CN112870089A - Soluble hyaluronic acid mask with microneedle structure and preparation method thereof - Google Patents
Soluble hyaluronic acid mask with microneedle structure and preparation method thereof Download PDFInfo
- Publication number
- CN112870089A CN112870089A CN202110159831.3A CN202110159831A CN112870089A CN 112870089 A CN112870089 A CN 112870089A CN 202110159831 A CN202110159831 A CN 202110159831A CN 112870089 A CN112870089 A CN 112870089A
- Authority
- CN
- China
- Prior art keywords
- mask
- micro
- hyaluronic acid
- sodium hyaluronate
- follows
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0212—Face masks
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/91—Injection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0053—Methods for producing microneedles
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a soluble hyaluronic acid facial mask with a micro-needle structure and a preparation method thereof. The invention comprises the following operation steps: the material proportion of the mask solution, the preparation process of the mask solution and the curing of the mask. After the hyaluronic acid facial mask with the micro-needle structure is attached to the skin, the hyaluronic acid facial mask can be combined with water on the surface layer of the skin to swell, a thin film rich in water is formed on the surface layer of the skin, the functions of moisturizing and promoting repair are achieved, and meanwhile, the micro-needle can penetrate into the stratum corneum of a specific area of the face, and the deep water locking function of the specific area is achieved.
Description
Technical Field
The invention relates to the technical field of microneedle beauty, in particular to a soluble hyaluronic acid facial mask with a microneedle structure and a preparation method thereof.
Background
Hyaluronic acid, commonly known as hyaluronic acid, is an inherent component in human body, and is widely present in tissues such as articular cartilage, dermal layers of skin and the like, and is distributed in cytoplasm and intercellular substance in organs, so as to lubricate and nourish cells and cell organs contained in the organs. The moisture level of the skin is closely related to the content of hyaluronic acid, and exogenous sodium hyaluronate is used for supplementing endogenous sodium hyaluronate of the skin.
Due to the shielding effect of the stratum corneum of the outermost layer of the skin, most of active ingredients in the common facial mask are blocked on the surface layer of the skin, the micro-needles are a novel transdermal technology, and the micro-needles with the size of micron level can painlessly open channels on the stratum corneum of the outermost layer of the skin, so that the biological macromolecules can break through the shielding effect of the stratum corneum by the channels opened by the micro-needles and enter the dermis layer of the skin. Compared with the common coated microneedle prepared by coating the hyaluronic acid solution on the surface of the microneedle on the market, the soluble microneedle prepared from the hyaluronic acid solution can realize better biocompatibility and larger drug loading.
Therefore, the soluble hyaluronic acid facial mask with the micro-needle structure and the preparation method thereof are developed, and the soluble micro-needle technology is applied to the facial mask used daily, so that the soluble hyaluronic acid facial mask has good application potential.
Disclosure of Invention
The invention aims to provide a soluble hyaluronic acid mask with a micro-needle structure and a preparation method thereof, aiming at the defects of the prior art. After the microneedle mask prepared by taking sodium hyaluronate as a main material is penetrated into the skin, the sodium hyaluronate can be dissolved and retained in the skin, and the sodium hyaluronate with large molecular weight can form a moisture-preserving breathable film on the surface of the skin to keep the skin smooth and moist; the small molecular weight sodium hyaluronate can permeate into dermis, has the effects of slightly expanding capillary vessels, increasing blood circulation, improving intermediate metabolism, promoting skin nutrition absorption and achieving the effects of lubrication and plump. The hyaluronic acid microneedle prepared by proportioning the sodium hyaluronate with various molecular weights has high strength, and can be partially dissolved in skin to enhance the beautifying effect.
The specific technical scheme for realizing the purpose of the invention is as follows:
a preparation method of a soluble hyaluronic acid mask with a microneedle structure is characterized by comprising the following steps:
step 1, material proportioning of the mask solution: the facial mask solution is prepared from 3-5 parts of sodium hyaluronate mixed powder, 50-100 parts of absolute ethyl alcohol, 1000-2000 parts of deionized water and 1-10 parts of functional materials according to weight components;
step 2, preparation flow of the mask solution: adding the sodium hyaluronate mixed powder and the functional material into absolute ethyl alcohol, fully stirring and mixing, standing for 5-10 min, then adding deionized water, and stirring, wherein the rotating speed of a stirrer is as follows: 100-180 rpm; the stirring time is as follows: forming a mask solution after 10-15 min;
step 3, curing the mask: selecting a mask mould customized with micro-pinholes, filling a forming groove of the mask mould with the prepared mask solution, putting the mask mould into a cavity of a vacuum machine for vacuumizing, wherein the pressure of the vacuum machine is as follows: 0.01-0.05 mpa; the duration of the vacuum pumping is as follows: 12-15 min: standing the vacuumized mask mould for 8-10 min; then placing the mixture into a forced air drying oven for curing and molding, wherein the temperature of the drying oven is as follows: 30-40 ℃; the drying time is as follows: 5-24 h: and (3) demolding the mask mold, taking out the cured and molded mask, and packaging to obtain the soluble hyaluronic acid mask with the microneedle structure.
The sodium hyaluronate mixed powder is formed by mixing sodium hyaluronate powder with the molecular weight of 200-1400 kDa and the molecular weight of 3-10 kDa, and is configured according to mass percentage, wherein the sodium hyaluronate powder with the molecular weight of 200-1400 kDa accounts for 2-4% of the mass percentage, and the sodium hyaluronate powder with the molecular weight of 3-10 kDa accounts for 96-98% of the mass percentage.
The functional material is prepared by mixing 10-20% of butanediol, 10-20% of agar, 5-10% of xanthan gum, 10-20% of nicotinamide and 20-50% of dipropylene glycol according to mass percentage.
The mask mold with the micro-pinholes is characterized in that a forming groove of the mask is formed in the mask mold, micro-pinholes which are obtained by metal processing and laser processing and distributed according to a matrix are arranged in positions, corresponding to the eye pockets, the fishtail lines, the statute lines, the raising lines and the herringbone lines, of the forming groove, the row spacing and the column spacing of the matrix are both 1-5 mm, the micro-pinholes are conical holes, the diameter of the conical bottom of each micro-pinhole is 0.1-0.5 mm, and the height of each micro-pinhole is 0.05-0.3 mm.
A soluble hyaluronic acid facial mask with a micro-needle structure prepared by the method.
The soluble microneedle mask is prepared by matching the materials of the mask solution and adopting the mask mould corresponding to a recipient, has better biocompatibility and larger drug-loading rate, has obvious moisturizing and repair promoting effects on the face, and has the advantages of high strength, capability of being partially dissolved in the skin and enhancement of the beautifying effect, simple production process and convenience in use.
The invention has the advantages that:
(1) the invention selects sodium hyaluronate powder with different molecular weights, and the active ingredients in the prepared solution are mutually coordinated by the proportion of sodium hyaluronate with proper molecular weight and the addition of functional materials, so that the absorption of the active ingredients is promoted, and excellent water replenishing and repair promoting functions are realized.
(2) Different from the common hyaluronic acid facial mask in the market, the hyaluronic acid facial mask is prepared by soaking a hyaluronic acid solution in a non-woven fabric or facial mask paper, but a cured sodium hyaluronate solution is directly used as a base material of the facial mask, so that the hyaluronic acid facial mask prepared by the method does not have the problem that effective components are lost along with time.
(3) After the hyaluronic acid facial mask with the micro-needle structure is attached to the skin, the hyaluronic acid facial mask can be combined with moisture on the surface layer of the skin and swell, a film rich in moisture is formed on the surface layer of the skin, the functions of moisturizing and promoting repair are achieved, meanwhile, the micro-needles can penetrate into the stratum corneum of a specific area of the face, the deep water locking function of the specific area is achieved, and the hyaluronic acid facial mask has obvious effects of fading black eye circles and reducing wrinkles of the specific area of the face.
After the microneedle mask prepared by taking sodium hyaluronate as a main material is penetrated into the skin, the sodium hyaluronate can be dissolved and retained in the skin, and the sodium hyaluronate with large molecular weight can form a moisture-preserving breathable film on the surface of the skin to keep the skin smooth and moist; the small molecular weight sodium hyaluronate can permeate into dermis, has the effects of slightly expanding capillary vessels, increasing blood circulation, improving intermediate metabolism, promoting skin nutrition absorption and achieving the effects of lubrication and plump.
Drawings
Fig. 1 is a schematic diagram of a prepared soluble hyaluronic acid mask with a microneedle structure;
FIG. 2 is a schematic view of the appearance of the mask mold;
fig. 3 is a schematic structural diagram of a micro-needle of the hyaluronic acid soluble mask under a microscope.
Detailed Description
Referring to fig. 1, 2 and 3, the preparation of the present invention includes the following steps:
step 1, material proportioning of the mask solution: the facial mask solution is prepared from 3-5 parts of sodium hyaluronate mixed powder, 50-100 parts of absolute ethyl alcohol, 1000-2000 parts of deionized water and 1-10 parts of functional materials according to weight components;
step 2, preparation flow of the mask solution: adding the sodium hyaluronate mixed powder and the functional material into absolute ethyl alcohol, fully stirring and mixing, standing for 5-10 min, then adding deionized water, and stirring, wherein the rotating speed of a stirrer is as follows: 100-180 rpm; the stirring time is as follows: forming a mask solution after 10-15 min;
step 3, curing the mask: selecting a mask mould customized with micro-pinholes, filling a forming groove of the mask mould with the prepared mask solution, putting the mask mould into a cavity of a vacuum machine for vacuumizing, wherein the pressure of the vacuum machine is as follows: 0.01-0.05 mpa; the duration of the vacuum pumping is as follows: 12-15 min: standing the vacuumized mask mould for 8-10 min; then placing the mixture into a forced air drying oven for curing and molding, wherein the temperature of the drying oven is as follows: 30-40 ℃; the drying time is as follows: 5-24 h: and (3) demolding the mask mold, taking out the cured and molded mask, and packaging to obtain the soluble hyaluronic acid mask with the microneedle structure.
The sodium hyaluronate mixed powder is formed by mixing sodium hyaluronate powder with the molecular weight of 200-1400 kDa and the molecular weight of 3-10 kDa, and is configured according to mass percentage, wherein the sodium hyaluronate powder with the molecular weight of 200-1400 kDa accounts for 2-4% of the mass percentage, and the sodium hyaluronate powder with the molecular weight of 3-10 kDa accounts for 96-98% of the mass percentage.
The functional material is prepared by mixing 20-40% of butanediol, 10-20% of agar, 5-10% of xanthan gum, 10-20% of nicotinamide and 20-50% of dipropylene glycol according to mass percentage.
Referring to fig. 1, 2 and 3, a forming groove of the mask is arranged on the mask mold, micro pinholes which are obtained by metal processing and laser processing and are distributed according to a matrix are arranged at positions of the forming groove corresponding to the pouch, the fishtail line, the statute line, the raised line and the herringbone line, the row spacing and the column spacing of the matrix are both 1-5 mm, the micro pinholes are conical holes, the diameter of the conical bottom of the micro pinholes is 0.1-0.5 mm, and the height of the conical holes is 0.05-0.3 mm.
Examples
Referring to fig. 1, 2 and 3, the preparation of the soluble hyaluronic acid mask with a micro-needle structure according to the present invention includes the following steps:
step 1, material proportioning of the mask solution: the facial mask solution is prepared from 5g of sodium hyaluronate mixed powder, 100g of absolute ethyl alcohol, 2000g of deionized water and 1g of functional material according to weight components;
step 2, preparation flow of the mask solution: adding the sodium hyaluronate mixed powder and the functional material into absolute ethyl alcohol, fully stirring and mixing, standing for 10min, then adding deionized water and stirring, wherein the rotating speed of a stirrer is as follows: 100 rpm; the stirring time is as follows: forming facial mask solution for 15 min;
step 3, curing the mask: selecting a mask mould customized with micro-pinholes, filling a forming groove of the mask mould with the prepared mask solution, putting the mask mould into a cavity of a vacuum machine for vacuumizing, wherein the pressure of the vacuum machine is as follows: 0.05 mpa; the duration of the vacuum pumping is as follows: 15 min: standing the vacuumized mask mould for 10 min; then placing the mixture into a forced air drying oven for curing and molding, wherein the temperature of the drying oven is as follows: 40 ℃; the drying time is as follows: 24 h: and (4) demolding the facial mask mold, taking out the cured and molded micro-needle facial mask and packaging.
The 5g of sodium hyaluronate mixed powder is formed by mixing two kinds of sodium hyaluronate powder with different molecular weights, wherein 0.2g of sodium hyaluronate powder with the molecular weight of 3kDa and 4.8g of sodium hyaluronate powder with the molecular weight of 1300kDa are selected.
The functional material 1g is prepared by mixing 0.2g of butanediol, 0.1g of agar, 0.1g of xanthan gum, 0.1g of nicotinamide and 0.5g of dipropylene glycol.
The mask mold is provided with a forming groove of the mask, and micro pinholes which are distributed according to a matrix and are processed by combining metal processing and laser processing are arranged at positions of the forming groove corresponding to the eye pockets and the fishtail lines; the power of the laser engraving machine is 15w, the row spacing and the column spacing of the matrix are both 1mm, the micro-needle holes are taper holes, the diameter of the taper bottom of the micro-needle holes is 0.2mm, and the taper height of the micro-needle holes is 0.3 mm.
The mask of the present invention is applied as follows:
referring to fig. 1 and 3, the present invention is suitable for beauty salons or homes, where cleanliness and humidity of indoor environment are required to be maintained, can be used in combination with a micro-vibration device or under the guidance of a cosmetologist, before use, the face is cleaned firstly, then the face is hot compressed by a warm towel, the micro-needle facial mask is covered on the face of a user to relax the muscles of the face and open pores, and after the hyaluronic acid absorbs moisture and is softened, the micro-needle facial mask is attached to the face of the user, can be matched with a micro-vibration device to carry out micro-needle transdermal and massage on the face of a user, after micro-needles of the soluble micro-needle mask prepared by taking sodium hyaluronate as a main material penetrate into the skin, the sodium hyaluronate can be dissolved and retained in the skin, and the sodium hyaluronate with large molecular weight can form a moisture-keeping breathable film on the surface of the skin to keep the skin smooth and moist; the small molecular weight sodium hyaluronate can permeate into dermis, has the effects of slightly expanding capillary vessels, increasing blood circulation, improving intermediate metabolism, promoting skin nutrition absorption and achieving the effects of lubrication and plump. The microneedle facial mask prepared by proportioning the sodium hyaluronate with various molecular weights has high strength, and can be partially dissolved in the skin, so that the skin can better absorb the active ingredients of the microneedle facial mask.
Detection of microneedle masks:
referring to fig. 1 and 3, the microneedles corresponding to the pouch and the cheek of the prepared microneedle mask are observed in shape under an optical microscope of 40 times, the microneedles are all in a standard conical shape, and each microneedle has a uniform size, a smooth surface and no burrs.
Claims (3)
1. A preparation method of a soluble hyaluronic acid mask with a microneedle structure is characterized by comprising the following steps:
step 1, material proportioning of the mask solution: the mask solution is prepared from 5-100 parts by weight of sodium hyaluronate mixed powder, 50-100 parts by weight of absolute ethyl alcohol, 1000-2000 parts by weight of deionized water and 1-10 parts by weight of functional materials;
step 2, preparation flow of the mask solution: adding the sodium hyaluronate mixed powder and the functional material into absolute ethyl alcohol, fully stirring and mixing, standing for 5-10 min, then adding deionized water, and stirring, wherein the rotating speed of a stirrer is as follows: 100-180 rpm; the stirring time is as follows: forming a mask solution after 10-15 min;
step 3, curing the mask: selecting a mask mould customized with micro-pinholes, filling a forming groove of the mask mould with the prepared mask solution, putting the mask mould into a cavity of a vacuum machine for vacuumizing, wherein the pressure of the vacuum machine is as follows: 0.01-0.05 mpa; the duration of the vacuum pumping is as follows: 12-15 min; standing the vacuumized mask mould for 8-10 min; then placing the mixture into a forced air drying oven for curing and molding, wherein the temperature of the drying oven is as follows: 30-40 ℃; the drying time is as follows: 5-24 h; demoulding the mask mould, taking out the solidified and molded mask and packaging to obtain the soluble hyaluronic acid mask with the micro-needle structure; wherein:
the sodium hyaluronate mixed powder is formed by mixing sodium hyaluronate powder with the molecular weight of 200-1400 kDa and the molecular weight of 3-10 kDa, and is configured according to mass percent, wherein the sodium hyaluronate powder with the molecular weight of 200-1400 kDa accounts for 2-4% of the mass percent, and the sodium hyaluronate powder with the molecular weight of 3-10 kDa accounts for 96-98% of the mass percent;
the functional material is prepared by mixing 10-20% of butanediol, 10-20% of agar, 5-10% of xanthan gum, 10-20% of nicotinamide and 20-50% of dipropylene glycol according to mass percentage.
2. The preparation method of the soluble hyaluronic acid facial mask with the microneedle structure as claimed in claim 1, wherein the facial mask mold with the micro-pinholes is customized, the mold is provided with a molding groove of the facial mask, and the positions of the molding groove corresponding to the pouch, the fishtail line, the statute line, the raised line and the herringbone line are provided with the micro-pinholes which are obtained by combining metal processing and laser processing and are distributed according to a matrix; the row spacing and the column spacing of the matrix are both 1-5 mm, the micro-needle holes are taper holes, the diameter of the taper bottom is 0.1-0.5 mm, and the taper height is 0.05-0.3 mm.
3. A hyaluronic acid-soluble facial mask with a micro-needle structure prepared by the method of claim 1.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202110159831.3A CN112870089A (en) | 2021-02-05 | 2021-02-05 | Soluble hyaluronic acid mask with microneedle structure and preparation method thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202110159831.3A CN112870089A (en) | 2021-02-05 | 2021-02-05 | Soluble hyaluronic acid mask with microneedle structure and preparation method thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
CN112870089A true CN112870089A (en) | 2021-06-01 |
Family
ID=76057342
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202110159831.3A Pending CN112870089A (en) | 2021-02-05 | 2021-02-05 | Soluble hyaluronic acid mask with microneedle structure and preparation method thereof |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN112870089A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113384485A (en) * | 2021-06-02 | 2021-09-14 | 华东师范大学 | Soluble hyaluronic acid microneedle eye mask with composite structure and preparation method thereof |
CN114949344A (en) * | 2022-04-13 | 2022-08-30 | 吴力波 | Coating microneedle patch for skin filling |
KR102574987B1 (en) * | 2022-11-14 | 2023-09-06 | 장무경 | Manufacturing method of a functional microneedle dry mask pack coated with hydrophilic carboxymethylcellulose on the surface of a film formed with a functional mixture of hyaluronic acid mixed with betel nut and corn parasite |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105997530A (en) * | 2016-07-11 | 2016-10-12 | 北京化工大学 | Combined micro-needle mask for removing wrinkles and dark circles |
CN108888577A (en) * | 2018-09-11 | 2018-11-27 | 无锡元旭生物技术有限公司 | A kind of solubility sodium hyaluronate beauty microneedle patch and preparation method thereof |
CN108969880A (en) * | 2018-06-12 | 2018-12-11 | 上海白衣缘生物工程有限公司 | A kind of solubility micropin film and preparation method thereof |
WO2019059425A1 (en) * | 2017-09-19 | 2019-03-28 | 주식회사 엘지생활건강 | Hyaluronic acid filler using microneedle patch |
-
2021
- 2021-02-05 CN CN202110159831.3A patent/CN112870089A/en active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105997530A (en) * | 2016-07-11 | 2016-10-12 | 北京化工大学 | Combined micro-needle mask for removing wrinkles and dark circles |
WO2019059425A1 (en) * | 2017-09-19 | 2019-03-28 | 주식회사 엘지생활건강 | Hyaluronic acid filler using microneedle patch |
CN108969880A (en) * | 2018-06-12 | 2018-12-11 | 上海白衣缘生物工程有限公司 | A kind of solubility micropin film and preparation method thereof |
CN108888577A (en) * | 2018-09-11 | 2018-11-27 | 无锡元旭生物技术有限公司 | A kind of solubility sodium hyaluronate beauty microneedle patch and preparation method thereof |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113384485A (en) * | 2021-06-02 | 2021-09-14 | 华东师范大学 | Soluble hyaluronic acid microneedle eye mask with composite structure and preparation method thereof |
CN114949344A (en) * | 2022-04-13 | 2022-08-30 | 吴力波 | Coating microneedle patch for skin filling |
KR102574987B1 (en) * | 2022-11-14 | 2023-09-06 | 장무경 | Manufacturing method of a functional microneedle dry mask pack coated with hydrophilic carboxymethylcellulose on the surface of a film formed with a functional mixture of hyaluronic acid mixed with betel nut and corn parasite |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN112870089A (en) | Soluble hyaluronic acid mask with microneedle structure and preparation method thereof | |
KR102114979B1 (en) | Micro-spicule, Mold for Producing the Same and Method for Producing the Same | |
WO2017130793A1 (en) | Microneedle array, and microneedle sheet | |
CN109044907A (en) | Painless transdermal beauty microneedle patch of one kind and preparation method thereof | |
CN108379095A (en) | A kind of solubility microneedle patch and preparation method thereof | |
CN115400341B (en) | Soluble polymer microneedle and preparation method thereof | |
CN109331224A (en) | A kind of gel and its preparation method and application | |
CN113797128B (en) | Thermal response type borneol-based steam instant microneedle eye mask and preparation method and application thereof | |
CN108066160A (en) | The hydrogel patch for forming the manufacturing method of the hydrogel patch of micropunch and being manufactured using this method | |
CN113197814A (en) | Preparation method of hyaluronic acid microneedle patch | |
CN113384485A (en) | Soluble hyaluronic acid microneedle eye mask with composite structure and preparation method thereof | |
KR101819168B1 (en) | Hydrogel pack fixed with microneedles array | |
CN110812687A (en) | Preparation method of porous polymer microneedle | |
CN115430031B (en) | Multifunctional beauty microneedle patch and batch preparation method thereof | |
CN108703895A (en) | A kind of long-acting moisturizing gel and preparation method of percdation | |
CN108325068A (en) | A kind of auxotype solubility micropin and micropin slide glass | |
CN113116745B (en) | Hyaluronic acid noninvasive soluble microneedle patch and preparation method thereof | |
CN211751166U (en) | Microneedle leading-in type eye patch for moisturizing | |
CN114129887A (en) | Rapid water-soluble microneedle and preparation method thereof | |
CN210020844U (en) | Nutritional soluble microneedle and microneedle slide | |
TWM643895U (en) | Microneedle patch | |
CN114681354A (en) | Microneedle patch and preparation method thereof | |
CN115737531A (en) | Method for preparing microneedle array by double-permeation micro-perfusion method, microneedle array and application | |
Huang et al. | Sustained release microneedles: materials and applications in facial rejuvenation | |
CN115715755A (en) | Soluble microneedle for removing dark circles, and preparation method and application thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20210601 |
|
RJ01 | Rejection of invention patent application after publication |