CN112969470A - 用于扩增抗原特异性car-t细胞、组合物的方法及其相关用途 - Google Patents

用于扩增抗原特异性car-t细胞、组合物的方法及其相关用途 Download PDF

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CN112969470A
CN112969470A CN201980073697.6A CN201980073697A CN112969470A CN 112969470 A CN112969470 A CN 112969470A CN 201980073697 A CN201980073697 A CN 201980073697A CN 112969470 A CN112969470 A CN 112969470A
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cells
antigen
car
cell
expressing
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B·T·阿法塔卜
C·范
R·沈
M·吴
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Atara Biotherapeutics Inc
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CN201980073697.6A 2018-09-10 2019-09-10 用于扩增抗原特异性car-t细胞、组合物的方法及其相关用途 Pending CN112969470A (zh)

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US201862729089P 2018-09-10 2018-09-10
US62/729,089 2018-09-10
US201962896707P 2019-09-06 2019-09-06
US62/896,707 2019-09-06
PCT/US2019/050404 WO2020055862A1 (en) 2018-09-10 2019-09-10 Methods for expanding antigen-specific car-t cells, compositions and uses related thereto

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US (1) US20210301255A1 (https=)
EP (2) EP3849571B1 (https=)
JP (2) JP7528059B2 (https=)
KR (1) KR20210061361A (https=)
CN (1) CN112969470A (https=)
AU (1) AU2019338307A1 (https=)
BR (1) BR112021004465A2 (https=)
CA (1) CA3111796A1 (https=)
ES (1) ES3000183T3 (https=)
IL (1) IL281187A (https=)
MX (1) MX2021002702A (https=)
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Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES3000183T3 (en) * 2018-09-10 2025-02-27 Atara Biotherapeutics Inc Methods for expanding antigen-specific car-t cells, compositions and uses related thereto
SG11202104524YA (en) 2018-11-01 2021-05-28 Gracell Biotechnologies Shanghai Co Ltd Compositions and methods for t cell engineering
US12590148B2 (en) 2018-11-26 2026-03-31 Nkarta, Inc. Methods for the simultaneous expansion of multiple immune cell types, related compositions and uses of same in cancer immunotherapy
CN118931967A (zh) * 2018-12-07 2024-11-12 亘喜生物科技(上海)有限公司 用于免疫疗法的组合物和方法
AU2020232691B2 (en) 2019-03-05 2023-06-29 Nkarta, Inc. CD19-directed chimeric antigen receptors and uses thereof in immunotherapy
WO2022157500A1 (en) * 2021-01-20 2022-07-28 Coding Bio Limited Methods for high throughput screening of chimeric antigen receptors
EP4381050A4 (en) * 2021-08-06 2025-10-08 Seattle Childrens Hospital D/B/A Seattle Childrens Res Institute T CELL MANUFACTURING PROCESSES
WO2023159088A1 (en) * 2022-02-15 2023-08-24 Marker Therapeutics, Inc. Compositions and methods for antigen-specific t cell expansion
WO2023230276A1 (en) * 2022-05-27 2023-11-30 Kite Pharma, Inc. Compositions and methods for preparing engineered lymphocytes for cell therapy
WO2025076144A1 (en) * 2023-10-03 2025-04-10 Atara Biotherapeutics, Inc. Bispecific cd19/cd20-targeted chimeric antigen receptors and uses thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015154012A1 (en) * 2014-04-03 2015-10-08 Memorial Sloan-Kettering Cancer Center Clonogenic natural killer (nk) cell populations and methods of producing and using such populations
WO2016154628A1 (en) * 2015-03-26 2016-09-29 Xiuli Wang Bi-specific targeted chimeric antigen receptor t cells
WO2018075813A1 (en) * 2016-10-19 2018-04-26 City Of Hope Use of endogenous viral vaccine in chimeric antigen receptor t cell therapy
CN108064304A (zh) * 2015-02-10 2018-05-22 俄勒冈健康与科学大学 可用于产生非典型cd8+ t细胞应答的方法和组合物
CN108135938A (zh) * 2015-07-16 2018-06-08 耶达研究及发展有限公司 基因修饰的抗第三方中央型记忆t细胞及其在免疫疗法中的用途

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4501728A (en) 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
US5019369A (en) 1984-10-22 1991-05-28 Vestar, Inc. Method of targeting tumors in humans
US4837028A (en) 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
WO2003057171A2 (en) 2002-01-03 2003-07-17 The Trustees Of The University Of Pennsylvania Activation and expansion of t-cells using an engineered multivalent signaling platform
US7976845B2 (en) 2004-11-29 2011-07-12 The Council Of The Queensland Institute Of Medical Research Human cytomegalovirus immunotherapy
CN104769104A (zh) 2011-12-12 2015-07-08 细胞药物有限公司 扩大t细胞的方法
CA2889064A1 (en) 2012-10-19 2014-04-24 The Council Of The Queensland Institute Of Medical Research Improved human herpesvirus immunotherapy
CN104462128B (zh) 2013-09-22 2018-04-13 腾讯科技(深圳)有限公司 多媒体文件处理的方法、装置和终端设备
JP2019520332A (ja) 2016-05-23 2019-07-18 ザ カウンシル オブ ザ クイーンズランド インスティテュート オブ メディカル リサーチ Cmvエピトープ
MX2018013959A (es) 2016-05-25 2019-08-22 Council Queensland Inst Medical Res Metodos para tratar enfermedad autoinmune usando celulas t alogenicas.
KR20240133760A (ko) 2016-09-09 2024-09-04 더 카운실 오브 더 퀸즐랜드 인스티튜트 오브 메디컬 리서치 폴리오마바이러스에 대한 면역요법
AU2017326173B2 (en) * 2016-09-16 2022-08-18 Baylor College Of Medicine Platform for activation and expansion of virus-specific T-cells
JP7141725B2 (ja) 2017-07-07 2022-09-26 エイチ リー モフィット キャンサー センター アンド リサーチ インスティテュート インコーポレイテッド 変異cd28共刺激ドメインを有するキメラ抗原受容体
SG11202006050XA (en) 2017-12-29 2020-07-29 Memorial Sloan Kettering Cancer Center Enhanced chimeric antigen receptors and uses thereof
ES3000183T3 (en) * 2018-09-10 2025-02-27 Atara Biotherapeutics Inc Methods for expanding antigen-specific car-t cells, compositions and uses related thereto

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015154012A1 (en) * 2014-04-03 2015-10-08 Memorial Sloan-Kettering Cancer Center Clonogenic natural killer (nk) cell populations and methods of producing and using such populations
CN108064304A (zh) * 2015-02-10 2018-05-22 俄勒冈健康与科学大学 可用于产生非典型cd8+ t细胞应答的方法和组合物
WO2016154628A1 (en) * 2015-03-26 2016-09-29 Xiuli Wang Bi-specific targeted chimeric antigen receptor t cells
CN108135938A (zh) * 2015-07-16 2018-06-08 耶达研究及发展有限公司 基因修饰的抗第三方中央型记忆t细胞及其在免疫疗法中的用途
WO2018075813A1 (en) * 2016-10-19 2018-04-26 City Of Hope Use of endogenous viral vaccine in chimeric antigen receptor t cell therapy

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CLAUDIA ROSSIG等: ""Epstein-Barr virus–specific human T lymphocytes expressing antitumor chimeric T-cell receptors: potential for improved immunotherapy", 《GENE HERAPY》, vol. 99, no. 6, pages 2009, XP055625826, DOI: 10.1182/blood.V99.6.2009 *

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