CN112955154A - 肌肉靶向复合物及其用于治疗强直性肌营养不良的用途 - Google Patents

肌肉靶向复合物及其用于治疗强直性肌营养不良的用途 Download PDF

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CN112955154A
CN112955154A CN201980062906.7A CN201980062906A CN112955154A CN 112955154 A CN112955154 A CN 112955154A CN 201980062906 A CN201980062906 A CN 201980062906A CN 112955154 A CN112955154 A CN 112955154A
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complex
muscle
antibody
oligonucleotide
transferrin receptor
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罗梅什·R·苏布拉马尼亚
穆罕默德·T·卡塔纳尼
蒂莫西·威登
科迪·A·德雅尔丹
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Dyne Therapeutics Inc
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Dyne Therapeutics Inc
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CN201980062906.7A 2018-08-02 2019-08-02 肌肉靶向复合物及其用于治疗强直性肌营养不良的用途 Pending CN112955154A (zh)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201862713914P 2018-08-02 2018-08-02
US62/713,914 2018-08-02
US201862779161P 2018-12-13 2018-12-13
US62/779,161 2018-12-13
US201962855761P 2019-05-31 2019-05-31
US62/855,761 2019-05-31
US201962858888P 2019-06-07 2019-06-07
US62/858,888 2019-06-07
US201962859672P 2019-06-10 2019-06-10
US62/859,672 2019-06-10
PCT/US2019/044987 WO2020028861A1 (en) 2018-08-02 2019-08-02 Muscle targeting complexes and uses thereof for treating myotonic dystrophy

Publications (1)

Publication Number Publication Date
CN112955154A true CN112955154A (zh) 2021-06-11

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CN201980062906.7A Pending CN112955154A (zh) 2018-08-02 2019-08-02 肌肉靶向复合物及其用于治疗强直性肌营养不良的用途

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US (1) US20210308272A1 (enExample)
EP (1) EP3829596A4 (enExample)
JP (2) JP7705793B2 (enExample)
KR (1) KR20210081323A (enExample)
CN (1) CN112955154A (enExample)
AU (2) AU2019314538B2 (enExample)
CA (1) CA3108287A1 (enExample)
IL (2) IL321905A (enExample)
MX (1) MX2021001283A (enExample)
SG (1) SG11202100925VA (enExample)
WO (1) WO2020028861A1 (enExample)

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JP7506601B2 (ja) 2017-12-06 2024-06-26 アビディティー バイオサイエンシーズ，インク． 筋萎縮症と筋緊張性ジストロフィーを処置するための組成物および方法
US11911484B2 (en) 2018-08-02 2024-02-27 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating myotonic dystrophy
US12018087B2 (en) 2018-08-02 2024-06-25 Dyne Therapeutics, Inc. Muscle-targeting complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide and methods of delivering oligonucleotide to a subject
US11168141B2 (en) 2018-08-02 2021-11-09 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating dystrophinopathies
US12370264B1 (en) 2018-08-02 2025-07-29 Dyne Therapeutics, Inc. Complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide and method of delivering oligonucleotide to a subject
SG11202100934PA (en) 2018-08-02 2021-02-25 Dyne Therapeutics Inc Muscle targeting complexes and uses thereof for treating dystrophinopathies
SG11202100928QA (en) 2018-08-02 2021-02-25 Dyne Therapeutics Inc Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy
US12097263B2 (en) 2018-08-02 2024-09-24 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating myotonic dystrophy
WO2021142217A1 (en) * 2020-01-10 2021-07-15 Dyne Thereapeutics, Inc. Muscle targeting complexes and uses thereof for modulation of milck1
EP4656242A2 (en) * 2020-03-27 2025-12-03 Avidity Biosciences, Inc. Compositions and methods of treating muscle dystrophy
KR20230046297A (ko) * 2020-07-23 2023-04-05 다인 세라퓨틱스, 인크. 근육 표적화 복합체 및 안면견갑상완 근육 이영양증을 치료하기 위한 그의 용도
MX2023000958A (es) * 2020-07-23 2023-04-14 Dyne Therapeutics Inc Complejos dirigidos al musculo y usos de estos para el tratamiento de la distrofia miotonica.
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WO2022120132A1 (en) * 2020-12-04 2022-06-09 Dyne Therapeutics, Inc. Antibody-oligonucleotide complexes and uses thereof
EP4271816A4 (en) * 2020-12-31 2025-04-02 Dyne Therapeutics, Inc. MUSCLE TARGETING COMPLEXES AND RELATED USES FOR THE TREATMENT OF MYOTONIC DYSTROPHY
US11638761B2 (en) 2021-07-09 2023-05-02 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating Facioscapulohumeral muscular dystrophy
US11771776B2 (en) 2021-07-09 2023-10-03 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating dystrophinopathies
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US11969475B2 (en) 2021-07-09 2024-04-30 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy
MX2024000489A (es) 2021-07-09 2024-04-09 Dyne Therapeutics Inc Complejos dirigidos al musculo y formulaciones para el tratamiento de las distrofinopatías.
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