CN112839952A - 包含基于pd-1的嵌合蛋白的组合疗法 - Google Patents

包含基于pd-1的嵌合蛋白的组合疗法 Download PDF

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Publication number
CN112839952A
CN112839952A CN201980067213.7A CN201980067213A CN112839952A CN 112839952 A CN112839952 A CN 112839952A CN 201980067213 A CN201980067213 A CN 201980067213A CN 112839952 A CN112839952 A CN 112839952A
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cancer
binding
chimeric protein
pharmaceutical composition
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CN201980067213.7A
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Chinese (zh)
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T·施赖伯
G·弗罗姆
S·达西瓦
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Shattuck Labs Inc
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Shattuck Labs Inc
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K16/2887—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01K2207/00—Modified animals
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    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • C07K2319/00—Fusion polypeptide
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  • Pharmacology & Pharmacy (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
CN201980067213.7A 2018-08-29 2019-08-29 包含基于pd-1的嵌合蛋白的组合疗法 Pending CN112839952A (zh)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201862724600P 2018-08-29 2018-08-29
US62/724,600 2018-08-29
US201862734951P 2018-09-21 2018-09-21
US62/734,951 2018-09-21
US201962793235P 2019-01-16 2019-01-16
US62/793,235 2019-01-16
US201962832830P 2019-04-11 2019-04-11
US62/832,830 2019-04-11
US201962890217P 2019-08-22 2019-08-22
US62/890,217 2019-08-22
PCT/US2019/048923 WO2020047328A1 (en) 2018-08-29 2019-08-29 Combination therapies comprising pd-1-based chimeric proteins

Publications (1)

Publication Number Publication Date
CN112839952A true CN112839952A (zh) 2021-05-25

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CN201980067213.7A Pending CN112839952A (zh) 2018-08-29 2019-08-29 包含基于pd-1的嵌合蛋白的组合疗法
CN201980063224.8A Pending CN112771067A (zh) 2018-08-29 2019-08-29 包含基于SIRPα的嵌合蛋白的组合疗法

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CN201980063224.8A Pending CN112771067A (zh) 2018-08-29 2019-08-29 包含基于SIRPα的嵌合蛋白的组合疗法

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US (2) US20210379153A1 (https=)
EP (2) EP3844176A4 (https=)
JP (2) JP2022512541A (https=)
CN (2) CN112839952A (https=)
AU (2) AU2019327494A1 (https=)
CA (2) CA3109354A1 (https=)
IL (2) IL281095A (https=)
MX (2) MX2021002294A (https=)
WO (2) WO2020047319A1 (https=)

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WO2020047319A1 (en) * 2018-08-29 2020-03-05 Shattuck Labs, Inc. Combination therapies comprising sirp alpha-based chimeric proteins
WO2021195472A1 (en) * 2020-03-26 2021-09-30 Aetio Biotherapy, Inc. Bi-specific fusion proteins for depletion of regulatory t cells
WO2022053864A1 (en) * 2020-09-08 2022-03-17 Kwon Byoung S Pd-1 polypeptide variants
MX2023003142A (es) * 2020-09-17 2023-05-17 Shattuck Labs Inc Dosificacion clinica de proteina quimerica sirp1a.
AU2021378152A1 (en) * 2020-11-11 2023-06-22 Daiichi Sankyo Company, Limited COMBINATION OF AN ANTIBODY-DRUG CONJUGATE WITH ANTI-SIRPα ANTIBODY
EP4274852A4 (en) * 2021-01-11 2025-02-26 Eutilex Co., Ltd. BISPECIFIC EPITOP-BINDING PROTEIN WITH ANTI-4-1BB ANTIBODY AND PD-1 PROTEIN OR FRAGMENTS THEREOF AND USE THEREOF
EP4301470A4 (en) * 2021-03-05 2025-01-22 Shattuck Labs, Inc. COMBINATION THERAPIES WITH SIRP-ALPHA-BASED CHIMERIC PROTEINS
WO2024123812A1 (en) 2022-12-05 2024-06-13 Shattuck Labs, Inc. Fusion proteins for the treatment of cardiometabolic diseases

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