CN112798799B - Sample analysis system and sample testing method - Google Patents
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
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Abstract
A sample analysis system and a sample test method control the test of a test item for concurrent modification of a sample, and judge whether the test of the test item for concurrent modification is performed on the sample according to the test condition of the test item for concurrent modification of the sample, which improves the test flow and can play roles such as saving time, avoiding wasting reagent, avoiding wasting blood sample, and the like.
Description
Technical Field
The invention relates to a sample analysis system and a sample testing method.
Background
C-Reactive protein (CRP) is an acute phase protein synthesized by liver cells when an organism is subjected to inflammatory stimuli such as microbial invasion or tissue injury, CRP rises within a few hours after the initiation of inflammation, peaks in 48 hours, and then CRP also falls to a normal level along with lesion regression or tissue, structure and function recovery. Therefore, the detection of CRP is quite extensive in clinical application, and can be applied to the fields including, but not limited to, diagnosis and differential diagnosis of acute infectivity, monitoring of postoperative infection, observation of antibiotic curative effect, disease course detection and prognosis judgment.
One way to detect CRP is to detect CRP in serum mode. Specifically, a blood sample (whole blood) is collected from a human body, then serum is extracted from the whole blood, and then the serum is subjected to immunoassay detection, for example, a specific reagent is added into the serum, so that CRP in the serum reacts with the reagent to generate an agglutinate, then a reaction solution after generating the agglutinate is irradiated by using light waves with the wavelength of 600nm to 2400nm, and finally the concentration of CRP is obtained by analyzing the absorption or scattering degree of light. However, since this method requires serum to be extracted from whole blood, and in practice, whole blood is often required for other tests such as routine blood tests, etc., the total blood volume required to be collected is relatively large, which causes great trouble to patients with difficult blood collection, particularly pediatric patients.
Another way to detect CRP is to detect CRP in whole blood mode, i.e. directly from collected whole blood. Since CRP is an index of inflammation and is detected in this way using whole blood, it is quite often the case that the whole blood CRP detection is bundled with blood routine detection, for example, blood routine detection and whole blood CRP detection are performed separately using the same blood sample, and thus the total blood volume required to be collected can be reduced, which is friendly to patients with difficult blood collection, particularly pediatric patients.
However, there is still room for improvement in conducting CRP testing on whole blood and conventional testing procedures on blood.
Disclosure of Invention
The application provides a sample analysis system and a sample testing method.
According to a first aspect, an embodiment provides a sample analysis system comprising:
the first measuring module is used for carrying out a first type of test item on the sample;
the second measurement module is used for carrying out a second type of test item on the sample; the first type of test items at least comprise test items for concurrent modification, and the second type of test items at least comprise test items to be modified, wherein the test data of the test items for concurrent modification are used for modifying the test items to be modified;
and the controller is used for controlling the sample to be dispatched to the first measuring module to at least test the test item for concurrent modification, and judging whether the sample is dispatched to the second measuring module to test the test item to be modified according to the test condition of the test item for concurrent modification of the sample.
In an embodiment, the controller determines whether to control the sample to be scheduled to the second measurement module for testing the test item to be corrected according to the test condition of the test item for both correction of the sample, and includes:
And when the test of the test item which is used for correcting the sample is abnormal, the controller pauses to control the sample to be scheduled to the second measurement module for testing the test item which needs to be corrected.
In one embodiment, the controller pauses the control of the sample dispatching to the second measurement module for testing of the test item to be corrected, including:
the controller controls the scheduling of samples to locations for retrieval by a user;
when the sample is input again, the controller controls the sample to be scheduled to the first measuring module to at least test the dual-purpose correcting test item, and judges whether the sample is scheduled to the second measuring module to test the required correcting test item according to the test condition of the dual-purpose correcting test item of the sample; or,
when the sample is re-input, the controller directly controls the sample to be scheduled to the second measurement module for testing of the test item to be corrected.
In one embodiment, the controller pauses the control of the sample dispatching to the second measurement module for testing of the test item to be corrected, including:
the controller controls the samples to be dispatched to a buffer area for waiting;
Responding to a first test command, the controller controls the samples to be dispatched from the buffer area to the first measurement module to at least test the concurrently correcting test items, and judges whether to control the samples to be dispatched to the second measurement module to test the test items to be corrected according to the test condition of the concurrently correcting test items of the samples; or, in response to a second test command, the controller directly controls the sample to be dispatched to a second measurement module to perform the test of the test item to be corrected;
and responding to a third test command, controlling the sample to be dispatched to a position for taking out by a user by the controller, controlling the sample to be dispatched to the first measurement module to at least test the dual-correction test item when the sample is reentered, and re-judging whether the sample is dispatched to the second measurement module to test the required-correction test item according to the test condition of the dual-correction test item of the sample.
In one embodiment, the controller pauses the control of the sample dispatching to the second measurement module for testing of the test item to be corrected, including:
The controller controls the sample to stay in the first measurement module;
responding to a first test command, controlling a first measurement module to test the test item for the concurrent modification of the sample by the controller, and judging whether to control the sample to be dispatched to a second measurement module to test the test item for the modification according to the test condition of the test item for the concurrent modification of the sample; or, in response to a second test command, the controller directly controls the sample to be dispatched to a second measurement module to perform the test of the test item to be corrected;
and responding to a third test command, dispatching the sample to a position for taking out by a user by the controller, controlling the sample to be dispatched to the first measurement module to at least test the dual-correction test item by the controller when the sample is reentered, and re-judging whether the sample is dispatched to the second measurement module to test the required-correction test item according to the test condition of the dual-correction test item of the sample.
In one embodiment, the controller further generates alarm information for prompting the user when it is determined that the test of the sample dual-purpose test item is abnormal.
In one embodiment, the first measurement module is a blood routine module and the second measurement module is a whole blood CRP module.
According to a second aspect, an embodiment provides a sample testing method comprising:
receiving a sample;
controlling the test of the test item for the sample for the dual-purpose correction;
judging whether to test the test item to be corrected for the sample according to the test condition of the test item for the sample; the test data of the test item for correction is used for correcting the test item to be corrected.
In an embodiment, the determining whether to test the test item to be corrected for the sample according to the test condition of the test item to be corrected for the sample includes:
when the test of the test item which is used for correcting the sample is abnormal, controlling to pause the test of the test item which needs to be corrected on the sample.
In one embodiment, the controlling to suspend the test of the test item to be corrected on the sample includes:
controlling the sample to be dispatched to a position for retrieval by a user;
when the sample is input again, controlling to test at least the test item for concurrent modification on the sample, and judging whether to test the test item for concurrent modification on the sample according to the test condition of the test item for concurrent modification on the sample; or,
When the sample is input again, controlling the sample to be tested for the test item to be corrected and not to be tested for the test item for the dual-purpose correction.
In one embodiment, the controlling to suspend the test of the test item to be corrected on the sample includes:
controlling the sample to be dispatched to a buffer area for waiting;
responding to a first test command, controlling the samples to be dispatched from the buffer area to at least test the concurrent modification test items, and judging whether to test the concurrent modification test items of the samples according to the test conditions of the concurrent modification test items of the samples; or, in response to a second test command, controlling the samples to be dispatched from the buffer area to perform the test of the test item to be corrected and not to perform the test of the test item for concurrent correction;
and responding to a third test command, controlling to dispatch the sample to a position for taking out by a user, controlling to test at least the test item for concurrent modification on the sample when the sample is re-input, and judging whether to test the test item for concurrent modification on the sample according to the test condition of the test item for concurrent modification on the sample.
In one embodiment, the controlling to suspend the test of the test item to be corrected on the sample includes:
controlling the sample to stay at the current position;
responding to the first test command, controlling the test of the test item for concurrent modification to the sample, and judging whether the test of the test item to be modified is performed on the sample according to the test condition of the test item for concurrent modification of the sample; or, in response to the second test command, controlling the sample to continue the test of the test item to be corrected;
and responding to a third test command, controlling to dispatch the sample to a position for taking out by a user, controlling to test at least the test item for concurrent modification on the sample when the sample is re-input, and judging whether to test the test item for concurrent modification on the sample according to the test condition of the test item for concurrent modification on the sample.
In one embodiment, when it is determined that the test of the sample dual-purpose test item is abnormal, alarm information for prompting the user is also generated.
In one embodiment, the dual-purpose calibration test item is a blood routine test item, and the test item to be calibrated is a whole blood CRP test item.
According to a third aspect, an embodiment provides a computer readable storage medium comprising a program executable by a processor to implement a method as described in any of the embodiments herein.
According to the sample analysis system, the sample testing method and the computer readable storage medium of the above embodiments, the test of the dual-purpose test item for sample is controlled, and whether the test of the test item for sample to be corrected is performed is judged according to the test condition of the dual-purpose test item for sample, which improves the test flow, and can play roles such as saving time, avoiding wasting reagent, avoiding wasting blood sample, and the like.
Drawings
FIG. 1 is a schematic diagram of a sample analysis system according to one embodiment;
FIG. 2 (a) is a schematic diagram of a sample analysis system according to another embodiment; FIG. 2 (b) is a schematic diagram of a sample analysis system according to yet another embodiment;
FIG. 3 is a schematic diagram of a pre-processing module according to one embodiment;
FIG. 4 is a schematic diagram of an aftertreatment module of an embodiment;
FIG. 5 is a schematic diagram of a sample analysis system according to yet another embodiment;
FIG. 6 is a schematic diagram of a sample analysis system according to yet another embodiment;
FIG. 7 is a flow chart of a sample testing method according to an embodiment;
FIG. 8 is a flow chart of a sample testing method according to another embodiment.
Detailed Description
The invention will be described in further detail below with reference to the drawings by means of specific embodiments. Wherein like elements in different embodiments are numbered alike in association. In the following embodiments, numerous specific details are set forth in order to provide a better understanding of the present application. However, one skilled in the art will readily recognize that some of the features may be omitted, or replaced by other elements, materials, or methods in different situations. In some instances, some operations associated with the present application have not been shown or described in the specification to avoid obscuring the core portions of the present application, and may not be necessary for a person skilled in the art to describe in detail the relevant operations based on the description herein and the general knowledge of one skilled in the art.
Furthermore, the described features, operations, or characteristics of the description may be combined in any suitable manner in various embodiments. Also, various steps or acts in the method descriptions may be interchanged or modified in a manner apparent to those of ordinary skill in the art. Thus, the various orders in the description and drawings are for clarity of description of only certain embodiments, and are not meant to be required orders unless otherwise indicated.
The numbering of the components itself, e.g. "first", "second", etc., is used herein merely to distinguish between the described objects and does not have any sequential or technical meaning. The terms "coupled" and "connected," as used herein, are intended to encompass both direct and indirect coupling (coupling), unless otherwise indicated.
A description will be given of routine blood tests. Blood routine refers to an examination for judging Blood conditions and diseases by the number change and morphological distribution of Blood cells, and generally, blood routine tests include White Blood Cell (WBC), red Blood Cell (RBC), platelet count (PLT), hemoglobin concentration (HGB), hematocrit (HCT), and the like, and further, white Blood Cell count may be further classified into three, four, five, and the like.
When detecting CRP using whole blood, the resulting CRP concentration typically needs to be corrected, for example, by some of the results of the blood routine to correct the CRP concentration resulting from the whole blood detection. One way to correct is by correcting the hematocrit HCT in the blood routine, the formula can be as follows:
CRP’＝CRP*100/(100-HCT)；
wherein, CRP' is the corrected C-reactive protein concentration, CRP is the C-reactive protein before correction.
Other ways of correcting CRP concentration by other test results in the blood routine are not listed here. For convenience of description, herein, parameters in blood routine for correcting the concentration of CRP in whole blood are referred to as blood routine correction parameters.
Currently, for convenience of detection, a whole blood CRP module and a blood routine module are generally combined to form a pipelined system or a desktop combined system, so that blood routine detection and whole blood CRP detection are performed on blood samples in one system, and then the detection result of the whole blood CRP is corrected through the detection result in the blood routine detection. Specifically, samples can be firstly scheduled to a blood routine module for sample suction and testing, then the samples are rescheduled to a whole blood CRP module for sample suction and testing, and finally the detection results of the whole blood CRP are corrected by utilizing some detection results in the blood routine detection in the system.
The applicant has found that the above test procedure suffers from a number of problems in practice. In some test flows, after samples are dispatched to a blood routine module for sample suction and test, then, the samples are dispatched to a whole blood CRP module for sample suction and test continuously, and finally, if the blood routine detection is found to be abnormal, particularly, when the blood routine correction parameters are related to the abnormality, the blood routine result cannot correct the concentration of the whole blood CRP because the blood routine is abnormal, so that a user, such as a doctor, can redo the blood routine detection and the whole blood CRP on the samples under the condition, and the method needs improvement.
In view of the unreasonable test flow, the applicant proposes to schedule the sample to the blood routine module for testing, and then judge whether to continue to schedule the sample to the whole blood CRP module for testing according to the condition of the blood routine test, for example, if the blood routine test is abnormal, alarm is given to prompt the user for processing; if the blood routine test is normal, the sample is again scheduled to the whole blood CRP module for testing. This has a number of benefits: firstly, the time spent for detecting CRP in whole blood is generally 3 to 4 times longer than that of blood routine detection, so that the time can be saved compared with the prior proposal by the applicant; secondly, the cost of the test reagent of the whole blood CRP is higher, and the repeated test of the whole blood CRP is wasteful and the cost is increased as in the previous scheme; thirdly, the improvement scheme ensures that the CRP concentration of the whole blood can be effectively corrected, and the traditional scheme can possibly correct the CRP concentration of the whole blood by using abnormal blood routine correction parameters due to neglect of users, so that the clinical risk is increased; fourth, the whole blood CRP is tested once more, and thus, one consequence that the previous proposal may occur is that the conventional retested whole blood CRP and the insufficient whole blood CRP are caused by performing an ineffective whole blood CRP test, the patient needs to be found again for blood drawing, and the proposal avoids the occurrence of the situation as much as possible.
Further expanding, in some sample analysis systems, if there are some cases that the results of some items (for example, the item Test 1) are corrected depending on the results of other items (for example, the item Test 2), then the detection of the item Test2 can be performed first, then whether the detection of the item Test1 is continued on the sample is judged according to the Test condition of the item Test2, if the Test of the item Test2 is abnormal, an alarm is given, and the user is prompted to process; if the Test of item Test2 is normal, then the Test of item Test1 is continued on the sample.
Through the above analyses and studies, the applicant has proposed a sample analysis system. Referring to fig. 1, a sample analysis system of some embodiments may include a controller 70 and a plurality of measurement modules 10, wherein the measurement modules 10 are used to test a sample.
In some embodiments, the system configuration of the plurality of measurement modules 10 is a desktop combination configuration. In some examples, multiple measurement modules 10 may be integrated within a single device, and then samples transferred between the measurement modules 10 by some mechanism such as a robot, a dispatch cart, etc.
In other embodiments, the system configuration of the plurality of measurement modules 10 may be a pipelined configuration. In some examples, each measurement module 10 is a separate analysis device, which is then cascaded by rails or the like. Fig. 2 (a) and 2 (b) are two examples. Referring to fig. 2, the sample analysis system of some embodiments may further include an input module 20, a pre-processing module 30, a track 40, a scheduler 50, a post-processing module 60, and a display 80.
The input module 20 may be used to receive a sample to be tested that is placed by a user. In some embodiments, the input module 20 may also obtain identification information of the sample to be tested. The user may put the sample to be tested into the input module 20, and the input module 20 may scan the label such as a barcode or a two-dimensional code on the sample to be tested through the scanning device, so as to obtain the identification information of the sample to be tested. The identification information may include, for example, a sample number, a sample category, sample source information, and the like.
The preprocessing module 30 is configured to perform preprocessing on the sample to be tested received by the input module. Generally, after the user puts the sample into the input module 20, the input module 20 scans the sample, the dispatching device 50 dispatches the sample to the pre-processing module 30 for pre-processing, and the pre-processed sample is dispatched from the pre-processing module 30 to the corresponding measuring module 10 for testing. In one embodiment, referring to fig. 3, the pretreatment module 30 may include one or more of a centrifugation module 31, a serum detection module 32, a cap removal module 33, and a separation module 34. The centrifugation module 31 is used for centrifuging the sample to be centrifuged, and the number of the centrifugation modules 31 may be one or more. The serum detection module 32 is configured to detect whether the serum level of the sample is sufficient and/or whether the serum quality of the sample is acceptable to determine whether the centrifuged sample is available for subsequent testing. The cap removal module 33 is used to cap, membrane, cap and membrane the centrifuged sample, which is referred to herein as capping, membrane, cap and membrane the sample tube containing the sample; typically the sample after centrifugation requires removal of the cap for subsequent dispensing or pipetting by the dispensing module 34 or the measurement module. The parting block 34 is used to divide a sample, for example, a single sample into multiple samples, for separate feeding into different measurement modules 10 for measurement. One typical preprocessing flow for the preprocessing module 30 is: the centrifugation module 31 receives the samples scheduled by the input module 20 and performs centrifugation on the samples; the serum detection module 32 detects serum of the centrifuged sample to determine whether the sample is available for subsequent measurement, and if the serum is insufficient in quantity or quality is not acceptable, the sample cannot be used for subsequent measurement; if the detection is passed, the sample is dispatched to the cap removing module 33, the cap removing module 33 removes the cap of the sample, if the sample separating module 34 is provided, the sample separating module 34 separates the removed sample, then the separated sample is dispatched to the corresponding measuring module 10 for measurement, and if the sample separating module 34 is not provided, the sample is dispatched from the cap removing module 33 to the corresponding measuring module 10 for measurement. It should be noted that the preprocessing module 30 is an optional module, that is, the sample analysis system in some embodiments may include the preprocessing module 30, and the sample analysis system in some embodiments may not include the preprocessing module 30.
The track 40 is used to connect the devices together. For example, the track 40 connects the input module 20 and the plurality of measurement modules 10 such that samples may be dispatched from the input module 20 to each measurement module 10 for testing via the track 40. In some examples including the pre-processing module 30 and the post-processing module 60, the track 40 then connects the input module 20, the pre-processing module 30, each measurement module 10, and the post-processing module 60 in sequence.
The scheduler 50 is used to schedule samples through the track 40, for example from the input module 20 into the measurement modules 10, to be scheduled from one measurement module 10 into another measurement module 10.
The post-processing module 60 is used for completing post-processing of the sample. In one embodiment, referring to fig. 4, the post-processing module 60 includes one or more of a film/capping module 61, a refrigerated storage module 62, and a film/capping module 63. The film/cap module 61 is used for film or cap the sample; the refrigerated storage module 62 is used for storing samples; the stripping/capping module 63 is used to strip or cap the sample. One typical post-processing flow of the post-processing module 60 is: after the samples are sucked in all the measuring modules 10 to be measured, the samples are then dispatched to a film adding/covering module 61, the film adding/covering module 61 adds films or covers the measured samples, and then dispatched to a cold storage module 62 for storage; if the sample needs to be retested, the sample is dispatched from the refrigerated storage module 62 and removed from the film or lid in the film/lid removal module 63 and then dispatched to the corresponding measurement module 10 for testing. It should be noted that the post-processing module 60 is an optional module, that is, the sample analysis system in some embodiments may include the post-processing module 60, and the sample analysis system in some embodiments may not include the post-processing module 60.
The display 80 is used to display information, such as a related user interface on which a user may view information, interact, etc. It should be noted that display 80 is optional, i.e., display 80 may be included in the sample analysis system in some embodiments, and display 80 may not be included in the sample analysis system in some embodiments.
Fig. 5 is a schematic diagram of another structure of a sample analysis system including a pre-processing module 30 and a post-processing module 60 according to the present invention. As shown in fig. 5, each module may be further provided with a module buffer, the track 40 may also have a track buffer, and the entire track may be a circulating track. It should be noted that many modules are shown in the drawings, but those skilled in the art will understand that the number is not limited herein, for example, the centrifugal module 31 may be plural, the decap module 33 may be plural, etc.
The foregoing is a description of the structure of a sample analysis system according to some embodiments of the invention.
Referring to fig. 6, in the sample analysis system according to some embodiments of the present invention, there are at least two measurement modules 10, one of which is a first measurement module 11 and the other is a second measurement module 12, and the first measurement module 11 and the second measurement module 12 are described below.
The first measurement module 11 is configured to perform a first type of test item on the sample, and the second measurement module 12 is configured to perform a second type of test item on the sample, where the first type of test item includes at least a dual-purpose test item for correction, and the second type of test item includes at least a test item for correction, and test data of the dual-purpose test item for correction is used for correcting the test item for correction. The test data herein includes test process data and/or result data.
In some embodiments, the first measurement module 11 may be a blood routine module. The blood routine module is used to perform some blood routine testing of the sample, such as WBC, RBC, PLT, HGB and HCT, etc. exemplified above, and/or three-, four-, or five-class testing of leukocytes, etc. In some specific embodiments, the blood routine module may include one or more of a BASO test channel, a DIFF test channel, an HGB test channel, and an HCT test channel. In some embodiments, the BASO test channel is used to detect white blood cell count and basophil classification. In some embodiments, the DIFF test channel is used to detect four classes of white blood cells. In some embodiments, the HGB channel is used to detect hemoglobin concentration. In some embodiments the HCT test channel is used to detect counts and morphological parameters of red blood cells and platelets.
In some embodiments, the second measurement module 12 may be a whole blood CRP module. The whole blood CRP module is used for carrying out whole blood CRP project test. In some examples, the whole blood CRP module can be configured to perform a whole blood CRP concentration test on a blood sample using an immunonephelometry.
As described above, in some embodiments the first measurement module 11 may be a blood conventional module and in some embodiments the second measurement module 12 may be a whole blood CRP module; accordingly, the test item for correction may be a test item related to the blood routine correction parameter in the blood routine module, and the test item to be corrected may be a whole blood CRP test item.
After the first measurement module 11 and the second measurement module 12 are described, a description will be given below of how the controller 70 controls the sample to be tested in the first measurement module 11 and the second measurement module 12.
The controller 70 controls the sample to be dispatched to the first measurement module 11 to perform at least the test of the test item for concurrent modification, and determines whether to control the sample to be dispatched to the second measurement module 12 to perform the test of the test item for concurrent modification according to the test condition of the test item for concurrent modification of the sample.
In some embodiments, the test conditions of the test item for concurrent modification of the sample include two conditions, one is that the test of the test item for concurrent modification of the sample is abnormal and one is that the test of the test item for concurrent modification of the sample is normal. There are various reasons for the abnormality in the test, including sample abnormality and measurement module abnormality, which are described below.
Sample anomalies refer to anomalies in the test due to anomalies in the sample. For example, the sample is not sufficiently blood, resulting in the measurement module failing to draw enough blood sample for testing; for another example, the sample itself may be rejected, such as if the sample has clotted, or impurities may be introduced during the blood collection process; there are, of course, other circumstances that lead to anomalies in the sample, not specifically illustrated herein.
The abnormal measurement module refers to that the test is abnormal due to the abnormal measurement module. For example, bubbles are sucked in the sample sucking process of the measuring module, or impurities are in the sampling pipe, so that abnormal testing occurs; for another example, the measurement module may fail during the test; as another example, the measurement module may be abnormal in terms of reagents, such as contamination, expiration, or mishandling of reagents.
As described above, the controller 70 determines whether to control the sample to be scheduled to the second measurement module 12 for the test of the test item to be corrected according to the test condition of the test item for sample and correction; in some specific embodiments, it may be: when it is determined that an abnormality occurs in the test of the concurrently corrected test item of the sample, such as the sample abnormality mentioned above, or the measurement module abnormality, etc., the controller 70 pauses controlling the scheduling of the sample to the second measurement module 12 for the test of the test item to be corrected. In some embodiments, when it is determined that the test of the concurrently modified test item of the sample is normal, the controller 70 controls the sample to be scheduled to the second measurement module 12 for testing of the test item to be modified. For example, in the case of the existing sample S, the controller 70 controls the sample S to be scheduled to the first measurement module 11 to perform at least the test of the dual-purpose test item, and then, when determining that the test of the dual-purpose test item of the sample S is abnormal, pauses the control to schedule the sample S to the second measurement module 12 to perform the test of the test item to be corrected; if the test of the test item with the function of correcting the sample S is determined to be normal, the sample S is scheduled to the second measuring module 12 for testing the test item to be corrected.
When it is determined that the test of the test item for sample and correction is abnormal, the controller 70 pauses to control the sample to be scheduled to the second measurement module 12 for the test of the test item for correction, and several specific implementations are provided, and the following tests are performed.
In some embodiments, the controller 70 pauses the scheduling of samples to the second measurement module 12 for testing of the test item to be modified, which may be:
(1) The controller 70 controls the scheduling of samples to locations for retrieval by the user; the user can check the test state of the test item to be corrected, check what problem is detected, determine whether the sample is abnormal or the measurement module is abnormal, and remove the fault accordingly, for example, by shaking the test tube to determine whether the blood volume of the sample is sufficient, whether there is a clot or not, if the blood volume is insufficient or there is a clot, the blood needs to be collected again, for example, by checking the interface of the display 80 to check whether there is a fault alarm currently, if so, take corresponding measures to remove the fault alarm, and the like; after the user determines that the status of both the sample and the measurement module are normal, the user re-enters the sample into the sample analysis system. It should be noted that, the sample is re-input to the sample in this document, which refers to the sample of the same patient, not necessarily the same sample, for example, if the sample is abnormal, a sample needs to be taken again for the patient and then input to the system.
(2) When the sample is input again, the controller 70 controls the sample to be dispatched to the first measurement module 11 to perform at least the test of the dual-purpose test item for correction, and judges whether to control the sample to be dispatched to the second measurement module 12 to perform the test of the test item for correction according to the test condition of the dual-purpose test item for correction of the sample; alternatively, when the sample is re-input, the controller 70 directly controls the sample to be scheduled to the second measurement module 12 for testing the test item to be corrected—for example, in some cases of false alarms, such measures may be taken, and in specific implementation, after the sample is re-input into the system, the user issues a corresponding command through an input tool such as a mouse or a keyboard, and the controller 70 controls the sample to be scheduled to the second measurement module 12 for testing the test item to be corrected in response to the command.
In some embodiments, the controller 70 pauses the scheduling of samples to the second measurement module 12 for testing of the test item to be modified, which may be:
(1) The controller 70 controls the scheduling of samples to a buffer to wait. In the process, a user can check the testing state of the test item to be corrected, see what problem is found, and if the testing state is abnormal, the testing state of the measuring module is eliminated after the measuring module is abnormal, so that the user can give a first testing command through input tools such as a mouse or a keyboard; if the measurement module is determined to have no problem, a false alarm occurs, and then the user can issue a second test command through input tools such as a mouse or a keyboard; otherwise, if the user determines that the measurement module is not abnormal and suspects that the sample is abnormal, the user can issue a third test command through an input tool such as a mouse or a keyboard to take the sample out.
(2) In response to the test first command, the controller 70 controls the samples to be dispatched from the buffer to the first measurement module 11 to perform at least the test of the concurrently corrected test item, and judges whether to control the samples to be dispatched to the second measurement module 12 to perform the test of the test item to be corrected according to the test condition of the concurrently corrected test item of the samples; alternatively, in response to the test second command, the controller 70 directly controls the scheduling of samples to the second measurement module 12 for testing of the test item to be modified.
(3) In response to the test third command, the controller 70 controls the scheduling of the samples to locations for retrieval by the user. The user can then check the test status of the test item to be corrected, check what problems are detected, determine whether the sample is abnormal, and remove the fault accordingly, for example, by shaking the test tube to see if the blood volume of the sample is sufficient, if there is a clot, etc., and if the blood volume is insufficient or there is a clot, then the blood needs to be collected again. When the sample is re-input, the controller 70 controls the sample to be scheduled to the first measurement module 11 for at least the test of the dual-purpose test item for correction, and re-determines whether to control the sample to be scheduled to the second measurement module 12 for the test of the test item for correction according to the test condition of the dual-purpose test item for correction of the sample.
In some embodiments, the controller 70 pauses the scheduling of samples to the second measurement module 12 for testing of the test item to be modified, which may be:
(1) The controller 70 controls the sample to stay in the first measurement module 11. In the process, a user can check the testing state of the test item to be corrected, see what problem is found, and if the testing state is abnormal, the testing state of the measuring module is eliminated after the measuring module is abnormal, so that the user can give a first testing command through input tools such as a mouse or a keyboard; if the measurement module is determined to have no problem, a false alarm occurs, and then the user can issue a second test command through input tools such as a mouse or a keyboard; otherwise, if the user determines that the measurement module is not abnormal and suspects that the sample is abnormal, the user can issue a third test command through an input tool such as a mouse or a keyboard to take the sample out.
(2) In response to the first test command, the controller 70 controls the first measurement module 11 to perform the test of the test item for concurrent modification on the sample again, and determines whether to control the sample to be scheduled to the second measurement module 12 for the test of the test item for concurrent modification according to the test condition of the test item for concurrent modification on the sample; alternatively, in response to the test second command, the controller 70 directly controls the scheduling of samples to the second measurement module 12 for testing of the test item to be modified.
(3) In response to testing the third command, the controller 70 dispatches the sample to a location for retrieval by the user. The user can then check the test status of the test item to be corrected, check what problems are detected, determine whether the sample is abnormal, and remove the fault accordingly, for example, by shaking the test tube to see if the blood volume of the sample is sufficient, if there is a clot, etc., and if the blood volume is insufficient or there is a clot, then the blood needs to be collected again. When the sample is re-input, the controller 70 controls the sample to be scheduled to the first measurement module 11 for at least the test of the dual-purpose test item for correction, and re-determines whether to control the sample to be scheduled to the second measurement module 12 for the test of the test item for correction according to the test condition of the dual-purpose test item for correction of the sample.
In order to prompt the user to process as soon as possible, the controller 70 in some embodiments also generates alert information for prompting the user when it is determined that the test of the sample concurrently correcting test item is abnormal, while the controller 70 pauses the process of controlling the dispatch of the sample to the second measurement module 12 for the test of the test item to be corrected.
The foregoing is a description of sample analysis systems according to some embodiments of the invention. The invention also discloses a sample testing method. Referring to fig. 7, the sample testing method in some embodiments includes steps 100 to 300, which are described in detail below.
Step 100: samples are received.
Step 200: and controlling the test of the test item for the sample and the correction.
Step 300: judging whether to test the test item to be corrected for the sample according to the test condition of the test item for the sample; the test data of the test item for correction is used for correcting the test item to be corrected. In some embodiments, the concurrently revised test item may be a test item related to a blood routine revision parameter in a blood routine module, and the test item to be revised may be a whole blood CRP test item.
In some embodiments, referring to fig. 8, step 300 may include steps 310 to 330, which are described in detail below.
Step 310: and judging whether the test condition of the test item for the sample and the correction is normal or abnormal. The test conditions of the test item for the sample and the correction include two conditions, one is that the test of the test item for the sample and the correction is abnormal, and the other is that the test of the test item for the sample and the correction is normal; the abnormal occurrence of the test has various reasons, such as sample abnormality and measurement module abnormality, and more specific contents can be found in the description of the corresponding parts above, and will not be repeated here. If it is determined in step 310 that the test of the sample dual-purpose test item is normal, step 320 is performed, whereas if it is determined that the test of the sample dual-purpose test item is abnormal, step 330 is performed.
Step 320: and when the test of the test item which is used for the correction of the sample is normal, controlling the test of the test item which needs to be corrected on the sample.
Step 330: when the test of the test item which is used for correcting the sample is abnormal, controlling to pause the test of the test item which needs to be corrected on the sample. There are various implementations of step 330, and several are discussed below.
In some embodiments, step 330 controls suspending the testing of the sample for the test item to be modified may include:
(1) Control dispatches samples to locations for retrieval by the user. The user can check the test state of the test item to be corrected, check what problem is detected, determine whether the sample is abnormal or the measurement module is abnormal, and remove the fault accordingly, for example, by shaking the test tube to determine whether the blood volume of the sample is sufficient, whether there is a clot or not, if the blood volume is insufficient or there is a clot, the blood needs to be collected again, for example, by checking the interface of the display 80 to check whether there is a fault alarm currently, if so, take corresponding measures to remove the fault alarm, and the like; after the user determines that the status of both the sample and the measurement module are normal, the user re-enters the sample into the sample analysis system. It should be noted that, the sample is re-input to the sample in this document, which refers to the sample of the same patient, not necessarily the same sample, for example, if the sample is abnormal, a sample needs to be taken again for the patient and then input to the system.
(2) When the sample is input again, controlling to test at least the test item for concurrent modification on the sample, and judging whether to test the test item for concurrent modification on the sample according to the test condition of the test item for concurrent modification on the sample; alternatively, when the sample is re-entered, control may take the test of the test item for correction and not the test of the test item for concurrent correction on the sample—such as may be the case in some false alarms.
In one embodiment, step 330 controls to suspend the test of the sample for the test item to be modified, and may include:
(1) Control schedules samples to a buffer to wait. In the process, a user can check the testing state of the test item to be corrected, see what problem is found, and if the testing state is abnormal, the testing state of the measuring module is eliminated after the measuring module is abnormal, so that the user can give a first testing command through input tools such as a mouse or a keyboard; if the measurement module is determined to have no problem, a false alarm occurs, and then the user can issue a second test command through input tools such as a mouse or a keyboard; otherwise, if the user determines that the measurement module is not abnormal and suspects that the sample is abnormal, the user can issue a third test command through an input tool such as a mouse or a keyboard to take the sample out.
(2) Responding to a first test command, controlling the samples to be dispatched from the buffer area to at least test the concurrent modification test items, and judging whether to test the concurrent modification test items of the samples according to the test conditions of the concurrent modification test items of the samples; or, in response to a second test command, controlling the samples to be dispatched from the buffer area to perform the test of the test item to be corrected and not to perform the test of the test item for concurrent correction;
(3) In response to testing the third command, control dispatches the sample to a location for retrieval by the user. The user can then check the test status of the test item to be corrected, check what problems are detected, determine whether the sample is abnormal, and remove the fault accordingly, for example, by shaking the test tube to see if the blood volume of the sample is sufficient, if there is a clot, etc., and if the blood volume is insufficient or there is a clot, then the blood needs to be collected again. When the sample is input again, controlling to test at least the test item for concurrent modification on the sample, and judging whether to test the test item for concurrent modification on the sample according to the test condition of the test item for concurrent modification on the sample.
In one embodiment, step 330 controls to suspend the test of the sample for the test item to be modified, and may include:
(1) Control holds the sample at the current position. In the process, a user can check the testing state of the test item to be corrected, see what problem is found, and if the testing state is abnormal, the testing state of the measuring module is eliminated after the measuring module is abnormal, so that the user can give a first testing command through input tools such as a mouse or a keyboard; if the measurement module is determined to have no problem, a false alarm occurs, and then the user can issue a second test command through input tools such as a mouse or a keyboard; otherwise, if the user determines that the measurement module is not abnormal and suspects that the sample is abnormal, the user can issue a third test command through an input tool such as a mouse or a keyboard to take the sample out.
(2) Responding to the first test command, controlling the test of the test item for concurrent modification to the sample, and judging whether the test of the test item to be modified is performed on the sample according to the test condition of the test item for concurrent modification of the sample; or in response to the second test command, controlling the sample to continue the test of the test item to be corrected.
(3) In response to testing the third command, control dispatches the sample to a location for retrieval by the user. The user can then check the test status of the test item to be corrected, check what problems are detected, determine whether the sample is abnormal, and remove the fault accordingly, for example, by shaking the test tube to see if the blood volume of the sample is sufficient, if there is a clot, etc., and if the blood volume is insufficient or there is a clot, then the blood needs to be collected again. When the sample is input again, controlling to test at least the test item for concurrent modification on the sample, and judging whether to test the test item for concurrent modification on the sample according to the test condition of the test item for concurrent modification on the sample.
In order to prompt the user to process as soon as possible, in some embodiments, when it is determined that the test of the sample concurrently correcting test item is abnormal, alert information for prompting the user may also be generated, in step 330, by suspending the process of controlling the scheduling of the sample to the second measurement module 12 for the test of the test item to be corrected.
In the above embodiments, it may be implemented in whole or in part by software, hardware, firmware, or any combination thereof. Additionally, as will be appreciated by one of skill in the art, the principles herein may be reflected in a computer program product on a computer readable storage medium preloaded with computer readable program code. Any tangible, non-transitory computer readable storage medium may be used, including magnetic storage devices (hard disks, floppy disks, etc.), optical storage devices (CD-to-ROM, DVD, blu-Ray disks, etc.), flash memory, and/or the like. These computer program instructions may be loaded onto a general purpose computer, special purpose computer, or other programmable data processing apparatus to produce a machine, such that the instructions which execute on the computer or other programmable data processing apparatus create means for implementing the functions specified. These computer program instructions may also be stored in a computer-readable memory that can direct a computer or other programmable data processing apparatus to function in a particular manner, such that the instructions stored in the computer-readable memory produce an article of manufacture including means which implement the function specified. The computer program instructions may also be loaded onto a computer or other programmable data processing apparatus to cause a series of operational steps to be performed on the computer or other programmable apparatus to produce a computer implemented process such that the instructions which execute on the computer or other programmable apparatus provide steps for implementing the functions specified.
While the principles herein have been shown in various embodiments, many modifications of structure, arrangement, proportions, elements, materials, and components, which are particularly adapted to specific environments and operative requirements, may be used without departing from the principles and scope of the present disclosure. The above modifications and other changes or modifications are intended to be included within the scope of this document.
The foregoing detailed description has been described with reference to various embodiments. However, those skilled in the art will recognize that various modifications and changes may be made without departing from the scope of the present disclosure. Accordingly, the present disclosure is to be considered as illustrative and not restrictive in character, and all such modifications are intended to be included within the scope thereof. Also, advantages, other advantages, and solutions to problems have been described above with regard to various embodiments. The benefits, advantages, solutions to problems, and any element(s) that may cause any benefit, advantage, or solution to occur or become more pronounced are not to be construed as a critical, required, or essential feature. The terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, system, article, or apparatus. Furthermore, the term "couple" and any other variants thereof are used herein to refer to physical connections, electrical connections, magnetic connections, optical connections, communication connections, functional connections, and/or any other connection.
Those skilled in the art will recognize that many changes may be made to the details of the above-described embodiments without departing from the underlying principles of the invention. Accordingly, the scope of the invention should be determined only by the following claims.
Claims (7)
1. A sample analysis system, comprising:
the first measuring module is used for carrying out a first type of test item on the sample;
the second measurement module is used for carrying out a second type of test item on the sample; the first type of test items at least comprise test items for concurrent modification, and the second type of test items at least comprise test items to be modified, wherein the test data of the test items for concurrent modification are used for modifying the test items to be modified;
the controller is used for controlling the sample to be dispatched to the first measuring module to at least test the concurrently correcting test item, judging whether the sample is dispatched to the second measuring module to test the to-be-corrected test item according to the test condition of the concurrently correcting test item of the sample, and when the abnormal test of the concurrently correcting test item of the sample is confirmed, suspending the control of dispatching the sample to the second measuring module to test the to-be-corrected test item by the controller, and carrying out the following mode one, mode two or mode three:
Mode one:
the controller controls the scheduling of samples to locations for retrieval by a user;
when the sample is input again, the controller controls the sample to be scheduled to the first measuring module to at least test the dual-purpose correcting test item, and judges whether the sample is scheduled to the second measuring module to test the required correcting test item according to the test condition of the dual-purpose correcting test item of the sample; or when the sample is input again, the controller directly controls the sample to be scheduled to a second measurement module for testing the test item to be corrected;
mode two:
the controller controls the samples to be dispatched to a buffer area for waiting;
responding to a first test command, the controller controls the samples to be dispatched from the buffer area to the first measurement module to at least test the concurrently correcting test items, and judges whether to control the samples to be dispatched to the second measurement module to test the test items to be corrected according to the test condition of the concurrently correcting test items of the samples; or, in response to a second test command, the controller directly controls the sample to be dispatched to a second measurement module to perform the test of the test item to be corrected; or, in response to a third test command, the controller controls the sample to be dispatched to a position for the user to take out, and when the sample is re-input, the controller controls the sample to be dispatched to the first measurement module to at least conduct the test of the dual-purpose test item for correction, and re-judges whether the sample is controlled to be dispatched to the second measurement module to conduct the test of the test item for correction according to the test condition of the dual-purpose test item for correction of the sample;
Mode three:
the controller controls the sample to stay in the first measurement module;
responding to a first test command, controlling a first measurement module to test the test item for the concurrent modification of the sample by the controller, and judging whether to control the sample to be dispatched to a second measurement module to test the test item for the modification according to the test condition of the test item for the concurrent modification of the sample; or, in response to a second test command, the controller directly controls the sample to be dispatched to a second measurement module to perform the test of the test item to be corrected; or, in response to the third test command, the controller dispatches the sample to a position for the user to take out, and when the sample is input again, the controller controls the sample to be dispatched to the first measurement module to at least conduct the test of the dual-purpose test item for correction, and re-judges whether the sample is controlled to be dispatched to the second measurement module to conduct the test of the test item for correction according to the test condition of the dual-purpose test item for correction of the sample.
2. The sample analysis system according to claim 1, wherein the controller further generates alarm information for prompting a user when it is determined that an abnormality occurs in the test of the concurrently corrected test item of the sample.
3. The sample analysis system of claim 1, wherein the first measurement module is a blood routine module and the second measurement module is a whole blood CRP module.
4. A method of testing a sample, comprising:
receiving a sample;
controlling the test of the test item for the sample for the dual-purpose correction;
judging whether to test the test item to be corrected for the sample according to the test condition of the test item for the sample for the concurrent correction, and controlling to pause the test of the test item to be corrected for the sample when the test of the test item for the concurrent correction for the sample is abnormal, and performing the following mode one, mode two or mode three; the test data of the test item for correction is used for correcting the test item to be corrected;
mode one:
controlling the sample to be dispatched to a position for retrieval by a user;
when the sample is input again, controlling to test at least the test item for concurrent modification on the sample, and judging whether to test the test item for concurrent modification on the sample according to the test condition of the test item for concurrent modification on the sample; or when the sample is input again, controlling the sample to be tested for the test item to be corrected and not to be tested for the test item for the concurrent correction;
Mode two:
controlling the sample to be dispatched to a buffer area for waiting;
responding to a first test command, controlling the samples to be dispatched from the buffer area to at least test the concurrent modification test items, and judging whether to test the concurrent modification test items of the samples according to the test conditions of the concurrent modification test items of the samples; or, in response to a second test command, controlling the samples to be dispatched from the buffer area to perform the test of the test item to be corrected and not to perform the test of the test item for concurrent correction; or, in response to the third test command, controlling to dispatch the sample to a position for taking out by a user, and when the sample is re-input, controlling to test at least the dual-purpose test item for correction on the sample, and judging whether to test the dual-purpose test item for correction on the sample according to the test condition of the dual-purpose test item for correction on the sample;
mode three:
controlling the sample to stay at the current position;
responding to the first test command, controlling the test of the test item for concurrent modification to the sample, and judging whether the test of the test item to be modified is performed on the sample according to the test condition of the test item for concurrent modification of the sample; or, in response to the second test command, controlling the sample to continue the test of the test item to be corrected; or in response to the third test command, controlling to dispatch the sample to a position for taking out by a user, and when the sample is input again, controlling to test at least the dual-purpose test item for correction on the sample, and judging whether to test the dual-purpose test item for correction on the sample according to the test condition of the dual-purpose test item for correction on the sample.
5. The sample testing method according to claim 4, wherein when it is determined that the test of the concurrently corrected test item of the sample is abnormal, alarm information for prompting the user is also generated.
6. The sample testing method according to claim 4, wherein the concurrently corrected test item is a blood routine test item, and the test item to be corrected is a whole blood CRP test item.
7. A computer readable storage medium comprising a program executable by a processor to implement the method of any one of claims 4 to 6.
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