CN112940359A - Preparation method of long-acting sleep-aiding latex pillow - Google Patents
Preparation method of long-acting sleep-aiding latex pillow Download PDFInfo
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Abstract
The invention relates to the field of latex materials, and provides a preparation method of a long-acting sleep-aiding latex pillow aiming at the problem that effective components of the sleep-aiding pillow are released too fast, wherein the preparation method comprises the following steps of preparing raw materials according to a formula, uniformly stirring the raw materials, and then prevulcanizing the raw materials, wherein the raw materials comprise the following components in parts by weight: 100 parts of natural latex, 4-9 parts of vulcanizing agent, 1-6 parts of potassium oleate, 0.5-2 parts of castor oil, 0.1-2 parts of potassium pyrophosphate and 2-8 parts of sleep-aiding microspheres; then) foaming the prepared prevulcanized latex, and adding 2-10 parts of zinc oxide and 2-6 parts of a hardening agent in the foaming process; then carrying out high-temperature steam vulcanization treatment, and drying the finished product. The invention utilizes the microspheres to wrap the effective sleep-aiding components in the three-dimensional network material, controls the release speed, enables the effective components to be released continuously, prolongs the service life, simultaneously prevents the smell from being too strong, and prepares the effective sleep-aiding components into the microspheres for addition, thereby being beneficial to the uniform dispersion of the effective sleep-aiding components in the glue solution.
Description
Technical Field
The invention relates to the field of latex materials, in particular to a preparation method of a sleep-assisting latex pillow containing slow-release microspheres.
Background
With the continuous improvement of living standard, people pay more and more attention to sanitary, safe and healthy products, and latex products are more and more favored due to the characteristics of natural raw materials, high air permeability, ultra silence, high resilience and the like. Functionalized latex articles are also becoming increasingly popular with consumers. Because the pace of life of people is accelerated at present, the pressure of life is higher, people with poor sleep quality and even insomnia all night are gradually increased, and the sleep-assisting pillow is produced due to the fact that the mental asthenia caused by the poor sleep quality and the insomnia is more. For example, chinese patent CN110101268A discloses a filler for a sleep-aid pillow and a sleep-aid pillow, which are provided by the invention, by mixing mugwort, dragon, rhubarb flower, lavender and chrysanthemum, the advantages of each component are fully utilized, so that insomnia can be effectively improved, sleep is assisted, people with the conditions of dreaminess, easy waking, difficult falling asleep, uncomfortable sleep and the like can be helped to relax nerves, alleviate fatigue and achieve an ideal deep sleep state. However, the traditional Chinese medicine components for helping sleep are directly placed in the pillow in the form of the sachet and the sachet, so that the release of the effective components is fast, the effective use time is shortened, and meanwhile, the uncomfortable feeling is also brought to people due to the overhigh smell concentration. Accordingly, an ideal solution is needed.
Disclosure of Invention
The invention provides a preparation method of a long-acting sleep-aiding latex pillow, aiming at overcoming the problem that the effective components of the sleep-aiding pillow are released too fast, the effective components of the sleep-aiding pillow are wrapped in a three-dimensional network material by microspheres, the release speed is controlled, the effective components are released continuously, the service life is prolonged, meanwhile, the smell is not too strong, and the effective components of the sleep-aiding pillow are prepared into the microspheres for adding, so that the effective components of the sleep-aiding pillow are uniformly dispersed in glue solution.
In order to achieve the purpose, the invention adopts the following technical scheme:
a preparation method of a long-acting sleep-aiding latex pillow comprises the following steps,
(1) compounding and prevulcanizing
The preparation method comprises the following steps of preparing raw materials according to a formula, stirring uniformly, and then pre-vulcanizing for 6-15h, wherein the raw materials are prepared from the following components in parts by weight:
100 parts of natural latex, namely 100 parts of natural latex,
4-9 parts of a vulcanizing agent,
1-6 parts of potassium oleate, namely potassium oleate,
0.5 to 2 parts of castor oil,
0.1 to 2 portions of potassium pyrophosphate,
2-8 parts of sleep-aiding microspheres;
(2) foaming the prepared pre-vulcanized latex, and adding 2-10 parts of zinc oxide and 2-6 parts of a hardening agent in the foaming process;
(3) carrying out high-temperature steam vulcanization treatment;
(4) and (5) drying a finished product.
Preferably, the preparation method of the sleep-aiding microsphere comprises the following steps: adding santalol, linalool, linalyl acetate, lavender alcohol and an emulsifier into an aqueous solution of sodium alginate, keeping the temperature at 40-50 ℃, emulsifying for 5-20min by using a high-speed dispersion homogenizer at the rotation speed of 10000-12000r/min, dropwise adding the obtained emulsion into a calcium chloride solution while stirring, washing and drying to obtain the sleeping-aid microspheres.
Preferably, the sleep-aiding microsphere comprises the following components in parts by weight: 1-2 parts of santalol, 1-3 parts of linalool, 1-3 parts of linalyl acetate, 1-3 parts of lavender alcohol, 3-5 parts of an emulsifier and 100 parts of a sodium alginate aqueous solution.
Preferably, the emulsifier is shellac resin sodium salt.
Preferably, the concentration of the sodium alginate aqueous solution is 2-5 wt%.
Preferably, the concentration of the calcium chloride solution is 2 to 6 wt%.
Preferably, the step of adding the emulsion dropwise into the calcium chloride solution is performed by using a peristaltic pump at a flow rate of 1.0-5.0 ml/min.
Preferably, the sodium alginate is subjected to modification treatment: adding 1- (3-dimethylaminopropyl) -3-ethylcarbodiimide EDC and N-hydroxysuccinimide NHS into a sodium alginate Alg solution, activating for 10-30min, adding 6-monoaminodeoxy-beta-cyclodextrin beta-CD-EDA under stirring, standing overnight to generate gel, washing and drying to obtain modified sodium alginate gel for preparing the sleep-aiding microspheres, wherein the mass ratio of Alg, EDC and NHS is 30 (10-15): 5-8.
EDC reacts with carboxyl of sodium alginate to form intermediate with amino reaction activity, then carries out replacement reaction with hydrogen cation in NHS molecule to modify carboxyl into NHS active ester with amino reaction activity, and then the activated intermediate is subjected to-NH2The attack of the groups forms amide cross-links, which undergo amidation polycondensation with the amino groups of β -CD-EDA to form crosslinked macromolecules. The sleep-aiding component is coated after the 6-monoamino deoxy-beta-cyclodextrin (cyclodextrin for short) is used for modifying the sodium alginate, and various alcohols in the sleep-aiding component are combined with the cyclodextrin through intermolecular force. When the pillow is used, a certain pressure is applied to stimulate the cyclodextrin cavity to slightly deform, so that the storage space of the sleep-aiding component is squeezed, the inclusion effect is reduced, the release amount of the sleep-aiding component is improved, and the sleep of a user is promoted.
Preferably, the mass ratio of Alg to beta-CD-EDA is 30 (10-19). From the above principle it can be seen that the amount of grafting and the cavity deformation properties have an influence on the release of the sleep-aiding component, both of which are related to the amount of beta-CD-EDA used. On one hand, the more grafting, the tighter the gel-coated network structure, the less easily the sleep-assisting component is released, and the longer the effective time is; on the other hand, the pressure on the pillow during sleep is limited and the three-dimensional network structure of the cover cannot be so tight that the sleep-assisting component cannot be released under pressure. Through a large number of experiments, the better proportion of Alg and beta-CD-EDA is finally determined.
Therefore, the invention has the following beneficial effects: (1) the invention utilizes the microspheres to wrap the sleep-aiding effective components in the three-dimensional network material, controls the release speed, can effectively solve the problems, and not only can continuously release the effective components and prolong the service life, but also can not cause excessively strong smell; (2) the effective components for assisting sleep are difficult to be uniformly dispersed in the latex, and are prepared into microspheres for adding, so that the effective components for assisting sleep are favorably and uniformly dispersed in the glue solution, and the effective components in the obtained latex product are also uniformly dispersed; (3) the sleep-aiding component is coated after the 6-monoamino deoxy-beta-cyclodextrin (cyclodextrin for short) is used for modifying the sodium alginate, and various alcohols in the sleep-aiding component are combined with the cyclodextrin through intermolecular force, so that the sleep-aiding component is more stable than the sleep-aiding component coated with the sodium alginate and is difficult to release in a natural state, and thus, the sleep-aiding component cannot be released when the pillow is not used; when the pillow is used, a certain pressure is applied to stimulate the cyclodextrin cavity to slightly deform, so that the storage space of the sleep-aiding component is squeezed, the inclusion effect is reduced, the release amount of the sleep-aiding component is improved, and the sleep of a user is promoted.
Detailed Description
The technical solution of the present invention is further illustrated by the following specific examples.
In the present invention, unless otherwise specified, all the raw materials and equipment used are commercially available or commonly used in the art, and the methods in the examples are conventional in the art unless otherwise specified.
Example 1
A preparation method of a long-acting sleep-aiding latex pillow comprises the following steps,
(1) compounding and prevulcanizing
The preparation method comprises the following steps of preparing raw materials according to a formula, stirring uniformly, and then pre-vulcanizing for 10 hours, wherein the raw materials are prepared from the following components in parts by weight:
100 parts of natural latex, namely 100 parts of natural latex,
7 parts of a vulcanizing agent, namely 7 parts of,
4 parts of potassium oleate, namely 4 parts of potassium oleate,
1 part of castor oil, namely 1 part of castor oil,
0.5 part of potassium pyrophosphate, namely,
5 parts of sleep-aiding microspheres;
(2) foaming the prepared pre-vulcanized latex, and adding 4 parts of zinc oxide and 2 parts of a hardening agent in the foaming process;
(3) carrying out steam vulcanization treatment at 100 ℃;
(4) and (5) drying a finished product.
The preparation method of the sleep-aiding microsphere comprises the following steps: respectively weighing 1 part of santalol, linalool, linalyl acetate and lavender alcohol and 3 parts of lac resin sodium salt, adding the materials into 100 parts of a 2 wt% sodium alginate aqueous solution, keeping the temperature at 40 ℃, emulsifying the mixture by using a high-speed dispersion homogenizer for 10min at the rotating speed of 10000r/min, dropwise adding the obtained emulsion into a 2 wt% calcium chloride solution at a constant speed while stirring, dropwise adding the emulsion at a flow rate of 2.0ml/min by using a peristaltic pump, and washing and drying to obtain the sleeping-aid microspheres.
Example 2
A preparation method of a long-acting sleep-aiding latex pillow comprises the following steps,
(1) compounding and prevulcanizing
The preparation method comprises the following steps of preparing raw materials according to a formula, stirring uniformly, and then pre-vulcanizing for 6 hours, wherein the raw materials are prepared from the following components in parts by weight:
100 parts of natural latex, namely 100 parts of natural latex,
4 parts of a vulcanizing agent, namely 4 parts of,
1 part of potassium oleate, namely 1 part of potassium oleate,
0.5 part of castor oil, namely,
0.1 part of potassium pyrophosphate, namely,
2 parts of sleep-aiding microspheres;
(2) foaming the prepared pre-vulcanized latex, and adding 2 parts of zinc oxide and 4 parts of a hardening agent in the foaming process;
(3) carrying out steam vulcanization treatment at 100 ℃;
(4) and (5) drying a finished product.
The preparation method of the sleep-aiding microsphere comprises the following steps: respectively weighing 2 parts of santalol, 3 parts of linalool, 3 parts of linalyl acetate, 3 parts of lavender alcohol and 5 parts of lac resin sodium salt, adding the materials into 100 parts of a 5 wt% sodium alginate aqueous solution, keeping the temperature at 50 ℃, emulsifying the mixture for 5min by using a high-speed dispersion homogenizer at the rotating speed of 12000r/min, dropwise adding the obtained emulsion into a 6 wt% calcium chloride solution at a constant speed while stirring, dropwise adding the emulsion at the flow rate of 1.0ml/min by using a peristaltic pump, and washing and drying to obtain the sleeping-aid microspheres.
Example 3
A preparation method of a long-acting sleep-aiding latex pillow comprises the following steps,
(1) compounding and prevulcanizing
The preparation method comprises the following steps of preparing raw materials according to a formula, stirring uniformly, and then pre-vulcanizing for 15 hours, wherein the raw materials are prepared from the following components in parts by weight:
100 parts of natural latex, namely 100 parts of natural latex,
9 parts of a vulcanizing agent, namely 9 parts,
6 parts of potassium oleate, namely 6 parts of potassium oleate,
2 parts of castor oil, namely 2 parts of castor oil,
2 parts of potassium pyrophosphate, namely 2 parts of potassium pyrophosphate,
8 parts of sleep-aiding microspheres;
(2) foaming the prepared pre-vulcanized latex, and adding 10 parts of zinc oxide and 6 parts of a hardening agent in the foaming process;
(3) carrying out steam vulcanization treatment at 100 ℃;
(4) and (5) drying a finished product.
The preparation method of the sleep-aiding microsphere comprises the following steps: respectively weighing 2 parts of santalol, linalool, linalyl acetate, lavandulol and lac resin sodium salt, adding the materials into 100 parts of a 3 wt% sodium alginate aqueous solution, keeping the temperature at 45 ℃, emulsifying the mixture by using a high-speed dispersion homogenizer for 20min at the rotating speed of 11000r/min, dropwise adding the obtained emulsion into a 4 wt% calcium chloride solution at a constant speed while stirring, dropwise adding the emulsion at the flow rate of 5.0ml/min by using a peristaltic pump, and washing and drying to obtain the sleeping-aid microspheres.
Example 4
A preparation method of a long-acting sleep-aiding latex pillow comprises the following steps,
(1) compounding and prevulcanizing
The preparation method comprises the following steps of preparing raw materials according to a formula, stirring uniformly, and then pre-vulcanizing for 10 hours, wherein the raw materials are prepared from the following components in parts by weight:
100 parts of natural latex, namely 100 parts of natural latex,
7 parts of a vulcanizing agent, namely 7 parts of,
4 parts of potassium oleate, namely 4 parts of potassium oleate,
1 part of castor oil, namely 1 part of castor oil,
0.5 part of potassium pyrophosphate, namely,
5 parts of sleep-aiding microspheres;
(2) foaming the prepared pre-vulcanized latex, and adding 4 parts of zinc oxide and 2 parts of a hardening agent in the foaming process;
(3) carrying out steam vulcanization treatment at 100 ℃;
(4) and (5) drying a finished product.
The preparation method of the sleep-aiding microsphere comprises the following steps:
1) modified sodium alginate: dissolving sodium alginate (Alg) 30mg in 2-MES buffer solution 0.3mol/L, adding 1- (3-dimethylaminopropyl) -3-Ethylcarbodiimide (EDC) 12mg and N-hydroxysuccinimide (NHS) 6mg, activating for 20min, adding 6-monoaminodeoxy-beta-cyclodextrin (beta-CD-EDA) 15mg under stirring, standing overnight to form gel, sequentially adding Na2HPO4Soaking the aqueous solution, NaCl aqueous solution and distilled water, washing, removing impurities, and drying to obtain modified sodium alginate;
2) respectively weighing 1 part of santalol, linalool, linalyl acetate and lavender alcohol and 3 parts of lac resin sodium salt, adding the materials into 100 parts of a 2 wt% aqueous solution of modified sodium alginate, keeping the temperature at 40 ℃, emulsifying the mixture by using a high-speed dispersion homogenizer for 10min at the rotating speed of 10000r/min, dropwise adding the obtained emulsion into a 2 wt% calcium chloride solution at a constant speed while stirring, dropwise adding the emulsion at the flow rate of 2.0ml/min by using a peristaltic pump, and washing and drying to obtain the sleeping-aid microspheres.
Example 5
The difference from example 4 is that the preparation steps of the modified sodium alginate are as follows: dissolving sodium alginate (Alg) 30mg in 2-MES buffer solution 0.3mol/L, adding 1- (3-dimethylaminopropyl) -3-Ethylcarbodiimide (EDC) 10mg and N-hydroxysuccinimide (NHS) 5mg, activating for 10min, adding 6-monoaminodeoxy-beta-cyclodextrin (beta-CD-EDA) 10mg under stirring, standing overnight to form gel, sequentially adding Na2HPO4Soaking the aqueous solution, NaCl aqueous solution and distilled water, washing, removing impurities, and drying to obtain the modified sodium alginate.
Example 6
The difference from example 4 is that modified sodium alginate is preparedThe preparation method comprises the following steps: dissolving sodium alginate (Alg) 30mg in 2-MES buffer solution 0.3mol/L, adding 1- (3-dimethylaminopropyl) -3-Ethylcarbodiimide (EDC) 15mg and N-hydroxysuccinimide (NHS) 8mg, activating for 30min, adding 6-monoaminodeoxy-beta-cyclodextrin (beta-CD-EDA) 19mg under stirring, standing overnight to form gel, sequentially adding Na2HPO4Soaking the aqueous solution, NaCl aqueous solution and distilled water, washing, removing impurities, and drying to obtain the modified sodium alginate.
Example 7
The difference from example 4 is that the preparation steps of the modified sodium alginate are as follows: dissolving sodium alginate (Alg) 30mg in 2-MES buffer solution 0.3mol/L, adding 1- (3-dimethylaminopropyl) -3-Ethylcarbodiimide (EDC) 12mg and N-hydroxysuccinimide (NHS) 6mg, activating for 20min, adding 6mg of 6-monoaminodeoxy-beta-cyclodextrin (beta-CD-EDA) under stirring, standing overnight to form gel, sequentially adding Na2HPO4Soaking the aqueous solution, NaCl aqueous solution and distilled water, washing, removing impurities, and drying to obtain the modified sodium alginate.
Example 8
The difference from example 4 is that the preparation steps of the modified sodium alginate are as follows: dissolving sodium alginate (Alg) 30mg in 2-MES buffer solution 0.3mol/L, adding 1- (3-dimethylaminopropyl) -3-Ethylcarbodiimide (EDC) 12mg and N-hydroxysuccinimide (NHS) 6mg, activating for 20min, adding 6-monoaminodeoxy-beta-cyclodextrin (beta-CD-EDA) 25mg under stirring, standing overnight to form gel, sequentially adding Na2HPO4Soaking the aqueous solution, NaCl aqueous solution and distilled water, washing, removing impurities, and drying to obtain the modified sodium alginate.
Comparative example 1
A preparation method of a latex pillow for aiding sleep comprises the following steps,
(1) compounding and prevulcanizing
The preparation method comprises the following steps of preparing raw materials according to a formula, stirring uniformly, and then pre-vulcanizing for 10 hours, wherein the raw materials are prepared from the following components in parts by weight:
100 parts of natural latex, namely 100 parts of natural latex,
7 parts of a vulcanizing agent, namely 7 parts of,
4 parts of potassium oleate, namely 4 parts of potassium oleate,
1 part of castor oil, namely 1 part of castor oil,
0.5 part of potassium pyrophosphate, namely,
5 parts of sleep-aiding components;
(2) foaming the prepared pre-vulcanized latex, and adding 4 parts of zinc oxide and 2 parts of a hardening agent in the foaming process;
(3) carrying out steam vulcanization treatment at 100 ℃;
(4) and (5) drying a finished product.
The preparation method of the sleep-aiding microsphere comprises the following steps: weighing 1 part of santalol, linalool, linalyl acetate and lavender alcohol respectively, and 3 parts of lac resin sodium salt respectively, homogenizing and mixing.
Results testing
And (3) carrying out performance test on the prepared sleep-aiding latex pillow.
(1) Durability
The fragrance persistence of each sleep-aid latex pillow was measured, and in a natural state, the fragrance of the pillow of comparative example 1 was significantly reduced after 10 months, the fragrance of the pillows of examples 1 to 3 began to be reduced after 18 months, the fragrance concentration of the pillow of example 7 was reduced after 24 months, and the fragrance concentrations of the pillows of examples 4 to 6 and 8 were not reduced after 24 months.
It can be seen that, compared with the case of directly adding the sleep-assisting ingredient in the comparative example 1, the persistence of the sleep-assisting ingredient can be remarkably improved after the sleep-assisting ingredient is prepared into the microspheres in the examples 1 to 3, and the sustained-release function of the sleep-assisting ingredient is further improved by improving the microspheres in the examples 4 to 8, but the sustained-release function is improved to a limited extent because the dosage of the beta-CD-EDA is less and the grafting rate is low in the example 7.
(2) Pittsburgh sleep quality index PSQI value test
PSQI was used to assess the quality of sleep of the subjects for 1 month. Consisting of 19 self-rated items and 5 other rated items, wherein the 19 th self-rated item and 5 other rated items did not participate in scoring. The 18 self-rated entries make up 7 factors: sleep quality, time to fall asleep, sleep time, sleep efficiency, sleep disturbance, hypnotics, daytime function. Each factor is scored according to the grade of 0-3, the sum of the scores of all factors is the total score of PSQI, the total score range is 0-21, and the higher the score is, the worse the sleep quality is. The subject took 5 minutes to complete the challenge.
60 test subjects, 30 males and 30 females, aged 25-65 years. After 3 months of separation into similar 3 groups using pillows from example 1, example 4 and example 8 respectively, the tests were performed and the average was taken. Pittsburgh sleep quality index PSQI values were 6.8, 5.1, and 7.2, respectively.
Experimental results prove that the sleep-assisting latex pillow can reduce the PSQI value, effectively improve the stability of sleep-assisting components, slow down the volatilization speed of the sleep-assisting components and ensure the durability of the drug effect, thereby shortening the sleep-in time of a test object, prolonging the sleep time, eliminating sleep disorder and very effectively improving the sleep quality. The difference between example 4 and example 1 is that the microspheres are modified, and the combination of the durability test results shows that although the durability of example 4 is increased, the release amount of the sleep-assisting component is not sacrificed, and the sleep quality of a user is improved, because the modified pillow has extremely low release amount when not used, and can normally release fragrance with reasonable concentration when used, thereby helping sleep. However, the pillow of example 8 is not as good as that of example 1 before modification, and it is presumed that the excessive amount of β -CD-EDA in example 8 affects the release of sleep-aiding components and compromises the sleep-aiding function of the human body, so that the amount of β -CD-EDA used in the modification process needs to be controlled within a reasonable range.
The pillows manufactured in the above-described examples and comparative examples were subjected to an experiment,
although the present invention has been described with reference to a preferred embodiment, it should be understood that various changes, substitutions and alterations can be made herein without departing from the spirit and scope of the invention as defined by the appended claims.
Claims (9)
1. A preparation method of a latex pillow with long-acting sleep-aiding effect is characterized by comprising the following steps,
(1) compounding and prevulcanizing
The preparation method comprises the following steps of preparing raw materials according to a formula, stirring uniformly, and then pre-vulcanizing for 6-15h, wherein the raw materials are prepared from the following components in parts by weight:
100 parts of natural latex, namely 100 parts of natural latex,
4-9 parts of a vulcanizing agent,
1-6 parts of potassium oleate, namely potassium oleate,
0.5 to 2 parts of castor oil,
0.1 to 2 portions of potassium pyrophosphate,
2-8 parts of sleep-aiding microspheres;
(2) foaming the prepared pre-vulcanized latex, and adding 2-10 parts of zinc oxide and 2-6 parts of a hardening agent in the foaming process;
(3) carrying out high-temperature steam vulcanization treatment;
(4) and (5) drying a finished product.
2. The preparation method of the long-acting sleep-aid latex pillow as claimed in claim 1, wherein the preparation steps of the sleep-aid microspheres are as follows: adding santalol, linalool, linalyl acetate, lavender alcohol and an emulsifier into an aqueous solution of sodium alginate, keeping the temperature at 40-50 ℃, emulsifying for 5-20min by using a high-speed dispersion homogenizer at the rotation speed of 10000-12000r/min, dropwise adding the obtained emulsion into a calcium chloride solution while stirring, washing and drying to obtain the sleeping-aid microspheres.
3. The preparation method of the long-acting sleep-aid latex pillow as claimed in claim 2, wherein the sleep-aid microspheres comprise the following components in parts by weight: 1-2 parts of santalol, 1-3 parts of linalool, 1-3 parts of linalyl acetate, 1-3 parts of lavender alcohol, 3-5 parts of an emulsifier and 100 parts of a sodium alginate aqueous solution.
4. The method for preparing a long-acting sleep-aid latex pillow as claimed in claim 2, wherein said emulsifier is shellac resin sodium salt.
5. The method for preparing a long-acting sleep-aid latex pillow as claimed in claim 2, wherein the concentration of the sodium alginate aqueous solution is 2-5 wt%.
6. The method for preparing a long-acting sleep-aid latex pillow as claimed in claim 2 or 3, wherein the concentration of the calcium chloride solution is 2-6 wt%.
7. The method for preparing a long-acting sleep-aid latex pillow as claimed in claim 2, wherein the step of adding the emulsion dropwise into the calcium chloride solution is performed by using a peristaltic pump at a flow rate of 1.0-5.0 ml/min.
8. The preparation method of the long-acting sleep-aiding latex pillow as claimed in claim 2, wherein the sodium alginate is modified: adding 1- (3-dimethylaminopropyl) -3-ethylcarbodiimide EDC and N-hydroxysuccinimide NHS into a sodium alginate Alg solution, activating for 10-30min, adding 6-monoaminodeoxy-beta-cyclodextrin beta-CD-EDA under stirring, standing overnight to generate gel, washing and drying to obtain modified sodium alginate gel for preparing the sleep-aiding microspheres, wherein the mass ratio of Alg, EDC and NHS is 30 (10-15): 5-8.
9. The method for preparing a long-acting sleep-aiding latex pillow as claimed in claim 8, wherein the mass ratio of the Alg to the beta-CD-EDA is 30 (10-19).
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