CN112839928B - 用于制备3-[5-氨基-4-(3-氰基苯甲酰基)-吡唑化合物的合成方法 - Google Patents
用于制备3-[5-氨基-4-(3-氰基苯甲酰基)-吡唑化合物的合成方法 Download PDFInfo
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- CN112839928B CN112839928B CN201980063294.3A CN201980063294A CN112839928B CN 112839928 B CN112839928 B CN 112839928B CN 201980063294 A CN201980063294 A CN 201980063294A CN 112839928 B CN112839928 B CN 112839928B
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
- C07C243/10—Hydrazines
- C07C243/22—Hydrazines having nitrogen atoms of hydrazine groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/56—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and doubly-bound oxygen atoms bound to the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Health & Medical Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1815695.0 | 2018-09-26 | ||
| GBGB1815695.0A GB201815695D0 (en) | 2018-09-26 | 2018-09-26 | Synthetic method |
| PCT/GB2019/052718 WO2020065323A1 (en) | 2018-09-26 | 2019-09-26 | Synthetic method for the preparation of a 3-[5-amino-4-(3-cyanobenzoyl)-pyrazol compound |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN112839928A CN112839928A (zh) | 2021-05-25 |
| CN112839928B true CN112839928B (zh) | 2024-04-30 |
Family
ID=64024269
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201980063294.3A Active CN112839928B (zh) | 2018-09-26 | 2019-09-26 | 用于制备3-[5-氨基-4-(3-氰基苯甲酰基)-吡唑化合物的合成方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US11649213B2 (https=) |
| EP (1) | EP3856721B1 (https=) |
| JP (1) | JP7291782B2 (https=) |
| KR (1) | KR102711257B1 (https=) |
| CN (1) | CN112839928B (https=) |
| AU (1) | AU2019350525B2 (https=) |
| CA (1) | CA3112993A1 (https=) |
| DK (1) | DK3856721T3 (https=) |
| ES (1) | ES2943289T3 (https=) |
| GB (1) | GB201815695D0 (https=) |
| IL (1) | IL281636B2 (https=) |
| WO (1) | WO2020065323A1 (https=) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3658838A (en) * | 1968-11-16 | 1972-04-25 | Bayer Ag | Process for the preparation of 1 5-disubstituted-4-cyano-pyrazoles |
| US5922741A (en) * | 1996-04-24 | 1999-07-13 | Celltech Therapeutics Ltd. | 5-aminopyrazoles useful as tyrosine kinase inhibitors |
| US6103900A (en) * | 1992-12-17 | 2000-08-15 | Pfizer Inc | Pyrazoles and pyrazolopyrimidines having CRF antagonistic activity |
| CN1832928A (zh) * | 2003-06-26 | 2006-09-13 | 诺瓦提斯公司 | 以5元杂环为基础的p38激酶抑制剂 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4686221A (en) * | 1985-10-01 | 1987-08-11 | Kanebo, Ltd. | Quinolinecarboxylic acid compounds and antimicrobial agent containing the same |
| US6005109A (en) * | 1997-10-30 | 1999-12-21 | Pflizer Inc. | Pyrazoles and pyrazolopyrimidines having CRF antagonistic activity |
| FR2732967B1 (fr) | 1995-04-11 | 1997-07-04 | Sanofi Sa | 1-phenylpyrazole-3-carboxamides substitues, actifs sur la neurotensine, leur preparation, les compositions pharmaceutiques en contenant |
| HRP20000724A2 (en) * | 1998-05-05 | 2001-06-30 | Hoffmann La Roche | Pyrazole derivatives as p-38 map kinase inhibitors |
| WO2005007632A1 (en) | 2003-07-18 | 2005-01-27 | Pharmacia Corporation | Substituted pyridazinones as inhibitors of p38 |
| US7485657B2 (en) | 2004-05-12 | 2009-02-03 | Boehringer Ingelheim Pharmaceuticals, Inc. | Anti-cytokine heterocyclic compounds |
| ATE510836T1 (de) | 2006-01-19 | 2011-06-15 | Matrix Lab Ltd | Umwandlung eines aromatischen diazoniumsalzes in ein arylhydrazin |
| AU2008281594A1 (en) | 2007-08-02 | 2009-02-05 | Generics [Uk] Limited | Novel process |
| WO2009088025A1 (ja) | 2008-01-10 | 2009-07-16 | Hokko Chemical Industry Co., Ltd. | フェニルトリアゾリノン類の製造法 |
| JP5602387B2 (ja) | 2008-05-02 | 2014-10-08 | キヤノン株式会社 | インクジェット用インク、インクジェット記録方法、インクカートリッジ、記録ユニット、及びインクジェット記録装置 |
| CN102964270B (zh) | 2012-11-21 | 2015-01-07 | 合肥星宇化学有限责任公司 | 一种亚硫酸钠还原重氮盐合成肼的方法 |
| WO2018059533A1 (zh) | 2016-09-29 | 2018-04-05 | 南京明德新药研发股份有限公司 | p38αMAPK激酶抑制剂及其制备方法和应用 |
-
2018
- 2018-09-26 GB GBGB1815695.0A patent/GB201815695D0/en not_active Ceased
-
2019
- 2019-09-26 CN CN201980063294.3A patent/CN112839928B/zh active Active
- 2019-09-26 WO PCT/GB2019/052718 patent/WO2020065323A1/en not_active Ceased
- 2019-09-26 KR KR1020217008904A patent/KR102711257B1/ko active Active
- 2019-09-26 EP EP19780305.9A patent/EP3856721B1/en active Active
- 2019-09-26 IL IL281636A patent/IL281636B2/en unknown
- 2019-09-26 ES ES19780305T patent/ES2943289T3/es active Active
- 2019-09-26 US US17/279,553 patent/US11649213B2/en active Active
- 2019-09-26 CA CA3112993A patent/CA3112993A1/en active Pending
- 2019-09-26 JP JP2021516883A patent/JP7291782B2/ja active Active
- 2019-09-26 DK DK19780305.9T patent/DK3856721T3/da active
- 2019-09-26 AU AU2019350525A patent/AU2019350525B2/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3658838A (en) * | 1968-11-16 | 1972-04-25 | Bayer Ag | Process for the preparation of 1 5-disubstituted-4-cyano-pyrazoles |
| US6103900A (en) * | 1992-12-17 | 2000-08-15 | Pfizer Inc | Pyrazoles and pyrazolopyrimidines having CRF antagonistic activity |
| US5922741A (en) * | 1996-04-24 | 1999-07-13 | Celltech Therapeutics Ltd. | 5-aminopyrazoles useful as tyrosine kinase inhibitors |
| CN1832928A (zh) * | 2003-06-26 | 2006-09-13 | 诺瓦提斯公司 | 以5元杂环为基础的p38激酶抑制剂 |
Non-Patent Citations (3)
| Title |
|---|
| 1-甲基-5-氨基-4-氰基吡唑的合成;陆慧, 洪梅, 陈书明, 肖亚平;江苏化工(第03期);第35-36页 * |
| Microwave-assisted synthesis of a pyrazolyl ketone library for evaluation as p38 MAPK inhibitors in Werner syndrome cells;Bagley, Mark C et al.;《Future Medicinal Chemistry》;第2卷(第2期);第203-213页 * |
| Synthesis of 4-cyano- and 5-aminopyrazoles and deamination of 5-aminopyrazoles;Toche, R. B et al.;《Organic Preparations and Procedures International》;第40卷(第6期);第551-556页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2020065323A1 (en) | 2020-04-02 |
| KR102711257B1 (ko) | 2024-09-30 |
| US20210395207A1 (en) | 2021-12-23 |
| JP2022502400A (ja) | 2022-01-11 |
| EP3856721A1 (en) | 2021-08-04 |
| DK3856721T3 (da) | 2023-04-24 |
| US11649213B2 (en) | 2023-05-16 |
| EP3856721B1 (en) | 2023-03-29 |
| IL281636B2 (en) | 2024-08-01 |
| AU2019350525A1 (en) | 2021-04-15 |
| CN112839928A (zh) | 2021-05-25 |
| AU2019350525B2 (en) | 2024-05-02 |
| IL281636B1 (en) | 2024-04-01 |
| JP7291782B2 (ja) | 2023-06-15 |
| KR20210069044A (ko) | 2021-06-10 |
| IL281636A (en) | 2021-05-31 |
| CA3112993A1 (en) | 2020-04-02 |
| GB201815695D0 (en) | 2018-11-07 |
| ES2943289T3 (es) | 2023-06-12 |
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| GR01 | Patent grant | ||
| GR01 | Patent grant |