CN112891563A - 用在内窥镜诊断中的含染料的固体口服组合物 - Google Patents

用在内窥镜诊断中的含染料的固体口服组合物 Download PDF

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Publication number
CN112891563A
CN112891563A CN202110120798.3A CN202110120798A CN112891563A CN 112891563 A CN112891563 A CN 112891563A CN 202110120798 A CN202110120798 A CN 202110120798A CN 112891563 A CN112891563 A CN 112891563A
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CN
China
Prior art keywords
dye
human
composition
solid
solid composition
Prior art date
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Pending
Application number
CN202110120798.3A
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English (en)
Chinese (zh)
Inventor
卢吉·摩洛
亚历山德罗·雷皮奇
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cosmo Technologies Ltd
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Cosmo Technologies Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cosmo Technologies Ltd filed Critical Cosmo Technologies Ltd
Publication of CN112891563A publication Critical patent/CN112891563A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/006—Biological staining of tissues in vivo, e.g. methylene blue or toluidine blue O administered in the buccal area to detect epithelial cancer cells, dyes used for delineating tissues during surgery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/003—Thiazine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0069—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
    • A61K49/0076—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form dispersion, suspension, e.g. particles in a liquid, colloid, emulsion
    • A61K49/0084—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form dispersion, suspension, e.g. particles in a liquid, colloid, emulsion liposome, i.e. bilayered vesicular structure
    • A61K49/0086—Polymersome, i.e. liposome with polymerisable or polymerized bilayered-forming substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0069—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
    • A61K49/0089—Particulate, powder, adsorbate, bead, sphere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Optics & Photonics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN202110120798.3A 2012-10-19 2013-09-26 用在内窥镜诊断中的含染料的固体口服组合物 Pending CN112891563A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261715981P 2012-10-19 2012-10-19
EP12189206.1 2012-10-19
EP12189206.1A EP2722058A1 (en) 2012-10-19 2012-10-19 Solid oral composition containing dyes for use in endoscopic diagnosis
US61/715,981 2012-10-19
CN201380053741.XA CN104755107A (zh) 2012-10-19 2013-09-26 用在内窥镜诊断中的含染料的固体口服组合物

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201380053741.XA Division CN104755107A (zh) 2012-10-19 2013-09-26 用在内窥镜诊断中的含染料的固体口服组合物

Publications (1)

Publication Number Publication Date
CN112891563A true CN112891563A (zh) 2021-06-04

Family

ID=47137560

Family Applications (3)

Application Number Title Priority Date Filing Date
CN202110120798.3A Pending CN112891563A (zh) 2012-10-19 2013-09-26 用在内窥镜诊断中的含染料的固体口服组合物
CN201380053741.XA Pending CN104755107A (zh) 2012-10-19 2013-09-26 用在内窥镜诊断中的含染料的固体口服组合物
CN202311335014.4A Pending CN117462704A (zh) 2012-10-19 2013-09-26 用在内窥镜诊断中的含染料的固体口服组合物

Family Applications After (2)

Application Number Title Priority Date Filing Date
CN201380053741.XA Pending CN104755107A (zh) 2012-10-19 2013-09-26 用在内窥镜诊断中的含染料的固体口服组合物
CN202311335014.4A Pending CN117462704A (zh) 2012-10-19 2013-09-26 用在内窥镜诊断中的含染料的固体口服组合物

Country Status (27)

Country Link
US (4) US20150283268A1 (cg-RX-API-DMAC7.html)
EP (3) EP2722058A1 (cg-RX-API-DMAC7.html)
JP (1) JP6267210B2 (cg-RX-API-DMAC7.html)
KR (1) KR102207507B1 (cg-RX-API-DMAC7.html)
CN (3) CN112891563A (cg-RX-API-DMAC7.html)
AR (1) AR091984A1 (cg-RX-API-DMAC7.html)
AU (1) AU2013331964B2 (cg-RX-API-DMAC7.html)
BR (1) BR112015008772A2 (cg-RX-API-DMAC7.html)
CA (1) CA2886201C (cg-RX-API-DMAC7.html)
DK (2) DK2908866T3 (cg-RX-API-DMAC7.html)
ES (2) ES2721916T3 (cg-RX-API-DMAC7.html)
FI (1) FI3650048T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20190710T1 (cg-RX-API-DMAC7.html)
HU (1) HUE043112T2 (cg-RX-API-DMAC7.html)
IL (1) IL237907A (cg-RX-API-DMAC7.html)
IN (1) IN2015DN02818A (cg-RX-API-DMAC7.html)
LT (1) LT2908866T (cg-RX-API-DMAC7.html)
MX (1) MX361737B (cg-RX-API-DMAC7.html)
NZ (1) NZ706363A (cg-RX-API-DMAC7.html)
PL (1) PL2908866T3 (cg-RX-API-DMAC7.html)
PT (1) PT2908866T (cg-RX-API-DMAC7.html)
RS (1) RS59152B1 (cg-RX-API-DMAC7.html)
RU (1) RU2649783C2 (cg-RX-API-DMAC7.html)
TR (1) TR201905800T4 (cg-RX-API-DMAC7.html)
TW (1) TWI651102B (cg-RX-API-DMAC7.html)
WO (1) WO2014060199A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201502370B (cg-RX-API-DMAC7.html)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2019118459A (ru) * 2016-11-28 2020-12-28 Космо Текнолоджиз Лтд. Твердая пероральная композиция, содержащая красители
IT201900003113A1 (it) * 2019-03-04 2020-09-04 Azienda Ospedaliero Univ Policlinico S Orsola Malpighi Bologna Bevanda coadiuvante

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101897721A (zh) * 2002-10-25 2010-12-01 诺金公司 结肠清洗组合物
WO2011107945A1 (en) * 2010-03-04 2011-09-09 Cosmo Technologies Ltd. Solid composition for the oral administration of dyes and diagnostic use thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2129273C1 (ru) * 1997-11-26 1999-04-20 Московский научно-исследовательский онкологический институт им.П.А.Герцена Способ эндоскопической флюоресцентной диагностики злокачественных опухолей полых органов
WO2000076478A1 (en) 1999-06-14 2000-12-21 Cosmo S.P.A. Controlled release and taste masking oral pharmaceutical compositions
ITMI991316A1 (it) 1999-06-14 2000-12-14 Cip Ninety Two 92 S A Composizioni farmaceutiche orali a rilascio modificato di mesalazina
US7230088B2 (en) * 2001-07-03 2007-06-12 Mallinckrodt, Inc. Compounds for dual photodiagnosis and therapy
RU2253350C2 (ru) * 2003-06-30 2005-06-10 Государственное учреждение здравоохранения Иркутский Областной Диагностический Центр Способ эндоскопического исследования желудка
US20050244368A1 (en) * 2004-04-29 2005-11-03 Pashankar Dinesh S Pre-endoscopic use of polyethylene glycol compositions
FR2894253B1 (fr) * 2005-12-06 2009-11-13 Pentax Corp Composition d'histocolorant pour endoscope

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101897721A (zh) * 2002-10-25 2010-12-01 诺金公司 结肠清洗组合物
WO2011107945A1 (en) * 2010-03-04 2011-09-09 Cosmo Technologies Ltd. Solid composition for the oral administration of dyes and diagnostic use thereof

Also Published As

Publication number Publication date
WO2014060199A1 (en) 2014-04-24
EP3650048A1 (en) 2020-05-13
EP2908866B1 (en) 2019-02-27
ES3030697T3 (en) 2025-07-01
ZA201502370B (en) 2016-11-30
IN2015DN02818A (cg-RX-API-DMAC7.html) 2015-09-11
HUE043112T2 (hu) 2019-08-28
JP6267210B2 (ja) 2018-01-24
MX361737B (es) 2018-12-14
EP2908866A1 (en) 2015-08-26
US20230130628A1 (en) 2023-04-27
CN104755107A (zh) 2015-07-01
CN117462704A (zh) 2024-01-30
TW201420131A (zh) 2014-06-01
BR112015008772A2 (pt) 2017-07-04
AU2013331964A1 (en) 2015-04-09
TR201905800T4 (tr) 2019-05-21
TWI651102B (zh) 2019-02-21
HK1211465A1 (en) 2016-05-27
DK3650048T3 (da) 2025-05-26
EP3650048B1 (en) 2025-03-05
IL237907A (en) 2017-06-29
RS59152B1 (sr) 2019-10-31
LT2908866T (lt) 2019-06-10
US20250186626A1 (en) 2025-06-12
NZ706363A (en) 2019-03-29
RU2015118584A (ru) 2016-12-10
MX2015004935A (es) 2015-12-01
JP2015534956A (ja) 2015-12-07
US20200129643A1 (en) 2020-04-30
US20150283268A1 (en) 2015-10-08
HRP20190710T1 (hr) 2019-08-23
KR20150068412A (ko) 2015-06-19
ES2721916T3 (es) 2019-08-06
DK2908866T3 (da) 2019-05-06
EP2722058A1 (en) 2014-04-23
AU2013331964B2 (en) 2018-03-29
CA2886201C (en) 2021-03-23
FI3650048T3 (fi) 2025-05-26
PT2908866T (pt) 2019-05-24
CA2886201A1 (en) 2014-04-24
PL2908866T3 (pl) 2019-10-31
AR091984A1 (es) 2015-03-18
RU2649783C2 (ru) 2018-04-04
KR102207507B1 (ko) 2021-01-27

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Application publication date: 20210604