CN112852559B - Traditional Chinese medicine granulating equipment cleaning agent and application thereof - Google Patents

Traditional Chinese medicine granulating equipment cleaning agent and application thereof Download PDF

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Publication number
CN112852559B
CN112852559B CN202110001904.6A CN202110001904A CN112852559B CN 112852559 B CN112852559 B CN 112852559B CN 202110001904 A CN202110001904 A CN 202110001904A CN 112852559 B CN112852559 B CN 112852559B
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cleaning agent
parts
equipment
cleaning
chinese medicine
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CN112852559A (en
Inventor
邵谱
吴鹏飞
刘亚川
李定刚
陈静
张娜
牛婵娟
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Baoding Jizhong Biotechnology Co ltd
Baoding Jizhong Pharmaceutical Co ltd
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Baoding Jizhong Biotechnology Co ltd
Baoding Jizhong Pharmaceutical Co ltd
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    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/66Non-ionic compounds
    • C11D1/74Carboxylates or sulfonates esters of polyoxyalkylene glycols
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B08CLEANING
    • B08BCLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B3/00Cleaning by methods involving the use or presence of liquid or steam
    • B08B3/04Cleaning involving contact with liquid
    • B08B3/08Cleaning involving contact with liquid the liquid having chemical or dissolving effect
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B08CLEANING
    • B08BCLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B3/00Cleaning by methods involving the use or presence of liquid or steam
    • B08B3/04Cleaning involving contact with liquid
    • B08B3/10Cleaning involving contact with liquid with additional treatment of the liquid or of the object being cleaned, e.g. by heat, by electricity or by vibration
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B08CLEANING
    • B08BCLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B5/00Cleaning by methods involving the use of air flow or gas flow
    • B08B5/02Cleaning by the force of jets, e.g. blowing-out cavities
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/02Inorganic compounds ; Elemental compounds
    • C11D3/04Water-soluble compounds
    • C11D3/10Carbonates ; Bicarbonates
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16Organic compounds
    • C11D3/20Organic compounds containing oxygen
    • C11D3/2003Alcohols; Phenols
    • C11D3/2006Monohydric alcohols
    • C11D3/201Monohydric alcohols linear
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16Organic compounds
    • C11D3/20Organic compounds containing oxygen
    • C11D3/2075Carboxylic acids-salts thereof
    • C11D3/2086Hydroxy carboxylic acids-salts thereof
    • C11D2111/20
    • C11D2111/44

Abstract

The invention relates to the technical field of equipment cleaning, and provides a traditional Chinese medicine granulating equipment cleaning agent which consists of a cleaning agent A and a cleaning agent B; wherein the cleaning agent A is 5.5-11% of sodium bicarbonate in percentage by mass; the cleaning agent B comprises the following components in parts by weight: 35-55 parts of ethanol, 6-12 parts of citric acid, 1-4 parts of polysorbate-80 and 29-58 parts of water; or 35-55 parts of ethanol, 6-12 parts of malic acid, 1-4 parts of polysorbate-80 and 29-58 parts of water. Through the technical scheme, the problems that the field cleaning of traditional Chinese medicine granulation equipment in the prior art is not thorough, the field cleaning time is too long, and the service life of the equipment is influenced are solved.

Description

Traditional Chinese medicine granulating equipment cleaning agent and application thereof
Technical Field
The invention relates to the technical field of equipment cleaning, in particular to a cleaning agent for traditional Chinese medicine granulating equipment.
Background
In the production process of the traditional Chinese medicine granules, the cleaning of equipment is an important link in the production process rules of products, and the simple and quick cleaning method can shorten the production period and improve the production efficiency. Because the raw and auxiliary materials used for granulating the traditional Chinese medicine contain complex material components, for example, the raw traditional Chinese medicine contains a large amount of substances such as carbohydrate substances, lipid substances, proteins and the like, and the auxiliary materials also contain starch components, the components form a complex viscous mixture with water in the granulating process and are adhered to the surface of equipment, and the adhesion is firmer due to high-strength extrusion and friction. In the wet granulation production process of part of traditional Chinese medicine products, the common problems of equipment such as a groove type mixer, a swinging granulator, a high-speed stirring granulator and the like in the process of clearing away the field are as follows: the equipment rubs the materials for a long time in the running process, and the surface of the equipment in contact with the materials is covered with a layer of hard materials; the mode of soaking with water or shoveling is often used in the field cleaning; some equipment is inconvenient to soak in water, and the inside of the equipment with narrow space is not thoroughly cleaned; the field cleaning time is too long; the surface smoothness of the equipment is easy to damage, and further the material mixing process and the service life of the equipment are influenced.
Therefore, the cleaning of the traditional Chinese medicine granulating equipment is a great industrial problem. The prior art uses water, ethanol, or a scraper blade for cleaning. When the water is used for cleaning the field, the surface layer substances are soaked in water, the saccharides and the lipid substances in the surface layer substances are dissolved to form a layer of hydrated film, and the hydrated film has the effect of surface tension, so that the external water is prevented from entering the interior of the device, when the dissolved layer on the surface is scraped, the interior of the device is still dry, the device needs to be soaked for a long time and repeatedly wiped, when the water is used for cleaning the field, the mode of a scraper and a shovel is adopted, the space of the device is narrow, the field is not thoroughly cleaned, and the surface of the device is easily damaged due to over-high force.
Disclosure of Invention
The invention provides a cleaning agent for traditional Chinese medicine granulation equipment, which solves the problems that the field cleaning is not thorough, the field cleaning time is too long, and the service life of the equipment is influenced in the prior art.
The technical scheme of the invention is as follows:
the traditional Chinese medicine granulating equipment cleaning agent is applied to the refractory stains on the inner surfaces of the ground, doors, windows and parts.
The principle and the beneficial effects of the invention are as follows:
1. the active ingredients of the cleaning agent are pharmacopeia pharmaceutic adjuvant varieties, and the cleaning agent has no harmful residues and is safe to use.
2. The cleaning agent is divided into a part A and a part B, wherein the cleaning agent A is a 5.5-11% sodium bicarbonate solution and plays a role in providing a carbon (alkali) source in the cleaning process; the cleaning agent B is a mixed solution of ethanol, citric acid/malic acid and polysorbate-80, and is used as a wetting agent and an emulsifying agent in the cleaning process, and has the effects of reducing surface tension, providing a hydrogen (acid) source and promoting disintegration.
3. The components of the cleaning agent have no corrosion effect on the surface of equipment, and the smoothness of the surface of the equipment is not damaged; the water consumption is small, the water can be saved, the cleaning agent can be used for cleaning various traditional Chinese medicine products with complex components, and particularly the cleaning effect of products with water-insoluble components (such as essential oils and alcohol-dipped materials) is better; the device has the advantages of comprehensively cleaning no dead angle, saving time and labor, shortening the production period and improving the production efficiency.
4. The invention also provides a special using method aiming at the special formula of the invention, when in use, the cleaning agent B is firstly sprayed on the surface of the equipment, and then the cleaning agent A is further sprayed, thereby further ensuring the cleaning effect, and the dosage of the cleaning agent is less, and the evaluation standard of the dosage is the special 'visible water drop on the surface' of the formula of the invention.
5. At present, the cleaning of the traditional Chinese medicine granulation equipment comprises soaking in water or shoveling with a shovel, the cleaning effect is poor and the service life of the equipment is influenced.
6. In the formula of the invention, the component A is sodium bicarbonate, and the component B contains citric acid or malic acid, which are acidic substances. When the two are mixed, an acid-base reaction occurs, so that the cleaning effect cannot be achieved. Therefore, the skilled person will not think of combining two components which can be neutralized by acid and alkali for cleaning, but the present invention overcomes the technical prejudice of using the acid and alkali separately by a unique method to exert the respective effects to the maximum. Meanwhile, in the research process, the applicant finds that the cleaning agent B must be used firstly and then the cleaning agent A is used to obtain the efficient cleaning effect, and the problem of poor effect exists when the cleaning agent B and the cleaning agent A are exchanged in sequence.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any inventive step, are intended to be within the scope of the present invention.
Experiment 1: trough mixer (CH-400L) cleaning
Example 1
Preparing materials according to the following formula:
cleaning agent A: 5.5 percent of sodium bicarbonate by mass;
and (3) cleaning agent B: 35kg of ethanol, 6kg of citric acid, 1kg of polysorbate-80 and 29kg of water.
The cleaning agent is used for cleaning after wet granulation of a groove type mixer (CH-400L), the cleaning agent B is uniformly sprayed on the surface of equipment to be cleaned, the dosage is that visible water drops are formed on the surface, and the time is 3-5 minutes; spraying the cleaning agent A on the surface of the equipment soaked by the cleaning agent B, wherein visible water drops are formed on the surface layer according to the dosage, and the material adhered to the surface of the equipment is slowly dissolved and completely separated from the equipment; if the materials which are not separated exist, wiping the materials which are separated with a rag, and repeating the steps.
Comparative example 1
Soaking with water, and cleaning with a shovel.
Comparative example 2
Cleaning agent: 71 parts of 5.5% sodium bicarbonate, 35 parts of ethanol, 6 parts of citric acid, 1 part of polysorbate-80 and 29 parts of water by mass percent, and directly wetting and wiping the equipment by using the same amount as that of the embodiment 1 in each square meter.
Comparative example 3
Cleaning agent A: 5.5 percent of sodium bicarbonate by mass;
and (3) cleaning agent B: 35kg of ethanol, 6kg of citric acid, 1kg of polysorbate-80 and 29kg of water.
The same amount per square meter as in example 1 was used, except that cleaning agent A was sprayed first and then cleaning agent B was sprayed.
The amount of the cleaning agent, the time required for cleaning, and the cleaning effect in the above method were counted as in table 1.
TABLE 1 cleaning after Wet granulation of the trough mixer (CH-400L)
Figure BDA0002881686440000031
Experiment 2: cleaning the dried Chinese medicinal extract in vacuum drying oven (MZG-4)
Example 2
Preparing materials according to the following formula:
cleaning agent A: 8% by mass of sodium bicarbonate;
and (3) cleaning agent B: 45kg of ethanol, 9kg of citric acid, 3kg of polysorbate-80 and 45kg of water.
The cleaning agent is used for cleaning after drying the traditional Chinese medicine extract in a vacuum drying oven (MZG-4), the cleaning agent B is uniformly sprayed on the surface of equipment to be cleaned, the dosage is enough to form visible water drops on the surface, and the waiting time is 3-5 minutes; spraying the cleaning agent A on the surface of the equipment soaked by the cleaning agent B, wherein visible water drops are formed on the surface layer according to the dosage, and the material adhered to the surface of the equipment is slowly dissolved and completely separated from the equipment; if the materials which are not separated exist, wiping the materials which are separated with a rag, and repeating the steps.
Comparative example 4
Soaking in alcohol and water, and shoveling
Comparative example 5
Cleaning agent: 102 parts of sodium bicarbonate with the mass percentage of 8%, 45 parts of ethanol, 9 parts of citric acid, 3 parts of polysorbate-80 and 45 parts of water. The device was directly wet wiped using the same amount per square meter as in example 2.
Comparative example 6
Cleaning agent A: 8% by mass of sodium bicarbonate;
and (3) cleaning agent B: 45kg of ethanol, 9kg of citric acid, 3kg of polysorbate-80 and 45kg of water.
The same amount per square meter as in example 2 was used, except that cleaning agent A was sprayed first and then cleaning agent B was sprayed.
The amount of the cleaning agent, the time required for cleaning, and the cleaning effect in the above method were counted as in table 2.
TABLE 2 cleaning of dried Chinese medicinal extract in vacuum drying oven (MZG-4)
Figure BDA0002881686440000041
Experiment 3: cleaning of oscillating granulator (YK-160) after wet granulation
Example 3
Preparing materials according to the following formula:
cleaning agent A: the cleaning agent A is sodium bicarbonate with the mass percent of 11 percent;
and (3) cleaning agent B: 55kg of ethanol, 12kg of malic acid, 4kg of polysorbate-80 and 58kg of water.
The cleaning agent is used for cleaning after wet granulation of a swing granulator (YK-160), the cleaning agent B is uniformly sprayed on the surface of equipment to be cleaned, the dosage is that visible water drops are formed on the surface, and the time is 3-5 minutes; spraying the cleaning agent A on the surface of the equipment soaked by the cleaning agent B, wherein visible water drops are formed on the surface layer according to the dosage, and the material adhered to the surface of the equipment is slowly dissolved and completely separated from the equipment; if materials which are not separated exist, wiping the separated materials with a rag, repeating the steps until all the materials are separated, and cleaning.
Comparative example 7
Soaking with water, and cleaning with a shovel.
Comparative example 8
Cleaning agent: 129 parts of 11% sodium bicarbonate, 55 parts of ethanol, 12 parts of malic acid, 4 parts of polysorbate-80 and 58 parts of water. The device was directly wet wiped using the same amount per square meter as in example 3.
Comparative example 9
Cleaning agent A: the cleaning agent A is sodium bicarbonate with the mass percent of 11 percent;
and (3) cleaning agent B: 55kg of ethanol, 12kg of malic acid, 4kg of polysorbate-80 and 58kg of water.
The same amount per square meter as in example 3 was used, except that cleaning agent A was sprayed first and then cleaning agent B was sprayed.
The amount of the cleaning agent, the time required for cleaning, and the cleaning effect obtained by the above method are shown in Table 3.
TABLE 3 cleaning after Wet granulation of swing granulator (YK-160)
Figure BDA0002881686440000051
The cleaning agent disclosed by the invention is used for cleaning various traditional Chinese medicine equipment, so that the time and labor are saved, the production period is shortened, the production efficiency is improved, the consumption of the required cleaning agent is small, and the energy is saved. Meanwhile, it can be found that when the cleaning agent is used for cleaning, the cleaning effect can not be better when the cleaning agent B is used for soaking equipment firstly and then the cleaning agent A is used for the best effect, the cleaning agent B and the cleaning agent A are used for exchanging the sequence or directly mixing the cleaning agent B and the cleaning agent A, and the three types of equipment are cleaned by adopting the same dosage and time.
The present invention is not limited to the above preferred embodiments, and any modifications, equivalent substitutions, improvements, etc. within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims (5)

1. A cleaning agent for traditional Chinese medicine granulation equipment is characterized by consisting of a cleaning agent A and a cleaning agent B;
wherein the cleaning agent A is 5.5-11% of sodium bicarbonate in percentage by mass;
the cleaning agent B comprises the following components in parts by weight: 35-55 parts of ethanol, 6-12 parts of citric acid, 1-4 parts of polysorbate-80 and 29-58 parts of water, or 35-55 parts of ethanol, 6-12 parts of malic acid, 1-4 parts of polysorbate-80 and 29-58 parts of water;
the use method of the traditional Chinese medicine granulating equipment cleaning agent comprises the following steps:
s1, respectively preparing cleaning agents A and B according to the proportion, uniformly stirring, placing the cleaning agents A and B into different containers for standby, and preparing the cleaning agents A and B at present;
s2, uniformly spraying the cleaning agent B on the surface of the equipment, forming visible water drops on the surface according to the dosage, and waiting for 3-5 minutes;
s3, spraying the cleaning agent A on the surface of the equipment soaked by the cleaning agent B, wherein macroscopic water drops are formed on the surface layer according to the dosage, and materials adhered to the surface of the equipment are slowly dissolved and completely separated from the equipment;
and S4, if the materials which are not separated exist, wiping the separated materials by using a rag, and repeating the steps S2 and S3 to finish cleaning.
2. The traditional Chinese medicine granulating equipment cleaning agent as claimed in claim 1, which is composed of a cleaning agent A and a cleaning agent B;
wherein the cleaning agent A is sodium bicarbonate with the mass percent of 6-10%;
the cleaning agent B comprises the following components in parts by weight: 40-50 parts of ethanol, 8-10 parts of citric acid, 2-3 parts of polysorbate-80 and 40-50 parts of water, or 40-50 parts of ethanol, 8-10 parts of malic acid, 2-3 parts of polysorbate-80 and 40-50 parts of water.
3. The traditional Chinese medicine granulating equipment cleaning agent as claimed in claim 1, which is composed of a cleaning agent A and a cleaning agent B;
wherein the cleaning agent A is sodium bicarbonate with the mass percent of 8%;
the cleaning agent B comprises the following components in parts by weight: 45 parts of ethanol, 9 parts of citric acid, 3 parts of polysorbate-80 and 45 parts of water.
4. A use method of the traditional Chinese medicine granulating equipment cleaning agent is characterized in that the traditional Chinese medicine granulating equipment cleaning agent as claimed in any one of claims 1 to 3 is used, and the method comprises the following steps:
s1, respectively preparing cleaning agents A and B according to the proportion, uniformly stirring, placing the cleaning agents A and B into different containers for standby, and preparing the cleaning agents A and B at present;
s2, uniformly spraying the cleaning agent B on the surface of the equipment, forming visible water drops on the surface according to the dosage, and waiting for 3-5 minutes;
s3, spraying the cleaning agent A on the surface of the equipment soaked by the cleaning agent B, wherein macroscopic water drops are formed on the surface layer according to the dosage, and materials adhered to the surface of the equipment are slowly dissolved and completely separated from the equipment;
and S4, if the materials which are not separated exist, wiping the separated materials by using a rag, and repeating the steps S2 and S3 to finish cleaning.
5. The use of the cleaning agent for traditional Chinese medicine granulation equipment according to any one of claims 1 to 3 in treatment of intractable stains on the surface of traditional Chinese medicine granulation equipment.
CN202110001904.6A 2021-01-04 2021-01-04 Traditional Chinese medicine granulating equipment cleaning agent and application thereof Active CN112852559B (en)

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Application Number Priority Date Filing Date Title
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CN112852559B true CN112852559B (en) 2022-03-18

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0512328A1 (en) * 1991-05-06 1992-11-11 Miles Inc. Food safe cleaning composition
CN107384619A (en) * 2017-08-02 2017-11-24 广州立白企业集团有限公司 It is a kind of have remove effervescent table for cleaning of residual, the degerming effect of agriculture and preparation method thereof
CN111019769A (en) * 2019-12-02 2020-04-17 河南海利未来科技有限公司 Natural plant-derived antibacterial fruit and vegetable cleaning agent and preparation method thereof
CN111676098A (en) * 2019-12-02 2020-09-18 河南海利未来科技有限公司 Natural plant-derived antibacterial fruit and vegetable cleaning agent and preparation method thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0512328A1 (en) * 1991-05-06 1992-11-11 Miles Inc. Food safe cleaning composition
CN107384619A (en) * 2017-08-02 2017-11-24 广州立白企业集团有限公司 It is a kind of have remove effervescent table for cleaning of residual, the degerming effect of agriculture and preparation method thereof
CN111019769A (en) * 2019-12-02 2020-04-17 河南海利未来科技有限公司 Natural plant-derived antibacterial fruit and vegetable cleaning agent and preparation method thereof
CN111676098A (en) * 2019-12-02 2020-09-18 河南海利未来科技有限公司 Natural plant-derived antibacterial fruit and vegetable cleaning agent and preparation method thereof

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