CN112823038B - 用于移除生物膜的hmgb1蛋白衍生物 - Google Patents

用于移除生物膜的hmgb1蛋白衍生物

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Publication number
CN112823038B
CN112823038B CN201980063976.4A CN201980063976A CN112823038B CN 112823038 B CN112823038 B CN 112823038B CN 201980063976 A CN201980063976 A CN 201980063976A CN 112823038 B CN112823038 B CN 112823038B
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China
Prior art keywords
polypeptide
biofilm
lys
isolated
box
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English (en)
Chinese (zh)
Other versions
CN112823038A (zh
Inventor
史蒂文·大卫·古德曼
劳伦·奥普雷马克·巴卡莱茨
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Nationwide Childrens Hospital Inc
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Nationwide Childrens Hospital Inc
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Priority to CN202411517594.3A priority Critical patent/CN119569846A/zh
Publication of CN112823038A publication Critical patent/CN112823038A/zh
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Gram-negative bacteria
    • C07K16/1228—Enterobacterales (O), e.g. Citrobacter (G), Serratia (G), Proteus (G), Providencia (G), Morganella (G) or Yersinia (G)
    • C07K16/1232—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201980063976.4A 2018-10-05 2019-10-04 用于移除生物膜的hmgb1蛋白衍生物 Active CN112823038B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202411517594.3A CN119569846A (zh) 2018-10-05 2019-10-04 用于移除生物膜的hmgb1蛋白衍生物

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862742102P 2018-10-05 2018-10-05
US62/742,102 2018-10-05
PCT/US2019/054851 WO2020072993A1 (en) 2018-10-05 2019-10-04 Hmgb1 protein derivatives for the removal of biofilms cross-reference to related application

Related Child Applications (1)

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CN202411517594.3A Division CN119569846A (zh) 2018-10-05 2019-10-04 用于移除生物膜的hmgb1蛋白衍生物

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CN112823038A CN112823038A (zh) 2021-05-18
CN112823038B true CN112823038B (zh) 2025-10-03

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CN202411517594.3A Pending CN119569846A (zh) 2018-10-05 2019-10-04 用于移除生物膜的hmgb1蛋白衍生物

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Country Link
US (2) US12365710B2 (https=)
EP (1) EP3860718A4 (https=)
JP (2) JP2022504139A (https=)
KR (1) KR20210070331A (https=)
CN (2) CN112823038B (https=)
AU (2) AU2019354829B2 (https=)
BR (1) BR112021006321A2 (https=)
CA (1) CA3114905A1 (https=)
IL (1) IL281720B2 (https=)
MX (1) MX2021003838A (https=)
SG (1) SG11202103001PA (https=)
WO (1) WO2020072993A1 (https=)

Families Citing this family (7)

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US11274144B2 (en) 2013-06-13 2022-03-15 Research Institute At Nationwide Children's Hospital Compositions and methods for the removal of biofilms
WO2017023863A1 (en) 2015-07-31 2017-02-09 Research Institute At Nationwide Children's Hospital Peptides and antibodies for the removal of biofilms
JP7661008B2 (ja) 2017-01-04 2025-04-14 リサーチ インスティチュート アット ネイションワイド チルドレンズ ホスピタル バイオフィルム関連障害の処置のための抗体断片
WO2018170178A1 (en) 2017-03-15 2018-09-20 Research Institute At Nationwide Children's Hospital Composition and methods for disruption of bacterial biofilms without accompanying inflammation
AU2019354829B2 (en) 2018-10-05 2025-04-17 Research Institute At Nationwide Children's Hospital Hmgb1 protein derivatives for the removal of biofilms
CA3183196A1 (en) * 2020-07-07 2022-01-13 Steven D. Goodman Combination therapies for the treatment and prevention of biofilms
EP4615483A2 (en) * 2022-11-11 2025-09-17 Research Institute at Nationwide Children's Hospital Compositions and methods for treating biofilms and neutrophil extracellular trap formation

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JP2024128051A (ja) 2024-09-20
IL281720B1 (en) 2025-11-01
AU2019354829A1 (en) 2021-04-29
IL281720B2 (en) 2026-03-01
CN119569846A (zh) 2025-03-07
US12365710B2 (en) 2025-07-22
AU2019354829B2 (en) 2025-04-17
AU2025205453A1 (en) 2025-07-31
SG11202103001PA (en) 2021-04-29
EP3860718A1 (en) 2021-08-11
US20250368703A1 (en) 2025-12-04
MX2021003838A (es) 2021-05-27
WO2020072993A1 (en) 2020-04-09
EP3860718A4 (en) 2022-08-31
CA3114905A1 (en) 2020-04-09
US20210340198A1 (en) 2021-11-04
JP2022504139A (ja) 2022-01-13
BR112021006321A2 (pt) 2021-07-06
CN112823038A (zh) 2021-05-18
KR20210070331A (ko) 2021-06-14
IL281720A (en) 2021-05-31

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