve the compatibility of the system, improve the whitening effect and the taste of the anti-sensitivity polishing paste, and reduce the tooth cleaning irritation of the anti-sensitivity polishing paste, compared with sodium cocoyl glutamate; compared with sodium lauroyl glutamate, potassium lauroyl glutamate can further improve the anti-allergy effect of the anti-allergy polishing paste, and has better whitening effect and lower tooth cleaning irritation.
From examples 13 and 15 to 16 of the present application, it is understood that, in comparison with lauramidopropyl isethionate betaine, cocamidopropyl betaine, and betaine monohydrate, lauramidopropyl isethionate betaine and potassium lauroyl glutamate act together, and thus the anti-sensitivity polishing paste can be prevented from being dissolved into a liquid at high temperature, the stability of the system can be improved, the whitening effect of the anti-sensitivity polishing paste can be improved, and the irritation of tooth cleaning by the anti-sensitivity polishing paste can be reduced.
From the examples 16 to 20 of the present application, the sodium hyaluronate and xanthan gum are compounded as the thickener, and the mass ratio of the sodium hyaluronate to the xanthan gum is controlled to be (0.8-1.2): 1, the mouth feel of the anti-allergy polishing paste can be greatly improved, the whitening effect is better, and the tooth cleaning irritation of the anti-allergy polishing paste can be further reduced. Taken together, example 20 is a preferred embodiment of examples 16-20.
From examples 20 to 23 of the present application, it can be seen that the present application adopts glycerin and sorbitol as a humectant, and controls the mass ratio of the glycerin and the sorbitol, wherein when the mass ratio of the glycerin to the sorbitol is 1: when 0.8, the whitening effect of the anti-sensitivity polishing paste can be further improved, and the irritation to tooth cleaning can be reduced.
From the examples 3 and 24 to 26, it can be known that 0.2 to 0.4 part by weight of fluoride is added in the polishing paste and is compounded with the calcium potassium phosphosilicate bioglass, so that the toxic and side effects of the fluoride are reduced, calcium and phosphorus released by the calcium potassium phosphosilicate bioglass can improve the absorption of the fluoride on the surface of teeth and improve the remineralization effect of the enamel, and thus the sensitivity relieving effect and the durability of the sensitivity resisting effect of the sensitivity resisting polishing paste are improved, and the irritation of tooth cleaning is reduced.
The present embodiment is only for explaining the present application, and it is not limited to the present application, and those skilled in the art can make modifications of the present embodiment without inventive contribution as needed after reading the present specification, but all of them are protected by patent law within the scope of the claims of the present application.
Claims (2)
1. An anti-allergy polishing paste containing calcium potassium phosphosilicate bioglass is characterized by comprising the following raw materials in parts by weight: 2.5-7.5 parts of calcium potassium phosphosilicate bioglass, 5-15 parts of silicon dioxide, 30-50 parts of humectant, 2-4 parts of thickener, 3-5 parts of amino acid surfactant and 2-4 parts of betaine;
the amino acid surfactant is potassium lauroyl glutamate and/or sodium lauroyl glutamate;
the betaine is cocamidopropyl betaine and/or lauramidopropyl isethionate betaine;
the silicon dioxide is prepared from SJ-105 and SJ-26 in a mass ratio of (5-15): 1, mixing;
the thickening agent is prepared from carbomer and xanthan gum according to a mass ratio (0.8-1.2): 1, mixing;
the humectant is prepared from glycerol and sorbitol in a mass ratio of 1: (0.6-0.8) by mixing.
2. The anti-sensitivity polishing paste containing the potassium calcium phosphosilicate bioglass as claimed in claim 1, wherein the raw materials for the preparation further comprise 0.2 to 0.4 parts by weight of fluoride.
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