CN112912501A - 寡核苷酸分子及其在肿瘤治疗中的应用 - Google Patents
寡核苷酸分子及其在肿瘤治疗中的应用 Download PDFInfo
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Abstract
提供了用于治疗肿瘤的寡聚核酸,其可以为小激活核酸分子,所述小激活核酸分子可以是靶向LHPP基因启动子区的双链或单链RNA分子,包含第一核酸链和第二核酸链。还提供了包含所述小激活核酸分子和可选的药学上可接受的载体的药物组合物及其应用。使用所述小激活核酸分子以及使用所述药物组合物可以上调LHPP基因在细胞中的表达及治疗与LHPP基因表达不足或减少相关的疾病或状况。
Description
PCT国内申请,说明书已公开。
Claims (52)
- PCT国内申请,权利要求书已公开。
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CN201910092375 | 2019-01-30 | ||
CN2019100923758 | 2019-01-30 | ||
PCT/CN2019/092720 WO2020155534A1 (zh) | 2019-01-30 | 2019-06-25 | 寡核苷酸分子及其在肿瘤治疗中的应用 |
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CN104630219A (zh) * | 2013-11-15 | 2015-05-20 | 上海交通大学医学院附属瑞金医院 | 抑癌基因IRX1的saRNA分子及其组合物和其应用 |
CN106480028A (zh) * | 2016-10-12 | 2017-03-08 | 上海市第七人民医院 | TPO基因的saRNA分子及其应用 |
Patent Citations (2)
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CN104630219A (zh) * | 2013-11-15 | 2015-05-20 | 上海交通大学医学院附属瑞金医院 | 抑癌基因IRX1的saRNA分子及其组合物和其应用 |
CN106480028A (zh) * | 2016-10-12 | 2017-03-08 | 上海市第七人民医院 | TPO基因的saRNA分子及其应用 |
Non-Patent Citations (2)
Title |
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SRAVANTH K. HINDUPUR1 等: "The protein histidine phosphatase LHPP is a tumour suppressor", NATURE, vol. 555, no. 7698, pages 678 - 682, XP055837822, DOI: 10.1038/nature26140 * |
XING MENG等: "Small activating RNA binds to the genomic target sitein a seed-region-dependent manner", NUCLEIC ACIDS RESEARCH, vol. 44, no. 5, pages 2274 - 2282 * |
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KR20210121079A (ko) | 2021-10-07 |
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JP2022529562A (ja) | 2022-06-23 |
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