CN112933029A - Sea cucumber intestine and egg essence extract freeze-dried powder and preparation method thereof - Google Patents
Sea cucumber intestine and egg essence extract freeze-dried powder and preparation method thereof Download PDFInfo
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- CN112933029A CN112933029A CN201911255762.5A CN201911255762A CN112933029A CN 112933029 A CN112933029 A CN 112933029A CN 201911255762 A CN201911255762 A CN 201911255762A CN 112933029 A CN112933029 A CN 112933029A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0216—Solid or semisolid forms
- A61K8/022—Powders; Compacted Powders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/606—Nucleosides; Nucleotides; Nucleic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/84—Products or compounds obtained by lyophilisation, freeze-drying
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Birds (AREA)
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- Chemical & Material Sciences (AREA)
- Dermatology (AREA)
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Abstract
The invention discloses a freeze-dried powder of sea cucumber intestine and ovum essence extract, which comprises the following components in percentage by mass: 3 to 4 percent of mannitol, 81.5 to 2.5 percent of acetyl hexapeptide, 3 to 4 percent of trehalose, 1.5 to 2.5 percent of sea cucumber intestine and ovum extract, 0.5 to 1.5 percent of fibronectin, 1.5 to 2.5 percent of sodium hyaluronate, 0.03 to 0.07 percent of adenosine, 0.01 to 0.05 percent of fullerene, 0.03 to 0.07 percent of xanthan gum and 85 to 86 percent of water, wherein the preparation method comprises the following steps: s1, weighing sodium hyaluronate, mannitol and water, stirring and heating to obtain a transparent preparation I; s2, cooling the transparent first preparation liquid; s3, weighing acetyl hexapeptide-8, trehalose, sea cucumber intestine egg extract, fibronectin, adenosine, fullerene and xanthan gum, adding into the first transparent solution, stirring and heating to obtain a second transparent solution; and S4, filling the transparent preparation liquid II into a penicillin bottle, covering a bottle stopper, putting the penicillin bottle into freeze-drying equipment, and freeze-drying. The invention has the advantages that: the natural extract is adopted, so that the skin care product can effectively eliminate free radicals in the skin and delay skin aging, has no side effect and is convenient to use.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to a sea cucumber intestine egg essence extract freeze-dried powder and a preparation method thereof.
Background
Nowadays, social substance life is more and more abundant, people also more and more pay attention to the personal appearance problem, with the increase of age and the deterioration of living environment, the metabolism of skin is reduced, the function of absorbing various beneficial elements is reduced, water is easy to run off, and various harmful substances are easy to stay on the surface of the skin, so that the skin gradually loses the original elasticity, and the skin aging cosmetic, nowadays, skin-care anti-aging cosmetics become the subject of cosmetic development.
However, although skin care products on the market are full of various types, most skin care products are fine chemical products, only the surface layer problem of the skin is solved, the effects of repairing the skin and delaying skin aging cannot be fundamentally achieved, and some cosmetics are added with components such as hormone, the beauty effect is not obvious, the negative influence is caused on the human body, and the use safety performance is poor.
Disclosure of Invention
The invention aims to solve the technical problems and provides the sea cucumber intestine and egg essence extract freeze-dried powder which adopts natural extracts, can effectively remove free radicals in skin and delay skin aging, has no side effect and is convenient to use and a preparation method thereof.
In order to solve the technical problems, the technical scheme provided by the invention is as follows: a freeze-dried powder of sea cucumber intestine and egg essence extract comprises the following components by mass percent: 3 to 4 percent of mannitol, 81.5 to 2.5 percent of acetyl hexapeptide, 3 to 4 percent of trehalose, 1.5 to 2.5 percent of sea cucumber intestine and ovum extract, 0.5 to 1.5 percent of fibronectin, 1.5 to 2.5 percent of sodium hyaluronate, 0.03 to 0.07 percent of adenosine, 0.01 to 0.05 percent of fullerene, 0.03 to 0.07 percent of xanthan gum and 85 to 86 percent of water.
Preferably, the composition comprises the following components in percentage by mass: 3.3 to 3.7 percent of mannitol, 81.8 to 2.2 percent of acetyl hexapeptide, 3.3 to 3.7 percent of trehalose, 1.8 to 2.2 percent of sea cucumber intestine egg extract, 0.8 to 1.2 percent of fibronectin, 1.8 to 2.2 percent of sodium hyaluronate, 0.04 to 0.06 percent of adenosine, 0.02 to 0.04 percent of fullerene, 0.04 to 0.06 percent of xanthan gum and 85.3 to 85.9 percent of water.
Preferably, the composition comprises the following components in percentage by mass: 3.5% of mannitol, 82% of acetyl hexapeptide, 3.5% of trehalose, 2% of sea cucumber intestine egg extract, 1% of fibronectin, 2% of sodium hyaluronate, 0.05% of adenosine, 0.03% of fullerene, 0.05% of xanthan gum and 85.87% of water.
Preferably, the water is purified water after secondary filtration.
Preferably, the preparation method of the sea cucumber intestine egg essence extract freeze-dried powder comprises the following steps:
s1, weighing sodium hyaluronate, mannitol and water, stirring for 12-30 minutes, and heating at 70-80 ℃ to obtain a first transparent preparation;
s2, cooling the transparent first preparation solution to enable the transparent first preparation solution to be cooled to 15-30 ℃ at a constant speed;
s3, weighing acetyl hexapeptide-8, trehalose, sea cucumber intestine egg extract, fibronectin, adenosine, fullerene and xanthan gum, adding into the first transparent solution, stirring for 15-30 minutes, heating at 40-60 ℃ to obtain a second transparent solution;
s4, filling the transparent preparation liquid II into a penicillin bottle, covering a bottle stopper, putting the penicillin bottle into a freeze-drying device, and freeze-drying at the temperature of-15 to-5 ℃.
Compared with the prior art, the invention has the advantages that: according to the freeze-dried powder of the sea cucumber intestine egg essence extract and the preparation method thereof, trehalose can form a unique protective film on the cell surface under severe environmental conditions such as high temperature, high cold, high osmotic pressure, drying dehydration and the like, so that protein molecules can be effectively protected from being inactivated without denaturation, and skin cells can be well protected; acetyl hexapeptide-8 is a bioactive polypeptide, can locally block nerve transmission muscle contraction information, influence skin sac nerve conduction, relax facial muscles, smooth dynamic lines, static lines and fine lines, effectively reorganize collagen elasticity, increase elastin activity, relax facial lines, smooth wrinkles and improve skin relaxation; the sea cucumber intestine and egg extract has the functions of resisting radiation, fungi and cytotoxicity, prevents harmful substances from being accumulated on skin, can remove free radicals in vivo and delay skin aging; fibronectin has obvious effects on regenerating and repairing skin epidermal layers, dermis layers and subcutaneous tissues, inhibiting skin bacteria, improving skin glossiness, improving skin roughness, increasing stratum corneum water content and the like; the fullerene has strong oxidation resistance, and can play a role in activating skin cells and preventing skin decay; the xanthan gum can supplement moisture to the skin, prevent moisture loss, prevent wrinkles of the skin and resist aging; meanwhile, the freeze-drying synthesis process is adopted to fully extract the effective components in the raw materials, so that the freeze-drying powder is smeared on the face when in use, and the face mask is convenient to use and good in absorptivity.
Detailed Description
Example one
A freeze-dried powder of sea cucumber intestine and egg essence extract comprises the following components by mass percent: 3.3 percent of mannitol, 82.2 percent of acetyl hexapeptide, 3.3 percent of trehalose, 2.2 percent of sea cucumber intestine egg extract, 0.8 percent of fibronectin, 2.2 percent of sodium hyaluronate, 0.04 percent of adenosine, 0.04 percent of fullerene, 0.05 percent of xanthan gum and 85.87 percent of water.
The preparation method comprises the following steps:
s1, weighing sodium hyaluronate, mannitol and water, stirring for 18 minutes, heating to 73 ℃ to obtain a transparent first preparation solution;
s2, cooling the transparent first preparation solution to ensure that the temperature is reduced to 23 ℃ at a constant speed;
s3, weighing acetyl hexapeptide-8, trehalose, sea cucumber intestine egg extract, fibronectin, adenosine, fullerene and xanthan gum, adding into the first transparent solution, stirring for 15-30 minutes, heating to 46 ℃ to obtain a second transparent solution;
s4, filling the transparent preparation liquid II into a penicillin bottle, covering a bottle stopper, putting the penicillin bottle into freeze-drying equipment, and freeze-drying at the temperature of-7 ℃.
Example two
A freeze-dried powder of sea cucumber intestine and egg essence extract comprises the following components by mass percent: 3.5% of mannitol, 82% of acetyl hexapeptide, 3.5% of trehalose, 2% of sea cucumber intestine egg extract, 1% of fibronectin, 2% of sodium hyaluronate, 0.05% of adenosine, 0.03% of fullerene, 0.05% of xanthan gum and 85.87% of water.
The preparation method comprises the following steps:
s1, weighing sodium hyaluronate, mannitol and water, stirring for 20 minutes, heating to 76 ℃ to obtain a first transparent preparation solution;
s2, cooling the transparent first preparation solution to enable the temperature to be reduced to 25 ℃ at a constant speed;
s3, weighing acetyl hexapeptide-8, trehalose, sea cucumber intestine egg extract, fibronectin, adenosine, fullerene and xanthan gum, adding into the first transparent solution, stirring for 18 minutes, and heating at 48 ℃ to obtain a second transparent solution;
s4, filling the transparent preparation liquid II into a penicillin bottle, covering a bottle stopper, putting the penicillin bottle into freeze-drying equipment, and freeze-drying at the temperature of-10 ℃.
The above embodiments are preferred embodiments of the present invention, but the present invention is not limited to the above embodiments, and any other changes, modifications, substitutions, combinations, and simplifications which do not depart from the spirit and principle of the present invention should be construed as equivalents thereof, and all such changes, modifications, substitutions, combinations, and simplifications are intended to be included in the scope of the present invention.
Claims (5)
1. The freeze-dried powder of the essence extract of sea cucumber intestine and ovum is characterized by comprising the following components in percentage by mass: 3 to 4 percent of mannitol, 81.5 to 2.5 percent of acetyl hexapeptide, 3 to 4 percent of trehalose, 1.5 to 2.5 percent of sea cucumber intestine and ovum extract, 0.5 to 1.5 percent of fibronectin, 1.5 to 2.5 percent of sodium hyaluronate, 0.03 to 0.07 percent of adenosine, 0.01 to 0.05 percent of fullerene, 0.03 to 0.07 percent of xanthan gum and 85 to 86 percent of water.
2. The sea cucumber intestine and egg essence extract freeze-dried powder according to claim 1, which is characterized by comprising the following components in percentage by mass: 3.3 to 3.7 percent of mannitol, 81.8 to 2.2 percent of acetyl hexapeptide, 3.3 to 3.7 percent of trehalose, 1.8 to 2.2 percent of sea cucumber intestine egg extract, 0.8 to 1.2 percent of fibronectin, 1.8 to 2.2 percent of sodium hyaluronate, 0.04 to 0.06 percent of adenosine, 0.02 to 0.04 percent of fullerene, 0.04 to 0.06 percent of xanthan gum and 85.3 to 85.9 percent of water.
3. The sea cucumber intestine and egg essence extract freeze-dried powder according to claim 1, which is characterized by comprising the following components in percentage by mass: 3.5% of mannitol, 82% of acetyl hexapeptide, 3.5% of trehalose, 2% of sea cucumber intestine egg extract, 1% of fibronectin, 2% of sodium hyaluronate, 0.05% of adenosine, 0.03% of fullerene, 0.05% of xanthan gum and 85.87% of water.
4. The freeze-dried powder of essence extract of sea cucumber intestine and egg as claimed in claim 1, wherein: the water is purified water after secondary filtration.
5. The preparation method of the sea cucumber intestine egg essence extract freeze-dried powder according to claim 1, which is characterized by comprising the following steps:
s1, weighing sodium hyaluronate, mannitol and water, stirring for 12-30 minutes, and heating at 70-80 ℃ to obtain a first transparent preparation;
s2, cooling the transparent first preparation solution to enable the transparent first preparation solution to be cooled to 15-30 ℃ at a constant speed;
s3, weighing acetyl hexapeptide-8, trehalose, sea cucumber intestine egg extract, fibronectin, adenosine, fullerene and xanthan gum, adding into the first transparent solution, stirring for 15-30 minutes, heating at 40-60 ℃ to obtain a second transparent solution;
s4, filling the transparent preparation liquid II into a penicillin bottle, covering a bottle stopper, putting the penicillin bottle into a freeze-drying device, and freeze-drying at the temperature of-15 to-5 ℃.
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CN201911255762.5A CN112933029A (en) | 2019-12-10 | 2019-12-10 | Sea cucumber intestine and egg essence extract freeze-dried powder and preparation method thereof |
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CN201911255762.5A CN112933029A (en) | 2019-12-10 | 2019-12-10 | Sea cucumber intestine and egg essence extract freeze-dried powder and preparation method thereof |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN113576971A (en) * | 2021-08-10 | 2021-11-02 | 湖南本美生物科技有限公司 | Fibronectin freeze-dried powder preparation and preparation method thereof |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113576971A (en) * | 2021-08-10 | 2021-11-02 | 湖南本美生物科技有限公司 | Fibronectin freeze-dried powder preparation and preparation method thereof |
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Application publication date: 20210611 |