CN112956664A - Composite fruit cake beneficial to improving sleep function and preparation method thereof - Google Patents

Composite fruit cake beneficial to improving sleep function and preparation method thereof Download PDF

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Publication number
CN112956664A
CN112956664A CN202110329220.9A CN202110329220A CN112956664A CN 112956664 A CN112956664 A CN 112956664A CN 202110329220 A CN202110329220 A CN 202110329220A CN 112956664 A CN112956664 A CN 112956664A
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China
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parts
purified water
pulp
fruit
fructus
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CN202110329220.9A
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Chinese (zh)
Inventor
王艳宏
刘振强
陈忠新
郭玉岩
吕邵娃
关枫
韩凤娟
王荣
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Heilongjiang University of Chinese Medicine
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Heilongjiang University of Chinese Medicine
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
    • A23L19/09—Mashed or comminuted products, e.g. pulp, purée, sauce, or products made therefrom, e.g. snacks
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
    • A23L29/206—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin
    • A23L29/244—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin from corms, tubers or roots, e.g. glucomannan
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
    • A23L29/206—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin
    • A23L29/256—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin from seaweeds, e.g. alginates, agar or carrageenan
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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Abstract

The invention provides a compound fruit cake beneficial to improving sleep function, which is prepared from the following raw materials: colla Corii Asini, Succinum powder, Margarita powder, flos Rosae Rugosae, semen Persicae, fructus crataegi, grape seed, radix Angelicae sinensis, ramulus Cinnamomi, Mel Glycyrrhrizae radix, Poria, Coicis semen, radix astragali, mume fructus, semen Sesami, Lepidium Meyenii Walp, fructus Jujubae, fructus Lycii, arillus longan, dried Mori fructus, semen Nelumbinis, Bulbus Lilii and fresh Choerospondias axillaris, and compound gum and purified water, wherein the compound gum comprises carrageenan and konjac gum. The compound fruit cake has the effects of regulating the five internal organs, nourishing qi and blood, calming the heart and soothing the nerves by the compatibility of the medicines; no additional flavoring agent is added, the prescription is optimized through orthogonal experiments, and the proportion of the five fruit meat traditional Chinese medicines is scientifically matched to achieve the tastes of sweet and sour and delicious and unique flavor. Pharmacological experiments show that the compound fruit cake has the function of assisting in improving the sleep function.

Description

Composite fruit cake beneficial to improving sleep function and preparation method thereof
Technical Field
The invention relates to the technical field of food and functional food, in particular to a compound fruit cake beneficial to improving sleep function and a preparation method thereof.
Background
Sleep is an important physiological phenomenon for maintaining various physiological functions of the human body to be stable. With the continuous change of society, people face more and more pressure on various lives and work, which often exceeds the individual psychological bearing range, and various physiological or psychological diseases are generated. Among them, the insomnia is prominent, and the trouble and loss caused by the treatment difficulty are more and more obvious. Research shows that the incidence rate of insomnia in China is 10% -48%, and the incidence rate of insomnia in China is on an increasing trend. Insomnia is a physiological disorder disease with unsatisfactory continuous sleep time and sleep quality, and the insomnia refers to difficulty in falling asleep, low sleep quality, incapability of sleeping deeply, reduced sleep time, insomnia of serious patients all night, serious diseases which do not belong to critical diseases but obstruct normal life, work, learning and health of people, and symptoms such as palpitation, thoracic obstruction, dizziness, headache, apoplexy and the like can be aggravated or induced, so that the quality of life of the patients is greatly influenced. The clinical multi-purpose western medicine treats the disease, but the patient can generate certain drug resistance and has more adverse reactions after taking the medicine for a long time. Under the guidance of the theory of traditional Chinese medicine, the medicine-food homologous traditional Chinese medicine achieves the effect of improving sleep by regulating the five internal organs, nourishing qi and blood, calming the heart and soothing the nerves.
The fruit cake is an instant food which is prepared by taking sauce prepared by decocting fruits, fruit juice or fruits and vegetables, white granulated sugar, pectin and water as main materials, adding a proper amount of auxiliary materials, decocting, mixing, forming, cooling and drying. The processing of the fruit cake can keep most of the nutrition of the fruits, and the natural low-sugar nutritional food which does not contain starch, chemical pigment, essence and other chemical synthetic substances and has high fruit pulp content is formed. The fruit cake is different from preserved fruit, preserved fruit and common cake, contains the inherent nutrient components of fresh fruit, such as abundant vitamins, amino acids, trace elements, and the like, and is a pure natural healthy nutritional fruit product without pigment and starch. However, the traditional fruitcake in the current market is prepared by adding auxiliary materials such as white sugar, syrup and the like, and the product has single taste, low protein content and deficient nutrition. The use of children, the elderly, diabetes, obesity, etc. is limited. The compound fruitcake that requires under this patent comprises the donkey-hide gelatin that the national wei planning committee announced both medicine and food, amber powder, pearl powder, rose, peach seed, hawthorn, grape seed, chinese angelica, cassia twig, honey licorice, indian bread, Coicis semen, radix astragali, mume fructus, sesame, maca, jujube, wolfberry fruit, arillus longan, dried mulberry, lotus seed, lily and fresh choerospondias axillaris, do not add any taste-modifying agent in the course of making, its taste passes through the orthogonal screening, rely on the ratio between the composition, obtain sour and sweet moderate, compound fruitcake that the taste is abundant, accord with the low sugar health preserving concept of contemporary people. The compound fruitcake with the function of improving sleep in an auxiliary way is researched and developed, and the prospect is very wide.
Disclosure of Invention
The invention aims to provide the compound fruit cake which is composed of the traditional Chinese medicines with homology of medicine and food and has the function of improving sleep, and the compound fruit cake has the advantages of high nutritive value, unique flavor, good taste, convenient taking, safety and effectiveness. The invention overcomes the defects that the sugar content is too high, and the groups such as diabetes, obesity, children, old people and the like are not suitable for eating too much by adding the konjac gum and the carrageenan instead of cane sugar as excipients in the traditional preparation method of the fruit cake.
The invention is realized by the following technical scheme:
a compound fruit cake helpful for improving sleep function is characterized in that: the feed is prepared from the following raw materials in parts by weight: 7-21 parts of donkey-hide gelatin, 3-7 parts of amber powder, 3-7 parts of pearl powder, 14-35 parts of rose, 7-21 parts of peach kernel, 14-35 parts of hawthorn, 14-35 parts of grape seed, 3-7 parts of angelica, 3-7 parts of cassia twig, 14-35 parts of honey liquorice, 14-35 parts of poria cocos, 14-35 parts of coix seed, 3-7 parts of astragalus membranaceus, 14-35 parts of dark plum, 14-35 parts of sesame, 7-21 parts of maca, 14-35 parts of fresh choerospondias axillaris, 7-21 parts of denucleated jujube, 10-32 parts of longan pulp, 7-21 parts of wolfberry fruit, 10-32 parts of dried mulberry, 7-21 parts of lily, 7-21 parts of lotus seed, purified water and composite glue, wherein the purified water is 4-5 times of the weight of the pulp, and the mass of the composite glue is 1.5 percent of the sum of the pulp and, the composite glue is composed of carrageenan and konjac glucomannan according to the proportion of 1: 1-1: 2.
A compound fruit cake helpful for improving sleep function is characterized in that: is prepared by the following method:
(1) weighing colla Corii Asini, Succinum powder, Margarita powder, flos Rosae Rugosae, semen Persicae, fructus crataegi, grape seed, radix Angelicae sinensis, ramulus Cinnamomi, Mel Glycyrrhrizae radix, Poria, Coicis semen, radix astragali, mume fructus, semen Sesami, Lepidium Meyenii Walp, fresh Choerospondias axillaris, pitted fructus Jujubae, arillus longan, fructus Lycii, dried Mori fructus, Bulbus Lilii, and semen Nelumbinis, soaking in purified water, decocting with slow fire for softening, and grinding into uniform fruit paste with colloid mill;
(2) adding purified water into the fruit paste obtained in the step (1), decocting for 15min with slow fire, concentrating, and concentrating at 80 ℃ until the fruit paste is steeped but does not splash;
(3) adding composite glue, wherein the composite glue is composed of carrageenan and konjac gum, the mass of the composite glue is 1.5% of the sum of the mass of the pulp and the mass of the purified water, and continuously heating and stirring until the pulp is sticky;
(4) and (4) pouring the mixed fruit paste prepared in the step (3) into a mould while the mixed fruit paste is hot, standing for forming, drying and cutting into blocks of 20 g.
The quality standards of the raw materials in the invention all meet the requirements of pharmacopoeia of the people's republic of China.
The raw materials of the invention, carrageenan and konjac glucomannan are excipients in the compound fruitcake, and the quality standard of the excipient meets the national standard.
When the compound fruit cake beneficial to improving the sleep function is eaten, 2 times a day are recommended, and 1 piece of fruit cake is taken every time.
The invention has the following effects:
(1) donkey-hide gelatin, recorded in compendium of materia medica, records that donkey-hide gelatin has the effects of nourishing blood, dispelling wind, moistening dryness, eliminating phlegm, clearing away lung-heat, promoting urination, regulating large intestine, and holy herbs also indicate that donkey-hide gelatin has the effects of nourishing yin, moistening dryness, nourishing blood, enriching blood, eliminating phlegm, relaxing bowels and the like. Modern researches show that the donkey-hide gelatin contains various elements such as collagen, ossein, protein, calcium, potassium, sodium, magnesium, zinc and the like, and the contained protein can generate various essential amino acids after being hydrolyzed, thereby having the effects of strengthening the body, improving the sleep, strengthening the brain, improving the intelligence and delaying the aging.
(2) Amber powder is fossil powder formed by resin of ancient maple and pine trees after being buried in stratum for many years. Sweet in flavor and sexual. Has the effects of calming heart, tranquilizing mind, inducing diuresis and treating stranguria. Can be used for treating sleep disorder, stranguria, urinary obstruction, hematuria, etc.
(3) Pearl powder, recorded in compendium of materia medica, has the efficacies of tranquilizing and allaying excitement, nourishing yin and calming endogenous wind, improving eyesight and removing nebula, detoxifying and promoting granulation and the like. The pearl is reported to have the function of improving sleep, contains various amino acids, trace elements and taurine, is easy to be absorbed by organisms after the main chemical components of calcium carbonate are hydrolyzed, is beneficial to the growth and development of teeth and bones, keeps the balance of blood electrolytes and has certain nerve-soothing function.
(4) Rose flower, sweet, slightly bitter and warm. Enter liver and spleen meridians, promote qi circulation to relieve depression, harmonize blood, alleviate pain, promote qi circulation with fragrance, relieve diarrhea with bitter taste, and has the effects of soothing liver and relieving depression, activating spleen and stomach, promoting qi circulation and relieving pain. The rose has the pharmacological property of soothing the liver and regulating the flow of qi, and is also helpful for relieving negative emotion and improving sleep quality.
(5) Peach kernel, bitter and sweet in taste, neutral in nature, enters heart, liver and large intestine meridians. It has effects of promoting blood circulation, removing blood stasis, and loosening bowel to relieve constipation. The book of medical science: peach kernel, semen Persicae, bitter in flavor, can purge blood heat, moisten body and nourish intestinal dryness. Ben Cao Jing Shu (the book of materia Medica Prime and Dredging): tao ren is good at breaking blood. Clinical observation proves that peach kernel has the effect of improving blood flow blockage and blood circulation disorder and can restore the function of each organ and each tissue to be normal.
(6) Hawthorn, also known as Crataegus pinnatifida, Pyrus crassipes and Carnius asiatica, is a product used as both medicine and food. It is sweet and sour in taste, slightly warm in nature, and has effects of promoting appetite, resolving food stagnation, promoting blood circulation, removing blood stasis, eliminating phlegm, and relieving dysentery. Is suitable for treating meat stagnation, phlegm retention, dysentery, apoplexy, cervicodynia, omalgia, lumbago, skelalgia, neurasthenia, hypertension, and improving appetite and sleep.
(7) Grape seeds contain polyphenols (GPS), mainly catechins and proanthocyanidins. The catechin compounds comprise catechin, epicatechin and gallate thereof, are main monomers in grape seeds and are also constituent units of procyanidin oligomers and polymers, the oil grape seeds contain abundant oil accounting for 12-15% of the oil grape seeds, the oil contains a large amount of unsaturated fatty acids, and the content of linoleic acid is 58-78%. The volatile component grape seed also contains a small amount of volatile components, and most of the volatile components belong to alcohol, phenol and terpenoid, and have high biological activity. The grape seed contains crude protein, amino acids, vitamin A, E, D, K, P and various trace elements such as calcium, zinc, ferrum, magnesium, copper, potassium, sodium, and manganese in addition to the above substances, and has effects of resisting oxidation, preventing radiation, resisting aging, preventing sunburn, and improving cardiovascular and cerebrovascular activities.
(8) Dang Gui, Shen nong Ben Cao Jing: dang Gui is sweet in flavor and warm in nature. But for the diseases caused by blood deficiency and blood stagnation, Dang Gui can be used to treat them.
(9) Cassia twig, formula medicine comprehension: the cassia twig is a medicine for qi system and a medicine for blood system, has wide effects, and can release exterior and harmonize nutrient; it can not only transform qi and activate yang, but also activate blood and unblock collaterals, and descend qi and smooth Chong, but the dosage is large. Huang and recorded in the record of the heavy-dose traditional Chinese medicine, Gui Zhi has the actions of activating yang, tonifying yang, activating stagnancy, removing blood stasis, dredging and activating meridians, and regulating airway, water channel and blood channel, so it is not an essential herb for exogenous disease, and also a good agent for internal injury and miscellaneous diseases. Gui Zhi is pungent, sweet and warm in nature and can tonify and tonify, and also has the actions of tonifying yang, warming, dispersing and smoothing the flow of qi, so it is indicated for cold, damp, wind, stagnation, stasis, deficiency and excess syndromes, and also for warming meridians, dredging collaterals, tonifying yang and regulating qi. Cassia twig, ramulus Cinnamomi, pungent in flavor and warm in property, has mild nature, can tonify and move, can be ascended and descended, although the powder is also astringing, can dredge and soften, can move qi and blood, and can dredge channels and collaterals, modern experiments show that cassia twig water decoction has 5, 12 and 30g/kg of gastric lavage, has remarkable sedative and anxiolytic effects, and is in dosage dependence.
(10) Licorice root, radix Glycyrrhizae is sweet, mild and mild, can reduce the heat of heat-dissipating herbs and control the cold of cold-dissipating herbs, and is known as the main herb of many people, and it is one of the most frequently used herbs in ancient and modern Chinese herbs. Shennong herbal can relieve dysphoria with smothery sensation in chest, quench thirst in mouth, calm mood, and promote sleep through radix Glycyrrhizae.
(11) Poria, the dried sclerotium of Poria cocos (Schw.) wolf, a fungus of Polyporaceae, is often parasitic on the roots of Pinus densiflora or Pinus massoniana, etc., which are plants of Pinaceae. Mainly produced in Yunnan, Anhui, Hubei, Henan, Sichuan and so on. The raw material is ground or extracted for external use, and the properties and flavor are sweet, light and mild. Enter heart, spleen and kidney meridians, induce diuresis and drain dampness, invigorate spleen and tranquilize mind, and have mild property for treating restlessness of heart-mind such as palpitation and insomnia. Poria has effects in regulating immunity, promoting metabolism, moistening skin, tranquilizing mind, and improving sleep.
(12) Coix seed, semen coicis, sweet and light in taste and slightly cold in nature, enters spleen, stomach and lung channels, has the effects of promoting water and dampness, invigorating spleen, removing arthralgia, clearing heat and expelling pus, and is used for treating dysuria, edema, beriberi, spleen deficiency and diarrhea, damp arthralgia and contracture, intestinal abscess, pulmonary abscess and the like. Modern researches find that the coix seed contains various components such as coix seed oil, coix seed ester and the like, and has the effects of promoting sleep, resisting viruses, enhancing immunity and eliminating warts.
(13) Huang Qi, Huang Qi is sweet in flavor and slightly warm in nature, and is an important qi-tonifying drug, so it is indicated for all kinds of qi deficiency syndromes because it can tonify qi of the whole body. Modern pharmacological research shows that the medicine has the functions of strengthening heart and protecting liver and is a well-known good medicine for invigorating qi. The medicated diet made of the astragalus membranaceus can improve the symptoms of frequent micturition, soreness and weakness of waist and knees, dizziness and tinnitus, spermatorrhea, premature ejaculation, abnormal leucorrhea and the like, and can also increase appetite, moisten skin and benefit sleep.
(14) Dark plum, sour and mild in taste. Governing descending qi, removing heat, relieving restlessness, calming heart, limb pain, hemiplegia, dead skin, black nevus and malignant flesh. The dark plum is a Chinese product in Benjing, is prepared by processing nearly mature fruit of plum in Rosaceae, and has obvious sour taste and astringent effect in the original famous plum in Benjing. Whether cough or dyspnea is caused by the adverse rising of lung qi. The dark plum fruit is related to sour taste, is acidic and astringent, can astringe lung qi, contains citric acid, malic acid, succinic acid and fumaric acid, has the effects of tonifying spleen and stimulating appetite, can promote menstruation and blood circulation, and regulates sleep problems caused by liver fire hyperactivity.
(15) The sesame and the sesame have the effects of moistening intestines, promoting lactation, tonifying liver, tonifying kidney, nourishing hair, strengthening body and resisting aging. Has effects in nourishing liver and kidney, caring skin, resisting aging, moistening lung, reducing blood lipid, nourishing brain, improving intelligence, and improving sleep.
(16) MACA, MACA is a pure natural organic plant growing above 3500 m of altitude, besides abundant nutrient elements needed by human body, the MACA also contains two substances named by unique MACA, MACA alkene and MACA amide, the two alkaloid substances can activate the organs producing hormone, the hormone secretion level of the organism which is continuously reduced is promoted, the abundant taurine, protein and the like can condition and repair physiological functions, improve qi and blood and resist climacteric symptoms, relieve osteoporosis, the MACA extract can improve the sleep quality and accelerate the human sleep speed in all directions: and (3) regulating sleep quality: the patient can keep deep sleep state, and shallow sleep can be avoided. And clinical research shows that the traditional Chinese medicine composition has no toxic or side effect and is a good agent for improving sleep quality.
(17) Choerospondias axillaris is a fresh fruit of Choerospondias axillaris (Roxb.) Burtt et Hill of Anacardiaceae, also known as fructus Choerospondiatis, Ziziphi Spinosae, and semen Ziziphi Spinosae. It enters spleen and liver meridians. The choerospondias axillaris fruit contains flavonoids, sterols, organic acids, coumarins, saccharides, volatile oil, tannin and other phenolic components, further contains a large amount of vitamin C, the content of the vitamin C is 2-3 times of that of red dates and 20-30 times of that of citrus, the utilization rate of the choerospondias axillaris fruit in a human body can reach 86.3 percent, even the unit content of the choerospondias axillaris fruit is higher than that of kiwi fruits, and the choerospondias axillaris fruit is known as the king of vitamin C. The choerospondias axillaris is cool in nature, sour and astringent in taste, can 'calm five internal organs, lighten the body and prolong life', is a traditional medicinal material for Mongolian people, has the effects of promoting qi and blood circulation, nourishing the heart and soothing the nerves, and is used for treating symptoms such as qi stagnation and blood stasis, chest pain caused by obstruction of qi, palpitation and short breath, uneasiness and the like.
(18) Fructus Jujubae is dried mature fruit of Ziziphus jujuba Mill of Rhamnaceae. Sweet and warm. It enters spleen, stomach and heart meridians. Has the effects of invigorating spleen and replenishing qi, nourishing blood and tranquilizing. Can be used for treating spleen deficiency, anorexia, asthenia, loose stool, and hysteria of women. The Chinese date contains rich nutrient substances, such as protein, amino acid, polysaccharide, vitamin and the like, and also contains various trace elements, such as calcium, iron, potassium, magnesium, manganese, aluminum and the like, and the cAMP and cGMP have very high content in the fully mature Chinese date. The Chinese date has wide pharmacological actions of enhancing immunity, inhibiting cancer cell proliferation, protecting liver, resisting I type allergic reaction and the like, has certain curative effects on hypertension, diabetes, cardiogenic shock and the like, and is traditional food used as both medicine and food.
(19) Fructus Lycii is dried mature fruit of Lycium barbarum L. of Solanaceae. Sweet and neutral. It enters liver and kidney meridians. Has effects of nourishing liver and kidney, replenishing vital essence, and improving eyesight. Can be used for treating consumptive disease and essence deficiency, soreness of waist and knees, giddiness and tinnitus, sexual impotence and nocturnal emission, internal heat and thirst, blood deficiency and sallow complexion, and blurred vision. Modern researches show that the medlar contains components such as betaine, amino acid, vitamin, polysaccharide and the like, and has the effects of regulating immunity, resisting aging, resisting tumors, resisting fatigue, resisting radiation damage, regulating blood fat, reducing blood sugar, reducing blood pressure, protecting reproductive system, improving eyesight, improving respiratory disease resistance, maintaining beauty, keeping young, moistening skin, protecting liver, enhancing hematopoietic function and the like.
(20) Mulberry, which is a dry ear of Morus alba L. Sweet, sour and cold. It enters heart, liver and kidney meridians. Has the effects of nourishing yin, tonifying blood, promoting fluid production and moistening dryness. Can be used for treating liver and kidney yin deficiency, giddiness tinnitus, cardiopalmus insomnia, early white beard and hair, body fluid consumption thirst, internal heat diabetes, and constipation due to intestinal dryness. Mulberry contains various essential amino acids, microelements, flavonoids, anthocyanins, phenolic acids and polysaccharides, etc., and has the functions of protecting liver, resisting oxidation, resisting aging, reducing blood sugar, enhancing immunity, resisting inflammation, resisting cancer, reducing blood pressure, etc.
(21) Arillus longan is dried nearly mature fruit of Prunus mume (Sieb.) Sieb. et Zucc. of Rosaceae. Sour, astringent and neutral. It enters liver, spleen, lung and large intestine meridians. Has the effects of astringing lung, astringing intestine, promoting fluid production and calming ascaris. Can be used for treating lung deficiency, chronic cough, chronic diarrhea, dysentery, asthenia heat, diabetes, ascariasis, emesis, and abdominal pain.
(22) Lotus seeds are seeds of the aquatic herbaceous plant Nelumbo nucifera gaertn of the family of the Nymphaeaceae. Enter spleen, kidney and heart meridians. It has effects in clearing away heart-fire, activating spleen, invigorating spleen, relieving diarrhea, nourishing heart, tranquilizing mind, improving eyesight, invigorating spleen, invigorating stomach, stopping nocturnal emission, invigorating kidney, arresting seminal emission, and stopping leukorrhagia. Nourishing primordial qi, etc. It is often used to treat vexation, insomnia, spleen deficiency, chronic diarrhea, etc. Researches show that the lotus seed contains fatty acid, palmitic acid, oleic acid, linoleic acid, linolenic acid, protein, fat, dietary fiber, carbohydrate, thiamine, riboflavin, nicotinic acid, polysaccharide, flavonoid compounds (such as quercetin, rutin and hyperin) and various mineral substances such as zinc, selenium and the like. Alkaloid contained in the lotus plumule has a remarkable cardiotonic effect, and the liensinine has strong calcium and arrhythmia resisting effects, and has a good treatment effect on mild insomnia.
(23) Bulbus Lilii is dried fleshy scale leaf of Lilium Brownnii F.E.Brownvar.viriduum Baker of Liliaceae. It is cold in nature and sweet in flavor, and enters heart and lung meridians. Has effects in nourishing yin, clearing away lung heat, eliminating phlegm, relieving cough, calming heart, and tranquilizing mind. Modern researches have proved that lily contains various chemical components, such as starch, protein, fat, amino acids, trace elements, vitamins and dietary fibers. Has hypnotic, tranquilizing, and anticancer effects. The lily can shorten the time of falling asleep, improve sleep quality and promote sleep. Experiments show that the sleep time of pentobarbital sodium and the sleep rate of subliminal dose of mice drenched with the lily water extract are obviously increased, and the pentobarbital sodium has obvious sedative effect.
The 23 natural plant raw materials with homology of medicine and food are compatible according to the theory of traditional Chinese medicine, the formula is optimized through a scientific method, a flavoring agent is not additionally added, the proper taste can be achieved, and the modern pharmacology verifies that the natural plant raw materials have the function of improving sleep.
Compared with the prior art, the invention is characterized in that:
(1) the compound fruit cake with the sleep improving function is prepared from the raw materials of traditional Chinese medicines which are food and medicines, is safe and nontoxic, and is suitable for long-term administration.
(2) The traditional preparation method is improved, and the formula types and the proportion are optimized, specifically as follows: on the basis of the traditional wild jujube cake, other twenty-two traditional Chinese medicines with homology of medicine and food are added, and the carrageenin and the konjac glucomannan are used for replacing cane sugar, so that the defects that the sugar content is too high, diabetes mellitus, obesity, children, the old and other groups are not suitable for eating too much in the traditional preparation method of the wild jujube cake are overcome. The optimal component proportion is optimized by adopting an orthogonal experiment, so that the taste and the effect are both good.
(3) The traditional Chinese medicine composition is prepared according to the traditional Chinese medicine theory, the formula is optimized through a scientific method, and the effect of improving sleep is verified through modern pharmacology.
Detailed Description
The following description of the preferred embodiments of the present invention is provided for the purpose of illustration and description, and is in no way intended to limit the invention.
Example 1
A compound fruit cake helpful for improving sleep function is characterized in that: the feed is prepared from the following raw materials in parts by weight: 7 parts of donkey-hide gelatin, 3 parts of amber powder, 3 parts of pearl powder, 14 parts of rose, 7 parts of peach kernel, 14 parts of hawthorn, 14 parts of grape seed, 3 parts of angelica, 3 parts of cassia twig, 14 parts of honey liquorice, 14 parts of poria cocos, 14 parts of semen coicis, 3 parts of astragalus membranaceus, 14 parts of dark plum, 14 parts of sesame, 7 parts of maca, 14 parts of fresh choerospondias axillaris, 7 parts of denucleated Chinese date, 10 parts of longan pulp, 7 parts of wolfberry fruit, 10 parts of dried mulberry, 7 parts of lily, 7 parts of lotus seed, purified water and composite glue, wherein the weight of the purified water is 4 times that of the pulp, the mass of the composite glue is 1.5% of the sum of the mass of the pulp and the purified water, and the composite glue is composed of.
Example 2
A compound fruit cake helpful for improving sleep function is characterized in that: the feed is prepared from the following raw materials in parts by weight: 21 parts of donkey-hide gelatin, 7 parts of amber powder, 7 parts of pearl powder, 35 parts of rose, 21 parts of peach kernel, 35 parts of hawthorn, 35 parts of grape seed, 7 parts of angelica, 7 parts of cassia twig, 35 parts of honey liquorice, 35 parts of poria cocos, 35 parts of semen coicis, 7 parts of astragalus membranaceus, 35 parts of dark plum, 35 parts of sesame, 21 parts of maca, 35 parts of fresh choerospondias axillaris, 21 parts of pitted Chinese date, 32 parts of longan pulp, 21 parts of wolfberry fruit, 32 parts of dried mulberry, 21 parts of lily, 21 parts of lotus seed, purified water and compound gum, wherein the weight of the purified water is 5 times that of the pulp, the mass of the compound gum is 1.5% of the sum of the mass of the pulp and the purified water, and the compound gum is composed of.
Example 3
A compound fruit cake helpful for improving sleep function is characterized in that: the feed is prepared from the following raw materials in parts by weight: 10 parts of donkey-hide gelatin, 6 parts of amber powder, 6 parts of pearl powder, 17 parts of rose, 10 parts of peach kernel, 17 parts of hawthorn, 17 parts of grape seed, 6 parts of angelica, 6 parts of cassia twig, 17 parts of honey liquorice, 17 parts of poria cocos, 17 parts of semen coicis, 6 parts of astragalus mongholicus, 17 parts of dark plum, 17 parts of sesame, 10 parts of maca, 17 parts of fresh choerospondias axillaris, 10 parts of denucleated jujube, 13 parts of longan pulp, 10 parts of wolfberry fruit, 13 parts of dried mulberry, 10 parts of lily, 10 parts of lotus seed, purified water and composite glue, wherein the purified water is 4 times of the weight of the pulp, the mass of the composite glue is 1.5% of the mass sum of the pulp and the purified water, and the composite glue is composed of carrageenan and konjac glucomannan.
Example 4
A compound fruit cake helpful for improving sleep function is characterized in that: the feed is prepared from the following raw materials in parts by weight: 18 parts of donkey-hide gelatin, 4 parts of amber powder, 4 parts of pearl powder, 32 parts of rose, 18 parts of peach kernel, 32 parts of hawthorn, 32 parts of grape seed, 4 parts of angelica, 4 parts of cassia twig, 32 parts of honey licorice, 32 parts of poria cocos, 32 parts of semen coicis, 4 parts of astragalus membranaceus, 32 parts of dark plum, 32 parts of sesame, 18 parts of maca, 32 parts of fresh choerospondias axillaris, 18 parts of denucleated Chinese date, 29 parts of longan pulp, 18 parts of wolfberry fruit, 29 parts of dried mulberry, 18 parts of lily, 18 parts of lotus seed, purified water and composite glue, wherein the purified water is 4.5 times of the weight of the pulp, the mass of the composite glue is 1.5 percent of the mass sum of the pulp and the purified water, and the composite glue is composed of carrageenan and konjac gum in.
Example 5
A compound fruit cake helpful for improving sleep function is characterized in that: the feed is prepared from the following raw materials in parts by weight: 11 parts of donkey-hide gelatin, 5 parts of amber powder, 5 parts of pearl powder, 25 parts of rose, 11 parts of peach kernel, 25 parts of hawthorn, 25 parts of grape seed, 5 parts of angelica, 5 parts of cassia twig, 25 parts of honey liquorice, 25 parts of poria cocos, 25 parts of semen coicis, 5 parts of astragalus membranaceus, 25 parts of dark plum, 25 parts of sesame, 11 parts of maca, 25 parts of fresh choerospondias axillaris, 11 parts of denucleated jujube, 22 parts of longan pulp, 11 parts of wolfberry fruit, 22 parts of dried mulberry, 11 parts of lily, 11 parts of lotus seed, purified water and composite glue, wherein the weight of the purified water is 4 times that of the pulp, the mass of the composite glue is 1.5% of the sum of the mass of the pulp and the purified water, and the composite glue is composed of carrageenan.
Example 6
A compound fruit cake helpful for improving sleep function is characterized in that: the feed is prepared from the following raw materials in parts by weight: 10 parts of donkey-hide gelatin, 5 parts of amber powder, 4 parts of pearl powder, 20 parts of rose, 15 parts of peach kernel, 15 parts of hawthorn, 15 parts of grape seed, 5 parts of Chinese angelica, 5 parts of cassia twig, 15 parts of honey licorice, 25 parts of poria cocos, 25 parts of coix seed, 5 parts of astragalus membranaceus, 25 parts of dark plum, 25 parts of sesame, 20 parts of maca, 14 parts of fresh choerospondias axillaris, 14 parts of denucleated Chinese date, 32 parts of longan pulp, 21 parts of wolfberry fruit, 32 parts of dried mulberry, 7 parts of lily, 7 parts of lotus seed, purified water and composite glue, wherein the purified water is 4.5 times of the weight of the pulp, the mass of the composite glue is 1.5 percent of the mass sum of the pulp and the purified water, and the composite glue is composed of carrageenan and konjac.
Example 7
A compound fruit cake helpful for improving sleep function is characterized in that: is prepared by the following method:
(1) weighing colla Corii Asini, Succinum powder, Margarita powder, flos Rosae Rugosae, semen Persicae, fructus crataegi, grape seed, radix Angelicae sinensis, ramulus Cinnamomi, Glycyrrhrizae radix, Poria, Coicis semen, radix astragali, mume fructus, semen Sesami, Lepidium Meyenii Walp, fresh Choerospondias axillaris, enucleated fructus Jujubae, arillus longan, fructus Lycii, dried Mori fructus, Bulbus Lilii, and semen Nelumbinis according to the content of examples 1-6 respectively, soaking in purified water, decocting with slow fire for softening, and grinding with colloid mill into uniform fruit paste;
(2) adding purified water into the fruit paste obtained in the step (1), decocting for 15min with slow fire, concentrating, and concentrating at 80 ℃ until the fruit paste is steeped but does not splash;
(3) respectively adding composite glue according to the content of the embodiment 1-6, wherein the composite glue consists of carrageenan and konjac glucomannan, the mass of the composite glue is 1.5 percent of the sum of the mass of the pulp and the purified water, and continuously heating and stirring until the pulp is viscous;
(4) and (4) pouring the mixed fruit paste prepared in the step (3) into a mould while the mixed fruit paste is hot, standing for forming, drying and cutting into blocks of 20 g.
Example 8 screening test example of optimum formulation of Compound cake
In order to achieve the optimal taste, the optimal proportion of the embodiment 1-6 is optimized through a single-factor orthogonal experiment, and the water adding amount and the proportion of the carrageenan and the konjac gum in the forming process are optimized. The compound fruit cake was prepared according to the process flow of example 7.
The instruments, reagents, materials and the like used in the following experiments are conventional instruments, reagents, materials and the like in the prior art and are commercially available in a normal way unless otherwise specified. Unless otherwise specified, the experimental methods and detection methods related to the following experiments are all the experimental methods and detection methods known in the prior art.
Donkey-hide gelatin, amber powder, pearl powder, rose, peach kernel, hawthorn, grape seed, Chinese angelica, cassia twig, honey liquorice, tuckahoe, coix seed, astragalus, dark plum, sesame, maca, fresh choerospondias axillaris, pitted Chinese date, longan aril, medlar, dried mulberry, lily and lotus seed are purchased from a Harbin three-plant medicinal material market, and carrageenan and konjac glucomannan are purchased from a Harbin food wholesale market.
Orthogonal experiments prove that the compound fruit cake in example 6 is superior to other comparative examples in moldability, mouthfeel and flavor, and the compound fruit cake is prepared from 10 parts of donkey-hide gelatin, 5 parts of amber powder, 4 parts of pearl powder, 20 parts of rose, 15 parts of peach kernel, 15 parts of hawthorn, 15 parts of grape pip, 5 parts of Chinese angelica, 5 parts of cassia twig, 15 parts of honey licorice, 25 parts of poria cocos, 25 parts of coix seed, 5 parts of astragalus membranaceus, 25 parts of dark plum, 25 parts of sesame, 20 parts of maca, 14 parts of fresh choerospondias axillaris, 14 parts of denucleated Chinese date, 32 parts of longan pulp, 21 parts of wolfberry, 32 parts of dried mulberry, 7 parts of lily, 7 parts of lotus seed, purified water and compound gum, wherein the purified water is 4.5 times of the weight of the pulp, the mass of the compound gum is 1.5% of the sum of the pulp and the purified water, and the compound gum is prepared from the carrageenan and the konjac gum in.
Example 9 evaluation of Functionality of Complex fruit cake-experiment for improving sleep function of mouse
1. Method of producing a composite material
1.1 animals and groups
Healthy male ICR mice, female, body weight (20-25) g, were divided into a positive control group, a high dose group (30.1mg/g) (equivalent to 10 times the amount of human), a medium dose group (15.10mg/g) (equivalent to 5 times the amount of human), a low dose group (3.03mg/g) (equivalent to 1 time the amount of human), and a blank control group, each group consisting of 10 mice.
1.2 sample treatment: and adding a proper amount of purified water into the finished product of the example 1, and grinding for 15min to obtain the compound fruit cake intragastric lavage solution of the example 1.
1.3 administration of drugs
The positive drug control group was gavage daily (0.01g/kg) by weight (equivalent to 10 times the amount used in human); example 6 mice in the high dose group (30.1mg/g) (corresponding to 10 times the amount of human), the medium dose group (15.10mg/g) (corresponding to 5 times the amount of human), and the low dose group (3.03mg/g) (corresponding to 1 time the amount of human) were gavaged with the complex cake solution of example 6 per day by body weight. The blank control group was gavaged with purified water of equal volume. The administration is carried out continuously by gavage for 30 days at a dose of 1/day.
1.4 direct sleep experiment
After the mice were administered with the test substance by gavage, the direct sleep effect (sleep using disappearance of righting reflex as an index) was observed, and the number of sleeping animals and the sleep time were recorded.
1.5 experiment for prolonging sleep time of sodium pentobarbital
After 30 days after the test substance is administered to the mice by gastric lavage, the test substance is administered for the last 30 minutes, pentobarbital sodium (50mg/kg) is intraperitoneally injected, and the sleep time of each group of mice is recorded.
Pentobarbital sodium subthreshold dose hypnosis test: after 30 days after the test substance is administered to the mice by gavage, 30 minutes after the test substance is administered to the mice for the last time, pentobarbital sodium (25mg/kg) with the maximum subthreshold dose that the righting reflex does not disappear is injected into the abdominal cavity, and the number of the animals falling asleep within 30 minutes is recorded.
Barbiturate sodium sleep latency experiments: after 30 days after the test substance is administered to the mice by gastric lavage, and 30 minutes after the test substance is administered to the mice for the last time, barbiturate sodium (300mg/kg) is injected into the abdominal cavity, and the sleep latency time of each group of mice is recorded.
The experimental data results adopt the mean value plus or minus the standard deviation
Figure BDA0002995776600000133
Represents; p < 0.05 represents significant difference, P < 0.01 represents very significant difference;
2. results of the experiment
2.1 appearance of mice
Compared with the blank control group, the behavior state, emotional response, activity degree, diet, skin and hair, sleep and stool of the mice of each administration group are not abnormal.
2.2 direct sleep Effect on mice
The sleep phenomenon does not appear in all groups of mice after gastric lavage, which shows that the compound fruit cake in the example 6 has no direct sleep effect on the mice,
see Table 2 for details
TABLE 2 direct sleep effect of Compound fruit cake on mice by oral gavage EXAMPLE 6 (n ═ 10)
Figure BDA0002995776600000131
2.3 experiment for prolonging sleep time of sodium pentobarbital
Compared with a blank control group, the sleep time of the mice in the dose group in the example 6 is prolonged by 52.8 percent, and the effect is best, and the details are shown in a table 3.
TABLE 3 oral gavage EXAMPLE 1 Compound fruit cake extended sleep time pentobarbital sodium experiment (n ═ 10)
Figure BDA0002995776600000132
Figure BDA0002995776600000141
Note: p < 0.01 compared to control blank; compared with the positive control group, the delta P is less than 0.05, and the delta P is less than 0.01
Pentobarbital sodium subthreshold dose hypnosis test: compared with the blank control group, the positive control group and the high, medium and low dose groups of example 6 all have higher sleep rates, and the mice of the medium dose group of example 6 have higher sleep rates than the mice of the high and low dose groups. See table 4.
TABLE 4 gavage EXAMPLE 6 subthreshold dose hypnosis test of Compound fruit cake sodium pentobarbital (n ═ 10)
Figure BDA0002995776600000142
Pentobarbital sodium sleep latency experiments: the sleep latency was shortened in the positive control group and the high, medium and low dose groups of example 6, compared to the blank control group, and the sleep latency was shorter in the medium dose group of example 6 than in the high and low dose groups of example. See table 5.
TABLE 5 gavage EXAMPLE 6 composite fruit cake barbital sodium sleep latency experiment (n ═ 10)
Group of Sleep latency (min) The reduction rate of sleep latency%
Blank control group 42.3±2.1 -----
Positive control group 29.3±3.3** 30.7
Example 1 high dose group 38.6±2.7△△ 8.8
Dose groups of example 1 34.3±1.4△ 18.9
Example 1 Low dose group 36.9±2.6△ 12.8
Note: p < 0.01 compared to control blank; compared with the positive control group, the delta P is less than 0.05, and the delta P is less than 0.01
In the sub-threshold dose hypnosis experiment of sodium pentobarbital, the high, medium and low dose groups of example 6 can obviously increase the number of sleeping mice; in the barbiturate sodium sleep latency experiment, the high, medium and low dose groups of example 6 can significantly shorten the sleep latency of mice. The compound fruit cake in example 6 has the effect of assisting in improving the sleep function.
It will be apparent to those skilled in the art that various changes and modifications may be made in the present invention without departing from the spirit and scope of the invention. Thus, if such modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalents, the present invention is also intended to include such modifications and variations.

Claims (4)

1. A compound fruit cake helpful for improving sleep function is characterized in that: the feed is prepared from the following raw materials in parts by weight: 7-21 parts of donkey-hide gelatin, 3-7 parts of amber powder, 3-7 parts of pearl powder, 14-35 parts of rose, 7-21 parts of peach kernel, 14-35 parts of hawthorn, 14-35 parts of grape seed, 3-7 parts of angelica, 3-7 parts of cassia twig, 14-35 parts of honey liquorice, 14-35 parts of poria cocos, 14-35 parts of coix seed, 3-7 parts of astragalus membranaceus, 14-35 parts of dark plum, 14-35 parts of sesame, 7-21 parts of maca, 14-35 parts of fresh choerospondias axillaris, 7-21 parts of denucleated jujube, 10-32 parts of longan pulp, 7-21 parts of wolfberry fruit, 10-32 parts of dried mulberry, 7-21 parts of lily, 7-21 parts of lotus seed, purified water and composite glue, wherein the purified water is 4-5 times of the weight of the pulp, and the mass of the composite glue is 1.5 percent of the sum of the pulp and, the composite glue is composed of carrageenan and konjac glucomannan according to the proportion of 1: 1-1: 2.
2. The compound fruit cake beneficial to improving sleep function as claimed in claim 1, is characterized by being prepared from the following raw materials in parts by weight: 10 parts of donkey-hide gelatin, 5 parts of amber powder, 4 parts of pearl powder, 20 parts of rose, 15 parts of peach kernel, 15 parts of hawthorn, 15 parts of grape seed, 5 parts of Chinese angelica, 5 parts of cassia twig, 15 parts of honey licorice, 25 parts of poria cocos, 25 parts of coix seed, 5 parts of astragalus membranaceus, 25 parts of dark plum, 25 parts of sesame, 20 parts of maca, 14 parts of fresh choerospondias axillaris, 14 parts of denucleated Chinese date, 32 parts of longan pulp, 21 parts of wolfberry fruit, 32 parts of dried mulberry, 7 parts of lily, 7 parts of lotus seed, purified water and composite glue, wherein the purified water is 4.5 times of the weight of the pulp, the mass of the composite glue is 1.5 percent of the mass sum of the pulp and the purified water, and the composite glue is composed of carrageenan and konjac.
3. A method for preparing a compound fruitcake helpful for improving sleep function as claimed in any one of claims 1 to 2, wherein: is prepared by the following method:
(1) weighing colla Corii Asini, Succinum powder, Margarita powder, flos Rosae Rugosae, semen Persicae, fructus crataegi, grape seed, radix Angelicae sinensis, ramulus Cinnamomi, Mel Glycyrrhrizae radix, Poria, Coicis semen, radix astragali, mume fructus, semen Sesami, Lepidium Meyenii Walp, fresh Choerospondias axillaris, pitted fructus Jujubae, arillus longan, fructus Lycii, dried Mori fructus, Bulbus Lilii, and semen Nelumbinis, soaking in purified water, decocting with slow fire for softening, and grinding into uniform fruit paste with colloid mill;
(2) adding purified water into the fruit paste obtained in the step (1), decocting for 15min with slow fire, concentrating, and concentrating at 80 ℃ until the fruit paste is steeped but does not splash;
(3) adding composite glue, wherein the composite glue is composed of carrageenan and konjac gum, the mass of the composite glue is 1.5% of the sum of the mass of the pulp and the mass of the purified water, and continuously heating and stirring until the pulp is sticky;
(4) and (4) pouring the mixed fruit paste prepared in the step (3) into a mould while the mixed fruit paste is hot, standing for forming, drying and cutting into blocks of 20 g.
4. Use of the compound fruit cake for improving sleep function according to claim 1 in the preparation of functional food.
CN202110329220.9A 2021-03-27 2021-03-27 Composite fruit cake beneficial to improving sleep function and preparation method thereof Pending CN112956664A (en)

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CN105394637A (en) * 2015-11-13 2016-03-16 江苏福坊斋食品有限公司 Maca, cordyceps sinensis, black wolfberry fruit and poria cocos health hawthorn cakes and preparation process thereof
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Application publication date: 20210615