CN112933021A

CN112933021A - Nutrient solution for removing neck striae

Info

Publication number: CN112933021A
Application number: CN202110383744.6A
Authority: CN
Inventors: 高玉红; 王密阳
Original assignee: Beijing Meilamei Health Management Co ltd
Current assignee: Beijing Meilamei Health Management Co ltd
Priority date: 2021-04-09
Filing date: 2021-04-09
Publication date: 2021-06-11

Abstract

The invention provides a nutrient solution for removing neck striae, and relates to the technical field of cosmetology. A nutrient solution for removing neck striae comprises the following raw materials in parts by weight: 10-15 parts of ginseng, 10-20 parts of tortoise-plastron glue, 5-10 parts of pilose antler, 10-30 parts of soybean, 30-40 parts of combined freeze-dried powder, 20-30 parts of asiatic centella extract, 10-20 parts of honey and 40-50 parts of solvent. The combined freeze-dried powder comprises the following components in percentage by mass: 0.01-0.5% of mesenchymal stem cell freeze-dried powder and 99.9-99.5% of mannitol. The nutrient solution greatly improves the collagen regeneration capability of skin, and can form a rapid and stable carrier bracket when being suitable for skin regeneration, thereby realizing the effect of rapid tissue regeneration and effectively improving the neck wrinkle condition.

Description

Nutrient solution for removing neck striae

Technical Field

The invention relates to the technical field of beauty treatment, and particularly relates to a nutrient solution for removing neck striae.

Background

The skin is the largest organ covering the whole body surface, which is the protector of the internal organs and tissues of the human body, and is also the effect organ of the internal organs, spirit and the surrounding environment, which plays an important role in the health and beauty of the human body. Anti-aging skin care is one of the main functions of skin care products, and the gene beauty based on modern biotechnology achievements has become a worldwide trend to improve skin quality, delay aging and fade wrinkles from the aspect of skin cell structures. Wrinkles are one of the main manifestations of human aging, and loose wrinkles have a great influence on the psychology of people. Especially after 25 years old, the rate of collagen synthesis in the human body begins to be lower than the loss rate, especially in the neck, and problems such as relaxation and wrinkles easily occur. At present, nutrient solutions capable of effectively removing neck striae in the market have poor effect and many side effects.

Disclosure of Invention

The invention aims to provide the nutrient solution for removing the neck wrinkles, which greatly improves the collagen regeneration capacity of skin, and is suitable for forming a rapid and stable carrier bracket when the skin is regenerated, so that the effect of rapid tissue regeneration is realized, and the neck wrinkles can be effectively improved.

The technical problem to be solved by the invention is realized by adopting the following technical scheme.

The embodiment of the application provides a nutrient solution for removing neck striae, which comprises the following raw materials in parts by weight: 10-15 parts of ginseng, 10-20 parts of tortoise-plastron glue, 5-10 parts of pilose antler, 10-30 parts of soybean, 30-40 parts of combined freeze-dried powder, 20-30 parts of asiatic centella extract, 10-20 parts of honey and 40-50 parts of solvent;

the combined freeze-dried powder comprises the following components in percentage by mass: 0.01-0.5% of mesenchymal stem cell freeze-dried powder and 99.9-99.5% of mannitol.

In some embodiments of the invention, the above combination lyophilized powder further comprises one or more of the following components, by mass, 0.001-2% palmitoyl tripeptide-1, 0.001-2% palmitoyl pentapeptide-4, and 0.001-0.05% vitamin a.

In some embodiments of the present invention, the nutrient solution further comprises the following raw materials in parts by weight: 10-15 parts of collagen peptide, 8-12 parts of protein silk peptide, 5-10 parts of glutathione, 5-10 parts of nucleotide and 2-5 parts of chitosan derivative.

In some embodiments of the present invention, the nutrient solution further comprises the following raw materials in parts by weight: 5-10 parts of aloe vera leaves.

In some embodiments of the present invention, the nutrient solution further comprises the following raw materials in parts by weight: 10-20 parts of rheum officinale.

In some embodiments of the present invention, the solvent comprises the following components in percentage by mass: 1% dipeptide diaminobutyrylbenzylamide diacetate, 0.025% sodium hyaluronate, 0.025% phenoxyethanol and 98.95% water.

In some embodiments of the present invention, the above centella asiatica extract is prepared by the following preparation method: cleaning and drying 20-30 parts of centella asiatica, adding purified water with the volume 5-6 times of the centella asiatica, soaking and extracting, controlling the extraction temperature to be 45-65 ℃, extracting for 1-1.5 hours to obtain a primary extracting solution, adding purified water with the volume 4-6 times of the centella asiatica into filter residues, extracting for 1-2 hours, filtering at the extraction temperature of 50-60 ℃, obtaining a secondary filtrate, and combining the filtrates to obtain the centella asiatica extracting solution.

In some embodiments of the present invention, the tortoise-plastron glue is prepared by the following preparation method: weighing 5-15 parts of fresh tortoise plastron, 3-8 parts of kudzu root, 5-10 parts of radix rehmanniae, 10-30 parts of dendrobium officinale and 5-10 parts of lucid ganoderma according to the following weight parts, decocting for 5-6 hours by using medium fire, filtering out solid components by using a filter screen after decocting is finished, and keeping liquid; and continuously heating the liquid, stirring the liquid in the heating process, heating and stirring until the liquid is gelatinized, stopping heating, and cooling to obtain the tortoise-plastron glue.

In some embodiments of the present invention, the nutrient solution is prepared by the following preparation method:

1) preparing materials, cleaning and airing ginseng, pilose antler and soybean, and respectively grinding and sieving the aired ginseng, pilose antler and soybean to obtain ginseng powder, pilose antler powder and soybean powder for later use;

2) mixing, weighing the ginseng powder, the antler powder, the soybean powder, the combined freeze-dried powder, the asiatic centella extract, the honey and the solvent according to the weight part ratio, putting the asiatic centella extract and the honey into the solvent, uniformly stirring, then sequentially putting the ginseng powder, the antler powder, the soybean powder and the combined freeze-dried powder into the solvent, uniformly stirring to form a mixture, controlling the temperature to be 60-70 ℃ during stirring, adding the thickening agent into the mixture after obtaining the mixture, filtering while hot, and cooling to below 40 ℃.

In some embodiments of the present invention, the thickener comprises the following raw materials in parts by weight: 12-16 parts of chitosan, 4-6 parts of water-soluble lanolin and 12-14 parts of polyvinyl alcohol.

Compared with the prior art, the embodiment of the invention has at least the following advantages or beneficial effects:

the invention provides a nutrient solution for removing neck striae, which comprises the following raw materials in parts by weight: 10-15 parts of ginseng, 10-20 parts of tortoise-plastron glue, 5-10 parts of pilose antler, 10-30 parts of soybean, 30-40 parts of combined freeze-dried powder, 20-30 parts of asiatic centella extract, 10-20 parts of honey and 40-50 parts of solvent.

The ginseng has obvious effects on nervous system, cardiovascular system, endocrine system, digestive system, reproductive system, respiratory system and surgical application, and can promote the metabolism of ribonucleic acid (RNA), deoxyribonucleic acid (DNA), protein, cholesterol, fat and sugar, promote the mitosis of bone marrow cells, increase the number of red blood cells, white blood cells and nucleated cells in bone marrow, enhance the hematopoietic function of bone marrow and enhance the regeneration of human collagen. The peptide component in the ginseng can supplement nutrients such as collagen and the like, and also has multiple effects of moisturizing, locking water, whitening, resisting oxidation, resisting sugar, resisting blue light and the like. Not only can repair the skin barrier, but also can keep the skin smooth and fine. Preventing melanin generation, improving skin condition, and improving skin smoothness, wrinkle resistance, fineness, glossiness and skin color uniformity. Wherein the ginseng comprises ginseng peptide, and the ginseng peptide has the effects of slimming and beautifying, can maintain nutrition and balance, can promote collagen regeneration capacity of skin, repair skin wrinkles, and is suitable for people who are slimming and beautifying.

The colla Plastri Testudinis has effects of nourishing yin, tonifying blood, and stopping bleeding, and is rich in collagen protein and can provide various basic substances for collagen regeneration. Meanwhile, the tortoise-plastron contains the tetradecanoic acid sterol ester which can activate a Wnt/beta-catenin signal path in hair follicle stem cells to participate in the repair of skin wound surfaces, promote the proliferation of the hair follicle stem cells and participate in the reconstruction of skin tissues by regulating the Wnt/beta-catenin signal path in the hair follicle stem cells, accelerate the repair of acute wound surfaces and effectively promote the regeneration of autologous collagen of neck skin. Therefore, the effective components in the tortoise-plastron glue can accelerate the formation of collagen fibers, promote the reconstruction of tissue epimatrix and improve the quality of neck depression and wrinkle repair.

The cornu Cervi Pantotrichum refers to young horn of Cervus Nippon Temminck or Cervus Elaphus L with cornu Cervi Pantotrichum which is not ossified. The cornu Cervi Pantotrichum contains phospholipid, glycolipid, gum lipid, hormone, fatty acid, amino acid, protein, and calcium, phosphorus, magnesium, and sodium, wherein the amino acid component accounts for more than half of the total components. Ancient physicians thought that the essence of deer is in the horn, antler is the tender shoot of the horn, and the qi is full without excretion, so the most powerful of tonifying yang and nourishing blood. Ming Dynasty Li Shizhen called pilose antler in Ben Cao gang mu, which is good at tonifying kidney and strengthening yang, producing essence and benefiting blood, replenishing marrow and strengthening bone. The pilose antler contains a large amount of collagen, wherein the type I collagen accounts for about 90 percent, and is proved to have important significance for repairing, regenerating and reconstructing defective tissues as a medical biological material. Among them, type I collagen is the most abundant collagen in the human body. It forms large eosinophilic fibers, called collagen fibers. The collagen fiber is fiber nutrient solution mainly containing collagen, and amino acids such as glycine, proline, hydroxyproline and the like. Collagen fibers are the most widely distributed of the three fibers, the most abundant one. It is widely distributed in various organs, most abundantly on skin, sclera and tendon. The collagen fiber staining is mainly used for identifying muscle fibers. Collagen fibers are the main component in skin and account for 95% -98% of the total fiber mass of the skin, and fresh collagen fibers are white, so the collagen fibers are also called white fibers. In the HE staining specimen, the collagen fibers are stained pink, are thick and large, have the diameter of 0.5-20um, are distributed in bundles, are arranged closely and are interwoven into a net. Therefore, the type I collagen in the pilose antler can effectively promote the regeneration of skin collagen.

In addition, the pilose antler polypeptide enhances the activity of superoxide dismutase, has the function of eliminating excessive oxygen free radicals in the body, and has obvious effect on delaying senility.

After the ginseng and the pilose antler are combined, the oxidation activity can be obviously improved, and the ginseng and the pilose antler have synergistic effect. The compatibility of the two can further improve the regeneration capability of skin collagen and the oxidation resistance of human body. Meanwhile, the tetradecanoic acid sterol ester in the tortoise gum can activate a Wnt/beta-catenin signal path in hair follicle stem cells to participate in the repair of skin wound surfaces, the Wnt/beta-catenin signal path in the hair follicle stem cells is regulated and controlled, the hair follicle stem cells are promoted to proliferate and participate in the reconstruction of skin tissues, and the tetradecanoic acid sterol ester can further play a role in repairing neck wrinkles after being matched with ginseng and pilose antler.

The soybean is rich in soybean isoflavone, and the antioxidant effect of the soybean isoflavone is manifold. It has effects in inhibiting free radical formation, reducing lipid oxidation, and stimulating antioxidase synthesis. It is well known that free radicals are the main contributor to various diseases and aging of the human body. Medical research proves that the human body can generate free radicals in the metabolic process, and if the free radicals are excessive, the free radicals can easily induce various diseases and are also the basic reason of the aging of the appearance of the body. Recent studies have found that flavonoids derived from natural food materials, including quercetin, luteolin, soy isoflavones, etc., are excellent radical scavengers and good natural antioxidants, one. The soybean isoflavone has definite antioxidation on the whole animals and also has stronger antioxidation in vitro. Therefore, the soybean isoflavone has effective antioxidation effect, and can remarkably promote skin collagen regeneration, improve neck wrinkle smoothness, and inhibit wrinkle regeneration.

The herba Centellae is a creeping herb with cold, bitter and pungent properties, and can be used for treating skin ulcer, traumatic injury, sunstroke and diarrhea, removing toxic substance and relieving swelling. The centella asiatica wine not only has medicinal value, but also has super strong efficacy in the aspect of beauty, and the centella asiatica can increase the resistance of the skin epidermis, has the effects of anti-inflammation, sedation, detoxification and detumescence, endows the skin with elasticity, strengthens the softness of the skin, and can delay aging. Terpenoids in centella asiatica extract can significantly increase the content of collagen and cell layer fibronectin (fibronectin is widely involved in cell migration, adhesion, proliferation, hemostasis, skin tissue repair, etc.), and can stimulate the production of type I collagen which promotes scar maturation and reduce the generation of inflammatory response. In addition, the centella asiatica extract can reduce the production of proinflammatory mediators (IL-1, MMP-1), and improve and repair the barrier function of the skin. Centella asiatica extract can remarkably increase the hydration degree of stratum corneum, which is mainly related to triterpenoid saponin compounds in the centella asiatica extract, and the centella asiatica triterpenoid saponin is a hydrophilic sugar chain, mainly glucose and rhamnose, can be combined with water in occlusion layers, improves the barrier capability of epidermis and enhances the moisture of skin. Centella asiatica has antioxidant effect, and can remove aged horny layer, promote skin metabolism, increase skin elasticity, and supplement nutrients. The centella asiatica can tighten the connecting part of the epidermis and the dermis, so that the skin becomes soft, the phenomenon of skin relaxation is solved, and the skin is smoother and more elastic. The centella asiatica can tighten the connecting part of the epidermis and the dermis, can soften the skin, helps to promote the formation of collagen in the dermis, and has the effect of making the skin tight. Centella also promotes protein regeneration, and centella helps to promote collagen formation in the dermis of the skin, regenerate fibrin, reduce fine wrinkles of the skin, and tighten and smooth the skin. The centella asiatica is used as a neutral medicament for preparing the ginseng and the pilose antler, can effectively improve the activity of collagen regeneration promoting substances in the ginseng and the pilose antler, and further improves the collagen regeneration effect of skin.

The honey has obvious capability of promoting tissue regeneration, and can effectively promote collagen regeneration in skin repair.

The solvent is mainly used for melting the components to enable the components to be pasty, and is convenient to be directly used on human skin. Meanwhile, the solvent can also be used as a solvent to promote the activity of substances in the combined freeze-dried powder.

The composite freeze-dried powder comprises the following components in percentage by mass: 0.01-0.5% of mesenchymal stem cell freeze-dried powder and 99.9-99.5% of mannitol. The Mesenchymal Stem Cells (MSC) are a class of adult stem cells with self-renewal and multipotential differentiation and immunoregulatory capabilities. The source of the mesenchymal stem cells is wide, the mesenchymal stem cells can be separated from tissues such as bone marrow, fat, umbilical cord, placenta and the like, and the mesenchymal stem cells are widely used for clinical tests and basic research because the mesenchymal stem cells have low immunogenicity, do not generate immunological rejection after transplantation and have no tumorigenicity. Wound healing has been an important problem in the medical community, and skin, as a specific organ, is a barrier to external contact and plays a very important role in wound healing. Previous researches prove that the mesenchymal stem cells have important regulation and control functions in the aspects of promoting wound healing, reducing scar formation and the like, and are considered as ideal seed cells for constructing full-thickness skin. The mesenchymal stem cells can be recruited to the inflammation part by small molecular substances such as chemotactic factors and the like, so that the microenvironment of the injury part mediates the differentiation of the mesenchymal stem cells to epidermal cells, fibroblasts and vascular endothelial cells, and the inflammatory reaction is inhibited to achieve the purpose of reconstructing the skin. The mesenchymal stem cell freeze-dried powder is used as an effective storage body of the mesenchymal stem cells, and can effectively maintain the medicinal function of the mesenchymal stem cells for a long time.

The mesenchymal stem cell freeze-dried powder is combined with the ginseng, the tortoise-plastron glue, the pilose antler and the centella asiatica for use, so that the collagen regeneration capacity of human skin can be greatly enhanced, particularly, in the skin injury repair, the peptide component in the ginseng can greatly enhance the repair effect of the mesenchymal stem cell freeze-dried powder on the skin, and the collagen regeneration capacity of the skin is enhanced. Meanwhile, the saponin component in the ginseng can effectively resist skin cell apoptosis, promote blood circulation and play a role in promoting skin collagen regeneration. The collagen fiber in the antler has important significance for repairing, regenerating and reconstructing skin tissues, and in the process of promoting the regeneration of skin collagen by the mesenchymal stem cell freeze-dried powder, the type I collagen in the collagen fiber can be used as a raw material for promoting the regeneration of skin collagen.

The mannitol generally has the effects of moisturizing, moisturizing and supplementing water, and has the advantages that the mannitol has the advantages that the polymethyl group can be fused with water in a covalent bond mode, the moisturizing and supplementing effect is very good, and the mannitol can be used with mesenchymal stem cell freeze-dried powder to bring number-giving experience to users. Meanwhile, because the mesenchymal stem cell freeze-dried powder is generally low in dosage, mannitol can be used as an intermediate medium to facilitate the use of the mesenchymal stem cell freeze-dried powder, and neck wrinkles are effectively improved. The components are matched, so that the composition has no side effect and no harm to human bodies.

Therefore, the ginseng, the tortoise-plastron glue, the pilose antler, the soybean, the combined freeze-dried powder, the centella extract and the honey can promote the collagen regeneration capacity, and the ginseng, the tortoise-plastron glue, the pilose antler, the soybean, the combined freeze-dried powder, the centella extract and the honey are matched for use, so that the collagen regeneration capacity can be further improved on the basis of promoting the collagen regeneration capacity, and the capacity of repairing neck wrinkles is achieved. The nutrient solution greatly improves the collagen regeneration capability of the skin, and can form a rapid and stable carrier bracket when being suitable for skin regeneration, thereby realizing the effect of rapid tissue regeneration and effectively improving the neck wrinkle condition.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.

It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present invention will be described in detail below with reference to specific examples.

The ginseng has obvious effects on nervous system, cardiovascular system, endocrine system, digestive system, reproductive system, respiratory system and surgical application, and can promote the metabolism of ribonucleic acid (RNA), deoxyribonucleic acid (DNA), protein, cholesterol, fat and sugar, promote the mitosis of bone marrow cells, increase the number of red blood cells, white blood cells and nucleated cells in bone marrow, enhance the hematopoietic function of bone marrow and enhance the regeneration of human collagen. The peptide component in the ginseng can supplement nutrients such as collagen and the like, and also has multiple effects of moisturizing, locking water, whitening, resisting oxidation, resisting sugar, resisting blue light and the like. Not only can repair the skin barrier, but also can keep the skin smooth and fine. Preventing melanin generation, improving skin condition, and improving skin smoothness, wrinkle resistance, fineness, glossiness and skin color uniformity. Wherein the ginseng comprises ginseng peptide, and the ginseng peptide has the effects of slimming and beautifying, can maintain nutrition and balance, can promote collagen regeneration capacity of skin, and is suitable for people who are slimming and beautifying.

After the ginseng and the pilose antler are combined, the oxidation activity can be obviously improved, and the ginseng and the pilose antler have synergistic effect. The compatibility of the two can further improve the regeneration capability of skin collagen and the oxidation resistance of human body.

The soybean is rich in soybean isoflavone, and the antioxidant effect of the soybean isoflavone is manifold. It has effects in inhibiting free radical formation, reducing lipid oxidation, and stimulating antioxidase synthesis. It is well known that free radicals are the main contributor to various diseases and aging of the human body. Medical research proves that the human body can generate free radicals in the metabolic process, and if the free radicals are excessive, the free radicals can easily induce various diseases and are also the basic reason of the aging of the appearance of the body. Recent studies have found that flavonoids derived from natural food materials, including quercetin, luteolin, soy isoflavones, etc., are excellent radical scavengers and good natural antioxidants, one. The soybean isoflavone has definite antioxidation on the whole animals and also has stronger antioxidation in vitro. Therefore, the soybean isoflavone has effective antioxidation effect and can obviously promote the regeneration capability of collagen of the skin.

The herba Centellae is a creeping herb with cold, bitter and pungent properties, and can be used for treating skin ulcer, traumatic injury, sunstroke and diarrhea, removing toxic substance and relieving swelling. The centella asiatica wine not only has medicinal value, but also has super strong efficacy in the aspect of beauty, and the centella asiatica can increase the resistance of the skin epidermis, has the effects of anti-inflammation, sedation, detoxification and detumescence, endows the skin with elasticity, strengthens the softness of the skin, and can delay aging. Terpenoids in centella asiatica extract can significantly increase the content of collagen and cell layer fibronectin (fibronectin is widely involved in cell migration, adhesion, proliferation, hemostasis, skin tissue repair, etc.), and can stimulate the production of type I collagen which promotes scar maturation and reduce the generation of inflammatory response. In addition, the centella asiatica extract can reduce the production of proinflammatory mediators (IL-1, MMP-1), and improve and repair the barrier function of the skin. Centella asiatica extract can remarkably increase the hydration degree of stratum corneum, which is mainly related to triterpenoid saponin compounds in the centella asiatica extract, and the centella asiatica triterpenoid saponin is a hydrophilic sugar chain, mainly glucose and rhamnose, can be combined with water in occlusion layers, improves the barrier capability of epidermis and enhances the moisture of skin. Centella asiatica has antioxidant effect, and can remove aged horny layer, promote skin metabolism, increase skin elasticity, and supplement nutrients. The centella asiatica can tighten the connecting part of the epidermis and the dermis, so that the skin becomes soft, the phenomenon of skin relaxation is solved, and the skin is smoother and more elastic. The centella asiatica can tighten the connecting part of the epidermis and the dermis, can soften the skin, helps to promote the formation of collagen in the dermis, and has the effect of making the skin tight. Centella also promotes protein regeneration, and centella helps to promote collagen formation in the dermis of the skin, regenerate fibrin, reduce fine wrinkles of the skin, and tighten and smooth the skin. The centella asiatica is used as a neutral medicament for preparing the ginseng and the pilose antler, can effectively improve the activity of collagen regeneration promoting substances in the ginseng and the pilose antler, and further improves the collagen regeneration effect of skin, thereby improving the repair capability of wrinkles.

The mesenchymal stem cell freeze-dried powder is combined with the ginseng, the pilose antler and the centella asiatica for use, so that the collagen regeneration capacity of human skin can be greatly enhanced, particularly, in the skin injury repair, the peptide component in the ginseng can greatly enhance the repair effect of the mesenchymal stem cell freeze-dried powder on the skin, and the collagen regeneration capacity of the skin is increased. Meanwhile, the saponin component in the ginseng can effectively resist skin cell apoptosis, promote blood circulation and play a role in promoting skin collagen regeneration. The collagen fiber in the antler has important significance for repairing, regenerating and reconstructing skin tissues, and in the process of promoting the regeneration of skin collagen by the mesenchymal stem cell freeze-dried powder, the type I collagen in the collagen fiber can be used as a raw material to promote the regeneration of skin collagen and improve the repair capacity of neck wrinkles.

The mannitol generally has the effects of moisturizing, moisturizing and supplementing water, and has the advantages that the mannitol has the advantages that the polymethyl group can be fused with water in a covalent bond mode, the moisturizing and supplementing effect is very good, and the mannitol can be used with mesenchymal stem cell freeze-dried powder to bring number-giving experience to users. Meanwhile, because the mesenchymal stem cell freeze-dried powder is generally low in dosage, mannitol can be used as an intermediate medium to facilitate the use of the mesenchymal stem cell freeze-dried powder.

Therefore, the nutrient solution greatly improves the collagen regeneration capacity of the skin, and can form a rapid and stable carrier bracket when being suitable for skin regeneration, thereby realizing the effect of rapid tissue regeneration and effectively improving the neck wrinkle condition.

Furthermore, the composite freeze-dried powder also comprises one or more of the following components, by mass, 0.001-2% of palmitoyl tripeptide-1, 0.001-2% of palmitoyl pentapeptide-4 and 0.001-0.05% of vitamin A. The palmitoyl tripeptide-1 is a substance effective for preventing and smoothing wrinkles and firming the skin, and makes the skin younger, smoother and more elastic. The combination of the palmitoyl tripeptide-1 and the vitamin A can better promote the synthesis capacity of collagen and glycosaminoglycan, and avoids the stimulation and side effect of using the vitamin A alone. The palmitoyl tripeptide-5 can stimulate a tissue growth factor (TGF-beta) to generate collagen, and simultaneously protect the collagen from being decomposed by matrix metalloproteinase, and the palmitoyl tripeptide-5 and the matrix metalloproteinase have synergistic effect, so that wrinkles are effectively removed, and the skin quality is improved. The skin care product can stimulate the synthesis of collagen and glycosaminoglycan, reduce fine lines of skin, effectively improve wrinkles, enhance the skin tightness and glossiness, improve the skin color, resist wrinkles and aging, and improve the skin elasticity and moisture.

Further, the nutrient solution also comprises the following raw materials in parts by weight: 10-15 parts of collagen peptide, 8-12 parts of protein silk peptide, 5-10 parts of glutathione, 5-10 parts of nucleotide and 2-5 parts of chitosan derivative. The collagen peptide is a hydrolyzed collagen fragment obtained by hydrolyzing a collagen chain by an enzymatic method and then extracting the hydrolyzed collagen, but retains a three-helical polypeptide structure having a steric activity. Thus, collagen peptides can provide fragments for skin collagen regeneration. The protein silk peptide has the following effects: deeply enters into the bottom layer of the skin, so that the skin is fundamentally whitened without side effect; the NMF factor is ten times of that of the conventional plant or chemical humectant, so that the NMF factor can continuously and efficiently supplement water to the skin; nourishing and conditioning, having strong permeability, providing necessary nutrients for skin, promoting cell metabolism and improving skin quality; has effects in resisting aging, caring skin, activating skin cells, improving microcirculation, resisting aging, removing wrinkle, and caring skin; has antioxidant, external pollution resisting, skin pH value balancing maintaining, and skin immunity enhancing effects. The glutathione is an important antioxidant, can remove free radicals in human body, and has antioxidant effect and integrated detoxification effect. It can activate various enzymes, thereby promoting skin collagen regeneration. The chitosan derivative has strong affinity with human body cells, can be decomposed and absorbed by enzyme in vivo, has good hygroscopicity and moisture retention, and can inhibit bacteria to protect skin. The chitosan derivative can be filled in the skin dry crack, has the action with ceramide in the surface sebum membrane layer, and finally grows into a whole with the epidermis, so as to achieve the rust beautifying effect. In addition, the chitosan derivative is also an excellent cell growth induction factor which can stimulate and accelerate the regeneration speed of skin cells, and can further improve the collagen regeneration capability of the skin by being combined with the components capable of promoting the regeneration of skin gel, thereby achieving the effects of modification and beauty. The nucleotide is used as a coenzyme, and can further enhance the capability of the components for promoting skin collagen regeneration, thereby improving the capability of repairing neck wrinkles.

Further, the nutrient solution also comprises the following raw materials in parts by weight: 5-10 parts of aloe vera leaves. The aloe gel in the aloe vera leaves increases the cross-linking between the collagen proteins to increase their tensile strength. The wound hormone and the polypeptide mannose in the aloe have the functions of resisting virus infection and promoting wound healing and recovery, thereby achieving the purposes of diminishing inflammation and sterilizing, clearing heat and reducing swelling, softening skin and keeping cell activity. Aloe vera leaves also contain a compound called phytohemagglutinin, which is a combination of protein and carbohydrate, and which can attach to human cells to stimulate intracellular responses, promote cell growth and division, and accelerate healing and healing of injured tissues. Therefore, aloe vera leaves can promote collagen regeneration of the skin.

Chrysophanol contained in the rhubarb is a substance capable of promoting fibroblast proliferation. Fibroblasts participate in the overall process of repair, where they divide, proliferate, migrate, synthesize and secrete extracellular matrix, form connective tissue and repair wounds or skin depressions. Collagen is the most important tangible component in extracellular matrix, and at least 10 types of collagen have been found, wherein type i collagen and type iii collagen are the most main components and are the main roles of fibroblasts in repairing tissue wounds. The research shows that collagen fibers can activate a Discotic Domain Receptor (DDR)2, and the research shows that the collagen fibers can activate the Discotic Domain Receptor (DDR)2 through acting on Matrix Metalloproteinase (MMPs), and the collagen fibers are degraded through acting on the Matrix Metalloproteinase (MMPs) to participate in the synthesis and secretion of collagen and the reconstruction of extracellular matrix. The chrysophanol promotes the proliferation activity of fibroblasts to be increased, which indicates that the number of the cells is increased quickly, is favorable for generating more extracellular matrixes and is favorable for repairing tissue wounds. Combining the regulation and control effect of the chrysophanol on the expression of the type I collagen and the type III collagen, the chrysophanol can inhibit the expression of the type I collagen of the fibroblast, but can increase the proliferation activity of the fibroblast, thereby promoting the repair of tissue wounds. Meanwhile, chrysophanol promotes the expression of type III collagen, so that the mechanism is possible to promote the regeneration of skin collagen and reduce the formation of scars. Therefore, the combination of the rhubarb and the tortoise-plastron glue can further promote the autologous collagen regeneration of the neck wrinkles.

Further, the solvent comprises the following components in percentage by mass: 1% dipeptide diaminobutyrylbenzylamide diacetate, 0.025% sodium hyaluronate, 0.025% phenoxyethanol and 98.95% water. The sodium hyaluronate can play a role in moisturizing, and compared with other moisturizing agents, the moisturizing agent is less affected by the relative humidity of the surrounding environment. The phenoxyethanol can play a role in corrosion prevention and can effectively inhibit bacterial elongation. The dipeptide diaminobutyrylbenzylamide diacetate is used as a solvent component, and can be used as a solvent of the mesenchymal stem cell freeze-dried powder to promote the activity of the mesenchymal stem cell freeze-dried powder.

Further, the tortoise-plastron glue is prepared by the following preparation method: weighing 5-15 parts of fresh tortoise plastron, 3-8 parts of kudzu root, 5-10 parts of radix rehmanniae, 10-30 parts of dendrobium officinale and 5-10 parts of lucid ganoderma according to the following weight parts, decocting for 5-6 hours by using medium fire, filtering out solid components by using a filter screen after decocting is finished, and keeping liquid; and continuously heating the liquid, stirring the liquid in the heating process, heating and stirring until the liquid is gelatinized, stopping heating, and cooling to obtain the tortoise-plastron glue.

Further, the centella asiatica extract is prepared by the following preparation method: cleaning and drying 20-30 parts of centella asiatica, adding purified water with the volume 5-6 times of the centella asiatica, soaking and extracting, controlling the extraction temperature to be 45-65 ℃, extracting for 1-1.5 hours to obtain a primary extracting solution, adding purified water with the volume 4-6 times of the centella asiatica into filter residues, extracting for 1-2 hours, filtering at the extraction temperature of 50-60 ℃, obtaining a secondary filtrate, and combining the filtrates to obtain the centella asiatica extracting solution.

Further, the nutrient solution is prepared by the following preparation method:

1) preparing materials, cleaning and airing ginseng, pilose antler and soybean, and respectively grinding and sieving the aired ginseng, pilose antler and soybean to obtain ginseng powder, pilose antler powder and soybean powder for later use; 2) mixing, weighing the ginseng powder, the antler powder, the soybean powder, the combined freeze-dried powder, the asiatic centella extract, the honey and the solvent according to the weight part ratio, putting the asiatic centella extract and the honey into the solvent, uniformly stirring, then sequentially putting the ginseng powder, the antler powder, the soybean powder and the combined freeze-dried powder into the solvent, uniformly stirring to form a mixture, controlling the temperature to be 60-70 ℃ during stirring, adding the thickening agent into the mixture after obtaining the mixture, filtering while hot, and cooling to below 40 ℃. Processing Ginseng radix, cornu Cervi Pantotrichum and semen glycines into powder, dissolving Ginseng radix powder, cornu Cervi Pantotrichum powder, semen glycines powder, combined lyophilized powder, Mel and herba Centellae extractive solution with solvent, mixing to obtain mixture, and facilitating storage and use. The nutrient solution for removing the neck striae with good quality and stable effect can be prepared by the preparation method. The temperature is controlled to be 60-70 ℃ during stirring in the step 2). The temperature is controlled to be 60-70 ℃, so that all components can be effectively fused. The thickening agent can change the mixture from suspension to paste.

Further, the thickener comprises the following raw materials in parts by weight: 12-16 parts of chitosan, 4-6 parts of water-soluble lanolin and 12-14 parts of polyvinyl alcohol. The chitosan, water-soluble lanolin and polyvinyl alcohol can make the mixture into cream, and is more suitable for being applied on the surface of neck skin.

The features and properties of the present invention are described in further detail below with reference to examples.

Example 1

The embodiment provides a nutrient solution for removing neck striae, which comprises the following raw materials: 10g of ginseng, 10g of tortoise-plastron glue, 5-g of pilose antler, 10g of soybean, 30g of combined freeze-dried powder, 20g of asiatic centella extract, 10g of honey and 40g of solvent.

Wherein, the combination freeze-dried powder includes: 0.03g of mesenchymal stem cell freeze-dried powder and 29.97g of mannitol.

Wherein, the solvent comprises the following raw materials: 0.4g dipeptide diaminobutyrylbenzylamide diacetate, 0.01g sodium hyaluronate, 0.01g phenoxyethanol and 39.5g water.

1) Preparing materials, cleaning and airing ginseng, pilose antler and soybean, and respectively grinding and sieving the aired ginseng, pilose antler and soybean to obtain ginseng powder, pilose antler powder and soybean powder for later use; 2) mixing, weighing the ginseng powder, the antler powder, the soybean powder, the combined freeze-dried powder, the asiatic centella extract, the honey and the solvent according to the weight part ratio, putting the asiatic centella extract and the honey into the solvent, stirring uniformly, then putting the ginseng powder, the antler powder, the soybean powder and the combined freeze-dried powder into the solvent in sequence, stirring uniformly to form a mixture, controlling the temperature at 60 ℃ while stirring to obtain the mixture, adding the thickening agent into the mixture, filtering while hot, and cooling to below 40 ℃. The thickener comprises the following raw materials in parts by weight: 12.4g of chitosan, 4.2g of water-soluble lanolin and 12.2g of polyvinyl alcohol.

Example 2

The embodiment provides a nutrient solution for removing neck striae, which comprises the following raw materials: 10.5g of ginseng, 5.5g of pilose antler, 11g of tortoise-plastron glue, 12g of soybean, 31g of combined freeze-dried powder, 21g of asiatic centella extract, 11g of honey and 41g of solvent.

Wherein the combined lyophilized powder comprises 0.031g of mesenchymal stem cell lyophilized powder and 30.96g of mannitol.

Wherein, the solvent comprises the following raw materials: 0.41g dipeptide diaminobutyrylbenzylamide diacetate, 0.01g sodium hyaluronate, 0.01g phenoxyethanol and 40g water.

1) Preparing materials, cleaning and airing ginseng, pilose antler and soybean, and respectively grinding and sieving the aired ginseng, pilose antler and soybean to obtain ginseng powder, pilose antler powder and soybean powder for later use; 2) mixing, weighing the ginseng powder, the antler powder, the soybean powder, the combined freeze-dried powder, the asiatic centella extract, the honey and the solvent according to the weight part ratio, putting the asiatic centella extract and the honey into the solvent, stirring uniformly, then putting the ginseng powder, the antler powder, the soybean powder and the combined freeze-dried powder into the solvent in sequence, stirring uniformly to form a mixture, controlling the temperature at 62 ℃ during stirring to obtain the mixture, adding the thickening agent into the mixture, filtering while hot, and cooling to below 40 ℃. The thickener comprises the following raw materials in parts by weight: 12.8g of chitosan, 4.4g of water-soluble lanolin and 12.4g of polyvinyl alcohol.

Example 3

The embodiment provides a nutrient solution for removing neck striae, which comprises the following raw materials: 11g of ginseng, 13g of tortoise-plastron glue, 6g of pilose antler, 14g of soybean, 32g of combined freeze-dried powder, 22g of asiatic centella extract, 12g of honey and 42g of solvent.

Wherein the combined lyophilized powder comprises 0.032g of mesenchymal stem cell lyophilized powder and 31.96g of mannitol.

Wherein, the solvent comprises the following raw materials: 0.42 g of dipeptide diaminobutyrylbenzylamide diacetate, 0.01g of sodium hyaluronate, 0.01g of phenoxyethanol and 41.26g of water.

The nutrient solution is prepared by the following preparation method:

1) preparing materials, cleaning and airing ginseng, pilose antler and soybean, and respectively grinding and sieving the aired ginseng, pilose antler and soybean to obtain ginseng powder, pilose antler powder and soybean powder for later use; 2) mixing, weighing the ginseng powder, the antler powder, the soybean powder, the combined freeze-dried powder, the asiatic centella extract, the honey and the solvent according to the weight part ratio, putting the asiatic centella extract and the honey into the solvent, stirring uniformly, then putting the ginseng powder, the antler powder, the soybean powder and the combined freeze-dried powder into the solvent in sequence, stirring uniformly to form a mixture, controlling the temperature at 63 ℃ during stirring to obtain the mixture, adding the thickening agent into the mixture, filtering while hot, and cooling to below 40 ℃. The thickener comprises the following raw materials in parts by weight: 13.2g of chitosan, 4.6g of water-soluble lanolin and 12.6g of polyvinyl alcohol.

Example 4

The embodiment provides a nutrient solution for removing neck striae, which comprises the following raw materials: 11.5g of ginseng, 14g of tortoise-plastron glue, 6.5g of pilose antler, 16g of soybean, 33g of combined freeze-dried powder, 23g of asiatic centella extract, 13g of honey and 43g of solvent.

Wherein, the combination freeze-dried powder includes: 0.033g of lyophilized mesenchymal stem cell powder and 32.96g of mannitol.

Wherein, the solvent comprises the following raw materials: 0.43g dipeptide diaminobutyrylbenzylamide diacetate, 0.01g sodium hyaluronate, 0.01g phenoxyethanol and 42.55g water.

The nutrient solution is prepared by the following preparation method:

1) preparing materials, cleaning and airing ginseng, pilose antler and soybean, and respectively grinding and sieving the aired ginseng, pilose antler and soybean to obtain ginseng powder, pilose antler powder and soybean powder for later use; 2) mixing, weighing the ginseng powder, the antler powder, the soybean powder, the combined freeze-dried powder, the asiatic centella extract, the honey and the solvent according to the weight part ratio, putting the asiatic centella extract and the honey into the solvent, stirring uniformly, then putting the ginseng powder, the antler powder, the soybean powder and the combined freeze-dried powder into the solvent in sequence, stirring uniformly to form a mixture, controlling the temperature at 64 ℃ during stirring, adding the thickening agent into the mixture, filtering while hot, and cooling to below 40 ℃. The thickener comprises the following raw materials in parts by weight: 13.6g of chitosan, 4.8g of water-soluble lanolin and 12.8g of polyvinyl alcohol.

Example 5

The embodiment provides a nutrient solution for removing neck striae, which comprises the following raw materials: 12g of ginseng, 15g of tortoise-plastron glue, 7g of pilose antler, 18g of soybean, 34g of combined freeze-dried powder, 24g of asiatic centella extract, 14g of honey and 44g of solvent.

Wherein, the combination freeze-dried powder includes: 0.034g of lyophilized powder of mesenchymal stem cells and 33.96g of mannitol.

Wherein, the solvent comprises the following raw materials: 0.44g dipeptide diaminobutyrylbenzylamide diacetate, 0.01g sodium hyaluronate, 0.01g phenoxyethanol and 43.54g water.

The nutrient solution is prepared by the following preparation method:

1) preparing materials, cleaning and airing ginseng, pilose antler and soybean, and respectively grinding and sieving the aired ginseng, pilose antler and soybean to obtain ginseng powder, pilose antler powder and soybean powder for later use; 2) mixing, weighing the ginseng powder, the antler powder, the soybean powder, the combined freeze-dried powder, the asiatic centella extract, the honey and the solvent according to the weight part ratio, putting the asiatic centella extract and the honey into the solvent, stirring uniformly, then putting the ginseng powder, the antler powder, the soybean powder and the combined freeze-dried powder into the solvent in sequence, stirring uniformly to form a mixture, controlling the temperature at 65 ℃ while stirring to obtain the mixture, adding the thickening agent into the mixture, filtering while hot, and cooling to below 40 ℃. The thickener comprises the following raw materials in parts by weight: 14g of chitosan, 5g of water-soluble lanolin and 13g of polyvinyl alcohol.

Example 6

The embodiment provides a nutrient solution for removing neck striae, which comprises the following raw materials: 12.5g of ginseng, 16g of tortoise-plastron glue, 7.5g of pilose antler, 20g of soybean, 35g of combined freeze-dried powder, 25g of asiatic centella extract, 15g of honey and 45g of solvent.

Wherein the combined lyophilized powder comprises 0.035g of mesenchymal stem cell lyophilized powder and 34.96g of mannitol.

Wherein, the solvent comprises the following raw materials: 0.45 dipeptide diaminobutyrylbenzylamide diacetate, 0.01g sodium hyaluronate, 0.01g phenoxyethanol and 44.53g water.

The nutrient solution is prepared by the following preparation method:

1) preparing materials, cleaning and airing ginseng, pilose antler and soybean, and respectively grinding and sieving the aired ginseng, pilose antler and soybean to obtain ginseng powder, pilose antler powder and soybean powder for later use; 2) mixing, weighing the ginseng powder, the antler powder, the soybean powder, the combined freeze-dried powder, the asiatic centella extract, the honey and the solvent according to the weight part ratio, putting the asiatic centella extract and the honey into the solvent, stirring uniformly, then putting the ginseng powder, the antler powder, the soybean powder and the combined freeze-dried powder into the solvent in sequence, stirring uniformly to form a mixture, controlling the temperature at 66 ℃ during stirring to obtain the mixture, adding the thickening agent into the mixture, filtering while hot, and cooling to below 40 ℃. The thickener comprises the following raw materials in parts by weight: 14.4g of chitosan, 5.2g of water-soluble lanolin and 13.2g of polyvinyl alcohol.

Example 7

The embodiment provides a nutrient solution for removing neck striae, which comprises the following raw materials: 13g of ginseng, 17g of tortoise-plastron glue, 8g of pilose antler, 22g of soybean, 36g of combined freeze-dried powder, 26g of asiatic centella extract, 16g of honey and 46g of solvent.

Wherein the combined lyophilized powder comprises 0.036g of mesenchymal stem cell lyophilized powder and 35.96g of mannitol.

Wherein, the solvent comprises the following raw materials: 0.46g dipeptide diaminobutyrylbenzylamide diacetate, 0.01g sodium hyaluronate, 0.01g phenoxyethanol and 45.52g water.

The nutrient solution is prepared by the following preparation method:

1) preparing materials, cleaning and airing ginseng, pilose antler and soybean, and respectively grinding and sieving the aired ginseng, pilose antler and soybean to obtain ginseng powder, pilose antler powder and soybean powder for later use; 2) mixing, weighing the ginseng powder, the antler powder, the soybean powder, the combined freeze-dried powder, the asiatic centella extract, the honey and the solvent according to the weight part ratio, putting the asiatic centella extract and the honey into the solvent, stirring uniformly, then putting the ginseng powder, the antler powder, the soybean powder and the combined freeze-dried powder into the solvent in sequence, stirring uniformly to form a mixture, controlling the temperature at 67 ℃ during stirring to obtain the mixture, adding the thickening agent into the mixture, filtering while hot, and cooling to below 40 ℃. The thickener comprises the following raw materials in parts by weight: 14.8g of chitosan, 5.4g of water-soluble lanolin and 13.4g of polyvinyl alcohol.

Example 8

The embodiment provides a nutrient solution for removing neck striae, which comprises the following raw materials: 13.5g of ginseng, 18g of tortoise-plastron glue, 8.5g of pilose antler, 24g of soybean, 37g of combined freeze-dried powder, 27g of asiatic centella extract, 17g of honey and 47g of solvent.

Wherein the combined lyophilized powder comprises 0.037g of mesenchymal stem cell lyophilized powder and 36.96g of mannitol.

Wherein, the solvent comprises the following raw materials: 0.47g dipeptide diaminobutyrylbenzylamide diacetate, 0.01g sodium hyaluronate, 0.01g phenoxyethanol and 46.51g water.

The nutrient solution is prepared by the following preparation method:

1) preparing materials, cleaning and airing ginseng, pilose antler and soybean, and respectively grinding and sieving the aired ginseng, pilose antler and soybean to obtain ginseng powder, pilose antler powder and soybean powder for later use; 2) mixing, weighing the ginseng powder, the antler powder, the soybean powder, the combined freeze-dried powder, the asiatic centella extract, the honey and the solvent according to the weight part ratio, putting the asiatic centella extract and the honey into the solvent, stirring uniformly, then putting the ginseng powder, the antler powder, the soybean powder and the combined freeze-dried powder into the solvent in sequence, stirring uniformly to form a mixture, controlling the temperature at 68 ℃ during stirring to obtain the mixture, adding the thickening agent into the mixture, filtering while hot, and cooling to below 40 ℃. The thickener comprises the following raw materials in parts by weight: 15g of chitosan, 5.6g of water-soluble lanolin and 13.6g of polyvinyl alcohol.

Example 9

The embodiment provides a nutrient solution for removing neck striae, which comprises the following raw materials: 14g of ginseng, 19g of tortoise-plastron glue, 9g of pilose antler, 26g of soybean, 38g of combined freeze-dried powder, 28g of asiatic centella extract, 18g of honey and 48g of solvent.

Wherein the combined lyophilized powder comprises 0.038 g% of mesenchymal stem cell lyophilized powder and 37.96g of mannitol.

Wherein, the solvent comprises the following raw materials: 0.48g dipeptide diaminobutyrylbenzylamide diacetate, 0.01g sodium hyaluronate, 0.01g phenoxyethanol and 47.5g water.

The nutrient solution is prepared by the following preparation method:

1) preparing materials, cleaning and airing ginseng, pilose antler and soybean, and respectively grinding and sieving the aired ginseng, pilose antler and soybean to obtain ginseng powder, pilose antler powder and soybean powder for later use; 2) mixing, weighing the ginseng powder, the antler powder, the soybean powder, the combined freeze-dried powder, the asiatic centella extract, the honey and the solvent according to the weight part ratio, putting the asiatic centella extract and the honey into the solvent, stirring uniformly, then putting the ginseng powder, the antler powder, the soybean powder and the combined freeze-dried powder into the solvent in sequence, stirring uniformly to form a mixture, controlling the temperature at 69 ℃ during stirring to obtain the mixture, adding the thickening agent into the mixture, filtering while hot, and cooling to below 40 ℃. The thickener comprises the following raw materials in parts by weight: 15.4g of chitosan, 5.8g of water-soluble lanolin and 13.8g of polyvinyl alcohol.

Example 10

The embodiment provides a nutrient solution for removing neck striae, which comprises the following raw materials: 14.5g of ginseng, 20g of tortoise-plastron glue, 9.5g of pilose antler, 28g of soybean, 39g of combined freeze-dried powder, 29g of asiatic centella extract, 19g of honey and 49g of solvent.

Wherein the combined lyophilized powder comprises 0.039g of mesenchymal stem cell lyophilized powder and 38.96g of mannitol.

Wherein, the solvent comprises the following raw materials: 0.49g dipeptide diaminobutyrylbenzylamide diacetate, 0.01g sodium hyaluronate, 0.01g phenoxyethanol and 48.49g water.

The nutrient solution is prepared by the following preparation method:

1) preparing materials, cleaning and airing ginseng, pilose antler and soybean, and respectively grinding and sieving the aired ginseng, pilose antler and soybean to obtain ginseng powder, pilose antler powder and soybean powder for later use; 2) mixing, weighing the ginseng powder, the antler powder, the soybean powder, the combined freeze-dried powder, the asiatic centella extract, the honey and the solvent according to the weight part ratio, putting the asiatic centella extract and the honey into the solvent, stirring uniformly, then putting the ginseng powder, the antler powder, the soybean powder and the combined freeze-dried powder into the solvent in sequence, stirring uniformly to form a mixture, controlling the temperature at 70 ℃ during stirring to obtain the mixture, adding the thickening agent into the mixture, filtering while hot, and cooling to below 40 ℃. The thickener comprises the following raw materials in parts by weight: 15.8g of chitosan, 6g of water-soluble lanolin and 14g of polyvinyl alcohol.

Example 11

The embodiment provides a nutrient solution for removing neck striae, which comprises the following raw materials: 15g of ginseng, 20g of tortoise-plastron glue, 10g of pilose antler, 30g of soybean, 40g of combined freeze-dried powder, 30g of asiatic centella extract, 20g of honey and 50g of solvent.

Wherein the combined lyophilized powder comprises 0.04g of mesenchymal stem cell lyophilized powder and 49.96g of mannitol.

Wherein, the solvent comprises the following raw materials: 0.5g dipeptide diaminobutyrylbenzylamide diacetate, 0.01g sodium hyaluronate, 0.01g phenoxyethanol and 49.48g water.

The nutrient solution is prepared by the following preparation method:

1) preparing materials, cleaning and airing ginseng, pilose antler and soybean, and respectively grinding and sieving the aired ginseng, pilose antler and soybean to obtain ginseng powder, pilose antler powder and soybean powder for later use; 2) mixing, weighing the ginseng powder, the antler powder, the soybean powder, the combined freeze-dried powder, the asiatic centella extract, the honey and the solvent according to the weight part ratio, putting the asiatic centella extract and the honey into the solvent, stirring uniformly, then putting the ginseng powder, the antler powder, the soybean powder and the combined freeze-dried powder into the solvent in sequence, stirring uniformly to form a mixture, controlling the temperature at 70 ℃ during stirring to obtain the mixture, adding the thickening agent into the mixture, filtering while hot, and cooling to below 40 ℃. The thickener comprises the following raw materials in parts by weight: 16g of chitosan, 6g of water-soluble lanolin and 14g of polyvinyl alcohol.

Comparative example

The comparative example provides a commercially available nutrient solution for promoting neck wrinkle repair for use.

Test example 1

The cream test methods provided for example 2, example 4, example 6, example 8, example 10 and the comparative example are as follows:

70 unhaired mice were selected, and the mice were equally divided into 7 groups of 10 mice each, and the same sites of the mice were smeared with the creams provided in examples 2, 4, 6, 8, 10 and comparative examples, respectively, at the same amount and area. Meanwhile, a blank control group is arranged, and the mice of the blank control group are coated with normal saline, the coating amount is the same, and the coating area is the same. After 30 days of smearing, 5 mice are randomly selected from each group, the skin on the same side of the smearing part is taken for skin collagen content test, the average value is taken, and the average value of the skin collagen content of the blank control group is set to be 1 in the test result. The test results were as follows:

table 3 collagen content in example 2, example 4, example 6, example 8, example 10 and comparative example and blank control

From the above observation, it can be seen that the average collagen content of the mice smeared with the nutrient solutions provided in examples 2, 4, 6, 8 and 10 of the present invention is higher than that of the mice in the blank control group and the comparative example. The mean collagen content of the mice coated with the nutrient solutions provided in example 2, example 4, example 6, example 8 and example 10 was significantly improved compared to the mean collagen content of the mice in the blank control group, whereas the mean collagen content of the mice in the comparative example was not significantly improved. From the comparison results, the nutrient solution provided by the invention has the advantages that the collagen content is obviously improved, the collagen regeneration effect of the skin of a mouse is obviously promoted, the collagen regeneration capacity of the skin is strong, and the wrinkle repair can be greatly promoted, so that the nutrient solution provided by the invention has an excellent repair effect on the skin wrinkles.

Test example 2

The nutrient solutions prepared in examples 1, 3, 5, 7, 9 and 11 and the commercial nutrient solution in the comparative example were subjected to sensory evaluation, and the evaluation criteria are shown in table 1:

TABLE 1 sensory evaluation score sheet

The nutritional liquids prepared in example 1, example 3, example 5, example 7, example 9, example 11 and the creams in the comparative examples were organoleptically scored according to the evaluation criteria in the table above by selecting 70 volunteers and dividing into 7 groups on average, each group having 10 persons, and the evaluation results are shown in table 2:

table 2 sensory evaluation results of creams of example 1, example 3, example 5, example 7, example 9, example 11 and comparative example

As can be seen from the above table, it can be seen from the scoring results of the creams provided in examples 1, 3, 5, 7, 9, 11 and the comparative example that the neck skin color, neck skin smoothness, nutrient solution odor and adverse reaction after using the nutrient solutions provided in examples 1, 3, 5, 7, 9 and 11 are better than the cream provided by the comparative example. The nutrient solutions prepared in examples 1, 3, 5, 7, 9 and 11 have remarkable whitening, skin-refreshing and wrinkle-removing effects on neck skin, and substantially no adverse reactions occur.

The embodiments described above are some, but not all embodiments of the invention. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Claims

1. The nutrient solution for removing the neck striae is characterized by comprising the following raw materials in parts by weight: 10-15 parts of ginseng, 10-20 parts of tortoise-plastron glue, 5-10 parts of pilose antler, 10-30 parts of soybean, 30-40 parts of combined freeze-dried powder, 20-30 parts of asiatic centella extract, 10-20 parts of honey and 40-50 parts of solvent;

2. The nutrient solution for removing the neck striae according to claim 1, wherein the combined freeze-dried powder further comprises the following components in percentage by mass: 0.001-2% of palmitoyl tripeptide-1, 0.001-2% of palmitoyl pentapeptide-4 and 0.001-0.05% of vitamin A.

3. The nutrient solution for removing the neck striae according to claim 1, further comprising the following raw materials in parts by weight: 10-15 parts of collagen peptide, 8-12 parts of protein silk peptide, 5-10 parts of glutathione, 5-10 parts of nucleotide and 2-5 parts of chitosan derivative.

4. The nutrient solution for removing the neck striae according to claim 1, further comprising the following raw materials in parts by weight: 5-10 parts of aloe vera leaves.

5. The nutrient solution for removing the neck striae according to claim 1, further comprising the following raw materials in parts by weight: 10-20 parts of rheum officinale.

6. The nutrient solution for removing the neck striae as claimed in claim 1, wherein the solvent comprises the following components in percentage by mass: 1% dipeptide diaminobutyrylbenzylamide diacetate, 0.025% sodium hyaluronate, 0.025% phenoxyethanol and 98.95% water.

7. The nutrient solution for removing the neck striae as claimed in claim 1, wherein the centella asiatica extract is prepared by the following preparation method: cleaning and drying 20-30 parts of centella asiatica, adding purified water with the volume 5-6 times of the centella asiatica, soaking and extracting, controlling the extraction temperature to be 45-65 ℃, extracting for 1-1.5 hours to obtain a primary extracting solution, adding purified water with the volume 4-6 times of the centella asiatica into filter residues, extracting for 1-2 hours, filtering at the extraction temperature of 50-60 ℃, obtaining a secondary filtrate, and combining the filtrates to obtain the centella asiatica extracting solution.

8. The nutrient solution for removing the neck striae according to claim 1, wherein the tortoise-plastron glue is prepared by the following preparation method: weighing 5-15 parts of fresh tortoise plastron, 3-8 parts of kudzu root, 5-10 parts of radix rehmanniae, 10-30 parts of dendrobium officinale and 5-10 parts of lucid ganoderma according to the following weight parts, decocting for 5-6 hours by using medium fire, filtering out solid components by using a filter screen after decocting is finished, and keeping liquid; and continuously heating the liquid, stirring the liquid in the heating process, heating and stirring until the liquid is gelatinized, stopping heating, and cooling to obtain the tortoise-plastron glue.

9. The nutrient solution for removing the neck striae according to claim 1, which is prepared by the following preparation method:

10. The nutrient solution for removing the neck striae according to claim 9, wherein the thickener comprises the following raw materials in parts by weight: 12-16 parts of chitosan, 4-6 parts of water-soluble lanolin and 12-14 parts of polyvinyl alcohol.