CN1128935A - 多肿瘤抑制因子基因、其突变和用该基因序列诊断癌肿的方法 - Google Patents

多肿瘤抑制因子基因、其突变和用该基因序列诊断癌肿的方法 Download PDF

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Publication number
CN1128935A
CN1128935A CN95190376A CN95190376A CN1128935A CN 1128935 A CN1128935 A CN 1128935A CN 95190376 A CN95190376 A CN 95190376A CN 95190376 A CN95190376 A CN 95190376A CN 1128935 A CN1128935 A CN 1128935A
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Prior art keywords
mts
gene
seq
wild type
cell
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Pending
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CN95190376A
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English (en)
Chinese (zh)
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A·坎巴
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Myriad Genetics Inc
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Myriad Genetics Inc
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Publication of CN1128935A publication Critical patent/CN1128935A/zh
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702Regulators; Modulating activity
    • C07K14/4703Inhibitors; Suppressors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/05Animals comprising random inserted nucleic acids (transgenic)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN95190376A 1994-03-18 1995-03-17 多肿瘤抑制因子基因、其突变和用该基因序列诊断癌肿的方法 Pending CN1128935A (zh)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US21458294A 1994-03-18 1994-03-18
US21508894A 1994-03-18 1994-03-18
US21458194A 1994-03-18 1994-03-18
US08/214,581 1994-03-18
US08/214,582 1994-03-18
US08/215,088 1994-03-18
US22736994A 1994-04-14 1994-04-14
US08/227,369 1994-04-14
US25193894A 1994-06-01 1994-06-01
US08/251,938 1994-06-01
PCT/US1995/003316 WO1995025429A1 (en) 1994-03-18 1995-03-17 Mts gene, mutations therein, and methods for diagnosing cancer using mts gene sequence

Publications (1)

Publication Number Publication Date
CN1128935A true CN1128935A (zh) 1996-08-14

Family

ID=27539686

Family Applications (1)

Application Number Title Priority Date Filing Date
CN95190376A Pending CN1128935A (zh) 1994-03-18 1995-03-17 多肿瘤抑制因子基因、其突变和用该基因序列诊断癌肿的方法

Country Status (9)

Country Link
EP (1) EP0708592A4 (fi)
JP (1) JPH08510651A (fi)
CN (1) CN1128935A (fi)
AU (1) AU694502B2 (fi)
CA (1) CA2162147A1 (fi)
FI (1) FI955415A (fi)
NO (1) NO954494L (fi)
NZ (1) NZ283539A (fi)
WO (1) WO1995025429A1 (fi)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113321720A (zh) * 2021-03-24 2021-08-31 深圳市新靶向生物科技有限公司 一种与肝癌驱动基因突变相关的抗原肽及其应用

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995019369A1 (en) 1994-01-14 1995-07-20 Vanderbilt University Method for detection and treatment of breast cancer
US6689561B1 (en) * 1994-04-14 2004-02-10 The Regents Of The University Of California Tumor suppressor gene and methods for detection of cancer, monitoring of tumor progression and cancer treatment
AU724324B2 (en) 1995-07-17 2000-09-14 Board Of Regents, The University Of Texas System p16 expression constructs and their application in cancer therapy
US7163925B1 (en) 1995-07-17 2007-01-16 Board Of Regents, The University Of Texas System p16 expression constructs and their application in cancer therapy
US6407062B1 (en) 1995-09-27 2002-06-18 St. Jude Children's Research Hospital ARF-P19, a novel regulator of the mammalian cell cycle
US5723313A (en) 1995-09-27 1998-03-03 St. Jude Children's Research Hospital ARF-p19, a novel regulator of the mammalian cell cycle
US6586203B1 (en) 1995-09-27 2003-07-01 St. Jude Children's Research Hospital ARF-P19, a novel regulator of the mammalian cell cycle
US6747133B1 (en) 1995-12-08 2004-06-08 University Technologies International Inc. Antibodies against the tumor suppressor gene ING1
US6143522A (en) * 1995-12-08 2000-11-07 University Technologies International, Inc. Methods of modulating apoptosis
US6117633A (en) 1995-12-08 2000-09-12 University Technologies International Inc. DNA sequence encoding the tumor suppressor gene ING1
US6037121A (en) * 1995-12-08 2000-03-14 University Technologies International Inc. DNA sequence encoding a tumor suppressor gene
US5672508A (en) * 1996-01-23 1997-09-30 Mitotix, Inc. Inhibitors of cell-cycle progression, and uses related thereto
US5891857A (en) * 1996-02-20 1999-04-06 Vanderbilt University Characterized BRCA1 and BRCA2 proteins and screening and therapeutic methods based on characterized BRCA1 and BRCA2 proteins
WO1997038083A2 (en) * 1996-04-04 1997-10-16 Vlaams Interuniversitair Instituut Voor New member of the multiple-tumor aberrant growth gene family
US5876972A (en) * 1996-09-23 1999-03-02 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Nucleic acid molecules coding for tumor suppressor proteins and methods for their isolation
WO1998042830A2 (en) * 1997-03-21 1998-10-01 Board Of Regents, The University Of Texas System Noey2 gene compositions and methods of use
US6177410B1 (en) 1997-12-05 2001-01-23 Vanderbilt University Therapeutic methods for prostate cancer
US6440706B1 (en) 1999-08-02 2002-08-27 Johns Hopkins University Digital amplification
WO2002006481A1 (fr) * 2000-07-14 2002-01-24 Japan Science And Technology Corporation Cible d'un agent anticancereux
RU2484096C1 (ru) * 2012-02-08 2013-06-10 Общество с ограниченной ответственностью "Технофарма" ОДНОДОМЕННОЕ АНТИТЕЛО, СПЕЦИФИЧЕСКИ СВЯЗЫВАЮЩЕЕ БЕЛОК S100A4/Mts1, ПРИМЕНЕНИЕ ПОЛУЧЕННОГО АНТИТЕЛА ДЛЯ ДЕТЕКЦИИ ЭТОГО БЕЛКА
RU2732769C1 (ru) * 2020-01-10 2020-09-22 Федеральное государственное бюджетное образовательное учреждение высшего образования "Оренбургский государственный медицинский университет" Министерства здравоохранения Российской Федерации Способ прогнозирования высокого риска рецидива у пациенток с IB стадией рака шейки матки, получивших комбинированное лечение

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE152629T1 (de) * 1990-07-09 1997-05-15 Res Corp Technologies Inc Diagnose von krebs-metastasen durch das mts-1 gen
US6211334B1 (en) * 1992-10-16 2001-04-03 Cold Spring Harbor Cell-cycle regulatory proteins, and uses related thereto
JP3485186B2 (ja) * 1992-10-16 2004-01-13 コールド・スプリング・ハーバー・ラボラトリー サイクリン複合体の転位およびそれに関連する使用
US6689561B1 (en) * 1994-04-14 2004-02-10 The Regents Of The University Of California Tumor suppressor gene and methods for detection of cancer, monitoring of tumor progression and cancer treatment

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113321720A (zh) * 2021-03-24 2021-08-31 深圳市新靶向生物科技有限公司 一种与肝癌驱动基因突变相关的抗原肽及其应用
CN113321720B (zh) * 2021-03-24 2022-03-01 深圳市新靶向生物科技有限公司 一种与肝癌驱动基因突变相关的抗原肽组合及其应用

Also Published As

Publication number Publication date
EP0708592A1 (en) 1996-05-01
FI955415A0 (fi) 1995-11-10
NZ283539A (en) 1998-02-26
AU2186395A (en) 1995-10-09
WO1995025429A1 (en) 1995-09-28
NO954494L (no) 1996-01-17
JPH08510651A (ja) 1996-11-12
FI955415A (fi) 1996-01-09
NO954494D0 (no) 1995-11-08
AU694502B2 (en) 1998-07-23
EP0708592A4 (en) 1997-05-07
CA2162147A1 (en) 1995-09-28

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