CN112345778B - Cascade sample analysis system, device and quality control project out-of-control processing method - Google Patents

Cascade sample analysis system, device and quality control project out-of-control processing method Download PDF

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CN112345778B
CN112345778B CN201910723023.8A CN201910723023A CN112345778B CN 112345778 B CN112345778 B CN 112345778B CN 201910723023 A CN201910723023 A CN 201910723023A CN 112345778 B CN112345778 B CN 112345778B
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item
control
analysis module
sample
patient sample
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CN112345778A (en
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王鑫润
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Shenzhen Mindray Bio Medical Electronics Co Ltd
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Shenzhen Mindray Bio Medical Electronics Co Ltd
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/026Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having blocks or racks of reaction cells or cuvettes

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
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Abstract

A cascade sample analysis system, a sample analysis device and a quality control project out-of-control processing method comprise the following steps: controlling the quality control sample and the patient sample to be tested in parallel; judging whether any analysis module has out-of-control quality control items; and when judging that the quality control project of the analysis module is out of control, shielding the test of the out-of-control project of the analysis module. The invention provides an intelligent and automatic processing scheme after a project is out of control, when the out of control project appears on an instrument, the test of the out of control project is shielded on the instrument, so that the test of the out of control project can not be carried out on the instrument by a subsequent patient sample; therefore, the invention saves time and labor and has high automation degree.

Description

Cascade sample analysis system, device and quality control project out-of-control processing method
Technical Field
The invention relates to a cascade sample analysis system, a sample analysis device and a quality control project out-of-control processing method.
Background
The instrument for analyzing and measuring the sample is characterized in that before the sample test of the patient is carried out, the quality control test is carried out on test items of the patient, the purpose is to check the state of the corresponding items of the instrument, if the quality control test result is abnormal, namely out of control, the current state of the instrument cannot guarantee the accuracy of the test result obtained after the sample of the patient is carried out on the out-of-control items, the out-of-control items of the instrument are required to be subjected to out-of-control treatment at the moment, for example, the out-of-control items are required to be retested to confirm whether out of control is carried out, for example, the quality control items are replaced, for example, reagents are replaced, and the like, the sample of the patient cannot be tested until the out-of-control items are controlled again, because the instrument can guarantee the accuracy of the item test result of the sample of the patient.
Daily quality control tests generally take a relatively long time, for example, the quality control test time of an immunoluminescent program is typically 30 minutes to 50 minutes; although the accuracy of the detection result of the patient sample can be ensured to the greatest extent by performing the detection of the patient sample after the quality control is finished, the requirement of the result time of the patient sample project cannot be generally ensured; therefore, in order to meet the requirement of the patient sample item on the time of outputting results, currently, related clinical laboratory and the like usually adopt the situation of parallel detection of quality control test and patient sample test, and in this case, if a certain quality control item is out of control, some remedial treatment is required.
When the instrument is out of control, most of the instruments do not give any alarm processing, the patient samples still continue to be tested, and only the user can check out-of-control items made on the instrument and affected patient samples with out-of-control items made on the instrument, and on some instruments which give alarm processing, the user is only given an alarm signal simply to prompt that the items are out of control currently.
Disclosure of Invention
In order to solve the problems, the application provides a cascade sample analysis system, a sample analysis device and a method for processing out-of-control quality control items.
According to a first aspect, in one embodiment there is provided a cascaded sample analysis system comprising:
the analysis modules are used for testing the samples;
the system comprises a track connected with each analysis module and a scheduling device for scheduling samples to be tested to the corresponding analysis modules through the track;
the controller is used for controlling the parallel test of the quality control sample and the patient sample; in the testing process, for any analysis module, the controller judges whether the analysis module has out-of-control quality control items; and when judging that the quality control project of the analysis module is out of control, the controller shields the test of the out-of-control project of the analysis module.
In one embodiment, when it is determined that the analysis module has a quality control item out of control, the controller shields the analysis module from testing the out of control item, including: for patient samples which need to be tested to the analysis module, the controller controls the scheduling device to schedule the patient samples to the analysis module for testing of the under-control items and/or items for which the quality control results are not yet available.
In an embodiment, after the controller shields the test of the uncontrolled item of the analysis module, for the patient sample that needs to be tested for the uncontrolled item to the analysis module, when the controller determines that the uncontrolled item is under control on the other analysis modules, the controller controls the dispatching device to dispatch the patient sample to the other analysis modules to test for the uncontrolled item.
In one embodiment, after the controller shields the test of the uncontrolled item of the analysis module, for the patient sample that needs to be tested for the uncontrolled item to the analysis module, when the controller determines that the uncontrolled item is also out of control or the quality control result is not yet out of control on other analysis modules, the controller controls the dispatching device to dispatch the patient sample to a preset buffer area for waiting; until the uncontrolled item is judged to be controlled on any analysis module, the controller controls the scheduling device to schedule the patient sample from the buffer zone to the analysis module for testing the uncontrolled item; or,
after the controller shields the test of the out-of-control item of the analysis module, for the patient sample which needs to be tested for the out-of-control item to the analysis module, when the controller judges that the out-of-control item is out-of-control or the quality control result is not yet obtained on other analysis modules, the controller controls the dispatching device to dispatch the patient sample to a position for a user to take out; and if the patient sample is input again until the uncontrolled item is judged to be controlled on any analysis module, the controller controls the scheduling device to schedule the patient sample to the analysis module for testing the uncontrolled item.
In one embodiment, after the controller shields the test of the uncontrolled item of the analysis module, for the patient sample that needs to be tested for the uncontrolled item to the analysis module, the controller controls the scheduling device to schedule the patient sample to a preset buffer area for waiting; until when the out of control item is re-controlled on the analysis module, the controller controls the scheduling device to schedule the patient sample from the buffer zone to the analysis module for testing of the out of control item; or,
after the controller shields the test of the uncontrolled project of the analysis module, for the patient sample which needs to be tested for the uncontrolled project to the analysis module, the controller controls the dispatching device to dispatch the patient sample to a position for a user to take out; until when the out of control item is re-controlled on the analysis module, if the patient sample is re-entered, the controller controls the scheduling means to schedule the patient sample to the analysis module for testing of the out of control item.
In one embodiment, when the analysis module is judged to have a quality control item out of control, the controller also searches for a patient sample affected by the out of control item; the patient sample affected by the runaway item includes: patient samples of the uncontrolled item were also taken after the time point of the last time the uncontrolled item was tested at the time of control.
In one embodiment, the controller dispatches the patient sample affected by the out of control item to a predetermined buffer for waiting; when the uncontrolled item is judged to be controlled on any analysis module, the controller controls the scheduling device to schedule the patient sample from the buffer zone to the analysis module for retesting of the uncontrolled item; or,
the controller dispatches the patient sample affected by the out-of-control item to a location for retrieval by a user; when the out-of-control item is judged to be controlled on any analysis module, if the patient sample is input again, the controller controls the dispatching device to dispatch the patient sample to the analysis module for retesting of the out-of-control item.
In one embodiment, the controller dispatches the patient sample affected by the out of control item to a predetermined buffer for waiting; until when the out-of-control item is re-controlled at the analysis module where the out-of-control item is located, the controller controls the scheduling device to schedule the patient sample from the buffer zone to the analysis module for re-measurement of the out-of-control item; or,
the controller dispatches the patient sample affected by the out-of-control item to a location for retrieval by a user; and if the patient sample is input again until the out-of-control item is under control again in the analysis module where the out-of-control item is located, the controller controls the scheduling device to schedule the patient sample to the analysis module for retesting of the out-of-control item.
According to a second aspect, there is provided in one embodiment a sample analysis device comprising:
a measurement section for detecting a sample to obtain a sample detection result;
the sample component is used for bearing a sample to be tested, sucking the sample and providing the sample to the measuring component;
a reagent member for carrying a reagent, sucking the reagent and supplying the sucked reagent to the measuring member;
the controller is used for controlling the parallel test of the quality control sample and the patient sample; in the testing process, judging whether a quality control item is out of control or not; and when judging that the quality control item is out of control, the controller shields the test of the out-of-control item.
In one embodiment, when it is determined that the quality control item is out of control, the controller shields the test of the out of control item, including: for patient samples not yet tested for the uncontrolled item, the controller controls testing of the patient samples for items for which the controlled item and/or quality control results are not yet available.
In one embodiment, after the controller shields the test of the out of control item, the controller further controls the patient sample to be scheduled to a preset buffer for waiting; until the runaway item is again under control, the controller controls the patient sample to be dispatched from the buffer zone to conduct retesting of the runaway item; or,
After the controller shields the test of the out of control item, the controller also controls the scheduling of patient samples to a location for retrieval by a user; until when the runaway item is again under control, if the patient sample is again entered, the controller controls retesting the runaway item on the patient sample.
According to a third aspect, an embodiment provides a method for handling out-of-control items, including:
controlling the quality control sample and the patient sample to be tested in parallel;
judging whether any analysis module has out-of-control quality control items;
and when judging that the quality control project of the analysis module is out of control, shielding the test of the out-of-control project of the analysis module.
In one embodiment, when it is determined that the analysis module has a quality control item out of control, the testing of the out of control item of the analysis module is masked, including: for patient samples that need to be tested to the analysis module, control is provided to schedule the patient samples to the analysis module for testing of controlled items and/or items for which the quality control results are not yet available.
In one embodiment, after the test of the out of control item of the shielding analysis module, for the patient sample that needs to be tested for the out of control item to the analysis module, when the out of control item is judged to be in control on the other analysis module, the control dispatches the patient sample to the other analysis module to test for the out of control item.
According to a fourth aspect, an embodiment provides a computer readable storage medium comprising a program executable by a processor to implement a method as described in any of the embodiments herein
According to the cascade sample analysis system, the sample analysis device, the quality control project out-of-control processing method and the computer readable storage medium, an intelligent and automatic processing scheme after the project is out-of-control is provided, when the out-of-control project appears on an instrument, the test of the out-of-control project is shielded on the instrument, so that the subsequent patient sample can not be tested on the instrument any more; therefore, the invention saves time and labor and has high automation degree.
Drawings
FIG. 1 is a schematic diagram of a cascaded sample analysis system according to one embodiment;
FIG. 2 is a schematic diagram of a pipeline system of one embodiment;
FIG. 3 is a schematic diagram of a pre-processing module according to one embodiment;
FIG. 4 is a schematic diagram of an aftertreatment module of an embodiment;
FIG. 5 is a schematic diagram of a pipeline system of another embodiment;
FIG. 6 is a schematic diagram of a sample analyzer according to an embodiment;
FIG. 7 is a flow chart illustrating a method for handling out-of-control items according to an embodiment.
Detailed Description
The invention will be described in further detail below with reference to the drawings by means of specific embodiments. Wherein like elements in different embodiments are numbered alike in association. In the following embodiments, numerous specific details are set forth in order to provide a better understanding of the present application. However, one skilled in the art will readily recognize that some of the features may be omitted, or replaced by other elements, materials, or methods in different situations. In some instances, some operations associated with the present application have not been shown or described in the specification to avoid obscuring the core portions of the present application, and may not be necessary for a person skilled in the art to describe in detail the relevant operations based on the description herein and the general knowledge of one skilled in the art.
Furthermore, the described features, operations, or characteristics of the description may be combined in any suitable manner in various embodiments. Also, various steps or acts in the method descriptions may be interchanged or modified in a manner apparent to those of ordinary skill in the art. Thus, the various orders in the description and drawings are for clarity of description of only certain embodiments, and are not meant to be required orders unless otherwise indicated.
The numbering of the components itself, e.g. "first", "second", etc., is used herein merely to distinguish between the described objects and does not have any sequential or technical meaning. The terms "coupled" and "connected," as used herein, are intended to encompass both direct and indirect coupling (coupling), unless otherwise indicated.
As described above, in the existing solutions, when the instrument is out of control, most of the existing solutions do not give any alarm processing, and only the user can check the quality control result in real time to determine whether the item is out of control, on some instruments which give alarm processing, an alarm signal is simply given to the user to prompt that the item is out of control, for example, the instrument still tests the patient sample for the out of control item, the user needs to pick out the patient sample for which the out of control item is performed for retest, typically a scene, after learning the out of control item, the user needs to find out all patient samples for which the out of control item on the LIS system, specifically, the user needs to click on each patient sample one by one at the client of the LIS system to check whether each patient sample is made for the out of control item, and then apply retest on the patient sample for which is made for the out of control item on the client or the middleware of LIS, which is very time-consuming and labor. Therefore, the existing method for processing out-of-control projects is too simple, not intelligent enough and poor in usability. The inventor proposes an intelligent automatic processing scheme after the project is out of control through conception. In particular, when an out of control item occurs on the instrument, the testing of the out of control item is masked on the instrument so that subsequent patient samples are no longer tested on the instrument for the out of control item.
The present apparatus for testing and analyzing samples has a single machine form, and also has a cascade or pipeline system, the cascade or pipeline system is formed by combining a plurality of single machine form apparatuses, each single machine is connected through a track, etc., when the apparatus on the cascade or pipeline system is separated from the line, that is, becomes an off-line form, then the off-line apparatuses become independent single machines, the invention can be implemented on the single machine, and also can be implemented on the cascade or pipeline system, and the cascade system and the single machine are respectively described below.
Some description will be given first of the cascade system.
Referring to fig. 1, a cascaded sample analysis system in an embodiment may include a plurality of analysis modules 100, a track 110, a scheduler 120, and a controller 130. The track 110 is used for connecting each analysis module 100, and the dispatching device 120 dispatches the samples to the corresponding analysis module 100 through the track 110, and the analysis module 100 is used for testing the samples, such as a biochemical analysis module, an immune analysis module, a blood coagulation analysis module and the like. It will be appreciated that these cascaded analysis modules 100 may be the same type of analysis module, i.e. analysis modules for measuring the same items, or may be different types of analysis modules, i.e. analysis modules for measuring different items, which may be configured according to the requirements of the user and the department, e.g. the analysis modules 100 may be immune analyzers, biochemical analyzers, cellular analyzers, etc.; it should be noted that fig. 1 shows an example of three analysis modules 100, which is only for illustration, and is not intended to limit the number of analysis modules. In some examples, components for pre-processing and post-processing may be added to the sample analysis system, which may also be referred to as a pipeline system, to further increase the automation of sample testing.
For example, referring to fig. 2, the sample analysis system of an embodiment may further include one or more of an input module 140, a pre-processing module 150, a post-processing module 160, and the like, in addition to the cascaded analysis modules 100, the track 110, the scheduler 120, and the controller 130; the track 110 is used for connecting the modules, such as the input module 140, the pre-processing module 150, the analysis module 100, the post-processing module 160, etc., and the dispatching device 120 dispatches the samples to the corresponding analysis modules through the track 110; FIG. 2 shows an example of two analysis modules 100, which is for illustration only and not for limiting the number of analysis modules; the following describes each module.
The input module 140 is configured to receive an unmeasured sample placed by a user. The input module 140 in the pipeline system is typically an area where a user places samples, and during operation of the pipeline system, the input module 140 may automatically scan the samples placed therein, sort the samples, etc., for processing by the next module, such as the front processing module 150.
The preprocessing module 150 is used for completing preprocessing on the sample. In one embodiment, referring to fig. 3, the pre-processing module 150 may include one or more of a centrifugation module 151, a serum detection module 152, a decapping module 153, and a separation module 154. The centrifugation module 151 is used for centrifuging the sample to be centrifuged, and the number of the centrifugation modules 151 may be one or more. The serum detection module 152 is configured to detect whether the serum level of the sample is sufficient and/or whether the serum level of the sample is acceptable to determine whether the centrifuged sample is available for subsequent testing. The cap removing module 153 is used for removing caps from the centrifuged sample, and as will be understood, capping, filming, cap removing and film removing of the sample herein refers to capping, filming, cap removing and film removing of a sample tube containing the sample; typically, the sample after centrifugation requires removal of the cap for subsequent dispensing or pipetting by the dispensing module 154 or analysis module. The dispensing module 154 is used to separate samples, such as a single sample into multiple samples, for separate measurement in different analysis modules 100. One typical preprocessing flow for the preprocessing module 150 is: the centrifugation module 151 receives the samples scheduled by the input module 140 and centrifigates the samples; the serum detection module 152 detects serum of the centrifuged sample to determine whether the sample is available for subsequent measurement, and if the serum is insufficient in quantity or quality is not acceptable, the sample cannot be used for subsequent measurement; if the detection is passed, the sample is dispatched to the cap removing module 153, the cap removing module 153 removes the cap of the sample, if the cap separating module 154 is provided, the cap separating module 154 separates the cap removed sample, then the separated sample is dispatched to the corresponding analysis module 100 for measurement, and if the cap separating module 154 is not provided, the sample is dispatched from the cap removing module 153 to the corresponding analysis module 100 for measurement.
The analysis module 100 is used to test samples that have been centrifuged and uncapped.
The post-processing module 160 is used to complete post-processing of the sample. In one embodiment, referring to fig. 4, the post-processing module 160 includes one or more of a film/capping module 161, a refrigerated storage module 162, and a film/capping module 163. The membrane/cap module 161 is used for membrane or cap the sample; the refrigerated storage module 162 is used for storing samples; the membrane/cap removal module 163 is used to remove membranes or caps from the sample. One typical post-processing flow of the post-processing module 160 is: after the analysis module 100 is sucked, the samples are dispatched to the film adding/capping module 161, and the film adding/capping module 161 adds films or caps to the samples after the measurement, and then dispatches to the cold storage module 162 for storage. If the sample needs to be retested, the sample is dispatched from the refrigerated storage module 162 and removed from the film or lid in the film/lid removal module 163 and then dispatched to the analysis module 100 for testing.
FIG. 5 is a schematic diagram of a pipeline system of endless tracks, with the direction of the dashed arrow in the figure being the direction and path of travel of the sample, and the upper right-hand curved track being an example of a system buffer.
The sample analysis system of the present invention may also include an input component, a display component, etc., which are commonly used components and will not be described in detail herein. In addition, the analysis module 100 is about to become independent stand alone after the analysis module 100 is taken off line, whether in a normal sample analysis system or a special sample analysis system (i.e., a pipeline system).
The above is some structures of the sample analysis system, when an out-of-control item appears in the sample analysis system, two aspects of processing can be mainly carried out, firstly, the test of the out-of-control item is automatically shielded on an analysis module where the out-of-control item is located, so that the out-of-control item is not needed to be shielded manually any more, and after the out-of-control item is out-of-control, the patient sample test on the out-of-control item is basically avoided, and the number of patient samples which are needed to be retested as a result and subsequent manual operation are effectively reduced; secondly, searching patient samples affected by the uncontrolled project, which makes it unnecessary to manually check and find out patient samples for the uncontrolled project, thereby saving labor and time; the following will specifically describe each.
For any analysis module, when the controller 130 determines that the analysis module 100 has a quality control item out of control, the controller 130 shields the analysis module 100 from testing the out of control item; for example, in some examples, for patient samples that are required to be tested by the analysis module, the controller 130 controls the scheduler 120 to schedule the patient samples to the analysis module 100 for testing of the controlled item; for another example, for patient samples that need to be tested to the analysis module, the controller 130 controls the scheduler 120 to schedule the patient samples to the analysis module 100 for testing of items for which the quality control results are not yet available; for another example, for a patient sample that is desired to be tested to the analysis module, the controller 130 controls the patient sample not to be tested for the runaway item on the analysis module 100.
In one embodiment, after the controller 130 shields the analysis module from the test of the uncontrolled item, for the patient sample that needs to be tested for the uncontrolled item to the analysis module 100 where the uncontrolled item is located, when the controller 130 determines that the uncontrolled item is under control on the other analysis module, the controller controls the dispatching device 120 to dispatch the patient sample to the other analysis module 100 for testing the uncontrolled item. If the out of control item is also out of control or the quality control result is not yet available on other analysis modules, the controller 130 may control the scheduler 120 to schedule the patient sample to a predetermined buffer for the sample analysis system that may call back the patient sample or have a buffer until the controller 130 controls the scheduler 120 to schedule the patient sample from the buffer to the analysis module (e.g., the first analysis module 100 described above) for the out of control item test when the out of control item is determined to be in control on any analysis module 100, e.g., the first analysis module 100 is in control; for sample analysis systems that cannot call back a patient sample, the controller 130 controls the scheduler 120 to schedule the patient sample to a location for retrieval by a user until the out of control item is tested by the scheduler 120 to the analysis module 100 (e.g., the first analysis module 100 described above) if the patient sample is again entered when it is determined that the out of control item is in control on any of the analysis modules, e.g., the first analysis module 100 is in control.
In some cases, the patient sample needs to be tested at the designated analysis module 100, i.e. the designated test, in which case, in one embodiment, after the controller 130 shields the test of the uncontrolled item of the analysis module, in order to ensure consistency and accuracy of the test result, some of the uncontrolled item needs to be tested at the designated analysis module, if some of the uncontrolled item is designated to be tested at the originally allocated analysis module 100 for the patient sample of the uncontrolled item, the controller 130 controls the dispatcher 120 to dispatch the patient sample to a preset buffer for waiting; until when the runaway item is again under control on the analysis module, the controller 130 controls the scheduler to schedule the patient sample from the buffer to the analysis module 100 for testing of the runaway item-this is for a sample analysis system that can callback or buffer the patient sample; for sample analysis systems that cannot call back a patient sample, after the controller 130 masks the testing of the analysis module for the out of control item, for patient samples that are required to be tested for the out of control item to the analysis module 100, the controller 130 controls the scheduler 120 to schedule the patient sample to a location for retrieval by a user until, when the out of control item is re-controlled on the analysis module 100, if the patient sample is re-entered, the controller 130 controls the scheduler 120 to schedule the patient sample to the analysis module 100 for the testing of the out of control item.
The above is an illustration of some of the processing of patient samples that have been tested for uncontrolled items by the sample analysis system. The sample analysis system will now be described with respect to the processing of patient samples that have been subjected to a runaway program at the module analysis 100.
In one embodiment, when the analysis module 100 determines that the quality control item is out of control, the controller 130 also searches for a patient sample affected by the out of control item; in one embodiment the patient sample affected by the runaway item comprises: patient samples of the uncontrolled item were also taken after the point in time at which the uncontrolled item was last tested at the time of control by the analysis module 100. The test time point of an item may refer to the time point at which the item is blotted.
In one embodiment, the controller 130 dispatches the patient sample affected by the out of control item to a predetermined buffer for waiting; when it is determined that the runaway item is under control on any of the analysis modules 100, the controller 130 controls the scheduler 120 to schedule the patient sample from the buffer to the analysis module 100 for retesting of the runaway item-for example, for sample analysis systems where the patient sample may be recalled or buffered, the controller 130 may do so. In one embodiment, the controller 130 dispatches the patient sample affected by the out of control item to a location for retrieval by the user; when it is determined that the out of control item is under control on any of the analysis modules 100, if the patient sample is again entered, the controller 130 controls the scheduler 120 to schedule the patient sample to the analysis module 100 for retesting the out of control item-for example, for a sample analysis system that cannot call back the patient sample, the controller 130 may do so.
In some cases, the patient sample affected by the out of control item needs to be tested at the original analysis module 100, i.e. retested as is, in which case in an embodiment the controller 130 may schedule the patient sample affected by the out of control item to a preset buffer waiting until when the out of control item is again under control at the analysis module 100, the controller 130 controls the scheduler 120 to schedule the patient sample from the buffer to the analysis module 100 for retesting the out of control item-for example, for a sample analysis system that may call back the patient sample or have a buffer, the controller 130 may take such a procedure; in one embodiment, the controller 130 may schedule the patient sample affected by the out of control item to a location for retrieval by the user until, when the out of control item is re-controlled at the analysis module 100 where it is located, if the patient sample is re-entered, the controller 130 controls the scheduler 120 to schedule the patient sample to the analysis module 100 for re-testing of the out of control item-for example, for a sample analysis system that cannot recall the patient sample, the controller 130 may do so.
It will be appreciated that the scheduling and retesting process described above is for patient samples affected by uncontrolled items, whether not on-board or on-board, as is the case with sample analysis systems. If a patient sample affected by an out of control item is not already in the sample analysis system, then when the out of control item is in control of the original analysis module 100 or the other analysis module 100, if the patient sample is again entered, the controller 40 controls the dispatch of the patient sample to the original analysis module 100 or the other analysis module 100 for retesting of the out of control item.
The above is a description of the sample analysis system as a cascade system, and a description of a single machine for testing and analyzing samples is provided below.
In one embodiment, a sample analysis device is disclosed. The sample analysis device may be a biochemical analysis device, an immunoassay device, a blood coagulation analysis device, or the like. Referring to fig. 6, in an embodiment, the sample analyzer may include a sample unit 10, a reagent unit 20, a measurement unit 30, and a controller 40, and in an embodiment, may further include any one or both of an input unit 50 and a display unit 60, and each of the following sections will be described.
The sample unit 10 is used for carrying a sample to be tested, and the sample is sucked and then provided to the measurement unit 30. Sample assembly 10 may have a variety of implementations. Sample assembly 10 may include sample distribution modules (SDM, sample Delivery Module) and front end rails in some examples; in other examples, the sample section 10 may be a sample tray that includes a plurality of sample sites where sample tubes, for example, may be placed, and the sample tray may be rotated to maneuver samples to corresponding locations for aspiration. The sample block 10 in some examples may further include a buffer for aiding in the scheduling of samples, providing a location for intermediation and buffering of the scheduling of samples, the buffer being sized and dimensioned according to the daily throughput or throughput of the sample analysis device.
The reagent unit 20 is for carrying a reagent, and the reagent is supplied to the measurement unit 30 after being suctioned. In some examples the reagent component 30 may be a reagent disk provided with reagent needles, the reagent disk being arranged in a disk-like configuration with a plurality of positions for carrying reagent containers, the reagent disk being rotatable and carrying reagent containers for rotating the reagent containers to a specific position, for example a position for sucking reagent by the reagent needles.
The measurement section 30 is for detecting a sample to obtain a sample detection result. The controller 40 is used to control the operation of the various components. The input means 50 may be used for inputting commands by a user, and the input means 50 may typically be a mouse, a keyboard or the like. The display unit 60 is used for displaying content, such as a software interface related to the sample analysis device, typically a sample application interface, a test result interface, and the like.
The above is some structures of the sample analysis device, when an out-of-control item appears in the sample analysis device, two aspects of treatment can be mainly carried out, firstly, the test of the out-of-control item is automatically shielded, so that the out-of-control item does not need to be shielded manually any more, and after the out-of-control item is out-of-control, the patient sample test on the out-of-control item is basically not carried out, and the number of patient samples which need to be retested as a result is effectively reduced and the subsequent manual operation is carried out; secondly, searching patient samples affected by the uncontrolled project, which makes it unnecessary to manually check and find out patient samples for the uncontrolled project, thereby saving labor and time; the following will specifically describe each.
In one embodiment, when it is determined that a quality control item is out of control, the controller 40 masks the test for the out of control item, e.g., for a patient sample for which the out of control item test has not been performed, the controller 40 controls the test for the out of control item not to be performed on the patient sample. In some examples, for patient samples that have not been tested for the uncontrolled item, the controller 40 may control the patient sample to be tested for the controlled item and/or for items for which the quality control results have not been shown, in addition to controlling the patient sample not to be tested for the uncontrolled item. In one embodiment, the controller 40 may also control the scheduling of patient samples to a predetermined buffer for waiting after the test for the mask runaway item; until the runaway item is again in control, the controller 40 then controls the patient sample to be dispatched from the buffer for testing of the runaway item-for example, for sample analysis devices that may call back patient samples or have buffers, the controller 40 may do so; the controller 40 in one embodiment may also control the scheduling of patient samples to locations for retrieval by the user after testing to mask the out of control item; until when the runaway item is again in control, if the patient sample is again entered, the controller 40 controls the testing of the patient sample for the runaway item-for example, for a sample analysis device that cannot call back the patient sample, the controller 40 may do so.
In one embodiment, when it is determined that there is a runaway of the quality control item, the controller 40 looks for a patient sample that is affected by the runaway item. In one embodiment, the patient sample affected by the runaway item comprises: patient samples of the runaway item were also taken after the point in time at which the runaway item was last tested at the time of control on the sample analysis device. The test time point of an item may refer to the time point at which the item is blotted. After locating the patient samples affected by the runaway item, the controller 40 may control the patient samples to retest after the runaway item is again under control. For example, in one embodiment controller 40 may schedule the patient sample affected by the runaway item to a predetermined buffer for waiting; until the runaway item is again in control, the controller 40 then controls the dispatch of the patient sample from the buffer for retesting of the runaway item-for example, for sample analysis devices that may call back the patient sample or have buffers, the controller 40 may do so; for another example, the controller 40 may in one embodiment schedule the patient sample affected by the out of control item to a location for retrieval by the user; until when the runaway item is again in control, if the patient sample is again entered, the controller 40 controls retesting of the runaway item on the patient sample-for example, for a sample analysis device that cannot call back the patient sample, the controller 40 may do so. The above is the case where the patient sample affected by the runaway item is also in the sample analysis device; if a patient sample affected by an out of control item is not already in the sample analysis device, then when the out of control item is re-controlled, the controller 40 controls re-testing of the out of control item for the patient sample if the patient sample is re-entered.
The embodiment of the invention also discloses a processing method (hereinafter referred to as a processing method) for the out-of-control quality control project. Referring to fig. 7, the processing method in an embodiment includes steps S100 to S130.
Step S100: and controlling the quality control sample and the patient sample to be tested in parallel.
Step S110: and judging whether any analysis module has out-of-control quality control items.
Step S120: and when judging that the quality control project of the analysis module is out of control, shielding the test of the out-of-control project of the analysis module. Step S120, when it is determined that the quality control item of the analysis module is out of control, the test of the out of control item of the analysis module is masked, for example, in some examples, step S120 controls the patient sample to be scheduled to the analysis module for the test of the in-control item; for another example, for patient samples that need to be tested to the analysis module, step S120 controls the scheduling of the patient samples to the analysis module for testing items for which the quality control results are not yet available; for another example, for a patient sample that is required to be tested to the analysis module, step S120 controls the patient sample not to be tested for the runaway item on the analysis module. The testing of how to shield the analysis module from uncontrolled events is described in detail above and is not repeated here.
Step S130: after the test of the out-of-control item of the shielding analysis module, judging whether the out-of-control item is controlled on other analysis modules or not for a patient sample which needs to be subjected to the out-of-control item test by the analysis module; when the out of control item is determined to be in control on the other analysis module, step S140 controls the scheduling of the patient sample to the other analysis module for testing of the out of control item. In some examples, after screening out a test for an out of control item of an analysis module, for patient samples that require the out of control item to be tested to the analysis module, if the out of control item is also out of control or quality control results on other analysis modules, for sample analysis systems that can call back or buffer the patient sample to a preset buffer waiting until the out of control item is scheduled from the buffer to an analysis module (e.g., the first analysis module described above) for the test for the out of control item when the out of control item is in control on any analysis module; for sample analysis systems that are unable to recall a patient sample, control dispatches the patient sample to a location for retrieval by a user until when the out of control item is in control on any of the analysis modules, such as the first analysis module, if the patient sample is re-entered, control dispatches the patient sample to the analysis module (such as the first analysis module described above) for testing of the out of control item. In some cases, after the test of the out-of-control item of the shielding analysis module, in order to ensure the consistency and accuracy of the test result, some out-of-control items need to be tested on patient samples of the out-of-control item by the designated analysis module, if the out-of-control item is designated on the originally allocated analysis module for testing, the patient samples can be controlled to be scheduled to a preset buffer area for waiting; until when the runaway item is again under control on the analysis module, control dispatches the patient sample from the buffer to the analysis module for testing of the runaway item-this is for a sample analysis system that can callback the patient sample or have a buffer; for sample analysis systems that cannot call back patient samples, the patient samples that need to be tested for the runaway item to the analysis module may be scheduled to a location for retrieval by a user after the testing of the runaway item by the analysis module is masked until the patient samples are again controlled to be scheduled to the analysis module for the testing of the runaway item if the patient samples are again entered when the runaway item is again under control on the analysis module. For more specific description, reference is made to the above description of the controller 130, and no further description is given here. It should be noted that step S130 and step S140 are not necessary in some examples. In addition, the processing method in other examples may also include related steps and procedures for searching for patient samples affected by the uncontrolled item, and in particular, the above description of how the sample analysis system and the sample analysis device search for patient samples affected by the uncontrolled item and retest the patient samples will not be repeated herein.
Reference is made to various exemplary embodiments herein. However, those skilled in the art will recognize that changes and modifications may be made to the exemplary embodiments without departing from the scope herein. For example, the various operational steps and components used to perform the operational steps may be implemented in different ways (e.g., one or more steps may be deleted, modified, or combined into other steps) depending on the particular application or taking into account any number of cost functions associated with the operation of the system.
In the above embodiments, it may be implemented in whole or in part by software, hardware, firmware, or any combination thereof. Additionally, as will be appreciated by one of skill in the art, the principles herein may be reflected in a computer program product on a computer readable storage medium preloaded with computer readable program code. Any tangible, non-transitory computer readable storage medium may be used, including magnetic storage devices (hard disks, floppy disks, etc.), optical storage devices (CD-to-ROM, DVD, blu-Ray disks, etc.), flash memory, and/or the like. These computer program instructions may be loaded onto a general purpose computer, special purpose computer, or other programmable data processing apparatus to produce a machine, such that the instructions which execute on the computer or other programmable data processing apparatus create means for implementing the functions specified. These computer program instructions may also be stored in a computer-readable memory that can direct a computer or other programmable data processing apparatus to function in a particular manner, such that the instructions stored in the computer-readable memory produce an article of manufacture including means which implement the function specified. The computer program instructions may also be loaded onto a computer or other programmable data processing apparatus to cause a series of operational steps to be performed on the computer or other programmable apparatus to produce a computer implemented process such that the instructions which execute on the computer or other programmable apparatus provide steps for implementing the functions specified.
While the principles herein have been shown in various embodiments, many modifications of structure, arrangement, proportions, elements, materials, and components, which are particularly adapted to specific environments and operative requirements, may be used without departing from the principles and scope of the present disclosure. The above modifications and other changes or modifications are intended to be included within the scope of this document.
The foregoing detailed description has been described with reference to various embodiments. However, those skilled in the art will recognize that various modifications and changes may be made without departing from the scope of the present disclosure. Accordingly, the present disclosure is to be considered as illustrative and not restrictive in character, and all such modifications are intended to be included within the scope thereof. Also, advantages, other advantages, and solutions to problems have been described above with regard to various embodiments. The benefits, advantages, solutions to problems, and any element(s) that may cause any benefit, advantage, or solution to occur or become more pronounced are not to be construed as a critical, required, or essential feature. The terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, system, article, or apparatus. Furthermore, the term "couple" and any other variants thereof are used herein to refer to physical connections, electrical connections, magnetic connections, optical connections, communication connections, functional connections, and/or any other connection.

Claims (15)

1. A cascaded sample analysis system, comprising:
the analysis modules are used for testing the samples;
the system comprises a track connected with each analysis module and a scheduling device for scheduling samples to be tested to the corresponding analysis modules through the track;
the controller is used for controlling the parallel test of the quality control sample and the patient sample; in the testing process, for any analysis module, the controller judges whether the analysis module has out-of-control quality control items; when the analysis module is judged to have the quality control project out of control, the controller shields the patient sample from testing the out of control project on the analysis module.
2. The sample analysis system of claim 1, wherein when the analysis module is determined to have a quality control item out of control, the controller shields the patient sample from testing for the out of control item on the analysis module, comprising: and controlling to stop the test of the uncontrolled item on the analysis module with the uncontrolled item and/or for the patient sample which needs to be tested to the analysis module, wherein the controller controls the scheduling device to schedule the patient sample to the analysis module for only testing the controlled item and/or the item with the quality control result not yet displayed.
3. A sample analysis system as claimed in claim 1 or claim 2, wherein the controller masks the test of an uncontrolled item for an analysis module, and when the controller determines that the uncontrolled item is in control on another analysis module for a patient sample for which the uncontrolled item test is required for that analysis module, the controller controls the scheduling means to schedule the patient sample to the other analysis module for the test of the uncontrolled item.
4. The sample analysis system of claim 1 or 2, wherein after the controller shields the analysis module from the test of the uncontrolled item, when the controller determines that the uncontrolled item is also out of control or the quality control result is not out of control on other analysis modules, the controller controls the dispatching device to dispatch the patient sample to a preset buffer for waiting; until the uncontrolled item is judged to be controlled on any analysis module, the controller controls the scheduling device to schedule the patient sample from the buffer zone to the analysis module for testing the uncontrolled item; or,
after the controller shields the test of the out-of-control item of the analysis module, for the patient sample which needs to be tested for the out-of-control item to the analysis module, when the controller judges that the out-of-control item is out-of-control or the quality control result is not yet obtained on other analysis modules, the controller controls the dispatching device to dispatch the patient sample to a position for a user to take out; and if the patient sample is input again until the uncontrolled item is judged to be controlled on any analysis module, the controller controls the scheduling device to schedule the patient sample to the analysis module for testing the uncontrolled item.
5. A sample analysis system as claimed in claim 1 or claim 2, wherein the controller is arranged to control the scheduling means to schedule a patient sample to a predetermined buffer for waiting after the controller masks out of control testing of the analysis module for the patient sample for which out of control testing is required to the analysis module; until when the out of control item is re-controlled on the analysis module, the controller controls the scheduling device to schedule the patient sample from the buffer zone to the analysis module for testing of the out of control item; or,
after the controller shields the test of the uncontrolled project of the analysis module, for the patient sample which needs to be tested for the uncontrolled project to the analysis module, the controller controls the dispatching device to dispatch the patient sample to a position for a user to take out; until when the out of control item is re-controlled on the analysis module, if the patient sample is re-entered, the controller controls the scheduling means to schedule the patient sample to the analysis module for testing of the out of control item.
6. The sample analysis system of claim 1, wherein when the analysis module is judged to have a quality control item out of control, the controller further looks for a patient sample affected by the out of control item; the patient sample affected by the runaway item includes: patient samples of the uncontrolled item were also taken after the time point of the last time the uncontrolled item was tested at the time of control.
7. The sample analysis system of claim 6, wherein the controller schedules the patient sample affected by the runaway item to a predetermined buffer wait; when the uncontrolled item is judged to be controlled on any analysis module, the controller controls the scheduling device to schedule the patient sample from the buffer zone to the analysis module for retesting of the uncontrolled item; or,
the controller dispatches the patient sample affected by the out-of-control item to a location for retrieval by a user; when the out-of-control item is judged to be controlled on any analysis module, if the patient sample is input again, the controller controls the dispatching device to dispatch the patient sample to the analysis module for retesting of the out-of-control item.
8. The sample analysis system of claim 6, wherein the controller schedules the patient sample affected by the runaway item to a predetermined buffer wait; until when the out-of-control item is re-controlled at the analysis module where the out-of-control item is located, the controller controls the scheduling device to schedule the patient sample from the buffer zone to the analysis module for re-measurement of the out-of-control item; or,
The controller dispatches the patient sample affected by the out-of-control item to a location for retrieval by a user; and if the patient sample is input again until the out-of-control item is under control again in the analysis module where the out-of-control item is located, the controller controls the scheduling device to schedule the patient sample to the analysis module for retesting of the out-of-control item.
9. A sample analysis device, comprising:
a measurement section for detecting a sample to obtain a sample detection result;
the sample component is used for bearing a sample to be tested, sucking the sample and providing the sample to the measuring component;
a reagent member for carrying a reagent, sucking the reagent and supplying the sucked reagent to the measuring member;
the controller is used for controlling the parallel test of the quality control sample and the patient sample; in the testing process, judging whether a quality control item is out of control or not; when it is determined that there is a quality control item out of control, the controller masks the testing of the patient sample for the out of control item.
10. The analytical device of claim 9, wherein when it is determined that there is a runaway of the quality control item, the controller masks testing of the runaway item, comprising: stopping the test of the out-of-control item, and/or for a patient sample not yet tested for the out-of-control item, controlling the test of only the in-control item and/or the item for which the quality control result is not yet obtained by the controller.
11. The analytical device of claim 9, wherein after the controller masks the testing of the runaway item, the controller further controls the scheduling of patient samples to a predetermined buffer waiting; until the runaway item is again under control, the controller controls the patient sample to be dispatched from the buffer zone to conduct retesting of the runaway item; or,
after the controller shields the test of the out of control item, the controller also controls the scheduling of patient samples to a location for retrieval by a user; until when the runaway item is again under control, if the patient sample is again entered, the controller controls retesting the runaway item on the patient sample.
12. A method for handling uncontrolled control of a quality control project, comprising:
controlling the quality control sample and the patient sample to be tested in parallel;
judging whether any analysis module has out-of-control quality control items;
and when judging that the analysis module has the quality control project out of control, shielding the patient sample from testing the out of control project on the analysis module.
13. The method of claim 12, wherein when it is determined that the analysis module has a quality control item out of control, masking the testing of the analysis module for the out of control item, comprising: and controlling to stop the test of the uncontrolled item on the analysis module with the uncontrolled item and/or controlling to dispatch the patient sample to the analysis module for the test of the item which is not yet controlled by the control item and/or the quality control result for the patient sample which needs to be tested by the analysis module.
14. A method of processing according to claim 12 or 13, wherein after screening out a test for an uncontrolled item of an analysis module, for a patient sample for which the uncontrolled item test is required to be performed to the analysis module, when the uncontrolled item is determined to be in control on another analysis module, control is provided to dispatch the patient sample to the other analysis module for the test for the uncontrolled item.
15. A computer readable storage medium comprising a program executable by a processor to implement the method of any one of claims 12 to 14.
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