CN112843223A - Medicinal and edible traditional Chinese medicine weight-losing composition - Google Patents

Medicinal and edible traditional Chinese medicine weight-losing composition Download PDF

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CN112843223A
CN112843223A CN202110234127.XA CN202110234127A CN112843223A CN 112843223 A CN112843223 A CN 112843223A CN 202110234127 A CN202110234127 A CN 202110234127A CN 112843223 A CN112843223 A CN 112843223A
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extract
weight
powder
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parts
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不公告发明人
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Shaanxi Beikangjian Biotechnology Co ltd
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Shaanxi Beikangjian Biotechnology Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/62—Nymphaeaceae (Water-lily family)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/718—Starch or degraded starch, e.g. amylose, amylopectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/02—Algae
    • A61K36/03—Phaeophycota or phaeophyta (brown algae), e.g. Fucus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815—Lycium (desert-thorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/894—Dioscoreaceae (Yam family)
    • A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8969—Polygonatum (Solomon's seal)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/55—Liquid-liquid separation; Phase separation

Abstract

The invention relates to the technical field of health care products, in particular to a traditional Chinese medicine weight-losing composition with homology of medicine and food, which comprises the following components: the weight-losing tea comprises a lotus leaf extract, ginseng, a kelp extract, angelica sinensis, a medlar extract, Chinese yam, a momordica grosvenori extract, rhizoma polygonati, resistant dextrin and whey protein, and has the advantages of good weight-losing effect and no side effect.

Description

Medicinal and edible traditional Chinese medicine weight-losing composition
Technical Field
The invention relates to the technical field of health care products, in particular to a traditional Chinese medicine weight-losing composition with homology of medicine and food.
Background
With the continuous improvement of the life quality of people, the amount of nutrient substances taken by people every day is far beyond the requirement of normal growth of the body, and in addition, many people lack of exercise now, so that more and more obese patients are caused. Obesity refers to a condition of excess accumulation of body fat, especially triglycerides, due to a degree of significant overweight and an excessively thick fat layer. It does not mean a simple weight gain, but a state in which an excess of adipose tissues is accumulated in the body. Excessive accumulation of fat in the body due to excessive food intake or altered metabolism of the body causes excessive weight gain and causes pathological, physiological changes or latency in the human body.
Excessive obesity affects the physical health of the human body, resulting in the occurrence of various diseases. Obesity is likely to cause chronic diseases such as hypertension and heart disease, and the heavier the person is, the greater the load the body bears, and the higher the chance of suffering from cerebral apoplexy. Many researches show that excessive fat cells need the pancreas to secrete excessive insulin, so that sugar in blood is converted into energy, but when the pancreas is overwhelmed, the function of the pancreas becomes extremely weak, so that the sugar in the blood is greatly increased and cannot be fully utilized to be discharged out of the body, and the obesity is also susceptible to diabetes. In addition, obesity affects the body shape of a human body, and for women, the body is fat, so that the women cannot wear clothes, and therefore, many women are interested in losing weight. The weight-losing method has various methods, and some people lose weight by exercising, some people lose weight by eating no food, and other people lose weight by eating various weight-losing medicines. For most people, weight loss by eating without food or drug is the simplest two methods, but the weight loss by eating without food causes that enough nutrition cannot be absorbed by intestines and stomach of a human body for a long time, the functions of the intestines and stomach can be influenced after the weight loss by eating without food for a long time, even the intestines and stomach are atrophied, the drug weight loss is realized by promoting excretion, and the damage to the human body is easily caused.
At present, weight-reducing medicines on the market are full of precious and full of precious medicines, but most medicines have the defects, such as amphetamine weight-reducing medicines, which can inhibit the hypothalamus ingestion center and reduce appetite, but adverse reactions such as addiction, insomnia, hallucination and the like can be generated after long-term large-scale taking; diarrhea medicine type weight-reducing medicines achieve the purpose of reducing weight by causing intermittent diarrhea, reducing gastric acid and reducing appetite, but the weight is easy to rise after the medicine taking is stopped, and anemia and gastrointestinal diseases can also occur if the medicine is taken frequently.
Chinese patent application CN110755562A discloses a traditional Chinese medicine composition for losing weight, which comprises the following components in parts by weight: 20-40 parts of fried coix seeds; 5-15 parts of lotus leaves; 5-15 parts of chrysanthemum; 5-15 parts of red bean; 10-20 parts of hawthorn; 5-15 parts of radish seeds; 2-8 parts of semen cassiae; 5-15 parts of endothelium corneum gigeriae galli; 5-15 parts of astragalus. The preparation method comprises grinding the above materials into powder and mixing. The traditional Chinese medicine composition for losing weight provided by the invention has the effects of inducing diuresis to alleviate edema, reducing blood fat, reducing cholesterol and losing weight.
Chinese patent application CN111281949A discloses a weight-losing and slimming traditional Chinese medicine composition and a preparation method thereof, wherein the weight-losing and slimming traditional Chinese medicine composition comprises the following components in parts by weight: 15-35 parts of raw coix seeds, 5-25 parts of cassia seeds, 20-40 parts of konjak and 5-25 parts of red beans. The components are powder processed by the following method: (1) slicing rhizoma Amorphophalli, and steaming with steam together with other medicinal materials in a steamer; (2) taking out the steamed raw materials, and airing; repeating the operation for five times according to the method of the step (1) and the step (2), and drying after the last steaming; (4) and (3) putting the dried raw materials into an oven for drying, grinding into powder, and uniformly mixing to obtain the powder. Compared with the prior art, the invention has the beneficial effects that: the Chinese medicinal powder is prepared by steaming five parts and drying five parts of pure Chinese medicinal raw materials in the sun, avoids direct oral administration, has good weight-losing effect, takes effect quickly, is safer to use, has a simple preparation process, and is worthy of popularization.
Chinese patent application CN110694039A discloses a weight-reducing traditional Chinese medicine composition and a preparation method thereof, wherein the traditional Chinese medicine composition adopts raw materials comprising fennel fruit, rhubarb, senna leaf extract, alisma orientale, pueraria flower, polygonatum, ginger, mulberry leaf extract, pseudo-ginseng, borneol and camphor. The invention has the beneficial effects that: the Chinese medicinal composition adopts pure natural Chinese medicinal components, starts from the aspects of tonifying qi, strengthening spleen, reducing phlegm and the like, adjusts viscera and endocrine, ensures that qi and blood of a body run better, discharges stasis substances and toxin in the body, and recovers the normal energy metabolism of the human body, thereby achieving the aims of health, slimming, compactness and plasticity; and the traditional Chinese medicine is hot-compressed, and enters blood circulation after being absorbed through hair follicles of the abdomen, sebaceous glands, sweat gland veins, keratinocytes and cell gaps, without being metabolized by the liver, thereby avoiding toxin expelling and operation burden of the liver, and meeting the modern medical advocated healthy concept of percutaneous, mucosal or rectal absorption.
However, the applications all contain a plurality of traditional Chinese medicine components, the action mechanism is not clear, side effects are easy to generate, and the weight-losing effect needs to be improved.
Therefore, the development of a traditional Chinese medicine composition with homology of medicine and food, which can solve the technical problems, is very necessary.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provides a traditional Chinese medicine weight-losing composition which has a good weight-losing effect, no side effect and homology of medicine and food.
The invention is realized by the following technical scheme:
a traditional Chinese medicine weight-losing composition with homology of medicine and food comprises the following components: lotus leaf extract, ginseng, kelp extract, angelica, medlar extract, yam, momordica grosvenori extract, polygonatum, resistant dextrin and whey protein.
Preferably, the traditional Chinese medicine weight-losing composition comprises the following components in parts by weight: 0.05-0.2 part of lotus leaf extract, 0.1-0.5 part of ginseng, 1.0-5.0 parts of kelp extract, 2.0-5.0 parts of angelica, 2.0-5.0 parts of medlar extract, 1.0-5.0 parts of yam, 0.5-2.0 parts of momordica grosvenori extract, 0.2-1.0 part of rhizoma polygonati, 20-25 parts of resistant dextrin and 50-65 parts of whey protein.
Preferably, the preparation process of the lotus leaf extract comprises the following steps: pulverizing folium Nelumbinis, soaking in 90-95% ethanol, filtering to remove residue to obtain extractive solution, and recovering ethanol to obtain extract; adding 25-35% ethanol into the extract, settling, collecting precipitate, adding 90-95% ethanol, settling, collecting supernatant, recovering ethanol, and drying.
More preferably, the preparation process of the lotus leaf extract comprises the following steps:
pulverizing folium Nelumbinis to particle size of 1-3cm, soaking in 12-18 times of 90-95% ethanol, extracting for 6-10 hr, filtering to remove residue to obtain leaching solution, and recovering ethanol to obtain extract; adding 25-35% ethanol into the extract, settling for 4-8h, collecting precipitate, adding 90-95% ethanol, settling for 18-22h, collecting supernatant, recovering ethanol, and drying.
The ethanol concentration in the present invention is a volume concentration unless otherwise specified.
Preferably, the preparation process of the kelp extract comprises the following steps: soaking dried herba Zosterae Marinae in water, boiling, filtering to obtain extractive solution, concentrating to obtain extract A, precipitating with 95% ethanol, collecting supernatant, recovering ethanol to obtain extract B, precipitating with 90% ethanol, collecting supernatant, recovering ethanol, and drying.
More preferably, the preparation process of the kelp extract comprises the following steps: soaking dried herba Zosterae Marinae in water for 6-10 hr, completely soaking, and cutting into 2-5cm pieces3Boiling with 6-10 times of water for 1-3h, filtering to obtain extractive solution, repeatedly extracting for 1-2 times, concentrating the extractive solution to obtain extract A, precipitating with 95% ethanol for 10-15h, collecting supernatant, recovering ethanol to obtain extract B, precipitating with 90% ethanol for 20-25h, collecting supernatant, recovering ethanol, and drying.
Preferably, the preparation process of the momordica grosvenori extract comprises the following steps: crushing fresh fructus Siraitiae Grosvenorii, boiling in water, filtering to obtain extractive solution, and concentrating.
More preferably, the preparation process of the momordica grosvenori extract comprises the following steps: crushing fresh fructus Siraitiae Grosvenorii, boiling with 3-8 times of water for 2-4 hr, filtering to obtain extractive solution, repeatedly extracting for 1-2 times, mixing extractive solutions, and concentrating to remove water.
Preferably, the preparation process of the medlar extract comprises the following steps: boiling fructus Lycii in water, filtering to obtain extractive solution, and concentrating.
More preferably, the preparation process of the medlar extract comprises the following steps: boiling fructus Lycii in 4-8 times of water for 1-3 hr, filtering to obtain extractive solution, repeatedly extracting for 1-2 times, mixing extractive solutions, and concentrating to remove water.
The invention also relates to a preparation process of the traditional Chinese medicine weight-losing composition, which comprises the following steps:
(1) mixing Ginseng radix, radix Angelicae sinensis, rhizoma Dioscoreae and rhizoma Polygonati, pulverizing, boiling in water, filtering to remove residue to obtain leaching solution, concentrating, drying, and pulverizing to obtain powder A;
(2) mixing fructus Siraitiae Grosvenorii extract with part A of resistant dextrin, drying, and pulverizing to obtain powder B;
(3) mixing the medlar extract with the resistant dextrin of the part B, drying and crushing to obtain powder C;
(4) mixing powder A, powder B, powder C, folium Nelumbinis extract, herba Zosterae Marinae extract, residual resistant dextrin and lactalbumin.
Preferably, in the step (1), ginseng, angelica, yam and polygonatum are mixed, crushed, added with 3-6 times of water and boiled for 3-5h, filtered to remove residues to obtain leaching liquor, concentrated, dried and crushed to obtain powder A.
Preferably, the part a resistant dextrin is 5-15% resistant dextrin and the part B resistant dextrin is 20-40% resistant dextrin.
Preferably, the powder a, the powder B, the powder C, the lotus leaf extract, the kelp extract, the residual resistant dextrin and the whey protein are mixed in sequence in the step (4).
The invention also relates to the application of the traditional Chinese medicine weight-losing composition or the traditional Chinese medicine weight-losing composition prepared by the preparation process in preparing weight-losing health products or medicines.
The invention has the beneficial effects that:
the invention optimizes the composition and dosage ratio of the traditional Chinese medicine weight-losing extract, has the synergistic effect of all the components, has obvious weight-losing effect and has no side effect.
In the preparation process of the composition, the ginseng, the angelica, the Chinese yam and the rhizoma polygonati are mixed and extracted, so that the weight-losing effect is better.
The invention optimizes the preparation process of each extract, and simultaneously mixes the resistant dextrin with each effective component step by step, so that the prepared composition has higher stability and better weight-losing effect.
Detailed Description
The invention will be further described with reference to specific embodiments, and the advantages and features of the invention will become apparent as the description proceeds. These examples are illustrative only and do not limit the scope of the present invention in any way. It will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention, and that such changes and modifications may be made without departing from the spirit and scope of the invention.
The resistant dextrins of the various examples and comparative examples of the present application were purchased from Zhengzhou Yujunzhi Biotech, Inc., cat # YK 09; whey protein was purchased from sienna baichuan biotechnology limited with a specification of 80%.
Example 1
A traditional Chinese medicine weight-losing composition with homology of medicine and food comprises the following components in parts by weight: 0.05 part of lotus leaf extract, 0.1 part of ginseng, 1.0 part of kelp extract, 2.0 parts of angelica, 2.0 parts of medlar extract, 1.0 part of yam, 0.5 part of momordica grosvenori extract, 0.2 part of rhizoma polygonati, 20 parts of resistant dextrin and 50 parts of whey protein.
The preparation process of the lotus leaf extract comprises the following steps: pulverizing folium Nelumbinis to particle size of 1cm, soaking in 12 times of 90% ethanol for 6 hr, filtering to remove residue to obtain leaching solution, and recovering ethanol to obtain extract; adding 25% ethanol into the extract, settling for 4h, collecting precipitate, adding 90% ethanol, settling for 18h, collecting supernatant, recovering ethanol, and drying.
The preparation process of the kelp extract comprises the following steps: soaking dried herba Zosterae Marinae in water for 6 hr, completely soaking, and cutting into 2cm pieces3Boiling with 6 times of water for 1h, filtering to obtain extractive solution, repeatedly extracting for 1 time, mixing extractive solutions, concentrating to obtain extract A, adding 95% ethanol, settling for 10h, collecting supernatant, recovering ethanol to obtain extract B, adding 90% ethanol, settling for 20h, collecting supernatant, recovering ethanol, and drying.
The preparation process of the momordica grosvenori extract comprises the following steps of: crushing fresh fructus Siraitiae Grosvenorii, boiling with 3 times of water for 2 hr, filtering to obtain extractive solution, repeatedly extracting for 1 time, mixing extractive solutions, and concentrating to remove water.
The preparation process of the medlar extract comprises the following steps: boiling fructus Lycii in 4 times of water for 1 hr, filtering to obtain extractive solution, repeatedly extracting for 1 time, mixing extractive solutions, and concentrating to remove water.
The preparation process of the traditional Chinese medicine weight-losing composition comprises the following steps:
(1) mixing Ginseng radix, radix Angelicae sinensis, rhizoma Dioscoreae and rhizoma Polygonati, pulverizing, sieving with 20 mesh sieve, adding 3 times of water, boiling for 3 hr, filtering to remove residue to obtain leaching solution, concentrating, drying, and pulverizing to obtain powder A;
(2) mixing fructus Siraitiae Grosvenorii extract with 5% resistant dextrin (by weight of total resistant dextrin), drying, and pulverizing to obtain powder B;
(3) mixing the medlar extract with 20% of resistant dextrin (the mass fraction of the total resistant dextrin), drying and crushing to obtain powder C;
(4) sequentially mixing the powder A, the powder B, the powder C, the lotus leaf extract, the kelp extract, the residual resistant dextrin and the whey protein to obtain the sea-tangle powder.
Example 2
A traditional Chinese medicine weight-losing composition with homology of medicine and food comprises the following components in parts by weight: 0.2 part of lotus leaf extract, 0.5 part of ginseng, 5.0 parts of kelp extract, 5.0 parts of angelica, 5.0 parts of medlar extract, 5.0 parts of Chinese yam, 2.0 parts of momordica grosvenori extract, 1.0 part of rhizoma polygonati, 25 parts of resistant dextrin and 65 parts of whey protein.
The preparation process of the lotus leaf extract comprises the following steps: pulverizing folium Nelumbinis to particle size of 3cm, soaking in 18 times of 95% ethanol for 10 hr, filtering to remove residue to obtain leaching solution, and recovering ethanol to obtain extract; adding 35% ethanol into the extract, settling for 8h, collecting precipitate, adding 95% ethanol, settling for 22h, collecting supernatant, recovering ethanol, and drying.
The preparation process of the kelp extract comprises the following steps: soaking dried herba Zosterae Marinae in water for 10 hr, completely soaking, and cutting into 5cm pieces3Boiling with 10 times of water for 3h, filtering to obtain extractive solution, repeatedly extracting for 2 times, concentrating the extractive solution to obtain extract A, adding 95% ethanol, settling for 15h, collecting supernatant, recovering ethanol to obtain extract B, adding 90% ethanol, settling for 25h, collecting supernatant, recovering ethanol, and drying.
The preparation process of the momordica grosvenori extract comprises the following steps of: crushing fresh fructus Siraitiae Grosvenorii, boiling with 8 times of water for 4 hr, filtering to obtain extractive solution, repeatedly extracting for 2 times, mixing extractive solutions, and concentrating to remove water.
The preparation process of the medlar extract comprises the following steps: boiling fructus Lycii in 8 times of water for 3 hr, filtering to obtain extractive solution, repeatedly extracting for 2 times, mixing extractive solutions, and concentrating to remove water.
The preparation process of the traditional Chinese medicine weight-losing composition comprises the following steps:
(1) mixing Ginseng radix, radix Angelicae sinensis, rhizoma Dioscoreae and rhizoma Polygonati, pulverizing, sieving with 20 mesh sieve, adding 6 times of water, boiling for 5 hr, filtering to remove residue to obtain leaching solution, concentrating, drying, and pulverizing to obtain powder A;
(2) mixing fructus Siraitiae Grosvenorii extract with 15% resistant dextrin (by weight of total resistant dextrin), drying, and pulverizing to obtain powder B;
(3) mixing the medlar extract with 40% of resistant dextrin (the mass fraction of the total resistant dextrin), drying and crushing to obtain powder C;
(4) sequentially mixing the powder A, the powder B, the powder C, the lotus leaf extract, the kelp extract, the residual resistant dextrin and the whey protein to obtain the sea-tangle powder.
Example 3
A traditional Chinese medicine weight-losing composition with homology of medicine and food comprises the following components in parts by weight: 0.1 part of lotus leaf extract, 0.3 part of ginseng, 3 parts of kelp extract, 4 parts of angelica, 3 parts of medlar extract, 3 parts of Chinese yam, 1.2 parts of momordica grosvenori extract, 0.6 part of sealwort, 22 parts of resistant dextrin and 58 parts of whey protein.
The preparation process of the lotus leaf extract comprises the following steps: pulverizing folium Nelumbinis to particle size of 2cm, soaking in 15 times of 92% ethanol for 8 hr, filtering to remove residue to obtain leaching solution, and recovering ethanol to obtain extract; and adding 30% ethanol into the extract, settling for 6h, adding 92% ethanol into the precipitate, continuing settling for 20h, taking the supernatant, recovering ethanol, and drying to obtain the final product.
The preparation process of the kelp extract comprises the following steps: soaking dried herba Zosterae Marinae in water for 8 hr, completely soaking, and cutting into 3cm pieces3Boiling with 8 times of water for 2 hr, filtering to obtain extractive solution, repeatedly extracting for 2 times, concentrating the extractive solution to obtain extract A, adding 95% ethanol, settling for 12 hr, collecting supernatant, and recovering ethanolAnd (3) performing alcohol treatment to obtain an extract B, adding 90% ethanol, settling for 22h, taking supernate, recovering ethanol, and drying to obtain the extract B.
The preparation process of the momordica grosvenori extract comprises the following steps of: crushing fresh fructus Siraitiae Grosvenorii, boiling with 6 times of water for 3 hr, filtering to obtain extractive solution, repeatedly extracting for 1 time, mixing extractive solutions, and concentrating to remove water.
The preparation process of the medlar extract comprises the following steps: boiling fructus Lycii in 6 times of water for 2 hr, filtering to obtain extractive solution, repeatedly extracting for 1 time, mixing extractive solutions, and concentrating to remove water.
The preparation process of the traditional Chinese medicine weight-losing composition comprises the following steps:
(1) mixing Ginseng radix, radix Angelicae sinensis, rhizoma Dioscoreae and rhizoma Polygonati, pulverizing, sieving with 20 mesh sieve, adding 4 times of water, boiling for 4 hr, filtering to remove residue to obtain leaching solution, concentrating, drying, and pulverizing to obtain powder A;
(2) mixing fructus Siraitiae Grosvenorii extract with 10% resistant dextrin, drying, and pulverizing to obtain powder B;
(3) mixing the fructus Lycii extract with 30% resistant dextrin, drying, and pulverizing to obtain powder C;
(4) sequentially mixing the powder A, the powder B, the powder C, the lotus leaf extract, the kelp extract, the residual resistant dextrin and the whey protein to obtain the sea-tangle powder.
Comparative example 1
The difference from the embodiment 3 is that the dosage and the proportion of each component of the traditional Chinese medicine weight-reducing composition are different, the other conditions are the same, and the specific conditions are as follows:
a traditional Chinese medicine weight-losing composition with homology of medicine and food comprises the following components in parts by weight: 0.03 part of lotus leaf extract, 0.6 part of ginseng, 0.5 part of kelp extract, 6 parts of angelica, 6 parts of medlar extract, 2 parts of Chinese yam, 1 part of momordica grosvenori extract, 0.6 part of rhizoma polygonati, 22 parts of resistant dextrin and 58 parts of whey protein.
Comparative example 2
The difference from the embodiment 3 is only that the preparation process of the traditional Chinese medicine weight-losing composition is different, ginseng, angelica, Chinese yam and rhizoma polygonati are respectively extracted, and the other conditions are the same, specifically as follows:
the preparation process of the traditional Chinese medicine weight-losing composition comprises the following steps:
(1) pulverizing Ginseng radix, sieving with 20 mesh sieve, adding 4 times of water, boiling for 4 hr, filtering to remove residue to obtain leaching solution, concentrating, drying, and pulverizing to obtain powder A1; pulverizing radix Angelicae sinensis, sieving with 20 mesh sieve, adding 4 times of water, boiling for 4 hr, filtering to remove residue to obtain leaching solution, concentrating, drying, and pulverizing to obtain powder A2; pulverizing rhizoma Dioscoreae, sieving with 20 mesh sieve, adding 4 times of water, boiling for 4 hr, filtering to remove residue to obtain leaching solution, concentrating, drying, and pulverizing to obtain powder A3; pulverizing rhizoma Polygonati, sieving with 20 mesh sieve, adding 4 times of water, boiling for 4 hr, filtering to remove residue to obtain leaching solution, concentrating, drying, and pulverizing to obtain powder A4; mixing powders A1, A2, A3 and A4 to obtain powder A;
(2) mixing fructus Siraitiae Grosvenorii extract with 10% resistant dextrin, drying, and pulverizing to obtain powder B;
(3) mixing the fructus Lycii extract with 30% resistant dextrin, drying, and pulverizing to obtain powder C;
(4) sequentially mixing the powder A, the powder B, the powder C, the lotus leaf extract, the kelp extract, the residual resistant dextrin and the whey protein to obtain the sea-tangle powder.
Comparative example 3
The difference from the embodiment 3 is only that the preparation process of the traditional Chinese medicine weight-losing composition is different, the resistant dextrin is added at one time, and the other conditions are the same, specifically as follows:
the preparation process of the traditional Chinese medicine weight-losing composition comprises the following steps:
(1) mixing Ginseng radix, radix Angelicae sinensis, rhizoma Dioscoreae and rhizoma Polygonati, pulverizing, sieving with 20 mesh sieve, adding 4 times of water, boiling for 4 hr, filtering to remove residue to obtain leaching solution, concentrating, drying, and pulverizing to obtain powder A;
(2) drying and pulverizing fructus Siraitiae Grosvenorii extract to obtain powder B;
(3) drying and pulverizing fructus Lycii extract to obtain powder C;
(4) sequentially mixing powder A, powder B, powder C, folium Nelumbinis extract, herba Zosterae Marinae extract, resistant dextrin and lactalbumin.
Comparative example 4
The difference from example 3 is only that the concentration of ethanol used for sedimentation in the preparation of the kelp extract is different, and the rest conditions are the same, specifically as follows:
the preparation process of the kelp extract comprises the following steps: soaking dried herba Zosterae Marinae in water for 8 hr, completely soaking, and cutting into 3cm pieces3Boiling with 8 times of water for 2h, filtering to obtain extractive solution, repeatedly extracting for 2 times, concentrating the extractive solution to obtain extract A, adding 85% ethanol, settling for 12h, collecting supernatant, recovering ethanol to obtain extract B, adding 95% ethanol, settling for 22h, collecting supernatant, recovering ethanol, and drying.
Test example 1
Experimental animals: SPF grade C57 male mice weighing 17.0 + -0.5 g were purchased from Beijing Huafukang Biotech GmbH.
Experiment feed: the common feed is provided by the laboratory animal center of Guangzhou Chinese medicinal university, and the high-fat feed is purchased from Beijing Huafukang biotech GmbH 10045.
Four-week-old C57 mice were adaptively fed for 5 days and divided into two groups, one group was a control group (8 mice) and fed with normal feed, the other group was a model-making group and fed with high-fat feed, the mice were fed with free food and water during the feeding period, the weight of the mice was measured every two days, and the food intake was weighed. After 5 weeks of feeding, the weight gain of the modeling group was significantly different from that of the control group, and the modeling was successful. The food intake of the model group and the control group is not obviously changed by observation.
Mice successfully modeled were randomly divided into 8 groups of 8 mice each. Wherein, 1 group is high fat group, and is fed with high fat feed; the other 7 groups are drug groups, except for feeding with high fat feed, the traditional Chinese medicine weight-reducing compositions of examples 1-3 (implementation group) and comparative examples 1-4 (comparative group) are respectively used for intragastric administration at 10 am every day, before intragastric administration, the traditional Chinese medicine weight-reducing compositions are dissolved into suspension by distilled water, the intragastric administration dosage is 0.4g/kg/d, and the same volume of distilled water is used for intragastric administration of the high fat group.
The body weights of the mice were measured at 0 week and 7 weeks, respectively, and the results are shown in table 1. In addition, the food intake of the mice in the drug group and the mice in the high fat group has no obvious change through observation, which shows that the pharmaceutical composition of the invention does not influence the food intake and has no side effect, and the weight reduction of the mice in the drug group has no direct relation with the food intake.
TABLE 1
Week 0 (g) 7 weeks (g)
High fat group 28.01±1.10 33.57±1.86a
Example 1 28.04±1.78 29.73±1.34b
Example 2 28.12±1.42 29.92±1.21b
Example 3 28.07±0.97 29.61±1.47b
Comparative example 1 28.03±1.04 32.98±1.05c
Comparative example 2 28.15±1.53 32.35±1.68c
Comparative example 3 28.11±1.26 31.84±1.53c
Comparative example 4 28.08±1.39 31.26±1.92c
a. b indicates that there is a significant difference between the high fat group and the treatment group.
b. c indicates that there was a significant difference between the working group and the comparative group.
The above detailed description is specific to one possible embodiment of the present invention, and the embodiment is not intended to limit the scope of the present invention, and all equivalent implementations or modifications without departing from the scope of the present invention should be included in the technical scope of the present invention.

Claims (10)

1. A traditional Chinese medicine weight-losing composition with homology of medicine and food is characterized by comprising the following components: lotus leaf extract, ginseng, kelp extract, angelica, medlar extract, yam, momordica grosvenori extract, polygonatum, resistant dextrin and whey protein.
2. The traditional Chinese medicine composition for losing weight according to claim 1, which is characterized by comprising the following components in parts by weight: 0.05-0.2 part of lotus leaf extract, 0.1-0.5 part of ginseng, 1.0-5.0 parts of kelp extract, 2.0-5.0 parts of angelica, 2.0-5.0 parts of medlar extract, 1.0-5.0 parts of yam, 0.5-2.0 parts of momordica grosvenori extract, 0.2-1.0 part of rhizoma polygonati, 20-25 parts of resistant dextrin and 50-65 parts of whey protein.
3. The traditional Chinese medicine composition for losing weight as claimed in claim 1, wherein the preparation process of the lotus leaf extract comprises the following steps: pulverizing folium Nelumbinis, soaking in 90-95% ethanol, filtering to remove residue to obtain extractive solution, and recovering ethanol to obtain extract; adding 25-35% ethanol into the extract, settling, collecting precipitate, adding 90-95% ethanol, settling, collecting supernatant, recovering ethanol, and drying.
4. The traditional Chinese medicine composition for losing weight according to claim 1, wherein the preparation process of the kelp extract comprises the following steps: soaking dried herba Zosterae Marinae in water, boiling, filtering to obtain extractive solution, concentrating to obtain extract A, precipitating with 95% ethanol, collecting supernatant, recovering ethanol to obtain extract B, precipitating with 90% ethanol, collecting supernatant, recovering ethanol, and drying.
5. The traditional Chinese medicine weight-losing composition as claimed in claim 1, wherein the preparation process of the momordica grosvenori extract comprises the following steps: crushing fresh fructus Siraitiae Grosvenorii, boiling in water, filtering to obtain extractive solution, and concentrating.
6. The traditional Chinese medicine composition for losing weight according to claim 1, wherein the preparation process of the medlar extract comprises the following steps: boiling fructus Lycii in water, filtering to obtain extractive solution, and concentrating.
7. A process for preparing a Chinese medicinal composition for weight loss as claimed in any one of claims 1 to 6, comprising the steps of:
(1) mixing Ginseng radix, radix Angelicae sinensis, rhizoma Dioscoreae and rhizoma Polygonati, pulverizing, boiling in water, filtering to remove residue to obtain leaching solution, concentrating, drying, and pulverizing to obtain powder A;
(2) mixing fructus Siraitiae Grosvenorii extract with part A of resistant dextrin, drying, and pulverizing to obtain powder B;
(3) mixing the medlar extract with the resistant dextrin of the part B, drying and crushing to obtain powder C;
(4) mixing powder A, powder B, powder C, folium Nelumbinis extract, herba Zosterae Marinae extract, residual resistant dextrin and lactalbumin.
8. The process of claim 7, wherein the partially A resistant dextrin is 5-15% resistant dextrin and the partially B resistant dextrin is 20-40% resistant dextrin.
9. The process according to claim 7, wherein the powder A, the powder B, the powder C, the lotus leaf extract, the kelp extract, the residual resistant dextrin and the whey protein are mixed in the step (4) in this order.
10. Use of the traditional Chinese medicine weight-reducing composition according to any one of claims 1 to 6 or the traditional Chinese medicine weight-reducing composition prepared by the preparation process according to any one of claims 7 to 9 in preparation of weight-reducing health products or medicines.
CN202110234127.XA 2021-03-03 2021-03-03 Medicinal and edible traditional Chinese medicine weight-losing composition Pending CN112843223A (en)

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